EA038326B1 - Applicator device - Google Patents

Abstract

Provided is an applicator device (1) comprising an applicator tip (100) and: (i) a container (210) comprising a container wall (211), a valve (220), a plunger (230), and (ii) a plunger advance system (300) for expelling at least part of a liquid to said tip (100), wherein the following is applied: (a) the valve (220) comprises a first spring system (225) comprising stainless steel comprising a molybdenum content in the range of 0.5-7 wt.%, and (b) the plunger advance system (300) comprises a second spring system (325) comprising stainless steel comprising a molybdenum content in the range of 0.5-7 wt.%; the plunger advance system (300) comprises a polymer (310) selected from the group of polypropylene (PP), ethylene chlorotrifluoroethylene (ECTFE), and polyoxymethylene (POM), wherein the plunger advance system (300) comprises a ratchet system (353) comprising a first element (355) and a second element (356) configured to engage on each other.

Description

The technical field to which the invention relates

The invention relates to an application device and its use.

Background of the invention

Various formulations are known for treating skin lesions such as warts, calluses and growths, actinic keratosis, hair keratosis, acne, tattoo removal / correction, treatment of skin hyperpigmentation and / or nail damage such as ingrown toenails, and / or lesions on the mucous membranes, such as herpes of the lips and mouth sores. WO 2012007584, for example, describes a composition for treating superficial lesions, in particular skin lesions, mucosal lesions and / or nail lesions, an applicator containing such a composition, and the use of such a composition. The composition contains an effective amount of trichloroacetic acid, at least one thickening agent and a physiologically acceptable solvent. The composition is considered effective against a variety of superficial injuries selected from the group consisting of simple warts, congenital warts, water warts (molluscum contagiosum), corns and skin growths, and skin hyperpigmentation: age spots, solar lentigo, senile lentigines; acne, hair keratosis, actinic keratosis, oral ulcers (ulcerative stomatitis), herpes of the lips, ingrown toenails, onychomycosis, xanthelasma of the eyelids.

WO 2007139378 describes a device for cold treating fabrics. The invention also relates to an assembly of such a device and a container containing a cryogenic liquid, such as an aerosol can. In addition, the invention relates to a method for treating fabric with cold.

WO 2012007584 describes a composition for treating superficial lesions, in particular skin lesions, mucosal lesions and / or nail lesions, an applicator containing such a composition, and the use of such a composition. The composition contains an effective amount of trichloroacetic acid, at least one thickener and a physiologically acceptable solvent and is effective against a variety of superficial lesions selected from the group consisting of simple warts, congenital warts, water warts (molluscum contagiosum), corns and skin growths, and skin hyperpigmentation : age spots, solar lentigo, senile lentigo, acne, hair keratosis, actinic keratosis, oral ulcers (ulcerative stomatitis), lip herpes, ingrown toenails, onychomycosis, eyelid xanthelasma.

US 2005025558 describes a device for dispensing substances, including substances for personal care, cosmetics and drugs. The device dispenses a metered amount of the substance by actuating a push button that indirectly contacts the retractable rod, which causes the piston to be actuated to push the substance out of the reservoir into the applicator. The device can be operated with one human hand and does not have any twisting or pivoting mechanism.

US 20100308082 describes a substance dispensing device having a dispensing outlet from which the substance can be dispensed, a dispensing element movable in the dispensing direction from a first position to a second position, said movement during use causes the substance to be dispensed to be dispensed. , from the dispensing outlet, and an actuator for moving the dispensing member from the first position to the second position. The actuator has a first element movable in a predetermined direction and a second element rotatable on the first element to rotate in a predetermined direction of rotation. The actuator is designed so that the movement of the first element in a predetermined direction leads to the movement of the second element together with it and the rotation of the second element in a predetermined direction of rotation, and the specified rotation of the second element in a predetermined direction of rotation leads to the displacement of the dispensing element from the first position to the second position.

EP 2223811 discloses an applicator that can eject a liquid for application in an approximately constant amount, regardless of the viscosity of the liquid for application. The applicator is designed such that when the user clicks down on the rear end of the inner cylinder, the aforementioned valve mechanism is actuated by moving the inner cylinder relative to the outer cylinder, whereby the application fluid is supplied to the application member located adjacent to the front end of the outer cylinder, and as the valve seat and valve stem member move relative to each other, the valve mechanism can assume a first position in which the piston portion on the front side of the valve stem member slides into the front sealed portion inside a valve seat element, a second position in which both the piston section on the front of the valve stem element and the piston section on the back of the valve stem element do not enter the sliding sleeve ct with corresponding sealed portions within the valve seat, and a third position in which the piston portion on the rear side of the valve stem member slides into the rear sealed portion within the valve seat.

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EP 1277595 discloses an applicator comprising a tubular rod-like main portion in which a liquid is contained, a squeezing device located adjacent to the rear of the tubular rod-shaped main portion for compressing the liquid, a non-return device located near the rear of the liquid and adapted to move when a decrease in the amount of liquid, and a valve mechanism located between the non-return device and the compression means.

US 2011293354 discloses an airless applicator that can supply high / low viscosity liquids or semi-liquids and includes a valve for regulating the flow between the product reservoir and the intermediate storage zone, whereby a narrow opening between the intermediate storage zone and the product dispensing chamber provides flow control between them. This design prevents backflow into the product tank, making it impossible for contaminants to enter it. The product is fed by means of specially adapted application heads.

The essence of the invention

Many prior art treatments for warts or other skin lesions are ineffective or insufficiently effective. In addition, some of the prior art methods, such as treating warts with liquid nitrogen, require special care and medical supervision. In addition, many of the prior art applicators contain materials that deteriorate over time. In particular, some prior art applicators may be short-lived. In addition, many of the prior art applicators do not provide control of the dosage of the treatment / care fluid.

It is therefore an object of the invention to provide an alternative method and / or applicator, which preferably additionally makes it possible to eliminate, at least in part, one or more of the above-described disadvantages and which are particularly safe.

In a first aspect of the invention, an application device is provided. The application device (applicator or device) contains an application tip and a container part. The container portion comprises: (i) a container containing a container wall, a valve and a plunger, wherein the container wall, valve and plunger jointly define a (variable) storage space intended, in particular, to retain a liquid, such as an acidic liquid, while the plunger contains a peripheral wall in contact with the wall of the container to ensure tightness; and (ii) a plunger advancement system operatively coupled to the plunger and configured to provide plunger advancement to reduce storage space for displacing at least a portion of the fluid through said valve into said tip, the plunger advancement system being located outside the storage space. In particular, one or more of the following are applicable: (a) the valve comprises a first spring system comprising a first spring material selected in particular from the group consisting of a noble metal, polypropylene and a stainless steel material, in particular a material , which is stainless steel, the material being stainless steel, in particular, has a molybdenum content in the range of 0.1-7 wt.%, for example in the range of 0.5-7 wt.%, in particular in the range 2- 7 wt%, and (b) the plunger advancement system comprises a second spring system comprising a second spring material selected in particular from the group consisting of a noble metal, polypropylene and a stainless steel material having, in particular, a content molybdenum selected in the range of 0.1-7 wt.%, for example in the range of 0.5-7 wt.%, in particular in the range of 2-7 wt.%. In certain embodiments, the valve comprises a first spring system and the plunger advancement system comprises a second spring system. In addition, in certain embodiments, the plunger advancement system comprises a polymer selected from the group consisting of polypropylene (PP), ethylene chlorotrifluoroethylene (ECTFE), and polyoxymethylene (POM), in particular polypropylene or ethylene chlorotrifluoroethylene, more particularly polypropylene.

In embodiments, when the valve is open, the application tip is in fluid communication with the storage space, and when the valve is closed, the application tip is in fluid communication with the storage space. When the valve is open, a fluid, in particular a liquid, can pass through the valve. When the valve is closed, no fluid, in particular no liquid, can pass through the valve. Therefore, in the closed position, the fluid connection is (temporarily) interrupted.

The application device described in this document, in particular, is configured with the ability to retain liquid. In this document, the term liquid refers to a fluid having, in particular, a viscosity at an indoor temperature of from about 0.1 mPa-s (cP) to 1000 Pa-s, selected, in particular, in the range of 0.2 mPa-s - 250 Pa-s, even more particularly in the range 1 mPa-s - 60 Pa-s, for example in the range 1-15 Pa-s, in particular in the range 2.5-10 Pa-s (2500-10000 cP).

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Therefore, the term liquid can also refer to a gel, paste, or semi-solid. In embodiments, the viscosity of the liquid (gel) is selected to be about 6000 mPa-s, for example in the range of 4000-8000 mPa-s at 25 ° C (see also below, including the method for determining the viscosity). In particular, the liquid has a fluidity that allows it to be displaced from the storage space when manually actuating the plunger advancement system, for example, using the thumb.

The liquid may contain a composition. The composition is preferably a fluid to allow easy application and release of the active ingredient to the surface of the skin or nail. Fluids include liquid and gel compositions, as well as semi-solid compositions. As used herein, the terms treatment / care liquid and liquid refer specifically to a composition / formulation and vice versa. The liquid / formulation may contain trichloroacetic acid (TCA), see further below. In additional embodiments, the composition does not contain trichloroacetic acid. In other additional embodiments, the composition does not contain any acid (see also below). The composition can be used, for example, in a treatment for exfoliating dead cells / peeling of the skin, for the treatment or cosmetic treatment of skin lesions selected from the group consisting of warts, calluses and skin growths, and for the treatment of nails, including ingrown toenails. The proposed mechanism of action is that the formulation containing trichloroacetic acid softens the skin or nail and allows for the separation of damage to the skin or nail. Serious damage may require many treatments. By means of the compositions according to the invention, both cosmetic care and treatment can be performed. Other active ingredients may be added to aid in the treatment of injury. For example, salicylic acid is another component that is effective against skin or nails and can be used as an additional active ingredient in combination with trichloroacetic acid.

The liquid carrier can be a single solvent or a mixture of solvents and additives capable of dissolving trichloroacetic acid or miscibility with trichloroacetic acid at the concentration used. The preferred liquid carrier is water or a water-based mixture. Water can be mixed with organic solvent. You can also use an anhydrous carrier, which preferably uses volatile solvents. The use of evaporating solvents makes it possible to achieve a relatively high concentration of trichloroacetic acid in the treated area on the skin or nail. Suitable evaporating solvents include methanol, ethanol, propanol, methyl ethyl ketone, acetone, ethyl acetate, and mixtures thereof.

The thickener imparts increased viscosity to the formulation, which facilitates concentration of the active ingredient at the intended site on the skin or nails while preventing to some extent the formulation from spreading to sites where it is undesirable. In addition, the thickener provides an increase in the time that the active ingredient remains on the treated surface, which increases the effectiveness of the formulation.

The thickener can be a single compound, but can also contain a mixture of compounds. The thickener is preferably a gelling agent compatible with the liquid carrier used.

The composition preferably has a viscosity of at least 3000 mPas, measured using a rotary viscometer at 25 ° C. The viscosity is measured according to the protocol for a rotary viscometer in the European Pharmacopoeia Ph. Eur (01/2005: 20210) Ph. Eur 5th edition, volume 1, page 29, chapter 2.2.10. Such formulations have the ability to adhere significantly to the skin and / or nail, which allows for spot treatment. Compositions with viscosities up to about 60,000 mPas are considered suitable; higher viscosity liquid formulations are considered difficult to handle.

In a preferred embodiment, the composition is a sprayable liquid having a viscosity in the range of about 1.0 mPa-s to about 2000 mPa-s at 25 ° C. Spraying is an easy and quick way to apply the compound to the surface to be treated.

In another preferred embodiment, the composition has a viscosity of at least 5000 mPas measured at 25 ° C according to the protocol for a rotary viscometer in the European Pharmacopoeia Ph. Eur (01/2005: 20210) Ph. Eur 5th edition, volume 1, page 29, chapter 2.2.10. Rotating Viscometer Method. This viscosity gives the composition a particularly desirable adhesion to skin and nails. The composition is preferably a gel composition having a viscosity in the range of about 3000 to 60,000 mPas at 25 ° C. The gel formulation is relatively easy to apply, either by hand or using a suitable applicator, and has a relatively high stickiness. The gel is particularly suitable for selectively applying the composition to a specific location, such as a wart.

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The composition preferably has a viscosity in the range of 450 to 10,000 mPa-s at 25 ° C, more preferably 5,000 to 10,000 mPa-s at 25 ° C. Such a composition exhibits sufficient adhesion while still being relatively easy to apply and process.

Preferably, the liquid carrier is an aqueous carrier. The water-based formulation is relatively easy to prepare and dissolves trichloroacetic acid well. The water can be mixed with other solvents such as C1-C6 alcohols or ketones and additives such as surfactants. The carrier liquid is preferably at least 50% water.

The formulation preferably has a pH less than 4. Low pH formulations appear to provide better processing results. In addition, low pH formulations appear to have an additional effect on microbiological hazards in the skin and nails, including bacteria, fungi and yeasts, in particular onychomycosis (nail fungus).

