EA199700395A1 - METHOD FOR OBTAINING INHIBITORS OF THE VIRUS PROTEASE OF HUMAN IMMUNODEFICIENCY - Google Patents

METHOD FOR OBTAINING INHIBITORS OF THE VIRUS PROTEASE OF HUMAN IMMUNODEFICIENCY

Info

Publication number
EA199700395A1
EA199700395A1 EA199700395A EA199700395A EA199700395A1 EA 199700395 A1 EA199700395 A1 EA 199700395A1 EA 199700395 A EA199700395 A EA 199700395A EA 199700395 A EA199700395 A EA 199700395A EA 199700395 A1 EA199700395 A1 EA 199700395A1
Authority
EA
Eurasian Patent Office
Prior art keywords
human immunodeficiency
virus protease
obtaining inhibitors
inhibitors
obtaining
Prior art date
Application number
EA199700395A
Other languages
Russian (ru)
Other versions
EA000637B1 (en
Inventor
Дэвид Аскин
Джесс В. Сейджер
Кай Россен
Ральф П. Воланте
Пол Дж. Рейдер
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199700395A1 publication Critical patent/EA199700395A1/en
Publication of EA000637B1 publication Critical patent/EA000637B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Способ получения Соединения J, клинически эффективного ингибитора ВИЧ протеазы, сокращается на одну стадию посредством усовершенствованного альтернативного синтеза промежуточного продукта 2(S)-4-пиколил-2-пиперазин-трет-бутилкарбоксамида.Международная заявка была опубликована вместе с отчетом о международном поиске.A method for preparing Compound J, a clinically effective HIV protease inhibitor, is reduced by one stage through improved alternative synthesis of intermediate 2 (S) -4-picolyl-2-piperazine-tert-butylcarboxamide. The international application was published along with an international search report.

EA199700395A 1995-05-18 1996-05-14 Process for making hiv protease inhibitors EA000637B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/443,631 US5612484A (en) 1995-05-18 1995-05-18 Process for making HIV protease inhibitors
PCT/US1996/006846 WO1996036629A1 (en) 1995-05-18 1996-05-14 Process for making hiv protease inhibitors

Publications (2)

Publication Number Publication Date
EA199700395A1 true EA199700395A1 (en) 1998-08-27
EA000637B1 EA000637B1 (en) 1999-12-29

Family

ID=23761574

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700395A EA000637B1 (en) 1995-05-18 1996-05-14 Process for making hiv protease inhibitors

Country Status (8)

Country Link
US (1) US5612484A (en)
CN (2) CN1491945A (en)
AR (1) AR001889A1 (en)
AU (1) AU5746296A (en)
BR (1) BR9608467A (en)
EA (1) EA000637B1 (en)
TW (1) TW442475B (en)
WO (1) WO1996036629A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT805803E (en) * 1995-01-23 2003-03-31 Lonza Ag METHOD FOR PRODUCING AMIDES OF ACID 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID
US5698697A (en) * 1995-07-19 1997-12-16 Mitsubishi Chemical Corporation 2-cyanopiperazine and method of producing the same
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
NL1006305C2 (en) * 1997-06-13 1998-12-15 Dsm Nv Process for the preparation of (1S, 2R) -1-amino-2-indanol- (R, R) -tartrate methanol solvate.
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
US6521561B1 (en) 1998-05-01 2003-02-18 President And Fellows Of Harvard College Main-group metal based asymmetric catalysts and applications thereof
CA2513716A1 (en) * 2003-02-14 2004-08-26 Applied Research Systems Ars Holding N.V. Piperazine-2-carboxamide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
TW472047B (en) * 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors

Also Published As

Publication number Publication date
WO1996036629A1 (en) 1996-11-21
TW442475B (en) 2001-06-23
US5612484A (en) 1997-03-18
EA000637B1 (en) 1999-12-29
BR9608467A (en) 1998-12-29
CN1491945A (en) 2004-04-28
CN1190966A (en) 1998-08-19
AR001889A1 (en) 1997-12-10
AU5746296A (en) 1996-11-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU