EA045233B1 - SYSTEM AND METHODS OF IMPLEMENTATION OF A DEVICE FOR PROCESSING BIOLOGICAL FLUID - Google Patents

Description

Cross reference to related applications

This application claims priority to U.S. Provisional Patent Application No. 62/868

859, filed June 28, 2019, the contents of which are incorporated herein by reference in their entirety.

Field of invention

The present invention generally relates to systems, methods and devices for treating biological fluids, including mixtures of biological fluids and photochemical reagents, using light, and more particularly to a system architecture for implementing and coordinating various systems and subsystems of a biological fluid processing device.

State of the art

Systems and methods for treating biological fluids with light are well known. For example, US Pat. Nos. 7,459,695, 6,986,867, and 5,593,823 describe a system for treating a biological fluid with light to inactivate pathogens in a biological fluid. Light is emitted in a selected spectral range of wavelengths effective for inactivating pathogens in biological fluids, in particular by photochemical inactivation of pathogens. Other systems and methods for processing biological fluids with light include, for example, systems and methods described in US patents No. 6843961, 7829867, 9320817 and 8778263, as well as Schlenke, 2014, Transfus. Med. Hemother. 41:309-325.

For blood products, including, for example, platelets, plasma components and their derivatives, it is important to ensure the absence of pathogens to minimize the risk of infection to the individual receiving the blood product. The use of blood pathogen assays is limited by the list of pathogens for which testing is available and the sensitivity of the assay. As an alternative or adjunct to pathogen testing, methods are known in the art to inactivate pathogens using various substance-based (e.g., chemical, photochemical) inactivation methods to reduce the risk of transfusion transmission (e.g., as described in Schlenke et al., Transfus Med Hemother, 2014, 41, 309-325 and Prowse, Vox Sanguinis, 2013, 104, 183-199). Photochemical pathogen inactivation systems that use psoralens and ultraviolet light to process blood products include the commercially available INTERCEPT® Blood Processing System (Cerus Corporation), which uses disposable processing kits and an ultraviolet irradiation device (INT-100). Blood products, such as plasma or platelets, are mixed with psoralen, amotosalen in processing kits and then irradiated with ultraviolet A light. Several different disposable processing kits may be used depending on the type of blood product being processed and the specific properties of these products blood, in particular, for example, volume and platelet count.

Electronic devices that are configured to process biological fluids may typically comprise a different set of systems and subsystems that must operate in a coordinated manner to process the biological fluid. For example, an electronic device that is configured to irradiate (e.g., irradiate) a biological fluid (e.g., with or without a pathogen inactivating composition) to inactivate potential pathogens in the fluid may include a variety of systems, such as a lighting system, a device for shaking, safety system, etc. These various systems must function together to ensure proper performance of biological fluid treatment.

Although known systems and methods for processing biological fluids such as blood products, including, for example, platelets and plasma, as well as their derivatives, have generally worked satisfactorily, due to the high level of coordination that may be required from components within the device, the process fluid processing can be inefficient and expensive in terms of computing and hardware resources. Additionally, the system architectures of these devices may not be ideal for changes made to the device. For example, if a safety-critical or non-safety-critical component of a device is replaced or modified, such as due to enhancement or obsolescence, or if one or more additional safety-critical or non-safety-critical components are added to the device, the change may have a significant impact on other components inside the device. Such influences may include regulatory approvals or standards that such components and device must generally meet in order for the device to be approved for commercial use.

In addition, the device may include components that can be accessed externally (ie, through a connection to an external computer network), which may make them vulnerable to hacking or unauthorized access. Because the device contains many safety-critical components, if a malicious user could exploit

- 1 045233 external access to a device to gain control over it may compromise the security and efficiency of the processing protocols performed by the device.

Given the high level of coordination between complex systems that may be required in operating a body fluid treatment device, there may be a need to have a system and method of implementing a body fluid treatment device that maximizes the coordination of the various systems of the device while also minimizing cost, inefficiencies and /or safety hazards associated with the operation of such a device.

The essence of the invention

Disclosed herein are electronic devices for processing biological fluids and methods of operating said devices. Some examples of the present invention relate to an electronic device, wherein the electronic device includes a plurality of components configured together to process one or more biological fluids, and the device comprises: a first group of components, wherein the first group of components includes one or more components configured configured to receive one or more data inputs from a user of the device, a first controller communicatively coupled to the first group of components and configured to control the first group of components using one or more commands formatted using the first communication protocol; a second group of components, wherein the second group of components comprises: one or more platforms, each platform of the one or more platforms being configured to carry a biological fluid from the one or more biological fluids, one or more lighting devices, each lighting device being configured to irradiating a biological fluid from one or more biological fluids; and a second controller communicatively coupled to the second group of components and communicatively coupled to the first controller, wherein said second controller is configured to coordinate one or more operations associated with the second group of components, wherein the second controller communicates with the first the controller and a second group of components using a second communication protocol, wherein the second communication protocol is configured such that the second group of components operates in response to one or more commands received from the second controller using the second communication protocol.

In addition or as an alternative to one or more examples described above, the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using a second communication protocol. In addition or as an alternative to one or more of the examples described above, a message transmitted over a second communication protocol includes information about a component generating the message. In addition or as an alternative to one or more examples described above, the first group of components includes one or more components configured to allow an external user to interact with the device. In addition to or as an alternative to one or more examples described above, a first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. In addition or as an alternative to one or more of the examples described above, the device is configured to receive one or more data inputs from a device component, including a scanner or sensor. In addition or as an alternative to one or more examples described above, the display is a touch screen display configured to receive one or more touch inputs from a user of the device. In addition to or as an alternative to one or more of the examples described above, the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. In addition to or as an alternative to one or more of the examples described above, the scanner is configured to collect identifying information in visible form (e.g., bar code, QR code, etc.) or in radio wave form (e.g., RFID) , which is associated with a biological fluid (for example, on a container associated with a container). In addition to or as an alternative to one or more examples described above, the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from the one or more biological fluids such that distribute the biological fluid within a container that is located on a platform of one or more platforms of the device. In addition to or as an alternative to one or more examples described above, the device further comprises one or more processing chambers configured to receive a biological fluid from the one or more biological fluids, wherein each platform of the one or more platforms is configured to dispose in a processing chamber of one or more processing chambers. In addition to or as an alternative to one or more

- 2 045233 examples described above, the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid. In addition to or as an alternative to one or more examples described above, the one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid, and wherein the one or more groups of light sources are configured to emit light in the ultraviolet spectrum. In addition or as an alternative to one or more examples described above, each of the one or more groups of light sources includes a first light source channel configured to emit ultraviolet light with a first peak wavelength of from about 315 nm to about 350 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, each of which emits full-width half-maximum (FWHM) light. spectral band less than 20 nm. In addition or as an alternative to one or more examples described above, one or more groups of light sources comprise one or more light sources, each of which emits light with a full width at half maximum (FWHM) of a spectral band of less than 20 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, wherein the one or more light sources are light emitting diodes (LED). In addition or as an alternative to one or more examples described above, one or more light source groups comprise one or more light sources, wherein one or more light sources are light emitting diodes (LEDs). In addition or as an alternative to one or more of the examples described above, the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources. In addition or as an alternative to one or more examples described above, the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by one or more sensors. In addition or as an alternative to one or more examples described above, the device further comprises a first treatment chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to carry a first biological fluid and placed in the first treatment chamber; a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber. In addition to or as an alternative to one or more examples described above, the device is further configured to receive one or more data inputs from a user of the device, wherein the device is configured to: transmit one or more commands using a first communication protocol to the first controller wherein one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids; in the first controller, converting one or more commands in the first communication protocol into one or more commands in the second communication protocol, and transmitting one or more commands in the second communication protocol to the second controller; and in a second controller, converting the received one or more commands in the second communication protocol into one or more commands for controlling one or more components of the second group of components and transmitting one or more commands to one or more components of the second group of components, wherein the one or more commands for controlling one or more components of the second group of components, configured to cause the device to process a biological fluid of the one or more biological fluids. In addition or as an alternative to one or more examples described above, treating the one or more biological fluids involves irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids.

Some examples of the present invention relate to a method of processing one or more biological fluids in an electronic device, the method including: receiving one or more inputs from a user of the device; transmitting one or more commands via a first communication protocol to a first controller of the device, wherein the one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids, wherein the first controller is communicatively coupled to a first group of components of the device, and configured to control the first group of components using one or more commands formatted using the first communication protocol; in the first controller, converting the one or more commands in the first communication protocol into one or more commands in the second communication protocol and transmitting the one or more commands in the second protocol

- 3 045233 connections to the second device controller; and in a second controller, converting received one or more commands in a second communication protocol into one or more commands for controlling one or more components of a second group of device components, and transmitting one or more commands to one or more components of a second group of components, wherein one or more commands for controlling one or more components of the second group of components are configured to cause the device to process a biological fluid of the one or more biological fluids.

In addition to or as an alternative to one or more examples described above, a second set of components comprises one or more platforms, each platform of the one or more platforms configured to carry a biological fluid of the one or more biological fluids; and one or more lighting devices, each lighting device configured to irradiate a biological fluid from the one or more biological fluids. In addition or as an alternative to one or more examples described above, the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using a second communication protocol. In addition or as an alternative to one or more of the examples described above, a message transmitted over a second communication protocol includes information about a component generating the message. In addition or as an alternative to one or more examples described above, the first group of components includes one or more components configured to allow an external user to interact with the device. In addition to or as an alternative to one or more examples described above, the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. In addition or as an alternative to one or more examples described above, the display is a touch screen display configured to receive one or more touch inputs from a user of the device. In addition to or as an alternative to one or more of the examples described above, the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. In addition to or as an alternative to one or more examples described above, the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from the one or more biological fluids such that distribute the biological fluid within a container that is located on a platform of one or more platforms of the device. In addition or as an alternative to one or more examples described above, the electronic device includes one or more processing chambers configured to receive a biological fluid from one or more biological fluids, wherein each platform of the one or more platforms is configured to dispose in a processing chamber of one or more processing chambers. In addition or as an alternative to one or more examples described above, the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid. In addition to or as an alternative to one or more examples described above, the one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid from the one or more biological fluids, and wherein the one or more groups of light sources The lights are designed to emit light in the ultraviolet spectrum. In addition or as an alternative to one or more examples described above, each of the one or more groups of light sources includes a first light source channel configured to emit ultraviolet light with a first peak wavelength of from about 315 nm to about 350 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, each of which emits full-width half-maximum (FWHM) light. spectral band less than 20 nm. In addition or as an alternative to one or more examples described above, one or more groups of light sources comprise one or more light sources, each of which emits light with a full width at half maximum (FWHM) of a spectral band of less than 20 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, wherein the one or more light sources are light emitting diodes (LED). In addition or as an alternative to one or more examples described above, one or more light source groups comprise one or more light sources, wherein one or more light sources are light emitting diodes (LEDs). In addition or as an alternative to one or more of the examples described above, the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources. In addition to or as an alternative to one or more examples described above, the second controller

- 4 045233 is configured to enable or disable one or more components from the second group of components based on one or more signals transmitted by one or more sensors. In addition or as an alternative to one or more examples described above, the device further comprises: a first treatment chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to carry a first biological fluid and placed in the first treatment chamber; a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber. In addition or as an alternative to one or more examples described above, the device is further configured to receive one or more data inputs from a user of the device, wherein the device is configured to: transmit one or more commands using a first communication protocol to the first controller wherein one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids; in the first controller, converting one or more commands in the first communication protocol into one or more commands in the second communication protocol, and transmitting one or more commands in the second communication protocol to the second controller; and in a second controller, converting the received one or more commands in the second communication protocol into one or more commands for controlling one or more components of the second group of components and transmitting one or more commands to one or more components of the second group of components, wherein the one or more commands for controlling one or more components of the second group of components, configured to cause the device to process a biological fluid of the one or more biological fluids. In addition or as an alternative to one or more examples described above, treating the one or more biological fluids involves irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids.

Some examples of the present invention relate to a computer-readable storage medium storing one or more programs, wherein the one or more programs comprise instructions that, when executed by an electronic device configured to process one or more biological fluids, cause the device to do the following: receive one or more inputs data from the device user; transmitting one or more commands via a first communication protocol to a first controller of the device, wherein the one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids, wherein the first controller is communicatively coupled to a first group of components of the device, and configured to control the first group of components using one or more commands formatted using the first communication protocol; in a first controller, converting one or more commands in a first communication protocol into one or more commands in a second communication protocol, and transmitting one or more commands in a second communication protocol to a second device controller, and in a second controller converting received one or more commands in a second communication protocol into one or more commands for controlling one or more components of a second group of components of the apparatus, and transmitting one or more commands to one or more components of the second group of components, wherein the one or more commands for controlling one or more components of a second group of components are configured such that to enable the device to process a biological fluid from one or more biological fluids.

In addition to or as an alternative to one or more examples described above, a second set of components comprises one or more platforms, each platform of the one or more platforms configured to carry a biological fluid of the one or more biological fluids; and one or more lighting devices, each lighting device configured to irradiate a biological fluid from the one or more biological fluids. In addition or as an alternative to one or more examples described above, the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using a second communication protocol. In addition or as an alternative to one or more of the examples described above, a message transmitted over a second communication protocol includes information about a component generating the message. In addition or as an alternative to one or more examples described above, the first group of components includes one or more components configured to allow an external user to interact with the device. In addition to or as an alternative to one or more examples described above, the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. In addition or

- 5 045233 As an alternative to one or more of the examples described above, the display is a touch screen display configured to receive one or more touch inputs from a user of the device. In addition to or as an alternative to one or more of the examples described above, the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. In addition to or as an alternative to one or more examples described above, the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from the one or more biological fluids such that distribute the biological fluid within a container that is located on a platform of one or more platforms of the device. In addition or as an alternative to one or more examples described above, the electronic device includes one or more processing chambers configured to receive a biological fluid from one or more biological fluids, wherein each platform of the one or more platforms is configured to dispose in a processing chamber of one or more processing chambers. In addition or as an alternative to one or more examples described above, the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid. In addition to or as an alternative to one or more examples described above, the one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid from the one or more biological fluids, and wherein the one or more groups of light sources The lights are designed to emit light in the ultraviolet spectrum. In addition or as an alternative to one or more examples described above, each of the one or more groups of light sources includes a first light source channel configured to emit ultraviolet light with a first peak wavelength of from about 315 nm to about 350 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, each of which emits full-width half-maximum (FWHM) light. spectral band less than 20 nm. In addition or as an alternative to one or more examples described above, one or more groups of light sources comprise one or more light sources, each of which emits light with a full width at half maximum (FWHM) of a spectral band of less than 20 nm. In addition or as an alternative to one or more examples described above, the first channel of light sources includes one or more light sources, wherein the one or more light sources are light emitting diodes (LED). In addition or as an alternative to one or more examples described above, one or more light source groups comprise one or more light sources, wherein one or more light sources are light emitting diodes (LEDs). In addition or as an alternative to one or more of the examples described above, the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources. In addition or as an alternative to one or more examples described above, the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by one or more sensors. In addition or as an alternative to one or more examples described above, the device further comprises: a first treatment chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to carry a first biological fluid and placed in the first treatment chamber; a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber. In addition or as an alternative to one or more examples described above, the device is further configured to receive one or more data inputs from a user of the device, wherein the device is configured to transmit one or more commands using a first communication protocol to the first controller, wherein one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids; in the first controller, converting one or more commands in the first communication protocol into one or more commands in the second communication protocol, and transmitting one or more commands in the second communication protocol to the second controller; and in a second controller, converting the received one or more commands in the second communication protocol into one or more commands for controlling one or more components of the second group of components and transmitting one or more commands to one or more components of the second group of components, wherein the one or more commands to control one or more

- 6 045233 components from the second group of components are configured to allow the device to process a biological fluid from one or more biological fluids. In addition or as an alternative to one or more examples described above, treating the one or more biological fluids involves irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids.

Brief description of graphic materials

In fig. 1 shows an exemplary device for treating biological fluids in accordance with examples of the present invention.

In fig. 2A-2C show other illustrative views of the device described with reference to FIGS. 1, for treating biological fluids in accordance with examples of the present invention.

In fig. 3 shows another exemplary device for treating biological fluids in accordance with examples of the present invention.

In fig. 4 is an illustrative flow diagram of a system for treating biological fluid in accordance with examples of the present invention.

In fig. 5 is a perspective view of an exemplary system for treating biological fluid in accordance with examples of the present invention.

In fig. 6 is a perspective view of an exemplary system for treating biological fluid in accordance with examples of the present invention.

In fig. 7 is a perspective view of an exemplary system for treating biological fluid in accordance with examples of the present invention.

In fig. 8A-8B are perspective views of an exemplary system for treating biological fluid in accordance with examples of the present invention.

In fig. 9 shows an example of the internal hardware layout of a system for treating biological fluid in accordance with examples of the present invention.

In fig. 10 is an illustrative diagram of an irradiation system for treating biological fluids in accordance with examples of the present invention.

In fig. 11 illustrates an example of a component architecture of an irradiation system for treating biological fluids in accordance with examples of the present invention.

In fig. 12 is an illustrative block diagram of a system for treating biological fluids in accordance with examples of the present invention.

In fig. 13 illustrates an exemplary implementation of a domain-specific communication protocol in accordance with examples of the present invention.

In fig. 14 illustrates an exemplary method of operation of an exemplary system for treating biological fluids in accordance with examples of the present invention.

In fig. 15 illustrates an example of a computing device in accordance with examples of the present invention.

Detailed description of the invention

The following description sets forth exemplary methods, parameters, etc. However, it should be understood that the description is not intended to limit the scope of the present invention and serves only as a description of illustrative embodiments.

In the following description of the present invention and its embodiments, reference is made to the accompanying drawings, which show by way of illustration specific embodiments that may be practiced. It should be understood that other embodiments and examples may be practiced and changes may be made without departing from the scope of the present invention.

In addition, it should be understood that the singular forms used in the following description also include the plural forms unless the context clearly indicates otherwise. It is further understood that the term and/or as used herein means and covers any possible combinations of one or more related enumerated elements. It should also be understood that the terms includes, including, contains and/or containing as used herein indicate the presence of the specified features, quantities, steps, operations, elements, components and/or blocks, but do not exclude the presence or addition one or more other features, integers, stages, operations, elements, components, blocks and/or groups thereof.

Certain portions of the following detailed description are presented in terms of algorithms and symbolic representations of operations on data bits in computer memory. These algorithmic descriptions and representations are tools used by data scientists to most effectively convey the essence of their work to other experts in the field. In this document, an algorithm as a whole is understood as a self-consistent sequence of steps (commands) leading to the desired result. Stages are those that require physical manipulation of physical quantities. Typically, although not necessarily, these quantities take the form of electrical, magnetic or optical signals that can be stored, transmitted,

- 7 045233 be combined, compared and subject to other manipulations. It is sometimes convenient, mainly for reasons of common usage, to call these signals bits, values, elements, symbols, signs, terms, numbers, etc. In addition, it is sometimes convenient to also refer to certain arrangements of steps that require physical manipulation of physical quantities as modules or code devices without loss of generality.

However, all of these and similar terms must be associated with corresponding physical quantities and are simply convenient labels applied to these quantities. Unless specifically stated otherwise, as is apparent from the following discussion, it is to be understood that throughout the description, discussions using terms such as processing, computing, calculating, determining, displaying, or the like, refer to the operation and processes of a computer system or the like an electronic computing device that manipulates and transforms data represented as physical (electronic) quantities in storage devices or registers of a computer system or in other similar devices for storing, transmitting or displaying information.

Certain aspects of the present invention may include process steps and instructions described herein in algorithm form. It should be noted that the process steps and instructions of the present invention can be embodied in software, firmware or hardware, and when embodied in software, they can be downloaded for placement on various platforms used by various operating systems, and for work with them.

In fig. 1 illustrates an exemplary system 100 for treating biological fluids. As used herein, the term biological fluid means any fluid present in or derived from an organism (e.g., human, animal, plant, or microorganism) or that contains one or more components (e.g., biological products) present in, isolated from or obtained from the body, including their synthetic versions. Body fluids may include, but are not limited to, blood and blood products, vaccines, cells (e.g., germ cells, cell lines, cell cultures), natural and recombinant peptides or proteins (e.g., drugs, antibodies), bacterial cultures, viral suspensions, etc. As used herein, the term blood product means blood (eg, whole blood) or a component or derivative of blood, such as, for example, red blood cells, white blood cells, platelets, plasma or components thereof (eg, coagulation factors, albumin, fibrinogen), cryoprecipitate and cryosuppernatant. (i.e., cryoprecipitate-depleted) plasma, or a combination of one or more such components that have been isolated from blood. In still other examples, the biological fluid may further comprise a non-biological fluid, such as, for example, a saline solution (e.g., a dilution solution), including, but not limited to, saline, buffer, nutrient solution, platelet storage solution (PAS). additive solution) and/or anticoagulant solution. In still other examples, when the biological fluid is located (e.g., the biological fluid is in a container, such as a treatment bag, located or resting on a platform) in a chamber (not shown) of the biological fluid treatment system, the biological fluid is irradiated with light (e.g., visible light). radiation, ultraviolet radiation), characterized by a specific spectral profile, with specific intensity values over a specific period of time.

The system 100 includes a power switch 110, a display 120, a scanner 130, a platform 140, and a platform 150. Although the system 100 shown in FIG. 1 includes the described elements, examples of the system 100 may include various combinations of the described elements or additional elements without departing from the scope of the present invention. In some examples, system 100 may communicate via a wired or wireless connection with a computing device (eg, computer, mobile device) (not shown).

In some examples, in response to operation of the power switch 110, electrical power is supplied to the system 100. For example, the power switch 110 may be a mechanical button. When the system 100 is de-energized, electrical power is supplied to the system 100 in response to the operation of the power switch 110 (eg, the system 100 turns on). When the system 100 is turned on, in response to the pressing of the power switch 110, the supply of electrical power to the system 100 is stopped (eg, the system 100 is turned off). In some examples, system 100 remains turned on during processing and does not turn off in response to the power switch being pressed.

As another example, the power switch 110 may be a capacitive switch that can be activated by touch (eg, by placing a user's finger on the power switch). As another example, the power switch may be a button having two or more states. The power switch may be in the off state when the power switch is in the first position (eg, unpressed, toggled to the first side). The power switch may be able to

- 8 045233 is on when the power switch is in the second position (for example, pressed, switched to the other side).

In some examples, display 120 is a touch screen. For example, display 120 may be a touch screen or resistive touch screen. In some examples, the display 120 is configured to display a graphical user interface (GUI) for operating the system 100. In some embodiments, the display 120 is configured to receive input from the scanner 130. In yet other examples, the display 120 is configured to with the ability to accept input from the GUI. For example, a GUI object from a plurality of GUI objects displayed on the GUI may be selected by subjecting the user to manual input (eg, touching or hovering) on a touch screen. In response to receiving input, system 100 may perform an operation associated with the selected GUI object. For example, a GUI object may be associated with initiating biological fluid processing, and in response to receiving input when the GUI object is selected, the system 100 initiates the biological fluid processing process. In still other examples, the display 120 is configured to display instructions to a user operator (eg, operator instructions) on a GUI. In some embodiments, the display 120 is configured to display input from the scanner 130 to a user operator. In some embodiments, the display 120 is configured to display input from an audio signal received by an audio input device (e.g., one or more microphones) and converted (e.g., by speech-to-text) by one or more processors into a visual form (e.g., text command, command code) on the display 120 that the user is able to recognize as an input command, such as, for example, a user's voice command picked up by one or more microphones (for example, placed in any configuration inside, outside, and/or as part of the system's external enclosure 100) and converted by one or more processors into command text on display 120 that a user can recognize as an input command. In some embodiments, the display 120 is configured to display input from a user's visual body movement (e.g., a movement or hand gesture, an object in a sweeping motion) received by a motion sensor (e.g., one or more cameras) and translated (e.g., by converting the motion into text, motion-to-graphics conversions) by one or more processors into a visual form (command text, command code, command icons, command graphics) on the display 120 that the user is able to recognize as an input command, such as, for example, a user gesture (e.g. , hand wave) captured by one or more cameras (e.g., placed in any configuration inside, outside, and/or as part of the external enclosure of the system 100) and converted by one or more processors into visual text or visual graphics of a command on display 120 that a user can recognized as an input command. Although in FIG. 1 shows a single display 120; in some examples, the system 100 may include more than one display.

By using a touch screen as a data input component and/or input from the scanner 130, the user interface of the system 100 can be simplified. For example, the use of a touch screen may reduce the need for physical buttons corresponding to functions that could similarly be performed using a touch screen. Treatment of biological fluid by system 100 can be made more efficient with a simplified user interface.

Although the power switch 110 and display 120 are described as elements of the system 100 that may be configured to receive user input, other elements or input means may be included within the system 100 without departing from the scope of the present invention. For example, the system 100 may include direction input keys, a mouse pad, or a scroll wheel configured to navigate a GUI displayed on the display 120. In some embodiments, the system 100 is configured to receive user input from an audio signal received by the input audio device (e.g., one or more microphones) and converted (e.g., by speech-to-text conversion) by one or more processors into a language form (e.g., command text, command code) that system 100 is capable of recognizing as an input command, such as, e.g. , a user's voice command captured by one or more microphones (e.g., placed in any configuration inside, outside, and/or as part of the external enclosure of the system 100) and converted by one or more processors into command text may be recognized by the system 100 as an input command. In some embodiments, the system 100 is configured to receive input from a user's visual body movement (e.g., a movement or hand gesture, an object in a sweeping motion) received by a motion sensor (e.g., one or more cameras) and translated (e.g., by converting the motion into text) by one or more processors into a linguistic form (e.g., command text, command code), such as, for example, a user gesture (e.g., waving a hand) captured by one or more cameras (e.g.,

- 9 045233 placed in any configuration internally, externally and/or as part of the external enclosure of the system 100) and converted by one or more processors into command text that the system 100 can recognize as an input command. Alternatively or in addition, system 100 may be configured to receive input other than user input, such as, for example, from one or more sensors implemented for system 100. Non-limiting examples of various sensors that may be implemented (e.g. in the processing chamber), include one or more light sensors configured to measure the intensity of light in various sections of the processing chamber and/or the intensity of light falling on various areas of one or more biological fluids, one or more air flow sensors, one or more thermal sensors for measuring the temperature in the treatment chamber and/or the temperature of one or more biological fluids, one or more sensors that determine the presence and/or type of one or more biological fluids (for example, pressure sensors, optical reflex sensors, optical transmitting sensors, devices label readers, scanners, barcode scanners, RFID sensors, etc.), one or more sensors to determine the property (e.g., transmittance) of a biological fluid (e.g., optical sensors, spectroscopic sensors), one or more sensors to determine the presence of a photochemical compounds in a biological fluid (eg, fluorescence spectrometry); and one or more sensors (eg, ultrasonic sensors) positioned to determine fluid depth at a site (eg, various sites) of the one or more biological fluids.

In some embodiments, system 100 may be configured to receive input from one or more scanners implemented for system 100. In some examples, scanner 130 is configured to receive information relating to body fluids. In some examples, scanner 130 may be configured to obtain identifying information regarding biological fluids to be processed. For example, a biological fluid may be stored in a container (e.g., a hemocompatible bag, a treatment bag) (not shown), and the container or other containers in a multi-container arrangement (e.g., a disposable fluid handling kit) may include a tag, label, or dedicated area , containing identifying information in one form or another, such as a visual form (e.g. bar code, QR code, etc.) and/or a broadcast form (e.g. electronic identifier, radio frequency identifier (RFID - radio): frequency identification)). In some examples, the identifying information may be product information about the body fluid, such as biological or other parameters (e.g., delivery ID, product code, kit code, lot number, type of body fluid, volume of body fluid, composition of body fluid, such as platelet count ) and processing parameters. In some examples, biological or other parameters, optionally in combination with input from one or more sensors and/or user inputs, may determine a processing parameter. In some examples, multiple pieces of identifying information may be obtained. For example, multiple pieces of identifying information may be placed on one or more respective containers associated with (eg, containing or being part of a multi-container arrangement containing) a biological fluid, and these blocks of identifying information may be obtained from the respective containers using scanner 130. B In some examples, said scanner is a multi-scan scanner (e.g., a camera with multi-scan capability, a camera combined with circuitry (e.g., hardware and/or software) that has multi-scan processing functionality, a handheld scanner with multi-scan functionality, a handheld scanner combined with circuitry (for example, hardware and/or software) having multi-scan processing functionality, a label reader with a multiple-scan function, a label reader in combination with circuitry (for example, hardware and/or software) having multiple-scan processing functionality) made with the ability to sequentially or mostly simultaneously collect (e.g., receive) multiple blocks of identifying information (e.g., multiple bar codes, multiple QR codes, multiple labels, optical character recognition (OCR) of different strings or combinations alphanumeric text and/or symbols, image recognition, etc.) placed on one or more containers, such as, for example, collecting multiple blocks of identifying information in batches (for example, in response to a single user input or a single input data by a device that commands, invokes, or otherwise initiates a multiple scan operation that obtains multiple blocks of identifying information). A single multiple scanning operation may collect sequentially or substantially simultaneously (e.g., simultaneously) multiple pieces of identifying information (e.g., in a single operation, a camera may acquire one or more images of one or more labels indicating multiple parameters of a biological product, such as e.g. , identifier

- 10 045233 delivery, product code, kit code, batch number, type of biological fluid, volume of biological fluid, composition of biological fluid; In one operation, the multi-scan scanner can perform one or more readings of one or more labels containing several of the above parameters). In some embodiments, the multiple scanner (multiscanner) of the system 100 is configured to recognize (and/or convert to another form suitable for recognition by the multiscanner of the system 100) collected multiple blocks of identifying information (for example, recognition (and/or decryption) of bar codes , QR codes, alphanumeric text and/or symbols, images) read during a multiple scan operation. After collecting multiple pieces of identifying information (e.g., in captured image(s), scan(s) performed), the multi-scanner may transmit or communicate them (e.g., via wired or wireless communication) to system 100 in the recognized (and/or or converted) form (for example, in a language form that the system 100 is already able to recognize, for example, as parameter data) or unrecognized form (for example, as captured image(s), scan(s) performed). In the case of an unrecognized form, the system 100 is capable of converting the collected multiple blocks of identifying information into a recognized form. The system 100 is capable of assigning multiple pieces of identifying information to appropriate fields (eg, auto-populated information fields) of the GUI on the display 120 while displaying the GUI for a treatment chamber associated with the biological fluid to be treated. Thus, the multiple scanning operation can provide data for all or most of the body fluid parameters to populate multiple specific data fields through an auto-population technique, which can be convenient, efficient, and time-saving. For example, with a multiple scan operation, the user does not need to perform multiple scans in one order or another to collect multiple pieces of identifying information that can be presented in a particular order (for example, there is no need to scan each label on a container in order to visually display specific data fields , presented to the user on the GUI.

In some examples, the identifying information may be within the field of view of the scanner 130, and the scanner 130 may receive the identifying information while the information is within the field of view. For example, a user may hold a body fluid treatment container (eg, bag) with a bar code facing scanner 130, and scanner 130 may video capture, scan, or read the bar code; and based on the received barcode, the system 100 can determine product information about the biological fluid. In some examples, the identifying information may fall within the detection range of the scanner 130, and the scanner 130 may receive the identifying information when the information is within the detection range. For example, a user may hold a body fluid bag containing an RFID tag near the scanner 130, and the scanner 130 may detect the RFID tag; and based on the information obtained from the detected RFID tag, the system 100 can determine product information of the biological fluid.

Although in FIG. 1, scanner 130 is depicted as being located on an exterior surface of system 100; scanner 130 may be located in various locations of system 100. In yet other examples, scanner 130 is located within system 100. For example, scanner 130 may be located on top of a processing chamber of system 100. Scanner 130 can receive information regarding the biological fluid after the biological fluid is placed on the platform and/or in the chamber.

In some examples, scanner 130 may be included in a device coupled to system 100. For example, scanner 130 may be included in a hand-held scanner (e.g., bar code scanner, QR code scanner) coupled to system 100. In some examples, scanner 130 connected to the system 100 using a wired connection. In some examples, scanner 130 is connected to system 100 via a wireless connection.

Despite the fact that in FIG. 1 depicts a single scanner 130, system 100 may include more than one scanner 130. For example, system 100 may include multiple processing chambers, where each processing chamber may have a corresponding scanner (eg, an internal scanner). As another example, system 100 may include multiple platforms, where each platform may have a corresponding scanner (eg, an external scanner) located near or in the opening of the corresponding platform. As the platform moves through the opening, a container (eg, a treatment bag) containing a biological fluid may cross the field of view of the corresponding scanner, and information regarding the biological fluid presented in visual form on this container or a companion container of a multi-container arrangement can be obtained by the corresponding scanner.

In some examples, the platform 140 (eg, drawer, tray, well, plate, table) is configured to transport a biological fluid (eg, a container containing a biological fluid) during processing. In some examples of the present

- 11 045233 of the invention, the platform is movable (for example, sliding-movable, configured to move translationally from inside the processing chamber to the outside of the processing chamber) between the inside and outside of the processing chamber (for example, partially outside the processing chamber). In some examples, the platform further includes a first panel 180 movable between a closed position and an open position, wherein in the closed position, the first panel 180 blocks access to the first opening into the first processing chamber, and in the open position, the first panel 180 provides access to the first opening into the first processing chamber. In some embodiments, the first panel is attached to, integrated into, or integral with the platform 140 (eg, in a drawer configuration). In some examples, the first panel 180 is a structure independent of the platform 140 (e.g., a separate hinged door that closes and opens the first opening into the first processing chamber), and the platform 140 can be slid into and out of the processing chamber independently of the first panel 180.

In some examples, the platform and/or first panel may be locked to remain in a closed position during processing. The system 100 may prevent a user from prematurely accessing the contents of the platform 140 (eg, accessing the processing chamber) during processing by locking the first panel to remain in a closed position. In still other examples, the first panel may be locked by a pin (eg, a solenoid pin) or a magnetic locking mechanism. System 100 may provide the user with access to the contents of platform 140 before and after processing (e.g., loading biological fluid onto platform 140, unloading biological fluid from platform 140) or after data entry (e.g., inputting data into a GUI, operating a valve for unlocking or operating a push-button switch).

As shown in FIG. 1, the structure of the platform 150 symmetrically reflects the structure of the platform 140 about a vertical axis. In still other examples, platform 150 is substantially similar to platform 140 in size, shape, or orientation. As shown in the illustration, the platforms 140 and 150 are arranged horizontally such that the first biological fluid and the second biological fluid placed on the first platform and the second platform, respectively, are in the same plane. Just as the first panel 180 may be coupled to the platform 140 as described above, the second panel 190 may be coupled to the platform 150.

Although two platforms are shown in FIG. 1 as part of a system 100, the system 100 may include one platform or more than two platforms that are substantially the same as platform 140 or platform 150, without departing from the scope of the present invention. In general, the number of platforms and processing chambers depicted relating to systems 100-300 is illustrative; Embodiments of systems 100-300 may include varying numbers and combinations of platforms, processing chambers, and associated elements (eg, scanners, lighting arrays, compartments) without departing from the scope of the present invention. For example, in still other examples, the system may include only one camera with only one platform. In still other examples, the system may include just one camera with two or more platforms. In some embodiments, the system may include two cameras, each having only one platform. In some embodiments, the system may include two cameras, each having two or more platforms.

In some examples, the platform includes a first compartment and a second compartment separate from the first compartment. In some examples, the first compartment is configured to place (eg, place) a container (eg, a multi-container arrangement container) containing a biological fluid into an irradiation position. In some examples, the second compartment is configured to place a container (eg, a multi-container arrangement) containing no biological fluid in a non-irradiation position. In some examples, the platform is configured to separately accommodate at least a first container containing a first biological fluid and a second container containing a second biological fluid. In some examples, the platform is transparent (e.g., substantially transparent, greater than 95% transparent, greater than 90% transparent, greater than 80% transparent, greater than 80% transparent) to light with wavelengths in the 100 nm range ( e.g. 75 nm, 50 nm, 40 nm, 30 nm, 20 nm) peak wavelength of light used for irradiation. In some examples, the platform is transparent (e.g., substantially transparent, greater than 95% transparent, greater than 90% transparent, greater than 80% transparent, greater than 80% transparent) to ultraviolet light (e.g., UVA, UV-B and/or UV-C).

In fig. 2 illustrates an exemplary system 200 for treating biological fluids. In still other examples, system 200 is substantially similar to system 100 depicted in FIG. 1. The power switch 210 may correspond to the power switch 110. Display 220 may correspond to display 120. Platforms 240 and 250 may correspond to platforms 140 and 150, respectively. Panels 280 and 290 may correspond to panels 180 and 190, respectively.

- 12 045233

In some examples, the system 200 includes an external scanner 230. As illustrated, the external scanner 230 is located outside of a housing enclosing other elements and may be operably coupled to the processor of the system 200. In some examples, the external scanner 230 is a handheld scanner. Although the external scanner 230 is shown in FIG. 2A with a wireless connection, the external scanner 230 can be operably connected using a wired connection.

As shown in FIG. 2A, platforms 240 and 250 have a drawer configuration and are in an open position, as opposed to platforms 140 and 150 being in a closed position in FIG. 1. Although both platforms 240 and 250 are depicted in FIG. 2 open in a drawer configuration, only one platform in a drawer configuration can be opened at a time (for example, when the second platform remains closed).

In some embodiments, the first panel 280 and the second panel 290 associated with the platforms 240 and 250 are devoid of any handles. In some embodiments, a panel in the closed position may be opened by applying a force in the opposite direction to the opening direction (eg, pressing on the outside of the panel activates a push latch that unlocks the panel to open). In some embodiments, the panel in the closed position may be opened by using mechanical components (eg, motors, servos) to operate the panel (eg, as a hinged door, as part of a platform in a drawer configuration). In some embodiments, the system may allow the user to access the contents of the platform by opening the panel (eg, by a spring mechanism), further allowing the user to manually extend the platform. For example, in accordance with the determination that a treatment procedure is beginning or completed, the system may mechanically open one or more treatment-related panels to load or unload one or more biological fluid containers (eg, treatment bags).

In some examples, the platform includes a compartment 260 substantially similar to the compartments described herein. Although in FIG. 2A, the platform is depicted as having one visible compartment (eg, in the case of a platform in an open drawer configuration), each of the platforms in the system 200 may include any number of compartments without departing from the scope of this application.

In fig. 3 illustrates an exemplary system 300 for treating biological fluids. In some examples, system 300 is substantially similar to system 100, with the difference being that the processing chambers and platforms are vertical. The power switch 310 may correspond to the power switch 110. Display 320 may correspond to display 120. Scanner 330 may correspond to scanner 130. Unlike system 100, in which platforms 140 and 150 are arranged horizontally, platforms 340 and 350 are arranged vertically such that a first body fluid and a second body fluid placed on the first the platform and the second platform, respectively, are in parallel planes. Also unlike the 300 system, in which panels 180 and 190 are positioned horizontally, panels 380 and 390 are positioned vertically.

The examples shown in FIGS. 1-3 are intended to provide illustrative context for the system architectures described in more detail below, and should not be construed as any limitation of said architectures. The system architectures presented herein may be used in a variety of biological fluid processing devices that are not described above with reference to FIGS. 1-3.

In fig. 4 is an illustrative flow diagram of a system for treating biological fluid in accordance with examples of the present invention. The circuit 400 shown in FIG. 4 illustrates the various components of a body fluid treatment system and demonstrates what function each component performs in connection with the treatment process. In the example shown in FIG. 4, the circuit may include a plurality of processes 402, 404, 406, 408, and 410 that may function together to process a biological fluid. In one or more examples, an apparatus and system for processing a sample of a biological fluid may include a light measurement process 402 that is configured to monitor the amount of light (eg, UV light) exposed to a particular biological fluid. In one or more examples, one or more light sensors 412 (eg, photodiodes) may be used by (eg, by interacting with) a light characteristic measurement process 402 . Light sensor(s) 412 may be configured to convert light into electrical current. In one or more examples, the electrical current emanating from light sensor 412 may be proportional to the amount of light received by the light sensor. The light characteristics measurement process 402 may interact with one or more light sources 414 (eg, UV light sources). In one example, the process 402 for measuring light characteristics may include using one or more light sensors 412 to measure the characteristics

- 13045233 light generated by one or more light sources 414 (eg, UV light sources). In one or more examples, the current generated by the light sensors 412 based on the light generated by the light sources 414 (e.g., UV light sources) may be transmitted to the controller 416 to allow the controller 416 to ensure that the biological fluid being processed receives the proper amount of light that is needed to processing of biological fluid.

In one or more examples, a device and system for treating a biological fluid may include an irradiation process 404 that is configured to generate light (eg, UV light) that is applied to a particular biological fluid. The irradiation process 404 may include activating one or more light sources 414 (eg, UV light sources) to generate light (eg, UV light) (as discussed above) to treat the biological fluid. As depicted in diagram 400, the irradiation process 404 can target both a biological fluid, such as, for example, a blood component 428 (e.g., platelets/plasma) and a photoactive pathogen inactivating compound 430, such as psoralen and/or amotosalen. in biological fluid (for example, mixed with it).

In one or more examples, the device may include an agitation process 406. The agitation process 406 may be configured to agitate the contents of the treatment container (e.g., during irradiation treatment of a biological fluid) to distribute (e.g., uniformly distribute) the biological fluid and/or the pathogen inactivating composition in the biological fluid (e.g., mixed with her). Agitation may assist processing, for example, by providing agitation of the composition (eg, photochemical compound, pathogen inactivation composition) in the biological fluid or by maintaining a component (eg, platelets, cells) of the biological fluid in suspension. In one or more examples, the agitation process 406 may include activating a mechanical agitator 418 to agitate a biological fluid (eg, a biological fluid with a photoactive pathogen inactivating composition 430). In one or more examples, the controller 416 may control the operation of the agitator 418 so as to carry out the agitation process 406 . In one or more examples, one or more motors or servos (eg, mounted in or on a platform) may be configured as a mechanical agitator 418. One or more motors or servos may be physically coupled to the platform or portion thereof and may move the platform or portion thereof back and forth (e.g., along rails or guides) to agitate a biological fluid placed on the platform (e.g., a biological fluid in a container). The one or more motors or servos may be part of any agitator structure (e.g., a feed screw structure in which one or more motors and servos drive a feed screw attached to the platform or portion thereof, a drive belt structure in which one or more motors and servos move one or more belts that rotate one or more gears (e.g., gears) that engage and move one or more racks attached to a platform or portion thereof) and may operate in accordance with control signals from electrical wiring, electrically connected to the control loop. In one or more examples, the system may be configured to control (e.g., adjustable control) one or more aspects of the agitation motion, such as displacement (i.e., length of reciprocating stroke (e.g., linear, forward and reverse, etc.) .) movements during shaking), speed, acceleration and deceleration. In some embodiments, the agitation speed may be adjustable (e.g., set to different speeds for different processing sessions, configured to different speeds during a single processing session, configured according to a predetermined speed plan, configured dynamically in real time according to data input user in real time). Such a control loop may control the agitator device (eg, one or more motors or servos) in accordance with a control program implemented as control loop software and/or hardware.

In one or more examples, the device may include a movement process 408. In one or more examples, the transfer process 408 may include operations necessary to move biological fluid into and out of the treatment chamber. For example, the movement process 408 may include opening, closing, and locking or unlocking one or more doors of the irradiation chamber 420 depending on what part of the processing process the device is currently involved in. In one or more examples, the controller 416 may control the operation of the irradiation chamber 420 so as to carry out the movement process 408.

In one or more examples, the device may include a temperature control process 410. In one or more examples, the temperature control process 410 may include controlling the operation of one or more hardware components that are collectively configured to maintain the temperature of the device within a particular temperature range.

- 14 045233

In one or more examples, the temperature control process 410 may be configured to control the operation of one or more fans 426 that may act on ambient air 432 to cool the device when the internal temperature of the device exceeds a predetermined temperature threshold. In one or more examples, controller 416 may control operation of one or more fans 426 so as to implement temperature control process 410.

In fig. 5 is a perspective view of an exemplary body fluid treatment system 500. In some embodiments, system 500 is substantially similar to system 100 depicted in FIG. 1. An exemplary system 500 for treating body fluids includes a first treatment chamber 502 and a second treatment chamber 504 for receiving one or more body fluids 510 and a group of light sources 506 arranged to irradiate the one or more body fluids 510. In some embodiments, the group of light sources 506 may comprise only the light sources in the chamber 502 and 504 located for the purpose of irradiating one or more biological fluids 510. In other embodiments described below with reference to FIGS. 6, multiple groups of light sources may be used to irradiate one or more biological fluids located in different embodiments of chambers 502 and 504. As described herein, the term group of light sources refers to one or more light sources located on any two or more three-dimensional surface (eg, adjacent surface, non-adjacent surface).

One or more light source channels may be included in the group of light sources described in this disclosure. In some embodiments, one or more light source channels 508 are included in a group of light sources 506. Although specific light sources are depicted as belonging to a particular light source channel, it will be understood that different combinations of light sources may form different light source channels. Each light source channel 508 may be a set of one or more light sources having the same wavelength (eg, peak wavelength, maximum peak wavelength). In an example of such a set, one light source may have a peak wavelength. In another example of a set, two light sources may have the same peak wavelength. In yet another example of an array, each of the plurality of light sources may have a different wavelength. In yet another example of an array, a first subarray of one or more light sources may have one peak wavelength, and a second subarray of one or more light sources may have a different peak wavelength. Within a channel of light sources consisting of a plurality of light sources, all of the light sources may have respective peak wavelengths (eg, maximum peak wavelength) that are within a range of wavelengths (eg, within 1-20 nm, 1- 10 nm; e.g. 1 nm, 2 nm, 3 nm, 4 nm, 5 nm or more, above and/or below a certain wavelength) for a given channel of light sources. For example, in some embodiments, within a channel of light sources consisting of a plurality of light sources, all of the light sources may have peak wavelength values within the range set forth later in the present disclosure, such as, for example, from about 315 to about 350 nm (e.g., about 315 to about 335 nm, about 330 to about 350 nm, about 340 to about 350 nm). Each light source in the light source channel may be any light source emitting light with desired properties (e.g., peak wavelength, maximum peak wavelength, spectral bandwidth), including, but not limited to, solid state luminaire (SSL). solid-state lighting), light-emitting diodes (LED), organic light-emitting diodes (OLED), polymer light-emitting diodes (PLED) and laser diodes. Light source channels in a group of light sources may be connected into a series circuit, a parallel circuit, or a combination of series and parallel circuits. In a light source channel of a plurality of light sources, the light sources may be controlled jointly or separately.

Each channel of light sources can be configured or set to emit light of different intensities (eg, light dosage adjustment, energy dosage adjustment) in which light from one or more peak wavelengths is applied to one or more areas of the biological fluid. For example, each channel of light sources may emit light at a maximum intensity (eg, 100%) or at less than a maximum intensity (eg, about 90%, about 80%, about 70%, about 60%, about 50%, about 40%). , about 30%, about 20% or less).

Each channel of light sources can emit different types of light. For example, each channel of light sources may emit ultraviolet light, ultraviolet A light, ultraviolet B light, ultraviolet C light, and/or visible light. Additionally, each channel of the light sources can emit light at a different peak wavelength. For example, the peak wavelength value(s) of the emitted light may be in UV-A (eg, 315-400 nm), UV-B (eg, 280-315 nm), UV-C (eg, 100-280 nm, 200-280 nm, 240-280 nm) or in the visible spectrum

- 15 045233 light (for example, 400-800 nm). In some embodiments, the peak wavelength(s) of the emitted light may be from about 240 to about 250 nm, from about 245 to about 255 nm, from about 250 to about 260 nm, from about 255 to about 265 nm, from about 260 to about 270 nm, from about 265 to about 275 nm, from about 270 to about 280 nm, or about 275 nm and about 285 nm. In some embodiments, the peak wavelength(s) of the emitted light may be from about 280 to about 290 nm, from about 285 to about 295 nm, from about 290 to about 300 nm, from about 300 to about 310 nm, from about 305 to about 315 nm, or about 310 and about 320 nm. In some embodiments, the peak wavelength(s) of the emitted light may be from about 315 to about 325 nm, from about 320 to about 330 nm, from about 325 to about 335 nm, from about 330 to about 340 nm, from about 335 to about 345 nm, from about 340 to about 350 nm, from about 345 to about 355 nm, from about 350 to about 360 nm, from about 355 to about 365 nm, from about 360 to about 370 nm, from about 365 to about 375 nm, from about 370 to about 380 nm, from about 375 to about 385 nm, from about 380 to about 390 nm, from about 385 to about 395 nm, from about 390 to about 400 nm. In some embodiments, the peak wavelength of the emitted light may be about 240 nm, about 245 nm, about 250 nm, about 255 nm, about 260 nm, about 265 nm, about 270 nm, about 275 nm, about 280 nm, about 285 nm, about 290 nm, about 295 nm, about 300 nm, about 305 nm, about 310 nm, about 315 nm, about 320 nm, about 325 nm, about 330 nm, about 335 nm, about 340 nm, about 345 nm, about 350 nm, about 355 nm, about 360 nm, about 365 nm, about 370 nm, about 375 nm, about 380 nm, about 385 nm, about 390 nm, about 395 nm or about 400 nm. In some embodiments, the peak wavelength of the emitted light may be from about 255 nm to about 275 nm (eg, from about 260 nm to about 270 nm). In some embodiments, the peak wavelength of the emitted light may be from about 275 nm to about 295 nm (for example, from about 280 nm to about 290 nm). In some embodiments, the peak wavelength of the emitted light may be from about 300 nm to about 320 nm (for example, from about 305 nm to about 315 to about 310 nm). In some embodiments, the peak wavelength of the emitted light may be from about 315 nm to about 335 nm (for example, from about 320 nm to about 330 nm). In some embodiments, the peak wavelength of the emitted light may be from about 330 nm to about 350 nm (e.g., from about 335 nm to about 345 nm, from about 340 nm to about 350 nm, about 340 nm, about 345 nm). In some embodiments, the peak wavelength of the emitted light may be from about 355 nm to about 375 nm (for example, from about 360 nm to about 370 to about 365 nm). In some embodiments, the peak wavelength of the emitted light may be from about 375 nm to about 395 nm (for example, from about 380 nm to about 390 nm). In some embodiments, the peak wavelength of the emitted light may be in (1) the ultraviolet A spectrum (eg, 315-400 nm); and (2) ultraviolet B spectrum (eg, 280-315 nm) or ultraviolet C spectrum (eg, 100-280 nm, 200-280 nm, 240-280 nm). In some embodiments, the peak wavelength of the emitted light is in the ultraviolet A spectrum, from about 315 nm to about 350 nm (e.g., from about 320 nm to about 345 nm, from about 315 nm to about 335 nm, from about 330 nm to about 350 nm, from about 340 nm to about 350 nm).

In some embodiments, all light source channels of a group of light sources may emit light at approximately the same rate (e.g., within a dispersion of +1 nm, +2 nm, +3 nm, +4 nm, +5 nm, +6 nm, +7 nm, +8 nm, +9 nm, +10 nm) peak wavelength (e.g. maximum peak wavelength). For example, in some embodiments, all light source channels of a light source group may emit light with peak wavelengths of 325+10 nm, 330+10 nm, 335+10 nm, 340+10 nm, 325+5 nm, 330+5 nm, 335+5 nm, 340+5 nm, 345+5 nm, 345+4 nm, 345+3 nm or 345+2 nm. The light source channels may include a plurality of light sources with different peak wavelengths (eg, measured peak wavelength) within a spread. In some embodiments, the average peak wavelength across multiple light sources for one light source channel may be the same as the particular peak wavelength for a single light source in one light source channel. In other embodiments, the average peak wavelength across multiple light sources for one light source channel may differ (e.g., by 1 nm, 2 nm, 3 nm, 4 nm, 5 nm or more, greater than or less than) from all specific peak lengths waves of each light source in one light source channel. In some embodiments, some light source channels may emit light of a first peak wavelength, and other light source channels may emit light of a second peak wavelength. The first peak wavelength may differ from the second peak wavelength by at least (eg, more than) 5 nm, 10 nm, 15 nm, 20 nm, or more. For example, in a non-limiting embodiment, the first channel of light sources may emit light with a peak wavelength in the ultraviolet A spectrum as described above (e.g., about 315 to about 335 nm, about 330 to about 350 nm, about 340 to about 350 nm), and the second channel of light sources may emit light with a peak wavelength in the ultraviolet C spectrum as described above (e.g., about 250 to about 260 nm, about 260 to about 270 nm) or in the ultraviolet B spectrum, as described higher (for example, from about 305 to

- 16 045233 about 315 nm). In another non-limiting embodiment, the first channel of light sources may emit light with a peak wavelength in the ultraviolet A spectrum as described above (e.g., about 330 nm to about 350 nm, about 340 nm to about 350 nm), and the second channel of light sources may emit light with a peak wavelength also in the ultraviolet A spectrum as described above (eg, from about 315 to about 335 nm, from about 355 to about 375 nm). In some embodiments, the first peak wavelength is the average peak wavelength of one or more light sources of the first channel of light sources. In some embodiments, a group of light sources may comprise first, second, and third light source channels, each of which, respectively, emits light of a first, second, and third peak wavelength. In some embodiments, the first peak wavelength may differ from the second peak wavelength by at least (e.g., more than) 5 nm, 10 nm, 15 nm, 20 nm, or more, and/or the second peak wavelength may differ from the third peak wavelength of at least (eg, more than) 5 nm, 10 nm, 15 nm, 20 nm or more. Alternatively, each of the first, second and third peak wavelengths may differ from each other by at least (eg, more than) 5 nm, 10 nm, 15 nm, 20 nm, or more. In some embodiments, a group of light sources may comprise first, second, third, and fourth light source channels, each of which, respectively, emits light of a first, second, third, and fourth peak wavelength. In some embodiments, at least two, at least three, or at least four of said first, second, third wavelengths may differ from each other by at least (e.g., more than) 5 nm, 10 nm, 15 nm, 20 nm or more. Alternatively, each of the first, second, third and fourth peak wavelengths may differ from each other by at least (eg, more than) 5 nm, 10 nm, 15 nm, 20 nm, or more. Alternatively, the first peak wavelength may be approximately the same (e.g., equal, within dispersion +1 nm, +2 nm, +3 nm, +4 nm, +5 nm) as the third peak wavelength, second peak the wavelength may be approximately the same (e.g., equal) as the fourth wavelength, and the first peak wavelength may differ from the second peak wavelength by at least (e.g., more than) 5 nm, 10 nm, 15 nm, 20 nm.

In some embodiments, each channel of the light sources may emit light with a narrow spectral band. For example, the full width at half maximum (FWHM) of the spectral bandwidth of the light (e.g., the spectral bandwidth at maximum peak intensity) emitted by each channel of the light sources may be less than 20 nm, less than 18 nm, less than 16 nm, less than 14 nm, less 12 nm, less than 10 nm, less than 9 nm, less than 8 nm, less than 7 nm, less than 6 nm or less than 5 nm. In some embodiments, the full width at half maximum (FWHM) of the spectral band of light emitted by each channel of the light sources is within 10 nm less and/or greater than the peak wavelength (e.g., no more than 10 nm more , no more than 10 nm less than the peak wavelength). In some embodiments, the full width at half maximum (FWHM) of the spectral band of light emitted by each channel of the light sources may be greater than 1 nm, greater than 2 nm, greater than 3 nm, or greater than 4 nm or more. In other examples, 50% of the maximum peak light intensity emitted by each channel of the light sources is within 10 nm, within 9 nm, within 8 nm, within 7 nm, within 6 nm, within 5 nm, within 4 nm or within 3 nm of the peak wavelength (e.g., not more than 10 nm more, not more than 10 nm less than the peak wavelength; within 10 nm less, within 10 nm more than the peak wavelength). In other examples, the light intensity at 50% of the maximum peak light intensity emitted by each channel of the light sources is within a spectral bandwidth of less than 20 nm, less than 18 nm, less than 16 nm, less than 14 nm, less than 12 nm, less than 10 nm, less 9 nm, less than 8 nm, less than 7 nm, less than 6 nm, or less than 5 nm (e.g., no more than 10 nm more, no more than 10 nm less than peak wavelength; within 10 nm less, within 10 nm longer than the peak wavelength). Commercially available LEDs and laser diodes are non-limiting examples of light sources that can provide illumination with such a narrow spectral band at peak wavelengths as described above.

In some embodiments, it is possible to adjust or set one or more peak wavelength, spectral bandwidth, duration of emission, and emission intensity of each light source channel 508.

Adjustment of these various light source channel parameters may be accomplished by a control loop 520 operably coupled (eg, communicatively coupled) to processing cameras 502 and 504, light source arrays 506, and/or computing system 524. As used herein, the term operably interconnected refers to any wired or wireless connection between two or more components that enables the two or more components to exchange information, control commands, and/or control signals. As will be discussed in more detail below, control loop 520 may receive control commands and/or control signals from computing system 524 and send control commands and/or control signals to various components of cameras 502 and 504

- 17 045233 processing for adjusting or setting various parameters relating to various camera components 502 and 504. Adjustment of various parameters of chambers 502 and 504 may be desirable to ensure that processing parameters match the processing profiles of one or more biological fluids 510. It is recognized that in some examples, control loop 520 and/or control loop 520 functionality may be included in the computing system 524. In some examples, control loop 520 may include computing system 524 and/or functionality of computing system 524. In some examples, control loop 520 may be structurally attached to processing chambers 502 and 504 (e.g., attached to an exterior, top, and/or bottom surface processing chambers 502 and 504). In some examples, control loop 520 may be integrated with processing chambers 502 and 504 (eg, located within processing chambers 502 and 504 or forming part of the structure of processing chambers 502 and 504).

Computing system 524 may be operably coupled (wired or wireless) to control loop 520 and/or various sensors described herein. The computing system may include one or more processors 544 (544 in FIG. 5, 644 in FIG. 6), a storage device 542 (542 in FIG. 5, 642 in FIG. 6), and an input/output (I/O) interface 546. (546 in FIG. 5, 646 in FIG. 6) and user interface (UI) 548 (548 in FIG. 5, 648 in FIG. 6). The one or more processors 544 may be one or more processors of any type of general purpose computer processor. Storage device or computer readable media 542 may include one or more permanently accessible storage devices such as random access memory (RAM), read only memory (ROM), floppy disk, hard disk, optical storage media (e.g., CD-ROM) or digital video disc), flash drive or any other form of digital storage device, local or remote. In some examples, non-transitory computer-readable storage medium or memory 542 may be used to store instructions for irradiating one or more biological fluids in accordance with one or more treatment profiles, as described later herein. The computing system 524 may include any type of computing device, such as a personal computer (PC), desktop computer, laptop, computer terminal, server computer, tablet computer, smartphone, personal digital assistant (PDA), etc. In some examples, control loop 520 and/or control loop 520 functionality may be included in computing system 524.

Using UI 548, the user can enter one or more characteristics from a set of characteristics of one or more biological fluids (eg, biological fluid 510). Alternatively or in addition, one or more characteristics from a set of characteristics of one or more biological fluids may be determined based on feedback to the computing system 524 and/or control loop 520 from one or more sensors for a processing chamber (e.g., processing chamber 502, chamber 504 processing). Characteristics of the body fluid property set may include, for example, the type of body fluid (e.g., blood product such as plasma, platelets, red blood cells; cells such as eukaryotic cells; proteins such as antibodies; vaccines), photochemical reagent in the body fluid (eg, type, volume, concentration), volume of body fluid, permeability of body fluid, type and/or shape of container containing body fluid, and temperature of body fluid.

Using UI 548, the user can enter one or more parameters that constitute treatment profiles of one or more biological fluids (eg, biological fluid 510). Alternatively or in addition, the computing system 524 may automatically determine one or more parameters of one or more treatment profiles of one or more biological fluids (eg, biological fluid 510) based on a corresponding set of data characteristics of the one or more biological fluids. In particular, memory 542 may store a computer program containing instructions that convert one or more characteristics of a biological fluid into one or more biological fluid processing profile parameters for each biological fluid. These instructions, which convert one or more biological fluid characteristics into one or more biological fluid processing profile parameters for each biological fluid, may be implemented as a set of user programmable rules.

In some embodiments, a group of light sources 506 may be in thermal contact with a heat exchanger 528 (eg, a heat sink, a heat sink, a heat exchanger that may be operably coupled to and controlled by a control loop 520). Heat exchanger 528 may remove thermal energy from group 506 facing one or more biological fluids 510, thereby minimizing exposure of biological fluids 510 to thermal energy (eg, thermal energy may impair biological function). Further control over the temperature of chambers 502 and 504 and/or the temperature of one or more body fluids 510

- 18 045233 may be provided with a heating/cooling unit 526 that may be operably coupled to and controlled by a control loop 520 and configured to regulate or set the temperature of chambers 502 and 504. The heating/cooling unit 526 may be any technology known in the art equipment such as, for example, a fan, a heat pump, a Peltier cooling element and/or a heat pipe. The heating/cooling unit 526 may be located externally, internally, and/or integrated into chambers 502 and 504. For example, one or more fans may be located at the rear of the processing chamber(s) to provide air flow through an inlet in the outer casing of the system 500 and exhaust air through an outlet on the rear wall of the outer housing.

In some embodiments, the heating/cooling unit 526 may be a heating unit, a cooling unit, or a heating/cooling unit. During use of the heating/cooling unit 526, the system 500 is capable of controlling the heating/cooling unit 526 to maintain the temperature of the body fluid within a specified temperature range (e.g., 1°C range, 2°C range, 3°C range, etc.). d.) during the treatment of biological fluid with irradiation. For example, thermal or temperature sensors may provide readings or temperature measurements to control loop 520 or computer system 524 via control loop 520 . If control loop 520 and/or computing system 524 processes or interprets a temperature reading or measurement as indicating that a certain threshold or condition related to a temperature target or profile has been exceeded, control loop 520 and/or computing system 524 may issue an instruction or command or start or turn on or activate the heating/cooling unit 526 to take action to regulate the temperature of the chamber 502 or 504 and/or the temperature of one or more biological fluids 510. For example, the control loop 520 and/or the computing system 524 may issue an instruction or command or start , or turn on or activate one or more fans to start airflow to begin the cooling process, to speed up airflow to provide increased cooling intensity, to slow airflow to provide reduced cooling intensity, or to stop airflow to stop cooling. During irradiation treatment of a biological fluid, one or more fans may be operated in duty cycles under the control of control loop 520 and/or computer system 524 to maintain the temperature of the biological fluid within a specific temperature range (e.g., 1°C range, 2°C range). °C, in the range of 3°C, etc.). Control loop 520 and/or computing system 524 may instruct or command or start or enable or activate any other technology known in the art, such as, for example, a fan, a heat pump, a Peltier cooler and/or a heat pipe, or any combination of such technologies to take measures to regulate the temperature of the chamber 502 or 504 and/or the temperature of one or more biological fluids 510.

In some embodiments, one or more fans may be located at the rear of the treatment chamber(s). Said one or more fans may supply air from front to back, back to front, or both directions. In some embodiments, the one or more fans may draw air through the processing chamber and exhaust air through exhaust ducts at the rear of the system. Supply air may enter one or more fans through vents located on or adjacent to the front wall or side wall(s) of the treatment chamber(s), and exhaust air may exit through vents located at the rear of the treatment chamber(s). ) processing.

Treatment chambers 502 and 504 may further include a plurality of internal surfaces configured to absorb light (e.g., each configured to absorb light), such as, for example, one or more walls made of or coated with a layer of material (e.g., black plastic, black silicate, black paint) which absorbs light of certain wavelengths to a large extent. Alternatively or in addition, in some embodiments, processing chambers 502 and 504 may further include one or more internal surfaces configured to reflect light (e.g., each configured to reflect light), such as, for example, one or more walls made from or coated with a layer of material that largely reflects light of certain wavelengths.

Treatment chambers 502 and 504 may further include a platform 530 configured to receive one or more body fluids 510 (eg, body fluid containers). The platform 530 can be any supporting structure suitable for housing body fluids or containers containing body fluids. Platform 530 may be placed in a drawer configuration such that it can be manually moved to slide in and out of chambers 502 and 504. Platform 530 may automatically

- 19 045233 move with sliding using any suitable power drive, such as an electric motor or servo drive. The platform 530 with the body fluids 510 placed thereon may be placed on top of the light source group 506 so that the light source group 506 faces the platform 530. However, in other embodiments, the platform 530 with the one or more body fluids placed thereon may be located underneath the light source group 506 so that the light source group 506 faces the platform 530.

In some embodiments, system 500 includes one or more scanners 532 in processing chambers 502 and 504. One or more scanners 532 may be positioned above the biological fluids 510 when the fluids are placed for processing (eg, scanner 532A in the first processing chamber and scanner 532B in the second processing chamber). As illustrated, one or more scanners 532 (e.g., scanner 532C) may be positioned between the first and second processing chambers externally (e.g., in an outer housing, on an outer surface) of the system 500. The one or more scanners 532 may be substantially similar scanners described in this document. When biological fluids are loaded into a corresponding processing chamber, a corresponding scanner in the corresponding processing chamber can obtain identifying information about these biological fluids, as described herein. In some embodiments, one or more scanners are located in the first opening of the first processing chamber 502 or in the second opening of the second processing chamber 504 or in the openings of both chambers.

In fig. 6 is a perspective view of an exemplary body fluid treatment system 600. In some embodiments, system 600 is substantially similar to system 500 depicted in FIG. 5. An exemplary body fluid treatment system 600 includes a first treatment chamber 602 and a second treatment chamber 604 for receiving one or more body fluids 610, a first set of light sources 606 in each chamber positioned to irradiate the one or more body fluids 610 from below. , a second set 608 of light sources in each chamber arranged to irradiate one or more body fluids 610 from above, a platform 630 in each chamber configured to receive one or more body fluids 610 (e.g., body fluid containers), and a sensor ( for example, a scanner) 632 configured to obtain identifying information about a biological fluid loaded into the processing chamber. A first group of light sources 606 and a second group of light sources 608 located above and below one or more biological fluids 610 in each of the treatment chambers 602 and 604 provide irradiation of the biological fluid from one (i.e., above or below) or two ( i.e. both) directions.

System 600 may include a scanner 632A located externally (e.g., in an outer housing, on an outer surface) of the system 600 at a location associated with the first processing chamber 602 (e.g., in or near the opening of the first processing chamber 602), and a scanner 632B , located externally (eg, in the outer housing, on the outer surface) of the system 600 at a location associated with the second processing chamber 604 (eg, in or near the opening of the second processing chamber 604). The system 600 may also include a scanner 632C located within the system 600 (eg, on an interior wall, ceiling, or floor) between the first and second processing chambers 602 and 604. In some embodiments, scanner 632C may be configured to receive information from containers located in either or both processing chambers.

In fig. 7 is a perspective view of an exemplary body fluid treatment system 700. In some embodiments, system 700 is substantially similar to system 300 depicted in FIG. 3, and the system 600 shown in FIG. 6, except that the first treatment chamber 702 and the second treatment chamber 704 are arranged vertically (above and below each other) in the system 700. An exemplary body fluid treatment system 700 includes a first treatment chamber 702 and a second treatment chamber 704 for receiving one or more biological fluids 710, a first group 706 of light sources in each chamber positioned to irradiate the one or more biological fluids 710 from below, a platform 730 in each chamber configured to receive one or more biological fluids 710 (e.g., containers with biological fluids), and a sensor (eg, scanner) 732 configured to obtain identifying information about the biological fluid loaded into the processing chamber. The platform 730 with the body fluids 710 placed thereon may be placed on top of the light source group 706 so that the light source group 706 faces the platform 730. However, in other embodiments, the platform 730 with the one or more body fluids placed thereon may be located below the light source group 706 so that the light source group 706 faces the platform 730. Each of the light source chambers 702 and 704 may further include a second light source group (not shown) positioned above and below.

- 20 045233 one or more biological fluids 710, for example, similar to that in the system 600 shown in FIG. 6.

System 700 may include scanners 732A and 732B located within a first processing chamber 702 (e.g., in the ceiling above body fluid compartments 710A and 710B), and two scanners similarly located within a second processing chamber 704 (e.g., in the ceiling above body fluid compartments 710C and 710D). The system 700 may also include a scanner 732E located externally (eg, in an outer housing, on an outer surface) of the system 700 between the first and second processing chambers 702 and 704. In some embodiments, scanner 732E may be configured to receive information from containers located in either or both processing chambers (e.g., when a platform in a drawer configuration is in an open position within the field of view of scanner 732E when RFID- marks are in the detection range of the 732E scanner).

In fig. 8A is a perspective view of an exemplary system 800 for treating one or more biological fluids 806 and 808 comprising a light source array 804 located in a treatment chamber 812. A group of light sources 804 faces a body fluid platform 810 . A group of light sources 804 may be in thermal contact with a heat exchanger 816. The processing chamber 812 may include a platform 810 located below the group of light sources 804, which platform is configured to receive one or more biological fluids 806 and 808. The processing chamber 812 , a group of light sources 804, a heat exchanger 816, and a platform 810 may be operatively coupled to a control loop 818 that may regulate or adjust their respective parameters. In fig. 8B illustrates that the exemplary system 800 may also include a barrier 858 (eg, light barrier, safety barrier) and various sensors 812, 866, 868, 880 located in the processing chamber 812. In some embodiments, the barrier is transparent (e.g., substantially transparent, greater than 95% transparent, greater than 90% transparent, greater than 80% transparent, greater than 80% transparent) to light with a wavelength within 30 nm relative to the first peak wavelength (e.g., within 15 nm less, within 15 nm more than the first peak wavelength; no more than 15 nm more, no more than 15 nm less than the first peak wavelength). In some embodiments, the barrier is transparent (e.g., substantially transparent, greater than 95% transparent, greater than 90% transparent, greater than 80% transparent, greater than 80% transparent) to ultraviolet light, such as e.g. , light with a wavelength in the ultraviolet spectrum A. In some embodiments, the barrier is a light barrier (e.g., a light filter) configured to reduce (e.g., minimize, attenuate, block) the transmission of light, such as, for example, light with a wavelength wavelength less than the wavelength of light in the UV spectrum A. In some embodiments, the barrier is a light barrier configured to reduce the transmission of light of a wavelength less than the wavelength of light in the UV spectrum B. In some embodiments, the barrier is a light barrier (e.g., a light filter) configured to reduce (e.g., minimize, attenuate, block) the transmission of light with a wavelength of at least 20 nm less (e.g., at least 25 nm less, by at least 30 nm less than) the first peak wavelength and/or another peak wavelength (eg, at least 20 nm less than the second, third or fourth peak wavelength). In some embodiments, the barrier is a light barrier (e.g., a light filter) configured to reduce the transmission of light of a wavelength of at least 20 nm greater (e.g., at least 25 nm greater, at least 30 nm greater ) the first peak wavelength and/or another peak wavelength (eg, at least 20 nm greater than the second, third or fourth peak wavelength). A barrier 858 is located between a group of light sources 804 and a platform 810 (eg, one or more body fluids 806 and 808). Sensors 812, 866, 868 may be attached to or located on the platform 810. Sensors 880 may be attached (eg, above or below) to or located on barrier 858.

The light source group 804 may comprise a group of light source channels. Each light source channel included in the light source group 804 may be configured to emit light at the different peak wavelengths discussed above and at the various light source and light source channel arrangements discussed above.

The light source array 804 and platform 810 may be configured to move relative to each other to increase or decrease the distance 826 between them, as in the translation discussed above. The platform 810 may be lowered to the bottom of the processing chamber 812, which may be elevated above the outer bottom surface (e.g., the height of the structural base, including any components such as a sensor or control loop) or flush with the outer bottom surface (e.g. , floor, ground surface, desk, etc.). A group of light sources 804 may be raised to the ceiling of the processing chamber 812. In fig. 8B group 804 light sources, barrier

- 21 045233

858 and platform 810 may be configured to translate relative to each other to increase or decrease distances 826, 882, and 884 between any two of the group of lights 804, barrier 858, and platform 810. This translation may be accomplished by any number of power actuators (e.g., an electric motor, a servo, or the like) controlled by a control loop 818 that can separately control the forward motion of the light source group 804, the barrier 858, and the platform 810. In some embodiments, one or two of the light source group 804 light, barrier 858, and platforms 810 may be fixedly mounted in processing chamber 812. For example, barrier 858 may be fixedly mounted in processing chamber 812. In another example, the barrier 858 and the light source group 804 may be fixed relative to each other at a fixed distance 882 in the processing chamber 812, and the platform 810 may be configured to move in translation to increase or decrease the distances 826 and 884. In another example The barrier 858 and platform 810 may be fixedly mounted relative to each other at a fixed distance 884 in the treatment chamber 812, and the light source array 804 may be configured to move forward to increase or decrease the distances 826 and 882.

As discussed above with respect to FIG. 1-8(a and b), a body fluid treatment device may include various components and systems that must work in coordination with each other to safely and effectively treat body fluids. While the above examples may demonstrate an illustrative arrangement of components used to process one or more biological fluids, in an apparatus in which two treatment chambers are oriented horizontally relative to each other as described above, the treatment chambers may also be oriented vertically relative to each other. In fig. 9 shows another example of the internal hardware layout of a system for treating biological fluid in accordance with examples of the present invention. In an example device 900, the treatment chambers may be oriented vertically relative to each other so that when the device processes two biological fluids simultaneously, the biological fluids can be stacked on top of each other in the device.

Apparatus 900 may include two separate processing chambers 918 and 920, wherein in an example apparatus 900, processing chambers 918 and 920 may be oriented vertically relative to each other. In one or more examples, each of the treatment chambers 918 and 920 may include one or more platforms (e.g., drawers) and associated trays 908 that are configured to carry biological fluid (e.g., in a container) and provide access to biological fluid for the user to remove the biological fluid from the device and/or place the biological fluid into the device. In one or more examples, each platform 908 (e.g., drawer) may be configured with an agitator device (e.g., motor, servo), such as, for example, an integrated agitator device, such that any biological fluid placed on the platform 908 (e.g. , drawer and associated tray) could be agitated so as to disperse (e.g., evenly distribute) the body fluid and/or pathogen inactivating composition in the body fluid (e.g., mixed with the body fluid).

In one or more examples, each of the processing chambers 918 and 920 may also include one or more lighting device components 910. In one or more examples, lighting device components 910 of each of the processing chambers 918 and 920 may include one or more groups of light sources (e.g., UV light sources) that are configured to supply a desired amount of light (e.g., UV light) to the biological fluid located on the surface of each or in each of the processing chambers.

In one or more examples, as described in more detail below, the device may include a control system board 904 that is configured to coordinate the operation of one or more safety-critical components of the device. In one or more examples, the term safety-critical component may mean one or more components of a device that interact with a biological fluid being processed and whose improper operation could compromise the safety and efficiency (e.g., compliance with required specifications) of the biological fluid treatment process. In one or more examples, CSB 904 may communicate with and issue commands to each of the safety-critical components (described in more detail below) using a domain-specific, custom communication protocol configured to protect the safety-critical components from access by a malicious user. , and designed to provide device modularity and scalability with minimal disruption and/or compliance with regulations. In one or more examples, CSB 904 may be configured to exchange data among

- 22 045233 other, with the platform/tray/drawer 908 and lighting device components 910, since these components directly interact with the biological sample and incorrect operation of these components could compromise the safety and efficiency of the processing and control. In one or more examples, the CSB 904 may also be configured to control operation of one or more fans 912 to move air from the front of the device to the rear of the device to cool the device and the body fluid being processed to prevent overheating from occurring. In addition to controlling each of the components, the CSB 904 may be configured to evaluate results from each of the components, which in one or more examples may be continuously communicated to it. The CSB 904 may be configured to use these results to determine subsequent operating steps of the device, such as stopping agitation or ending a processing process.

In addition to the treatment chamber-specific components described above, in one or more examples, device 900 may include one or more components that are not dedicated to a specific treatment chamber, but are instead configured to operate the entire device and are therefore common to both processing chambers. In one or more examples, device 900 may include a user interface controller (UIC) 902, which may be configured to control the operation of one or more components of device 900. In one or more examples, UIC 902 may be configured to coordinate the operations of one or more non-safety-critical hardware and software components (described in more detail below). For example, in one or more examples, the UIC 902 may be configured to control the operation of one or more graphical user interfaces that are displayed on the display 914. The one or more graphical user interfaces may be configured to direct user actions during the process of processing and receiving input. data from the user to determine information about the biological fluid to be processed, as well as any other information that the device may need to carry out the processing process. In one or more examples, the display 914 may be implemented as a touch display where a user can touch the surface of the display to enter data or otherwise interact with the device during processing.

In one or more examples, UIC 902 may also communicate with and control the operation of scanner 916 (eg, a bar code scanner). The scanner 916 may be configured to scan one or more sources of identifying information (e.g., bar codes) found on the surface of a container that holds a biological fluid and contains information related to the identification of the biological fluid, as well as other information necessary to ensure proper material processing.

In fig. 10 is an illustrative diagram of an irradiation system for treating biological fluids in accordance with examples of the present invention. In one or more examples, the biological fluids processed by the system 1000 may include one or more of platelets, plasma, blood, and blood products. As described above with respect to FIG. 1-3, the device may treat a biological fluid by irradiating the fluid with light (eg, ultraviolet light, one or more wavelengths of light), such as in one or more examples with wavelengths in the ultraviolet A (UVA) spectrum. To treat a fluid with light, the device may be configured to apply light (eg, ultraviolet light, UVA light) to a biological fluid at specific intensities for a specified period of time to inactivate pathogens.

In one or more examples of the present invention, the system 1000 may include a control module 1016 and a processing module 1002. In one or more examples of the present invention, the processing module 1002 may include two subsystems: (1) a main subsystem 1004 and a security subsystem 1014. In one or more examples of the present invention, the main subsystem 1004 may include components and systems that perform light processing (e.g., UVA light processing), while the security subsystem (described in more detail below) may include components and systems that perform with the ability to monitor actions performed by the main subsystem 1004.

In one or more examples, the main subsystem 1004 may include one or more lighting devices 1006 that include a light source(s) (e.g., a group(s) of light sources) for processing a biological fluid. Each lighting device 1006 may include one or more light sources that may be configured to emit light of varying intensities (e.g., UVA light) and located within the device such that, when light is emitted by the light source, biological fluid within the device is exposed to light (eg, light waves) emanating from a light source. In some examples of the present invention, the biological fluid

- 23 045233 may be contained within a container (eg a bag) and may be positioned within a device, eg on a platform, such that it can be exposed to light (eg light waves) emanating from a light source.

The main subsystem 1004 may also include one or more chambers (not shown) for housing treatment containers (eg, bags) containing the biological fluid to be treated. The treatment container may be placed on a platform 1008 (eg, a drug tray) in the treatment chamber. Each processing chamber may have one or more lighting devices associated with it. For example, each chamber may receive light (eg, UVA light) from one or more lighting devices 1006 to process biological fluid contained in a treatment container within the treatment chamber. In one or more examples, processing may occur simultaneously in multiple processing containers (eg, bags) in multiple light processing chambers.

In some examples, the main subsystem may include an agitator 1010. The agitating device 1010 may be used to agitate the contents of the treatment container to distribute (eg, evenly distribute) the biological fluid and/or the pathogen inactivating composition in (eg, mixed with) the biological fluid. The main system may further include auxiliary components 1012 to perform various other functions that assist in the processing process. These functions may include, but are not limited to, the use of one or more sensors (eg, to detect light, light intensity, light dose), detect the placement of a treatment container, and employ marking mechanisms to demonstrate that a particular treatment container has been treated.

In some examples of the present invention, the security subsystem 1014 in the processing module 1002 may be used to monitor processing activities occurring in the main subsystem 1004. The functionality of the security subsystem 1014 may include, but is not limited to, interlocks, interlocks, hardware and software watchdogs, and the like.

In some examples, the irradiation system 1000 may include a control module 1016 that may allow a user to make a processing request and interact with the irradiation system 1000. In some examples, the control module 1016 may be made physically separate from the irradiation system 1000. When implemented as physically separate units, the control module 1016 may be connected to the irradiation system 1000 via a wired or wireless connection using a specified wireless communication standard, such as, for example, Bluetooth or WiFi. In some examples, a single control module 1016 may be associated with multiple systems, such as the irradiation system 1000.

In one or more examples of the present invention, the control module 1016 may include a user interface 1018. The user interface 1018 may be a display that allows a user to interact with the irradiation system 1000. In one or more examples, the user interface 1018 may be implemented as an LED display with a touch interface that uses user selectable buttons, icons, and text to facilitate user interaction with the device. The user interface may include input/output devices such as a touchpad, keyboard, mouse, barcode camera, and the like.

In one or more examples of the present invention, the system 1000 may include a common interface 1022. In some examples, the system 1000 is an electronic device for processing a biological fluid, and the common interface 1022 is a processing interface for the electronic device.

In some embodiments, the common interface 1022 is communicatively coupled to the control module 1016 (eg, the control subsystem 1020 included in the control module 1016), the main subsystem 1004, and the security subsystem 1014. The common interface 1022 may be configured to provide a communication path between the control module 1016 and the main subsystem 1004 or the security subsystem 1014. In some embodiments, the communication between the control module and the subsystem is caused by input of data through the user interface 1018. In some embodiments, the communication between the control module and the subsystem is caused by the input of the subsystem or component to the irradiation system (eg, a lighting device is installed in the system).

The above-mentioned modules, components and systems may include various components related to their functionality. These components can be arranged in a system architecture that can coordinate these components with each other to facilitate efficient and effective processing of one or more biological fluids.

In fig. 11 illustrates an example of a component architecture of an irradiation system for treating biological fluids in accordance with examples of the present invention. In one or more examples of the present invention, system architecture 1100 may include module 1116

- 24 045233 control and processing module 1102. The control module 1116 may include a control subsystem 1120 that may perform various functions. For example, control subsystem 1120 may control graphics icons, screen transitions, button presses, and other user actions on user interface 1118. It may print processing records. In addition, it can act as a communications manager by interacting with a network that is external to the radiation system 1100, such as through an Ethernet network. In one or more examples, control subsystem 1120 may also act as a data manager by maintaining a database of performed processing. In one or more examples, the control subsystem 1120 may also act as an event log manager by logging various events that occur with the irradiation system 1100 (eg, inside and/or outside the system). These events may include, but are not limited to, normal and abnormal environmental conditions, alarms, malfunctions, etc. In one or more examples, the controller may be a central processing unit (CPU) or a microprocessor and may include volatile memory and non-volatile memory.

In one or more examples, control subsystem 1120 may enable communication between control module 1116 and an external network via port 1126 (eg, an Ethernet port). For example, any devices that are external to the irradiation system 1100 may be connected to the control subsystem 1120 through port 1126. These devices may include, but are not limited to, an external personal computer, an external blood collection and donation control system for transmitting data to irradiation system 1100 to and from it, etc. For example, the blood procurement and donation management system may receive reports from the irradiation system 1100. It may also transmit software and data to the radiation system 200 to perform various control functions. These functions may include, but are not limited to, programming the treatment system 1100 with various processing profiles and user information, performing condition and performance checks (e.g., diagnostics) on the treatment system 1100, and the like.

In one or more examples, control module 1116 may be isolated from processing module 1102 using a common interface 1122 (described in more detail below). For example, such isolation may help physically separate critical functionality in processing module 1102 from non-critical functionality in control module 1116. In one or more examples of the present invention, isolating critical components from non-critical components may allow safety-critical software and hardware that requires more stringent testing to be placed in processing module 1102 and non-safety-critical software and hardware that requires less stringent testing to be placed in control module 1116. In this way, the impact of replacing non-critical components with critical components or modifying non-critical components to critical components of the device can be minimized.

In some embodiments, a common interface allows data exchange between control module 1116 and processing module 1102 through the use of a specified domain-specific communication protocol. For example, control subsystem 1120 (which in one or more examples may be implemented as a controller) in control module 1116 may communicate with a separate controller 1124 in processing module 1102.

In one or more examples, the control subsystem 1120 may be communicatively coupled to one or more non-safety-critical components located in the control module 1116, and may also be communicatively coupled to the processing module 1102 via a controller 1124. The controller 1124 is processing module 1102 may be communicatively coupled to one or more safety-critical components, such as lighting device 1128 and agitator 1110, and may also be communicatively coupled to a control subsystem 1120 included in control module 1116 .

In one or more examples, control subsystem 1120 may interact with components of processing module 1102 only through controller 1124, and controller 1124 may interact with components residing in control module 1116 only through control subsystem 1120. In this way, isolation of the non-safety-critical component in the control module 1116 from the safety-critical components in the processing module 1102 can be maintained. By maintaining this isolation through the use of two separate controllers, the impact that future component changes (ie, component changes or expansions) in control module 1116 have on processing module 502 can be minimized. Thus, changes to control module 1116 may not require costly retesting of components of processing module 1102 that must pass regulatory review. In addition, the use of a given domain-specific communication protocol 1122 to ensure the exchange

- 25 045233 data between the control subsystem 1120 and the controller 1124 may help maintain additional isolation between non-safety-critical components in the control module 1116 and the processing module 1102. The domain-specific interface protocol 522 used to communicate between the control subsystem 1120 and the controller 1124 may provide a means by which the two modules 1116 and 1120 will remain consistent despite any changes in the components comprising the control module 1116 and the processing module 1102 .

In one or more examples, controller 1124 may implement safety-related functions in processing module 1102. For example, the controller 1124 may monitor the safe and proper handling of the irradiation system 1100 and may also implement an interlock or lockout mechanism when unsafe or improper conditions are detected. The controller 1124 may also implement alarms programmed to indicate errors that occur during the processing process, as well as provide alarm information to the user through the user interface 1118. In some embodiments, the controller 1124 may also perform processing tasks by controlling the operation of various components in irradiation system 1100 in accordance with a specific treatment profile. For example, controller 1124 may control the amount of light energy (eg, UVA energy) exposed to a biological fluid (eg, a treatment bag containing a biological fluid) by controlling the timing of lighting devices 1106 on and off and the intensity of the light. In some examples, the controller 1124 may also control the wavelength of light emitted by the lighting devices and/or the speed of the agitator 1110. In some embodiments, controller 1124 may be a single board computer or a dedicated circuit board with a processor. The controller 1124 may include volatile memory and non-volatile memory.

In one or more examples of the present invention, the irradiation system 1100 may include one or more smart components 1128. These smart components 1128 may include components such as lighting devices 1106, controller 1124, user interface 1118, control subsystem 1120, but with embedded computing hardware that is independent for each component. The computing hardware of each smart component can be programmed to perform functions that are unique to that component. For example, the computing hardware in controller 1124 may execute algorithms to manage interactions between all components to carry out processing. In some embodiments, the smart component of the lighting device 1106 may have an algorithm for controlling the supplied light energy (eg, UV light energy) and adjusting the treatment time and radiation dose rate. Additionally, lighting device 1106 may be configured to receive directives and commands from controller 1124. In some embodiments, computing hardware in smart components 1128 may be implemented using an ASIC, FPGA, ASIC, and may include volatile memory and non-volatile memory.

In one or more examples of the present invention, the irradiation system 1100 may include one or more sensors (not shown). For example, lighting device 1106 may include a light sensor (e.g., a photodiode) for detecting the amount (e.g., total dose) of light (e.g., luminous energy) emitted by the light source(s) (e.g., LED) in lighting device 1106. and/or the amount of light (eg, light energy) supplied to the biological fluid, eg, in a treatment container. Other examples of sensors may include, but are not limited to, proximity sensors, mass sensors, pneumatic sensors, temperature sensors, and the like.

In some examples, system 1100 is an electronic device for processing biological fluid, and general interface 1122 is an electronic device processing interface. In some examples, a control module (eg, control module 1016, control module 1116) of the system includes a first controller and a second controller. The first controller may be communicable with a plurality of non-safety-critical components, such as the components described herein, and the second controller may be communicable with a plurality of safety-critical components, such as the components described herein , through the processing interface.

In some embodiments, in response to a plurality of non-safety-critical components communicating with a processing interface, and a plurality of safety-critical components communicating with a processing interface, the system detects, through the control module, the presence of a plurality of non-critical components.

- 26 045233 for component safety and many safety-critical components in an electronic device.

In some examples, the system may transmit first messages associated with non-safety-critical components between the first controller and the non-safety-critical component via a processing interface, and the system may transmit second messages between the second controller and the safety-critical component via the processing interface. In some embodiments, the first and second messages are based on a domain-specific interface language. For example, a domain-specific interface language is TCP/IP. In some embodiments, in response to receiving a message, the controller module or component may send a response (eg, message accepted, message rejected, message lost, recipient busy) to the sender to acknowledge receipt of the corresponding message.

In some examples, the system determines the states of non-safety-critical components based on the first messages and the states of the safety-critical components based on the second messages. For example, the states may be one or more of the following: uninitialized, initialized, ready, running, calibrated, disabled, serviced, and faulty. It should be understood that the conditions are not limited to the conditions described herein.

In some examples, the messages may include a message header and message data. The message header may include information related to the following: one or more commands, transaction number, message type, and message size. These messages may include information associated with one or more of the conditions described herein.

In some embodiments, the message may include system information. For example, system information may include the treatment dose associated with the biological fluid being processed, the maximum processing time for the biological fluid, the maximum allowable storage time after completion of treatment, the data update interface (e.g., how often the system receives information about the progress of the treatment process), speed component (for example, the current speed of the agitator in Hz). It should be understood that the information listed is illustrative and not restrictive. In some embodiments, the information in the message is user-defined parameters (eg, information derived from user-defined processing parameters).

In some examples, the message may include processing information. For example, the treatment information may include elapsed treatment time, dose applied, chamber temperature, body fluid temperature, and component speed (eg, the current speed of the agitator in Hz). It should be understood that the information listed is illustrative and not restrictive.

In some examples, the message may include information that will cause the system to stop operating (eg, stop processing). In some examples, the message may include information to notify the system that work has completed (eg, processing has completed) and data (eg, statistics) associated with the completed processing.

In some embodiments, the message may be related to system maintenance. In some examples, the message may be a request to start a service on the system. In some examples, the message includes information about a current service (eg, maintenance) performed on the system. In some examples, the message includes information about the shutdown of the service (eg, notification, service log).

In some embodiments, the message may be related to a system shutdown (eg, a request to shut down the system, a request to shut down the system at a specific time). In some embodiments, the message may be related to a system malfunction (eg, identification of the faulty component, instructions for correcting the fault, log associated with the fault). In some embodiments, the message may be related to system calibration (eg, calibration file transfer, configuration file transfer). In some embodiments, the message may be associated with a subsystem or component version (e.g., interface version, firmware version, operating system version, Basic Input and Output System (BIOS) version, hardware version, component, subsystem serial number). For example, messages related to subsystem or component versions can ensure that system security, reliability, or compatibility requirements are up to date.

In some examples, non-safety-critical components or safety-critical components may change states. For example, a non-safety-critical component or a safety-critical component is in the first state. The system may change state (for example, in response to user input) that is not safety critical

- 27 045233 component or safety-critical component from the first state to the second state. In some examples, in response to a change in state, the system sends a second message (eg, different from the first message) from the non-safety-critical component or the safety-critical component to the control module via a common interface. In some embodiments, the system receives at the first controller or the second controller a second message, wherein in response to receiving the second message, the system determines a second state of the processing component.

In some examples, electrical power is applied to the system, and the presence of a plurality of non-safety-critical components and a plurality of safety-critical components is detected in response to electrical power being applied to the system. For example, after electrical power is applied, the presence of these components is detected during system initialization.

In some examples, in response to electrical power being applied to the system, the system assigns local network addresses (eg, IP addresses, MAC addresses) and ports (eg, TCP ports) to a plurality of non-safety-critical components and a plurality of safety-critical components. In some embodiments, local network addresses and ports are based on a domain-specific interface language. For example, local addresses can be IP addresses or MAC addresses, and local ports can be TCP ports.

In fig. 12 is an illustrative block diagram of a system for treating biological fluids in accordance with examples of the present invention. The exemplary system 1200 shown in FIG. 12 may serve as a further illustrative system diagram with respect to the example provided above with reference to FIG. 11. In one or more examples, system 1200 may include a user interface controller 1202 that may interact with one or more non-safety-critical device components. In one or more examples, non-security-critical components may include a display 1208 (eg, a touch display), a scanner 1210 (eg, a bar code scanner), an Ethernet port 1212, and one or more USB ports 1214. Non-security-critical components may refer to components within the system 1200 that do not directly interact with one or more biological fluids processed by the device and whose operation does not have a significant impact on the safety and efficiency of the treatment process.

In one or more examples, UIC 1202 may control or interact with one or more system components that are accessed by an external user of the device. For example, in one or more examples, UIC 1202 may interface with a touch display 1208, which may be configured to display one or more graphical user interfaces and configured to receive one or more touch inputs from a user. In one or more examples, UIC 1202 may control one or more bar code scanners 1210, which may be configured to scan one or more bar codes that are associated with a biological fluid (e.g., on a container associated with a biological fluid) and that may contain identifying information about biological fluids, or interact with them. In one or more examples, UIC 1202 may interface with an Ethernet port 1212, which may be configured to be capable of connecting to an external computer network (such as the Internet or an enterprise computer system) so that a computer connected to the device via the Ethernet port 1212 , could control the operation of the device from the outside or gain access to it. In one or more examples, UIC 1202 may be configured to control or interact with one or more USB ports 1214. USB ports 1214 may provide the ability to attach external devices, such as a mouse or keyboard, to the system 1200.

In one or more examples, UIC 1202 may interact with one or more externally accessible components (i.e., components that can be controlled by a user or device that is not part of the system), without allowing the user or device to directly control the operation of one or more safety-critical components of the 1218 device. As will be described in more detail below, UIC 1202 may communicate with a control system board (CSB) 1206, which may be configured to receive commands from UIC 1202 and translate that command into one or more operations that are performed by one or more safety-critical operations. components 1218.

In one or more examples of the present invention, system 1200 may include a network switch 1204 that can route data transmissions between system components by switching packets to receive and forward data to a specific component in the system. In one or more examples, network switch 1204 may be configured to receive one or more packets (containing commands or information) from UIC 1202 to CSB 1206. For example, UIC 1202 may receive one or more data inputs made by an external user via touch display 1208 and can then send these commands to the CSB 1206 through the network switch

- 28 045233

1204 so that the CSB 1204 can control safety-critical components of the device based on user inputs. In one or more examples, network switch 1204 may also receive one or more packets from CSB 1204 and may route one or more packets to one or more security-critical components 1218 associated with a processing module, which may include both cameras 1220 and 1222 processing to control the operation of safety-critical components for processing biological fluids within the processing chambers 1220 and 1222.

As briefly described above, each of the processing chambers 1220 and 1222 may include one or more safety-critical components 1218. Safety-critical components 1218 may refer to sensors and hardware that are used by the device to process one or more biological fluids. In one or more examples, safety-critical components located within each processing chamber may include a Light Engine Components (LEC) module 1224, a temperature sensor 1226, a platform (e.g., drawer) latch sensor 1228. , a kit detection sensor 1230 , a tray position sensor 1232 , a platform 1234 (eg, a drawer), a platform (eg, a drawer) lock 1236 , and an agitator 1238 .

In one or more examples, LEC module 1224 may include one or more light sources (e.g., UV light sources) and light sensors, and is configured to apply light (e.g., UV light) to a biological fluid, as well as control the amount of light , delivered to a biological fluid and/or received by a biological fluid. In one or more examples of the present invention, the safety-critical components 1218 may include an agitation device that may be configured to agitate the contents of the treatment container to distribute (e.g., uniformly distribute) the biological fluid and/or pathogen inactivating composition in the biological liquid (for example, mixed with it). In one or more examples, agitator device 1238 may include a mechanical agitator device (e.g., motor, servo) configured to agitate a biological fluid or photoactive composition for inactivating pathogens in (e.g., mixed with) the biological fluid. In one or more examples, the safety-critical components may include a platform (e.g., drawer) lock 1236 that is configured to lock or unlock the platform (e.g., drawer) of the treatment chamber (i.e., prevent the platform (e.g., drawer) from opening drawer)) based on the command received from the CSB 1206.

The safety-critical components 1218 may further include a plurality of sensors that are configured to provide information regarding the operation of the device to the CSB 1206. In one or more examples, temperature sensor 1226 may be configured to monitor the temperature of the system and/or body fluid and may be configured to provide live temperature data of the body fluid and/or device to CSB 1206. In one or more examples of the present invention, a platform (e.g., drawer) latch sensor 1228 may be configured to detect whether a platform (e.g., drawer) latch (e.g., drawer) of a device (described in more detail above) is in the open or closed position, and may be configured to transmit to CSB 1206 a signal indicating the position of the latch. In one or more examples, a kit (e.g., treatment kit, fluid treatment kit) detection sensor 1230 may be configured to detect the presence of a container (e.g., bag) containing a biological fluid on or in a platform (e.g., a drawer corresponding to tray) and/or in the processing chamber, and may also be configured to transmit to CSB 1206 a signal indicating the presence or absence of a container (eg, a bag). In one or more examples of the present invention, the tray position sensor 1232 may be configured to sense the presence of a tray and/or the position of a device tray (described in more detail above), such as the presence of a tray and/or the position (e.g., movement) of a tray within a platform (e.g., drawer) and may also be configured to transmit to CSB 1206 a signal indicating the position of the platform/tray/drawer. In one or more examples, the platform (e.g., drawer) and/or associated sensor 1234 may be configured to determine the position of the platform (e.g., drawer) of the processing chamber (e.g., determine whether the platform (e.g., drawer) is located in a closed position within the processing chamber) and may be configured to transmit to CSB 120 a signal indicating the position of the drawer. In one or more examples, the term tray may refer to a removable member or platform component that holds a biological fluid during treatment and that can be made transparent (e.g., fully or partially transparent to transmit light) on one or more surfaces, such as, for example, the bottom (eg bottom) of a tray. In one or more examples, the term drawer may refer to a platform and associated frame that supports the tray, and may also

- 29 045233 fix the agitator motor. In one or more examples, the drawer may be configured to provide a tray to an operator. In one or more examples, the contents of the tray may be agitated during processing, such as by moving back and forth along a linear path within a platform (eg, a drawer).

In one or more examples of the present invention, the CSB 1206 may be configured to communicate directly with the device's power button to turn the device on or off, and thereafter issue commands to each of the safety-critical components 1218 to stop or start operation. The system 1200 may also include a power supply 1240 that can be used to provide an electrical signal to each of the components included in the system 1200 to power them.

As shown in FIG. 12, system 1200 may include two separate controllers, UIC 1202 and CSB 1206, to control non-safety-critical components and safety-critical components 1218, respectively. By employing two separate controllers, system 1200 can ensure that malicious activities or failures in operation of the device by external users or devices may have minimal impact on the operation of safety-critical components 1218. In order to further isolate safety-critical components from non-safety-critical components, UIC 1202 may be configured to communicate with non-safety-critical components using a first communication protocol, wherein the CSB 1206 can communicate with safety-critical components using a second communication protocol that is different from the first protocol. In one or more examples, system 1200 may also employ a domain-specific communication protocol that is system specific to communicate with and manage safety-critical components 1218. In the example shown in FIG. 12, a domain-specific communication protocol may be referred to as a Treatment Module Interface (TMI) protocol.

In one or more examples, the TMI protocol may be implemented such that safety-critical components respond only to commands sent from CSB 1206. Therefore, UIC 1202, which is configured to control all externally accessible components (i.e., components accessed accessible by an external user or device) cannot be used to directly control safety-critical components 1218, resulting in an additional layer of security for the processing process. Thus, in one or more examples, when a user enters data into one of the non-safety-critical components, such as the touch display 1208, and when a command requires one of the safety-critical components 1218 to take an action, that command may be transmitted from the UIC 1202 to the CSB 1206 via network switch 1204. In one or more examples, network switch 1204 may be optional, but not required to be present. Once the CSB 1206 receives a desired action from the UIC 1202, the CSB may generate one or more commands to the safety-critical component 1218 using the TMI protocol to control the operation of those components in accordance with the desired action registered by the UIC 1202.

To facilitate the interactions described above, in one or more examples, the TMI protocol may be configured to identify the sender/initiator of any packets such that the recipient of the packet can determine whether the command is coming from CSB 1206. In one or more examples of the present invention, the TMI protocol may be is designed such that only commands originating from the CSB 1206 can affect any safety-critical components 1218. Thus, any component considered safety-critical can be configured to receive only TMI packets from the CSB 1206 only.

In one or more examples, the TMI protocol may be implemented as a custom communication interface that may serve as a means of passing messages and commands between the CSB 1206 and processing module components. TMI can be implemented to support security and cyber defense (as described above) by separating non-safety-critical functionality from safety-critical functionality. In addition to supporting security, the TMI protocol can be further implemented to provide modularity and scalability of the device, as well as to improve the reliability and testability of the device. In one or more examples, the TMI protocol may use an Ethernet, UDP/IP transport medium to transport messages recorded in the protocol.

In fig. 13 illustrates an exemplary implementation of a domain-specific communication protocol in accordance with examples of the present invention. In the exemplary circuit 1300 shown in FIG. 13 illustrates a process by which a command from an external user is converted into one or more commands that are used to control individual components of an electronic body fluid treatment device.

- 30 045233

In one or more examples, the process shown in diagram 1300 may begin with a user 1302 issuing a command to the device to begin processing the biological fluid. In one or more examples, the user 1302 may issue a command 1316 through a user interface 1304. The user interface 1304 may include a display (e.g., a touch display), a speech command recognition component, a motion detection component, a keyboard, or any other device that can be configured with the ability to allow the user to input desired actions into the electronic device so that the device can act based on those commands.

In one or more examples, after the user interface 1304 receives a command 1316 from a user 1302, the user interface 1304 may convert the user's command into a command 1318 that is specifically formatted to be compatible with the user interface controller (UIC) 1306 (more details described above). UIC 1306, upon receiving command 1318, may process and validate the command, as shown at step 1320. If command 1318 received by UIC is successfully validated (i.e., the command is correct and, in one or more examples, authenticated), then UIC 1306 may transmit signal 1322 to the user interface 1304 so that the user interface 1304 can provide a visual indication to the user 1302 via the interface 1304 that processing has been successfully initiated.

In one or more examples, after processing and validating the received command 1318, the UIC 1306 may generate and transmit a command 1324 formatted using the TMI domain-specific communication protocol, which is configured to notify the system controller 1308 (described above in relation to FIG. 12) of the need the electronic device performs the functions desired by the user. In one or more examples, command 1324 formatted in the TMI protocol may include information about the sender of command 1324 (in this case UIC 1306), wherein the system controller may be configured to receive only commands to initiate processing sent via UIC 1306 When system controller 1308 receives TMI formatted message 1324 from UIC 1306, system controller 1308 may process and validate the command as shown in step 1326.

In one or more examples, after the system controller 1308 processes and validates the TMI formatted message 1324 from the UIC 1306 at step 1326, the system controller may generate and transmit one or more commands to each of the components 1310, 1312, and 1314 to initiate biological processing. liquids. In one or more examples, components 1310, 1312, and 1314 may be safety-critical components located in the processing chambers of the device, which in one or more examples may include lighting device components, agitator components, platform/tray/drawer latches and sensors, which are discussed in more detail above with reference to FIGS. 12. In one or more examples, the system controller may generate separate commands 1328, 1332, and 1336 for each of the components 1310, 1312, and 1314 that may be involved in the biological fluid processing process. In one or more examples, instructions 1328, 1332, and 1336 may be formulated using a domain-specific TMI communication protocol that is known only to components within the electronic device. In addition, commands 1328, 1332, and 1336 generated by the TMI communication protocol may include information about the source of the command (in this case, system controller 1308), and each of components 1310, 1312, and 1314 may be configured to respond only to commands that are determined to originate from the system controller 1308.

In one or more examples, the system controller 1308 may generate to the first processing camera component 1310 a TMI message 1328 that specifies an action that the component should take and that identifies the source of the message. After the first component 1310 receives the command 1328, it may process and validate the command at step 1330 to ensure that the command is not only correct, but also comes from the system controller 1308. In the event that the component 1310 determines that the command 1328 is incorrect, or it is not possible to determine that the command 1328 is coming from the system controller 1308, the component may send a message to the system controller 1308 that warns of an error (not shown). However, if the command is successfully validated and authenticated, in one or more examples, component 1310 may perform the action specified in message 1328. After component 1310 performs the action, it may generate message 1344, which is also formatted using the TMI protocol and which notifies system controller 1308 that the requested action has been completed.

In one or more examples, the system controller 1308 may generate to the second processing camera component 1312 a TMI message 1332 that specifies an action that the component should take and that identifies the source of the message. After the second component 1312 receives the command 1332, it may process and validate the command at step 1334.

- 31 045233 to ensure that the command is not only correct, but also comes from the system controller 1308. In the event that the component 1312 determines that the command 1332 is incorrect, or it is impossible to determine that the command 1332 comes from the system controller 1308, component 1312 may send a message to system controller 1308 that warns of an error (not shown). However, if the command is successfully validated and authenticated, in one or more examples, component 1312 may perform the action specified in message 1332. After component 1312 performs the action, it may generate message 1340, which is also formatted using the TMI protocol and which notifies system controller 1308 that the requested action has been completed.

In one or more examples, the system controller 1308 may generate for the third processing camera component 1314 a TMI message 1336 that specifies an action that the component should take and that identifies the source of the message. After the third component 1314 receives the command 1336, it may process and validate the command at step 1338 to ensure that the command is not only correct, but also comes from the system controller 1308. In the event that the component 1314 determines that the command 1336 is incorrect, or the command 1336 cannot be determined to come from system controller 1308, component 1314 may send a message to system controller 1308 that warns of an error (not shown). However, if the command is successfully validated and authenticated, in one or more examples, component 1314 may perform the action specified in message 1336. After component 1314 performs the action, it may generate message 1342, which is also formatted using the TMI protocol and which notifies system controller 1308 that the requested action has been completed.

Although the examples shown in FIGS. 13 illustrate a communication process for a device that includes three components 1310, 1312, 1314, this example can easily be applied to a device with any number of components without deviating from the methods and processes described above with reference to FIGS. 13. Thus, components 1310, 1312 and 1314 are for illustrative purposes and should not be construed as limiting.

In one or more examples, after system controller 1308 has received messages 1340, 1342, and 1344 from components 1310, 1312, and 1314, system controller 1308 may process and validate the received messages at step 1346 and may then generate and transmit to UIC 1306 a formatted TMI message 1348, which indicates the end of processing (eg, successful completion of processing). In one or more examples, after receiving a message 1348 from the system controller 1308 that indicates the end of processing, the UIC may transmit to the user interface 1304 a message 1350 (either in TMI format or another display-readable format) that instructs the user interface to display one or more graphical user interfaces that indicate to the user the end of the processing process.

As demonstrated above with respect to the example shown in FIG. 13, the device may be configured to provide isolation of components controlled by UIC 1306 from components controlled by system controller 1308 using the TMI domain-specific communication protocol. By configuring the TMI protocol so that safety-critical components used to process biological fluid can only accept commands generated in the TMI protocol (which is known only internally to the device) and only accept commands generated by the 1308 system controller, the possibility of that a malicious user or other entity will control the device without authorization. In one or more examples, the TMI communication protocol may be further configured to facilitate the addition of new components or the replacement of spent components in a processing chamber with minimal disruption to the operation of the device, since the system controller may be configured to detect new components and ensure that only it can issue commands to control them.

In one or more examples, the TMI communication protocol may serve as a means of transmitting messages and commands between the controller 1308 and components located in each processing chamber. The TMI communication protocol can support device security and cybersecurity by separating and isolating safety-critical components from non-safety-critical components, which provides modularity and scalability, and improves reliability and testability. In one or more examples, the TMI communication protocol may be configured using state-based design, which can reduce design complexity, reduce the likelihood of misuse, isolate errors among components, and efficiently report events to the device. In one or more examples, the TMI communication protocol may use an off-the-shelf commercial transport protocol, such as Ethernet or UDP/IP, to transport messages back and forth between various device components.

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In fig. 14 depicts an exemplary method 1400 of operating an exemplary system for treating biological fluids in accordance with examples of the present invention. In some examples, method 1400 may be implemented using devices and systems described herein.

Method 1400 includes connecting (step 1402) a non-safety-critical component or a safety-critical component to a processing interface. For example, with reference to FIG. 10 and 11, one of the non-safety-critical component or the safety-critical component is communicatively connected to a common interface 1022 or 1122.

The method includes, in response to the connection of the non-safety-critical component or the safety-critical component to the processing interface, detecting (step 1404) by the controller the presence of the non-safety-critical component or the safety-critical component in the electronic device. For example, with reference to FIG. 10 and 11, the presence of a non-safety-critical component or a safety-critical component is detected in response to the connection made at step 1402.

The method includes transmitting (step 1406) a message between the controller and a non-safety-critical component or a safety-critical component through a processing interface, wherein the message is based on a domain-specific interface language. For example, consider FIG. 10 and 11, a message as described herein is transmitted between the attached component and the controller module.

The method includes determining (step 1408) the state of the non-safety-critical component or the safety-critical component based on the message. For example, consider FIG. 10 and 11, the state, as described herein, of the attached component is determined based on the transmitted message at step 1406.

Although the general interface is described with respect to a system that includes a plurality of non-safety-critical components and safety-critical components, it should be understood that the above description also applies to an individual non-safety-critical component or an individual safety-critical component. For example, the system includes a control module, a non-safety-critical component, a safety-critical component, and a common interface (eg, a processing interface included in an electronic device for processing biological fluid). The interaction between a control module and a non-safety-critical component or a safety-critical component using a common interface may be substantially the same as the interactions using a common interface between a control module, non-safety-critical components and safety-critical components as described herein. . For brevity, interactions between the control module and a non-safety-critical component or a safety-critical component will not be described. It should be understood that these interactions are also within the scope of the present invention.

In fig. 15 depicts an example of a computing device in accordance with one embodiment of the present invention. Device 1500 may be a host computer connected to a network. Device 1500 may be a client computer or a server. As shown in FIG. 15, device 1500 may be any suitable type of microprocessor device, such as a personal computer, workstation, server, or portable computing device (portable electronic device), such as a mobile phone or tablet. The device may include, for example, one or more processors 1502, an input device 1506, an output device 1508, a storage device 1510, and a communication device 1504. Input device 1506 and output device 1508 may be generally as described above and may be either plug-in or integrated into the computer.

Input device 1506 may be any suitable device that provides data input, such as a touch screen, keyboard or keypad, mouse, or voice recognition device. Output device 1508 may be any suitable device that provides data output, such as a touch screen, a haptic feedback device, or an acoustic speaker.

The drive 1510 may be any suitable device that provides data storage, such as an electrical, magnetic, or optical storage device, including RAM, cache memory, a hard disk, or a removable data storage disk. Communication device 1504 may include any suitable device capable of transmitting and receiving signals over a network, such as a chip or network interface device. These computer components can be connected to each other in any suitable manner, for example, through a hardware bus or a wireless connection.

Software 1512, which may be stored in storage device 1510 and executed by processor 1510, may include, for example, software that implements the functionality of the present invention (eg, as implemented in the devices described above).

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The software 1512 may also be stored and/or transmitted on any non-transitory computer-readable storage medium for use with (or use in connection with) a system, apparatus, or command execution device, such as those described above, that is capable of executing software-related commands from the system , apparatus or device for executing commands, and execute these commands. In the context of the present invention, a computer-readable storage medium may be any storage medium, such as storage device 1510, that is capable of housing or storing software for use on (or use in connection with) a system, apparatus, or command execution device.

Software 1512 may also be distributed in any transport medium for use with (or use in connection with) a system, apparatus, or command execution device, such as those described above, that is capable of invoking commands associated with the software from the system, apparatus, or command execution device. , and execute these commands. In the context of the present invention, a transport medium can be any medium that is capable of communicating, distributing or transmitting software for use (or use in connection with) a system, apparatus or command executing device. Transportable machine-readable media may include, but are not limited to, electronic, magnetic, optical, electromagnetic or infrared wired or wireless media.

The device 1500 may be connected to a network, which may be any interconnected communication system. The network may use any suitable communication protocol and be protected by any suitable security protocol. The network may contain network links of any suitable architecture capable of transmitting and receiving network signals, such as wireless network connections, T1 or T3 lines, cable networks, digital subscriber lines (DSL) or telephone lines.

The device 1500 can run any operating system suitable for networking. The software 1512 may be written in any suitable programming language, such as C, C++, Java, or Python. In various embodiments, application software embodying the functionality of the present invention may be deployed in various configurations, such as a client-server architecture or through a web browser as a web application or web service, for example.

In one aspect, an electronic device for treating biological fluid includes a plurality of non-safety-critical components; a first controller communicatively coupled to the plurality of non-safety-critical components and configured to control the plurality of non-safety-critical components; a plurality of safety-critical components, wherein said safety-critical components comprise one or more platforms, each platform of the one or more platforms configured to carry one or more biological fluids; one or more lighting devices, each lighting device configured to irradiate a biological fluid; and one or more security components; wherein the one or more safety components are configured to monitor the operation of the safety-critical components; and a second controller communicatively coupled to the plurality of safety-critical components and communicatively coupled to the first controller, the second controller configured to coordinate one or more operations involving the plurality of safety-critical components; wherein the first controller and the second controller communicate with each other using a domain-specific interface language configured to isolate the plurality of non-safety-critical components from the plurality of safety-critical components.

While specific components, configurations, properties and functions are set forth above, one skilled in the art will appreciate that other embodiments may also be employed. In addition, although it may appear that a particular property is described in connection with a particular embodiment, one skilled in the art will appreciate that various properties of the described embodiments can be combined. Moreover, aspects described in connection with a particular embodiment of the present invention may stand alone.

In some embodiments, any of the above-described treatment systems and devices may be used to inactivate pathogen(s) in one or more biological fluids, including, for example, biological fluids mixed with one or more pathogen inactivating compositions (e.g., a photoactive composition for inactivation of pathogens, psoralen). In particular, any of the above-described treatment systems and devices may irradiate a mixture of one or more pathogen inactivating compositions and a biological fluid, such as, for example, blood or a blood product (e.g., platelet compositions, plasma compositions, and derivatives thereof), with light (e.g., ultraviolet light) of certain wavelengths to cause photochemical

- 34 045233 reaction and inactivate pathogen(s), such as viruses, bacteria, parasites and other contaminants, such as, for example, cellular contaminants (eg, white blood cells) that may be present in a biological fluid. In some embodiments, the pathogen inactivation composition specifically targets nucleic acids to photochemically form adducts and/or cross-links. For example, the device described in this disclosure can be used in a method of treating a biological fluid, including: obtaining the biological fluid in a mixture with a photoactive composition for inactivating pathogens (for example, psoralen, amotosalen) and irradiating the biological fluid with ultraviolet light, such as, for example , ultraviolet light with a first peak wavelength of about 315 to about 350 nm (e.g., from about 315 to about 335 nm, from about 330 to about 350 nm, from about 340 to about 350 nm, from about 340 nm, from about 345 nm) emitted by a set of one or more first light sources, wherein irradiation of the biological fluid occurs for a period of time and with an intensity sufficient to inactivate the pathogen in the biological fluid. In some examples, the device of the present invention may be used in a method of treating a biological fluid, comprising irradiating the biological fluid with ultraviolet light (eg, UV-A, UV-B, UV-C) emitted by an array of one or more first light sources, wherein irradiation of biological fluid occurs for a period of time and with an intensity sufficient to inactivate the pathogen in the biological fluid. In some embodiments, each of the one or more light sources emits light with a full width at half maximum (FWHM) spectral band of less than 20 nm. In some embodiments, each of the one or more first light sources is a light-emitting diode (LED).

The term pathogen inactivating composition means any suitable compound, such as a low molecular weight organic compound, that can be used to inactivate a pathogen that may be present in a biological fluid, such as, for example, blood or a blood product. A pathogen inactivating composition that is a photoactive, photoactivatable, photochemical or photosensitizing compound is a suitable composition that requires a certain level of light to sufficiently inactivate a particular pathogen. Such formulations are preferred for inactivating pathogens in biological products, as they provide control over the inactivation process. In some embodiments, the pathogen inactivating composition is a photoactive pathogen inactivating composition from the group of substances consisting of psoralen, isoalloxazine, alloxazine, phthalocyanine, phenothiazine, porphyrin, and merocyanine 540. In some embodiments, the pathogen inactivating composition is psoralen. In some embodiments, the pathogen inactivation composition is amotosalen (eg, S-59). Photoactivatable or photochemical pathogen inactivating compounds such as those described herein may include, but are not limited to, psoralens, isoalloxazines, alloxazines, phthalocyanines, phenothiazines, and porphyrins, provided that these terms cover the entire class of compounds, i.e. the main compound and its corresponding derivatives. For example, psoralens or psoralen are generally used to describe the main compound psoralen and any of its derivatives (e.g., amotosalen), isoalloxazines or isoalloxazine are generally used to describe the main compound of isoalloxazine and any of its derivatives (e.g., riboflavin), and so on . Such derivatives contain the structure of the main compound, as well as additional substituents on the base. Descriptions of such compounds include any salts thereof.

The term amotosalen should be understood to mean the compound 3-(2-aminoethoxymethyl)-2,5,9trimethylfuro[3,2-g]chromene-7-one and any of its salts. This compound may also be called 4'-(4amino-2-oxa)butyl-4,5',8-trimethylpsoralen. Where the methods described in this disclosure involve adding amotosalen-HCl (amotosalen chloride), removing the compound from a biological fluid, such as, for example, a blood product (e.g., platelet composition, platelet unit, plasma composition, whole blood composition, plasma composition ), is not limited to the removal of amotosalen-HCl, since amotosalen may be present in solution as other salts or as a free base. In the context of the methods described herein, removal of amotosalen means removal of this compound in any form, such as the free base or any salt, as measured by the assays described herein.

In some embodiments, the pathogen inactivating composition is a 4-primary amino-substituted psoralen, which is a psoralen compound in which the NH ₂ group is linked to the 4' position of psoralen by a hydrocarbon chain with a total length of 2-20 carbon atoms, in which from 0 to 6 carbon atoms independently substituted with NH or O, and each substitution point is separated from every other substitution point by at least two carbon atoms and is separated from psoralen by at least one carbon atom. 4'-primary amino-substituted psoralens may have additional substitutions at the 4, 5' and 8 positions of the psoralen, which substitutions include, but are not limited to,

- 35 045233 the following groups: H and (CH ₂ ) _n CH ₃ , where n=0-6. In some embodiments, the 4'-primary amino-substituted psoralen contains: a) an R ₁ substituent on the 4' carbon atom selected from the group consisting of -(CH ₂ ) _U -NH ₂ , -(CH ₂ ) _W -R ₂ - (CH ₂ ) _Z -NH ₂ , -(CH ₂ ) _w -R ₂ -(CH ₂ ) _x -R ₃ -(CH ₂ )z-NH ₂ and -(CH ₂ )wR ₂ -(CH ₂ )xR ₃ -(CH ₂ ) _y -R4-(CH ₂ ) _Z -NH ₂ ; wherein R2, _R3 , and _R4 are independently selected from the group consisting of O and NH, in which u is an integer from 1 to 10, w is an integer from 1 to 5, x is an integer from 2 to 5, y is an integer from 2 to 5, and z is an integer from 2 to 6; and b) substituents _R5 , R6 and R7 on the 4th, 5' and 8th carbon atoms, respectively, independently selected from the group consisting of H and ( _CH2 ) _vCH3 , where v is an integer from 0 to ₅ ; or its salt.

In some embodiments, the pathogen inactivating composition is a 5-primary amino-substituted psoralen, which is a psoralen compound in which an NH ₂ group is linked to the 5' position of psoralen by a hydrocarbon chain with a total length of 1 to 20 carbon atoms, in which there are from 0 to 6 carbon atoms independently substituted with NH or O, and each substitution point is separated from every other substitution point by at least two carbon atoms, and is separated from psoralen by at least one carbon atom. 5'-primary amino-substituted psoralens may have additional substitutions at the 4, 4' and 8 positions of the psoralen, which substitutions include, but are not limited to, the following groups: H and (CH ₂ ) _n CH ₃ , where n=0-6 . In some embodiments, the 5'-primary amino-substituted psoralen contains: a) an R ₁ substituent on the 5' carbon atom selected from the group consisting of -(CH2)u-NH2, -(CH2)w-R2-(CH2 )z-NH2, -(CH2)w-R2-(CH2)x-R3-(CH2)z-NH2, and -(CH2)w-R2-(CH2)x-R3-(CH2)y-R4( CH ₂ ) _Z -NH ₂ ; wherein R2, _R3 , and R4 are independently selected from the group consisting of O and NH, and wherein u is an integer from 1 to 10, w is an integer from 1 to 5, x is an integer from 2 to 5, y is an integer from 2 to 5, and z an integer from 2 to 6; and b) substituents R ₅ , R ₆ and R 7 on the 4, 4' and 8th carbon atoms, respectively, independently selected from the group consisting of H and (CH2)vCH3, where v is an integer from 0 to 5, where if R1 is selected from the group consisting of -(CH2) _U -NH2 _, then R7 is ( _CH2 ) _vCH3 , and where if _{R5 , R6, and R7 are (CH2)vCH3} ^, _then u is an integer from 3 to 10; or its salt. Examples of psoralen compounds are described, for example, in US Pat. No. 5,593,823.

In some embodiments, the biological fluid is mixed with a pathogen inactivation compound (PIC) in a platelet additive solution (PAS). In some embodiments, the PIC is mixed into the PAS prior to mixing with the biological fluid. Solutions for storing platelets are known in the art, for example, as disclosed in Alhumaidan et al. and Ringwald et al. (Alhumaidan, H. and Sweeney, J., J Clin Apheresis, 27: 93–98 (2012); Ringwald et al., Transfusion Medicine Reviews, 20: 158–64 (2006)), the contents of which are incorporated herein in their entirety via link. In some embodiments, the platelet storage solution (PAS) contains one or more of the following: chloride, acetate, citrate, sodium, magnesium, phosphate, gluconate, glucose, and bicarbonate. In some embodiments, the platelet storage solution (PAS) is a platelet storage solution approved by a regulatory agency or accreditation organization generally recognized in the art.

In some embodiments, the methods further include agitating the biological fluid. In some embodiments of any of the methods described in the present disclosure, the total dose of ultraviolet light irradiating a biological fluid (e.g., emitted by one or more light sources, emitted by a set of one or more light sources, emitted by a group of light sources) is from about 0 .5 to about 50 J/cm ² , for example, in any of the ranges from about 0.5 to about 10 J/cm ² , from about 0.5 to about 15 J/cm ² , from about 0.5 to about 25 J/ ^cm2 , from about 1 to about 10 J/ ^cm2 , from about 1 to about 15 J/ ^cm2 , from about 1 to about 25 J/ ^cm2 , from about 3 to about 10 J/ ^cm2 , from about 3 to about 15 J/cm ² , from about 3 to about 25 J/cm ² , from about 5 to about 10 J/cm ² , from about 5 to about 15 J/cm ² , from about 5 to about 25 J /cm ² , from about 10 to about 30 J/cm ² , from about 10 to about 20 J/cm ² , from about 15 to about 50 J/cm ² , from about 15 to about 35 J/cm ² , from about 20 to about 30 J/cm ² , from about 25 to about 50 J/cm ² , from about 30 to about 40 J/cm ² , or from about 40 to about 50 J/cm ² . In some embodiments, the total dose of ultraviolet light irradiating the biological fluid is about 0.5 J/cm ² or greater, such as any of 1 J/cm ² or greater, 2 J/cm ² or greater, 3 J/cm ² or more, 4 J/ ^cm2 or more, 5 J/ ^cm2 or more, 6 J/ ^cm2 or more, 7 J/cm2 or more, 8 J/ ^{cm2 or} more, 9 J/cm2 ^or more more, 10 J/ ^cm2 or more, 15 J/ ^cm2 or more, 20 J/ ^cm2 or more, 25 J/ ^cm2 or more, 30 J/ ^cm2 or more, 35 J/ ^cm2 or more, 40 J/ ^cm2 or more, 45 J/ ^cm2 or more, or 50 J/ ^cm2 or more. In some embodiments, the total dose of ultraviolet light irradiating the biological fluid is less than about 50 J/ ^cm2 , less than about 40 J/ ^cm2 , less than about 30 J/ ^cm2 , less than about 25 J/ ^cm2 , less than about 20 J/cm ² , less than about 15 J/cm ² or less than about 10 J/cm ² . In some embodiments, irradiation of the biological fluid occurs for a period of time and at an intensity sufficient to inactivate the pathogen in the biological fluid (eg, if one is present in the biological fluid). For example, in some embodiments, irradiation of the biological fluid occurs over a period

- 36 045233 time and intensity sufficient to provide a dose (e.g., a desired total dose, a given total dose, the above total dose) of ultraviolet light irradiating a biological fluid (e.g., any suitable combination of time period and intensity sufficient to provide a total dose of ultraviolet Sveta). In some embodiments, said intensity is from 1 to 1000 mW/ ^cm2 (eg, from 1 to 100 mW/ ^cm2 ). In some embodiments, the time period is from 1 second to 2 hours (eg, from 1 to 60 minutes).

It should be understood that treating a body fluid to inactivate a pathogen(s) that may be present does not necessarily inactivate all pathogens that may be present, but it does significantly reduce the number of pathogens, significantly reducing the risk posed by the presence of the pathogen(s). eg, infection associated with the introduction of a biological fluid contaminated with a pathogen, transfusion-associated disease from a blood product, transfusion-transmitted infection from a blood product). Pathogen inactivation can be analyzed by measuring the number of infectious pathogens (eg, viral particles, bacteria) in a defined volume, and the level of inactivation is typically reported as the log reduction in pathogen infectivity or the log reduction in titer. Methods for analyzing the log reduction in titer and measuring it to estimate inactivation levels are well known in the art. In some embodiments, the systems, devices, and/or treatment methods are sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs or more) of the pathogen in a biological fluid, if present. . In some embodiments, the post-irradiation biological fluid is suitable for infusion into a patient without further preparation to remove residual pathogen inactivation composition or photoproduct(s) thereof. In some embodiments, the systems, devices, and/or treatment methods are sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs or more) of the pathogen in a biological fluid, if present. , and the biological fluid contains no more than 10 µM of a composition for inactivating pathogens after irradiation of the biological fluid. In some embodiments, the systems, devices, and/or treatment methods are sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs or more) of the pathogen in a biological fluid, if present. , and the biological fluid contains no more than 7.5 µM of the composition for inactivating pathogens after irradiation. In some embodiments, the systems, devices, and/or treatment methods are sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs or more) of the pathogen in a biological fluid, if present. and the biological fluid contains no more than 5 μM (e.g., 4 μM or less, 3 μM or less, 2 μM or less, 1 μM or less, 0.5 μM or less) of the composition for inactivating pathogens after irradiation. In some embodiments, the concentration of the pathogen inactivation composition mixed with a biological fluid prior to irradiation is at least about 10 μM (e.g., at least about 30 μM, at least about 60 μM, at least about 90 μM, at least about 110 µM). In some embodiments, the concentration of the pathogen inactivation composition mixed with a biological fluid prior to irradiation is from about 15 to about 150 μM (e.g., from about 30 to about 110 μM, from about 60 to about 90 μM, about 75 μM). In some embodiments, the concentration of the pathogen inactivating composition mixed with the biological fluid after irradiation is at least 3 times lower than the concentration of the pathogen inactivating composition mixed with the biological fluid before irradiation. In some embodiments, the biological fluid retains sufficient biological activity after irradiation to make the biological fluid suitable for infusion into a patient. In any of these embodiments, the biological fluid may be a blood product (eg, platelets, plasma).

In some aspects of the above apparatus, the first controller includes an output port, wherein the first controller is configured to communicate with an external computer device using the output port.

In some aspects of the foregoing devices, isolating the plurality of non-safety-critical components from the plurality of safety-critical components includes configuring a domain-specific interface language to minimize the impact on the plurality of safety-critical components resulting from one or more modifications to the non-safety-critical components. components.

In some aspects of the foregoing devices, the device further comprises one or more processing chambers configured to receive a biological fluid, wherein each platform of the one or more platforms is configured to be located within the processing chamber of the one or more processing chambers.

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In some aspects of the foregoing devices, the safety-critical components further comprise one or more agitating devices, each agitating device configured to agitate the contents of at least one of the one or more platforms.

In some aspects of the above devices, the safety-critical components further comprise one or more sensors configured to detect light energy from the one or more lighting devices.

In some aspects of the above devices, one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid, and wherein one or more groups of light sources are configured to emit light in the ultraviolet spectrum.

In some aspects of the above devices, each of the one or more light source groups comprises a first light source channel configured to emit ultraviolet light with a first peak wavelength of about 315 nm to about 350 nm.

In some aspects of the above devices, the first channel of light sources includes one or more light sources, each of which emits light with a full width at half maximum (FWHM) spectral band of less than 20 nm.

In some aspects of the above devices, the first channel of light sources includes one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs).

In some aspects of the above devices, the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources.

In some aspects of the above devices, one or more safety-critical components include computing hardware configured to implement one or more algorithms and configured to store information about the operation of the electronic device.

In some aspects of the above devices, the second controller is configured to enable or disable one or more safety-critical components based on one or more operating states of the device.

In some aspects of the above devices, one or more security components are collectively configured to implement a hardware watchdog.

In some aspects of the above devices, one or more security components are collectively configured to implement a software watchdog.

In some aspects of the above devices, one or more non-safety-critical components include a display configured to provide information to a user of the device and/or receive input from a user of the device.

In some aspects of the above devices, a method of treating a biological fluid includes: preparing the biological fluid in a mixture with a photoactive composition to inactivate pathogens; and irradiating the biological fluid with ultraviolet light having a first peak wavelength of from about 315 nm to about 350 nm emitted by an array of one or more first light sources, wherein: 1) each of the one or more first light sources emits light with a full width at half maximum ( FWHM) spectral band less than 20 nm; or 2) each of the one or more first light sources is a light-emitting diode (LED), wherein irradiation of the biological fluid occurs for a period of time and at an intensity sufficient to inactivate the pathogen in the biological fluid.

In some aspects of the foregoing devices, the device further comprises a processing interface, wherein a first controller is communicable with a plurality of non-safety-critical components and a second controller is communicable with a plurality of safety-critical components via a processing interface; one or more processors; a storage device and one or more programs, wherein the one or more programs are stored in the storage device and are configured to be executed by one or more processors, wherein the one or more programs include instructions for doing the following: in response to a data communication connection of a plurality non-safety-critical components with a processing interface, and communicating with a plurality of safety-critical components with a processing interface, detecting, using the controller, the presence of a plurality of non-safety-critical components and a plurality of safety-critical components in an electronic device; transmitting first messages between the first controller and the non-safety-critical component via a processing interface; transmitting second messages between the second controller and the safety-critical component via a processing interface, the first and second messages being based on a domain-specific interface language; determination of non-critical states for

- 38 045233 component safety based on first messages; and determining the states of safety-critical components based on the second messages.

In some aspects of the foregoing devices, the non-safety-critical component or the safety-critical component is in a first state, wherein the one or more programs further include instructions to do the following: change the state of the non-safety-critical component or the safety-critical component from the first state to the second state state; in response to the state change, sending a second message from the non-safety-critical component or the safety-critical component to the first controller or the second controller via a processing interface; receiving the second message by the first controller or the second controller; and in response to receiving the second message, determining a second state of the processing component.

In some aspects of the above devices, the one or more programs further include instructions for providing electrical power to the electronic device; wherein the presence of a plurality of non-safety-critical components and a plurality of safety-critical components is further determined in response to electrical power being applied to the electronic device.

In some aspects of the foregoing devices, the one or more programs further include instructions for doing the following: in response to electrical power being applied to the electronic device, assigning local network addresses and ports to the plurality of non-safety-critical components and the plurality of safety-critical components, wherein the local network addresses or ports are based on the device's domain-specific interface language.

In some aspects of the above devices, one or more messages written in a domain-specific interface language may be transmitted using TCP/IP.

In another aspect, a method of treating a biological fluid includes preparing the biological fluid in a mixture with a photoactive composition to inactivate pathogens; and irradiating said biological fluid using any of the foregoing devices for a period of time and with an intensity sufficient to inactivate the pathogen in the biological fluid.

In another aspect, a method of operating an electronic device for processing a biological fluid is provided, the electronic device comprising a controller, a non-safety-critical component, a safety-critical component, and a processing interface, the method comprising: connecting the non-safety-critical component or the safety-critical component to the interface processing; in response to connecting the non-safety-critical component or the safety-critical component to the processing interface, detecting, by the controller, the presence of the non-safety-critical component or the safety-critical component in the electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component via a processing interface, said message being based on a domain-specific interface language; and determining the state of the non-safety-critical component or the safety-critical component based on the message.

In some aspects of the foregoing method, the electronic device further comprises a second controller coupled to a processing interface, wherein the safety-critical component is coupled to the processing interface, the method further comprising: connecting the non-safety-critical component to the processing interface; and isolating the non-safety-critical component from the safety-critical component, wherein said isolation includes configuring the domain-specific interface language to minimize the impact on the safety-critical component resulting from one or more modifications to the non-safety-critical component.

In some aspects of the above methods, the non-safety-critical component or the safety-critical component is in a first state, the method further including: changing the state of the non-safety-critical component or the safety-critical component from the first state to the second state; in response to the state change, sending a second message from the non-safety-critical component or the safety-critical component to the controller via a processing interface; receiving the second message by the controller; and, in response to receiving the second message, determining a second state of the processing component.

In some aspects of the foregoing methods, the safety-critical component is one of a platform, a lighting device, an agitator, and a safety component, wherein the one or more safety components are configured to monitor the operation of the safety-critical components.

In some aspects of the above methods, the method further includes isolating the processing interface from the external network using a domain-specific interface language.

- 39 045233

In some aspects of the above methods, the method further includes providing electrical power to the electronic device; wherein the presence of the processing component is further detected in response to electrical power being applied to the electronic device.

In some aspects of the above methods, the method further includes, in response to the application of electrical power to the electronic device, assigning local network addresses and ports to a non-safety-critical component or a safety-critical component, wherein the local network addresses or ports are based on a domain-specific interface language.

In some aspects of the above methods, one or more messages written in a domain-specific interface language may be transmitted using TCP/IP.

In another aspect, an electronic device for processing biological fluid comprises a controller, a non-safety-critical component, a safety-critical component, a processing interface, one or more processors; memory and one or more programs, wherein the one or more programs are stored in the storage device and are configured to be executed by one or more processors, wherein the one or more programs include instructions for doing the following: in response to a connection of a non-safety-critical component or a safety-critical component for the safety of a component with a processing interface, detecting, using a controller, the presence of a non-safety-critical component or a safety-critical component in an electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component to and through the processing interface, wherein said message is based on a domain-specific interface language; and determining the state of the non-safety-critical component or the safety-critical component based on the message.

In another aspect, a non-transitory computer-readable storage medium is provided that stores one or more programs, wherein the one or more programs comprise instructions that, when executed by an electronic device having one or more processors and memories, cause the device to do the following: connect a non-safety-critical component or a safety-critical component with processing interface; in response to connecting the non-safety-critical component or the safety-critical component to the processing interface, detecting, by the controller, the presence of the non-safety-critical component or the safety-critical component in the electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component to and through the processing interface, wherein said message is based on a domain-specific interface language; and determining the state of the non-safety-critical component or the safety-critical component based on the message.

In some embodiments, the electronic device includes: a plurality of non-safety-critical components; a first controller communicatively coupled to a plurality of non-safety-critical components; many safety-critical components; and a second controller communicatively coupled to the plurality of safety-critical components. In some embodiments, the electronic device includes a processing interface.

In some embodiments, the electronic body fluid processing device includes a plurality of non-safety-critical components; a first controller communicatively coupled to the plurality of non-safety-critical components and configured to control the plurality of non-safety-critical components; a plurality of safety-critical components, wherein said safety-critical components comprise one or more platforms, each platform of the one or more platforms configured to carry one or more biological fluids; one or more lighting devices, each lighting device configured to irradiate a biological fluid; and one or more security components; wherein the one or more safety components are configured to monitor the operation of the safety-critical components; and a second controller communicatively coupled to the plurality of safety-critical components and communicatively coupled to the first controller, the second controller configured to coordinate one or more operations involving the plurality of safety-critical components; wherein the first controller and the second controller communicate with each other using a domain-specific interface language configured to isolate the plurality of non-safety-critical components from the plurality of safety-critical components.

In some embodiments, the first controller includes an output port, wherein the first controller is configured to communicate with an external computing device using the output port.

- 40 045233

In some embodiments, isolating the plurality of non-safety-critical components from the plurality of safety-critical components includes configuring the domain-specific interface language to minimize the impact on the plurality of safety-critical components resulting from one or more modifications to the non-safety-critical components. .

In some embodiments, the device further comprises one or more processing chambers configured to receive a biological fluid, wherein each platform of the one or more platforms is configured to be located within the processing chamber of the one or more processing chambers.

In some embodiments, the safety-critical components further comprise one or more agitation devices, each agitator device configured to agitate the contents of at least one of the one or more platforms.

In some embodiments, the safety-critical components further comprise one or more sensors configured to detect light energy from the one or more lighting devices.

In some embodiments, the one or more lighting devices include one or more groups of light sources arranged to irradiate the biological fluid, and wherein the one or more groups of light sources are configured to emit light in the ultraviolet spectrum.

In some embodiments, each of the one or more light source groups comprises a first light source channel configured to emit ultraviolet light with a first peak wavelength of from about 315 nm to about 350 nm.

In some embodiments, the first channel of light sources includes one or more light sources, each of which emits light with a full width at half maximum (FWHM) spectral band of less than 20 nm.

In some embodiments, the first channel of light sources comprises one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs).

In some embodiments, the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources.

In some embodiments, the one or more safety-critical components include computing hardware configured to implement one or more algorithms and configured to store information about the operation of the electronic device.

In some embodiments, the second controller is configured to enable or disable one or more safety-critical components based on one or more operating states of the device.

In some embodiments, one or more security components are collectively configured to implement a hardware watchdog.

In some embodiments, one or more security components are collectively configured to implement a software watchdog.

In some embodiments, the one or more non-safety-critical components include a display configured to provide information to a user of the device and/or receive input from a user of the device.

In some embodiments, a method of treating a biological fluid includes preparing the biological fluid in a mixture with a photoactive composition to inactivate pathogens; and irradiating the biological fluid with ultraviolet light having a first peak wavelength of from about 315 nm to about 350 nm emitted by an array of one or more first light sources, wherein: 1) each of the one or more first light sources emits light with a full width at half maximum ( FWHM) of a spectral band of less than 20 nm, or 2) each of the one or more first light sources is a light-emitting diode (LED), wherein irradiation of the biological fluid occurs for a period of time and with an intensity sufficient to inactivate the pathogen in the biological fluid.

In some embodiments, the apparatus further comprises: a processing interface, the first controller being coupled to communicate with the plurality of non-safety-critical components and the second controller being coupled to communicating with the plurality of safety-critical components via the processing interface; one or more processors; memory; and one or more programs, wherein the one or more programs are stored in a storage device and configured to be executed by one or more processors, wherein the one or more programs include instructions for performing the following: in response to a communication connection, a plurality of non-critical component safety with

- 41 045233 processing interface, as well as communicating a plurality of safety-critical components with the processing interface, detecting, by means of a controller, the presence of a plurality of non-safety-critical components and a plurality of safety-critical components in an electronic device; transmitting first messages between the first controller and the non-safety-critical component via a processing interface; transmitting second messages between the second controller and the safety-critical component via a processing interface, the first and second messages being based on a domain-specific interface language; determining the states of non-safety-critical components based on the first messages; and determining the states of safety-critical components based on the second messages.

In some embodiments, the non-safety-critical component or the safety-critical component is in a first state, wherein the one or more programs further include instructions to do the following: change the state of the non-safety-critical component or the safety-critical component from the first state to the second state ; in response to the state change, sending a second message from the non-safety-critical component or the safety-critical component to the first controller or the second controller via a processing interface; receiving the second message by the first controller or the second controller; and in response to receiving the second message, determining a second state of the processing component.

In some embodiments, the one or more programs further include instructions for providing electrical power to the electronic device; wherein the presence of a plurality of non-safety-critical components and a plurality of safety-critical components is further determined in response to electrical power being applied to the electronic device.

In some embodiments, the one or more programs further include instructions for doing the following: in response to electrical power being applied to the electronic device, assigning local network addresses and ports to the plurality of non-safety-critical components and to the plurality of safety-critical components, wherein the local network addresses or ports are based on a domain-specific interface language.

In some embodiments, one or more messages written in a domain-specific interface language may be transmitted using TCP/IP.

In some embodiments, a method of treating a biological fluid includes obtaining the biological fluid in a mixture with a photoactive composition for inactivating pathogens and irradiating the biological fluid using any of the above-mentioned devices for a period of time and at an intensity sufficient to inactivate the pathogen in the biological fluid.

In some embodiments, a method of operating an electronic device for processing a biological fluid, the electronic device comprising a controller, a non-safety-critical component, a safety-critical component, and a processing interface, the method including connecting the non-safety-critical component or the safety-critical component to the processing interface ; in response to connecting the non-safety-critical component or the safety-critical component to the processing interface, detecting, by the controller, the presence of the non-safety-critical component or the safety-critical component in the electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component via a processing interface, said message being based on a domain-specific interface language; and determining the state of the non-safety-critical component or the safety-critical component based on the message.

In some embodiments, the electronic device further comprises a second controller coupled to the processing interface, wherein the safety-critical component is coupled to the processing interface, the method further including connecting the non-safety-critical component to the processing interface and isolating the non-safety-critical component from the safety-critical component. wherein said isolation includes configuring the domain-specific interface language to minimize the impact on the safety-critical component resulting from one or more modifications to the non-safety-critical component.

In some embodiments, the non-safety-critical component or the safety-critical component is in a first state, the method further including: changing the state of the non-safety-critical component or the safety-critical component from the first state to the second state; in response to the state change, sending a second message from the non-safety-critical component or the safety-critical component to the controller via a processing interface; receiving second message

- 42 045233 by the controller and in response to receiving the second message, determining the second state of the processing component.

In some embodiments, the safety-critical component is one of a platform, a lighting device, an agitator, and a safety component, wherein the one or more safety components are configured to monitor the operation of the safety-critical components.

In some embodiments, the method further includes isolating the processing interface from the external network using a domain-specific interface language.

In some embodiments, the method further includes providing electrical power to the electronic device; wherein the presence of the processing component is further detected in response to electrical power being applied to the electronic device.

In some embodiments, the method further includes, in response to electrical power being applied to the electronic device, assigning local network addresses and ports to the non-safety-critical component or the safety-critical component, wherein the local network addresses or ports are based on a domain-specific interface language.

In some embodiments, one or more messages written in a domain-specific interface language may be transmitted using TCP/IP.

In some embodiments, an electronic device for processing biological fluid comprises a controller, a non-safety-critical component, a safety-critical component, a processing interface, one or more processors; memory and one or more programs, wherein the one or more programs are stored in the storage device and are configured to be executed by one or more processors, wherein the one or more programs include instructions for doing the following: in response to a connection of a non-safety-critical component or a safety-critical component for the safety of a component with a processing interface, detecting, using a controller, the presence of a non-safety-critical component or a safety-critical component in an electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component to and through the processing interface, wherein said message is based on a domain-specific interface language; and determining the state of the non-safety-critical component or the safety-critical component based on the message.

In some embodiments, a non-transitory computer-readable storage medium is provided that stores one or more programs, wherein the one or more programs comprise instructions that, when executed by an electronic device having one or more processors and memory, cause the device to do the following: connect a non-safety-critical component or a safety-critical component component with a processing interface; in response to connecting the non-safety-critical component or the safety-critical component to the processing interface, detecting, by the controller, the presence of the non-safety-critical component or the safety-critical component in the electronic device; transmitting a message between the controller and the non-safety-critical component or the safety-critical component to and through the processing interface, said message being based on a domain-specific interface language, and determining the state of the non-safety-critical component or the safety-critical component based on the message.

Embodiments of the present invention other than those presented herein may become apparent to those skilled in the art upon reading the following description. It is expected that those skilled in the art will be able to apply such variations as appropriate and practice the compositions, methods and kits described herein differently than specifically described herein. Accordingly, the systems and methods described herein include all modifications and equivalents of the subject matter set forth in the appended claims as provided under applicable law. Moreover, any combination of the above-described elements in all possible variations is intended to be covered by the description unless otherwise indicated herein or clearly contrary to context. The following is a list of specific embodiments of the present invention. The list is illustrative and is not intended to limit the invention presented herein.

Embodiment 1:

An electronic device, wherein the electronic device comprises a plurality of components collectively configured to process one or more biological fluids, and the device comprises

- 43 045233 a first group of components, the first group of components including one or more components configured to receive one or more data inputs from a user of the device;

a first controller communicatively coupled to the first group of components and configured to control the first group of components using one or more commands formatted using a first communication protocol;

a second group of components, the second group of components comprising one or more platforms, each platform of the one or more platforms configured to carry a biological fluid from the one or more biological fluids;

one or more lighting devices, each lighting device configured to irradiate a biological fluid from the one or more biological fluids; and a second controller communicatively coupled to the second group of components and communicatively coupled to the first controller, the second controller configured to coordinate one or more operations associated with the second group of components;

wherein the second controller communicates with the first controller and the second group of components using a second communication protocol, wherein the second communication protocol is configured such that the second group of components operates in response to one or more commands received from the second controller using the second communication protocol.

Embodiment 2: The apparatus of Embodiment 1, wherein the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using a second communication protocol.

Embodiment 3: The apparatus of Embodiment 1 or Embodiment 2, wherein a message transmitted over a second communication protocol includes information about a component that generated the message.

Embodiment 4: The device as in any one of embodiments 1-3, wherein the first group of components includes one or more components configured to allow an external user to interact with the device.

Embodiment 5: The device as in any one of embodiments 1-4, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs.

Embodiment 6: The apparatus of Embodiment 5, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the apparatus.

Embodiment 7: The apparatus of any one of embodiments 1-6, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed.

Embodiment 8: The apparatus of any one of Embodiments 1 to 7, wherein the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from the one or more biological fluids such that to distribute a biological fluid within a container that is located on a platform of one or more platforms of the device.

Embodiment 9: The apparatus of any one of embodiments 1-8, comprising one or more processing chambers configured to receive a biological fluid of the one or more biological fluids, each platform of the one or more platforms configured to be located in the processing chamber from one or more processing chambers.

Embodiment 10: The device as in any one of embodiments 1-9, wherein the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid.

Embodiment 11: The apparatus of any one of Embodiments 1-10, wherein the one or more lighting devices includes one or more groups of light sources arranged to irradiate a biological fluid, and wherein the one or more groups of light sources are configured to emit light in the ultraviolet spectrum.

Embodiment 12: The apparatus of Embodiment 11, wherein each of the one or more light source groups comprises a first light source channel configured to emit ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm.

Embodiment 13: The apparatus of Embodiment 11 or Embodiment 12, wherein one or more light source groups comprise one or more

- 44 045233 light sources, each of which emits light with a full width at half maximum (FWHM) spectral band of less than 20 nm.

Embodiment 14: The apparatus as in any one of embodiments 11-13, wherein the one or more light source groups comprise one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs).

Embodiment 15: The apparatus of any one of embodiments 1-14, wherein the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources.

Embodiment 16: The apparatus of any one of embodiments 10-15, wherein the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by the one or more sensors.

Embodiment 17: The apparatus of any one of embodiments 9-16, comprising a first processing chamber configured to receive a first biological fluid;

a second processing chamber configured to receive a second biological fluid;

a first platform configured to carry a first biological fluid and placed in the first treatment chamber;

a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber.

Embodiment 18: The device as in any one of embodiments 1-17, wherein the device is configured to receive one or more data inputs from a user of the device, wherein the device is configured to transmit one or more commands using a first communication protocol to the first controller, wherein one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids;

in the first controller, converting one or more commands in the first communication protocol into one or more commands in the second communication protocol, as well as transmitting one or more commands in the second communication protocol to the second controller and in the second controller converting the received one or more commands in the second communication protocol into one or more commands for controlling one or more components of a second group of components and transmitting one or more commands to one or more components of a second group of components, wherein the one or more commands for controlling one or more components of a second group of components are configured such that cause the device to process a biological fluid from one or more biological fluids.

Embodiment 19: The apparatus of any one of embodiments 1-18, wherein treating the one or more biological fluids includes irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids.

Embodiment 20: A method of processing one or more biological fluids in an electronic device, the method including receiving one or more data inputs from a user of the device;

transmitting one or more commands via a first communication protocol to a first controller of the device, wherein the one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids, wherein the first controller is communicatively coupled to a first group of components of the device, and configured to control the first group of components using one or more commands formatted using the first communication protocol;

in a first controller, converting one or more commands in a first communication protocol into one or more commands in a second communication protocol, and transmitting one or more commands in a second communication protocol to a second device controller; and in a second controller, converting received one or more commands in a second communication protocol into one or more commands for controlling one or more components of a second group of components of the device and transmitting one or more commands to one or more components of a second group of components, wherein the one or more commands for controlling one or more components of a second group of components are configured to cause the device to process a biological fluid from one or more biological fluids.

Embodiment 21: The method of Embodiment 20, wherein the second group of components comprises

- 45 045233 one or more platforms, each platform of the one or more platforms configured to carry a biological fluid from one or more biological fluids and one or more lighting devices, each lighting device configured to irradiate a biological fluid from one or more biological fluids liquids.

Embodiment 22: The method of Embodiment 20 or Embodiment 21, wherein the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using the second communication protocol.

Embodiment 23: The method as in any one of embodiments 20-22, wherein the message transmitted over the second communication protocol includes information about the component that generated the message.

Embodiment 24: The method as in any one of embodiments 20-23, wherein the first group of components includes one or more components configured to allow an external user to interact with the device.

Embodiment 25: The method as in any one of embodiments 20-24, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs.

Embodiment 26: The method of Embodiment 25, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the device.

Embodiment 27: The method as in any one of embodiments 20-26, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed.

Embodiment 28: The method as in any one of embodiments 20-27, wherein the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from the one or more biological fluids such that to distribute a biological fluid within a container that is located on a platform of one or more platforms of the device.

Embodiment 29: The method as in any one of embodiments 20-28, wherein the electronic device comprises one or more processing chambers configured to receive a biological fluid from the one or more biological fluids, wherein each platform of the one or more platforms is configured to arrangement in a processing chamber of one or more processing chambers.

Embodiment 30: The method as in any one of embodiments 20-29, wherein the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid.

Embodiment 31: The method as in any one of embodiments 20-30, wherein the one or more lighting devices includes one or more groups of light sources arranged to irradiate a biological fluid from the one or more biological fluids, and wherein the one or more groups of light sources light sources are designed to emit light in the ultraviolet spectrum.

Embodiment 32: The method of Embodiment 31, wherein each of the one or more light source groups comprises a first light source channel configured to emit ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm.

Embodiment 33: The method of Embodiment 31 or Embodiment 32, wherein the one or more light source groups comprise one or more light sources each emitting light with a full width at half maximum (FWHM) of a spectral band of less than 20 nanometers.

Embodiment 34: The method as in any one of embodiments 31-33, wherein the one or more light source groups comprise one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs).

Embodiment 35: The method as in any one of embodiments 20-34, wherein the one or more lighting devices further comprise one or more sensors configured to detect light energy from the one or more groups of light sources.

Embodiment 36: The method as in any one of embodiments 30-35, wherein the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by the one or more sensors.

Embodiment 37: The method as in any one of embodiments 20-36, wherein the electronic device comprises a first processing chamber configured to receive a first biological fluid;

- 46 045233 a second processing chamber configured to receive a second biological fluid;

a first platform configured to carry a first biological fluid and placed in the first treatment chamber;

a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber.

Embodiment 38: The method of any one of embodiments 20-37, wherein treating the one or more biological fluids includes irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids.

Embodiment 39: A computer-readable storage medium storing one or more programs, wherein the one or more programs comprise instructions that, when executed by an electronic device configured to process one or more biological fluids, cause the device to do the following:

receiving one or more inputs from a user of the device;

transmitting one or more commands via a first communication protocol to a first controller of the device, wherein the one or more commands are configured to initiate a process for treating a biological fluid from the one or more biological fluids, wherein the first controller is communicatively coupled to a first group of components of the device, and configured to control the first group of components using one or more commands formatted using the first communication protocol;

in a first controller, converting one or more commands in a first communication protocol into one or more commands in a second communication protocol, and transmitting one or more commands in a second communication protocol to a second device controller; and in a second controller, converting received one or more commands in a second communication protocol into one or more commands for controlling one or more components of a second group of components of the apparatus, and transmitting one or more commands to one or more components of a second group of components, wherein the one or more commands for controlling one or more components of a second group of components are configured to cause the device to process a biological fluid from one or more biological fluids.

Embodiment 40: The computer-readable storage medium of Embodiment 39, wherein the second set of components comprises one or more platforms, each platform of the one or more platforms configured to carry a biological fluid of the one or more biological fluids; and one or more lighting devices, each lighting device configured to irradiate a biological fluid from the one or more biological fluids.

Embodiment 41: The computer readable storage medium of Embodiment 39 or Embodiment 40, wherein the second group of components is configured to operate only in response to one or more commands transmitted from the second controller using the second communication protocol.

Embodiment 42: The computer-readable storage medium of any one of embodiments 39-41, wherein the message transmitted over the second communication protocol includes information about the component that generated the message.

Embodiment 43: The computer-readable storage medium of any one of embodiments 39-42, wherein the first group of components includes one or more components configured to allow an external user to interact with the device.

Embodiment 44: The computer-readable storage medium of any one of embodiments 39-43, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs.

Embodiment 45: The computer-readable storage medium of embodiment 44, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the device.

Embodiment 46: The computer-readable storage medium of any one of embodiments 39-45, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed.

Embodiment 47: The computer-readable storage medium of any one of embodiments 39-46, wherein the second group of components further includes one or

- 47 045233 more agitating devices, wherein each agitating device is configured to agitate a biological fluid from one or more biological fluids so as to distribute the biological fluid within a container that is located on a platform of one or more device platforms.

Embodiment 48: The computer readable storage medium of any one of embodiments 39-47, wherein the electronic device comprises one or more processing chambers configured to receive a biological fluid from the one or more biological fluids, wherein each platform of the one or more platforms is configured to the possibility of arrangement in the processing chamber of one or more processing chambers.

Embodiment 49: The computer-readable storage medium of any one of embodiments 39-48, wherein the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid.

Embodiment 50: The computer-readable storage medium of any one of embodiments 39-49, wherein the one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid from the one or more biological fluids, and wherein the one or more groups of light sources are designed to emit light in the ultraviolet spectrum.

Embodiment 51: The computer readable storage medium of Embodiment 50, wherein each of the one or more light source groups comprises a first light source channel configured to emit ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm.

Embodiment 52: The computer-readable storage medium of Embodiment 50 or Embodiment 51, wherein the one or more light source groups comprise one or more light sources each emitting light with a full width at half maximum (FWHM) of a spectral band of less than 20 nm.

Embodiment 53: The computer-readable storage medium of any one of embodiments 50-52, wherein the one or more light source groups comprise one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs).

Embodiment 54: The computer-readable storage medium of any one of embodiments 39-53, wherein the one or more lighting devices further comprise one or more sensors configured to detect light energy from one or more groups of light sources.

Embodiment 55: The computer-readable storage medium of any one of embodiments 49-54, wherein the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by the one or more sensors.

Embodiment 56: The computer readable storage medium of any one of embodiments 39-55, wherein the electronic device comprises a first processing chamber configured to receive a first biological fluid;

a second processing chamber configured to receive a second biological fluid;

a first platform configured to carry a first biological fluid and placed in the first treatment chamber;

a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber.

Embodiment 57: The computer-readable storage medium of any one of embodiments 39-56, wherein treating the one or more biological fluids includes irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluid.

The above description, for purposes of explanation, has been made with reference to specific embodiments. However, the above description is not exhaustive and does not limit the invention to the specific forms described. Many modifications and variations are possible, taking into account the above ideas. The embodiments have been selected and described to best explain the principles and techniques for their practical application. Thus, others skilled in the art can best try the techniques and various embodiments with various modifications as are appropriate for the particular intended application.

Although the disclosure and examples have been fully described with reference to the accompanying figures, it should be noted that various variations and

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Claims (48)

modifications. However, it should be understood that such changes and modifications are within the scope of the present invention and the examples that are disclosed in the claims. CLAIM 1. An electronic device for processing one or more biological fluids, wherein the electronic device comprises a plurality of components collectively configured to process said one or more biological fluids, and the device comprises a first group of components, wherein the first group of components includes one or more components, configured to receive one or more data inputs from a user of the device; a first controller communicatively coupled to a first group of components and configured to control the first group of components using one or more commands formatted using a first communication protocol, wherein the device is configured to transmit one or more commands configured to initiate a process processing a biological fluid from said one or more biological fluids using a first communication protocol with a first controller; a second group of components, the second group of components comprising one or more platforms, each platform of the one or more platforms configured to carry a biological fluid from said one or more biological fluids; one or more lighting devices, each lighting device configured to irradiate a biological fluid from said one or more biological fluids; and a second controller communicatively coupled to the second group of components and communicatively coupled to the first controller, the second controller configured to coordinate one or more operations associated with the second group of components; wherein the second controller communicates with the first controller and the second group of components using a second communication protocol, wherein the second communication protocol is configured such that the second group of components operates in response to one or more commands received from the second controller using the second communication protocol. 2. The apparatus of claim 1, wherein the second set of components is configured to operate only in response to one or more commands transmitted from the second controller using the second communication protocol. 3. The apparatus of claim 1 or 2, wherein the message transmitted over the second communication protocol includes information about the component that generated the message. 4. The device according to any one of claims 1 to 3, wherein the first group of components includes one or more components configured to allow an external user to interact with the device. 5. The device of any one of claims 1 to 4, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. 6. The device of claim 5, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the device. 7. The device according to any one of claims 1 to 6, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. 8. The device according to any one of claims 1 to 7, wherein the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from said one or more biological fluids so that distribute the biological fluid inside a container that is located on a platform of said one or more platforms of the device. 9. The device according to any one of claims 1 to 8, containing one or more processing chambers configured to receive a biological fluid from the one or more biological fluids, each platform of the one or more platforms being configured to be located in the processing chamber of said one or more processing chambers. 10. The device according to any one of claims 1 to 9, wherein the second group of components further comprises one or more sensors configured to detect the operating state of the device or the properties of the biological fluid. 11. The device according to any one of claims 1 to 10, wherein said one or more lighting devices include one or more groups of light sources arranged to irradiate the biological - 49 045233 gical liquid, and wherein said one or more groups of light sources are configured to emit light in the ultraviolet spectrum. 12. The apparatus of claim 11, wherein each of said one or more groups of light sources comprises a first light source channel configured to emit ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm. 13. The apparatus of claim 11 or 12, wherein said one or more light source groups comprise one or more light sources each emitting light with a full width at half maximum (FWHM) spectral band of less than 20 nm. 14. The device according to any one of claims 11 to 13, wherein said one or more light source groups comprise one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs). 15. The device according to any one of claims 1 to 14, wherein said one or more lighting devices further comprise one or more sensors configured to detect light energy from said one or more groups of light sources. 16. The apparatus of any one of claims 10 to 15, wherein the second controller is configured to enable or disable one or more components of the second group of components based on one or more signals transmitted by said one or more sensors. 17. The device according to any one of claims 9 to 16, comprising a first processing chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to carry a first biological fluid and placed in the first treatment chamber; a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber. 18. The device according to any one of claims 1 to 17, wherein the device is configured to receive one or more data inputs from a user of the device, wherein the device is configured in a first controller to convert said one or more commands in the first communication protocol into one or more commands in a second communication protocol, and transmitting one or more commands in a second communication protocol to a second controller and, in a second controller, converting received one or more commands in a second communication protocol into one or more commands for controlling one or more components of a second group of components and transmitting said one or more commands to one or more components of the second group of components, wherein said one or more commands for controlling one or more components of the second group of components are configured to cause the device to process a biological fluid of said one or more biological fluids . 19. The device according to any one of claims 1 to 18, wherein treating said one or more biological fluids includes irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids. 20. A method of processing one or more biological fluids in an electronic device, the method comprising receiving one or more inputs from a user of the device; transmitting one or more commands using a first communication protocol to a first controller of the device, wherein said one or more commands are configured to initiate a biological fluid processing process from said one or more biological fluids, wherein the first controller is communicatively coupled to the first group of components device and configured to control the first group of components using one or more commands formatted using the first communication protocol; in a first controller, converting said one or more commands in a first communication protocol into one or more commands in a second communication protocol and transmitting said one or more commands in a second communication protocol to a second device controller; and in a second controller, converting the received one or more commands in a second protocol communication into one or more commands for controlling one or more components of a second group of components of the device and transmitting said one or more commands to one or more components of the second group of components, wherein said one or more commands for controlling one or more components of the second group of components are executed so as to enable the device to process a biological fluid from said one or more biological fluids. 21. The method according to claim 20, in which the second group of components contains - 50 045233 one or more platforms, each platform of said one or more platforms configured to carry biological fluid from said one or more biological fluids; and one or more lighting devices, each lighting device configured to irradiate a biological fluid from said one or more biological fluids. 22. The method of claim 20 or claim 21, wherein the second set of components is configured to operate only in response to one or more commands transmitted from the second controller using the second communication protocol. 23. The method according to any one of claims 20 to 22, wherein the message transmitted over the second communication protocol includes information about the component that generated the message. 24. The method according to any one of claims 20 to 23, wherein the first group of components includes one or more components configured to allow an external user to interact with the device. 25. The method of any one of claims 20 to 24, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. 26. The method of claim 25, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the device. 27. The method according to any one of claims 20 to 26, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. 28. The method according to any one of claims 20 to 27, wherein the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from said one or more biological fluids such that distribute the biological fluid inside a container that is located on a platform of said one or more platforms of the device. 29. The method according to any one of claims 20 to 28, wherein the electronic device comprises one or more processing chambers configured to receive biological fluid from said one or more biological fluids, wherein each platform of said one or more platforms is configured to location in the processing chamber of said one or more processing chambers. 30. The method according to any one of claims 20-29, in which the second group of components further comprises one or more sensors configured to detect the operating state of the device or the property of the biological fluid. 31. The method according to any one of claims 20 to 30, wherein said one or more lighting devices include one or more groups of light sources arranged to irradiate a biological fluid from said one or more biological fluids, and wherein the one or more groups light sources are designed to emit light in the ultraviolet spectrum. 32. The method of claim 31, wherein each of said one or more groups of light sources comprises a first light source channel configured to emit ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm. 33. The method of claim 31 or 32, wherein said one or more light source groups comprise one or more light sources each emitting light with a full width at half maximum (FWHM) spectral band of less than 20 nm. 34. The method according to any one of claims 31 to 33, wherein said one or more light source groups comprise one or more light sources, wherein the one or more light sources are light emitting diodes (LEDs). 35. The method according to any one of claims 20 to 34, wherein the one or more lighting devices further comprise one or more sensors configured to detect light energy from said one or more groups of light sources. 36. The method according to any one of claims 30 to 35, wherein the second controller is configured to enable or disable one or more components from the second group of components based on one or more signals transmitted by said one or more sensors. 37. The method according to any one of claims 20 to 36, wherein the electronic device comprises a first processing chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to carry a first biological fluid and placed in the first treatment chamber; a second platform configured to carry a second biological fluid and placed in the second processing chamber; and a first group of light sources located for the purpose of irradiating the first biological fluid in the first processing chamber, and a second group of light sources located for the purpose of irradiating the second biological fluid in the second processing chamber. 38. The method of any one of claims 20 to 37, wherein treating said one or more biological fluids comprises irradiating the biological fluids with a duration and intensity sufficient to inactivate the pathogen in the biological fluids. 39. A computer-readable storage medium storing one or more programs, wherein said one or more programs contain instructions that, when executed by an electronic device configured to process one or more biological fluids, cause the device to do the following: receiving one or more inputs from a user of the device; transmitting one or more commands using a first communication protocol to a first controller of the device, wherein the one or more commands are configured to initiate a process for treating a biological fluid from said one or more biological fluids, wherein the first controller is communicatively coupled to a first group of components of the device and configured to control the first group of components using one or more commands formatted using the first communication protocol; in a first controller, converting said one or more commands in a first communication protocol into one or more commands in a second communication protocol and transmitting said one or more commands in a second communication protocol to a second device controller; and in a second controller, converting the received one or more commands in a second protocol communication into one or more commands for controlling one or more components of a second group of components of the device and transmitting said one or more commands to one or more components of the second group of components, wherein said one or more commands for controlling one or more components of a second group of components are executed so as to enable the device to process a biological fluid from said one or more biological fluids. 40. The computer-readable storage medium of claim 39, wherein the second set of components comprises one or more platforms, each platform of said one or more platforms configured to carry a biological fluid from said one or more biological fluids; and one or more lighting devices, each lighting device configured to irradiate a biological fluid from said one or more biological fluids. 41. The computer-readable storage medium of claim 39 or 40, wherein the second set of components is configured to operate only in response to one or more commands transmitted from the second controller using the second communication protocol. 42. The computer-readable storage medium of any one of claims 39 to 41, wherein the message transmitted over the second communication protocol includes information about the component that generated the message. 43. The computer-readable storage medium of any one of claims 39 to 42, wherein the first group of components includes one or more components configured to allow an external user to interact with the device. 44. The computer-readable storage medium of any one of claims 39 to 43, wherein the first group of components includes a display configured to provide visual cues to a user of the device and configured to receive one or more data inputs. 45. The computer-readable storage medium of claim 44, wherein the display is a touch screen display configured to receive one or more touch inputs from a user of the device. 46. The computer-readable storage medium according to any one of claims 39 to 45, wherein the first group of components includes a scanner configured to collect identifying information associated with the biological fluid being processed. 47. The computer-readable storage medium according to any one of claims 39 to 46, wherein the second group of components further includes one or more agitation devices, each agitation device configured to agitate a biological fluid from said one or more biological fluids thereby to distribute the biological fluid within a container that is located on a platform of said one or more platforms of the device. 48. The computer-readable storage medium according to any one of claims 39 to 47, wherein the electronic device comprises one or more processing chambers configured to receive biological fluid from said one or more biological fluids, wherein each platform of said one or more platforms is configured with the possibility of being located in a processing chamber made of -