In a preferred embodiment, the composition comprises at least 1% trichloroacetic acid, more preferably at least 20 wt%, more preferably in the range of 20-50 wt%. Compositions having a concentration of at least 20 wt. %, show good results in the treatment of skin and nail lesions with a relatively short treatment. Although skin irritation sometimes occurs after treatment with trichloroacetic acid concentrations of less than 50%, concentrations of trichloroacetic acid in excess of 50% have been found to significantly increase the likelihood of skin irritation.

Preferably, the thickener comprises at least a thickener selected from a polysaccharide thickener, a crosslinked acrylic acid polymer and polysiloxanes or mixtures thereof. These thickeners show good compatibility with trichloroacetic acid. In addition, polysaccharide thickeners, in addition to their thickening action, have been shown to reduce the likelihood of skin irritation.

In a preferred embodiment, the thickener comprises at least one thickener selected from the group consisting of amylose, amylopectin, carbopol, silicones, xanthan gum, agar-agar, polydimethylsiloxane (and mixtures thereof), dimethicones, carrageenan, cellulose, carboxymethylcellulose or salts thereof , ethylcellulose, hydroxypropylcellulose and methylcellulose, natural rubber, beeswax, lanolin, petrolatum, paraffin, wood resin (and mixtures thereof). By using these thickeners, a viscosity of a composition having very good adhesion properties can be achieved. Carbopol is the trade name for crosslinked acrylic acid polymers and includes the commercially available products Carbopol 71G NF, Carbopol 971P NF, Carbopol 974P NF, Carbopol 934P NF, Carbopol 980P NF, Carbopol 981P NF, Carbopol 5984EP, Carbopol ETD 2020 NF, Carbopol 934 NF, Carbopol 934P NF, Carbopol 940 NF, Carbopol 941 NF, Carbopol 1342 NF, Pemulen TR-1 NF, Pemulen TR2-NF, Noveon AA-USP and Carbopol Ultrez 10 NF.

The thickener is preferably kept substantially stable in the presence of trichloroacetic acid. Some thickeners decompose in the presence of trichloroacetic acid, resulting in a colored product that may appear less appealing to some individuals. In addition, it may be difficult to control the color of the solution if a dye is used. A colorless formulation is generally considered more visually appealing and therefore more desirable.

Most preferably, the thickener contains carbopol. Carbopol shows very good stability in the presence of trichloroacetic acid, which allows colorless compositions to be obtained, or very good color control when the composition contains a colorant. Carbopol polymers, also called carbomers, are acrylic acid polymers crosslinked with polyalkenyl ethers or divinyl glycol.

Carbopol allows very good control of the viscosity of the formulation (treatment / care fluid). The composition preferably contains at least 0.5 wt% carbopol, preferably contains carbopol in the range of 0.5-3 wt%. Formulations containing 0.5-1% by weight of carbopol are very good sprayable products; products containing 1.5-2.5 wt.% form a well-applied gel. Products containing more than 3 wt% Carbopol may become too harsh for easy handling and application. Therefore, in embodiments, the liquid comprises a gel, the liquid in particular comprising trichloroacetic acid and crosslinked acrylic acid polymers, in particular carbopol. These crosslinked polymers are, in particular, acrylic acid polymers crosslinked with polyalkenyl ethers or divinyl glycol.

In a preferred embodiment, the formulation contains a combination of carbopol and glycerin. Although glycerin itself is not a thickener, the addition of glycerin to a composition of the invention using carbopol provides an increase in viscosity. Thus, the cost of a relatively high viscosity formulation can be reduced by using less relatively expensive carbopol by adding relatively cheap glycerin. Glycerin is preferably added in an amount ranging from about 1 to

- 4,038326 approx. 20 wt.% As an additional effect, glycerin has been found to reduce the likelihood of skin irritation caused by trichloroacetic acid.

In embodiments, the liquid (composition) may have a pH less than 7. In embodiments, the liquid comprises an acid. In additional embodiments, the implementation of the liquid contains trichloroacetic acid. However, in other embodiments, the implementation of the liquid (composition) may contain an alkaline liquid, in particular having a pH above 7. The liquid may additionally contain an aggressive / corrosive liquid. The liquid can also contain a liquid having a substantially neutral pH, in particular a pH in the range of 6-8. The applicator can in particular be configured to contain trichloroacetic acid (in a (variable) storage space). In particular, the pH of the liquid is equal to or less than 4.

The container part can be elongated. The container part can be shaped like a syringe. In embodiments, the container portion is shaped like a handle. The container part can also have a different type of shape and / or other relative dimensions. The container part can be, for example, disc-shaped or any other shape. The container part has, in particular, an elongated shape with a longitudinal axis or an axis of the main part (container part).

The storage space is, in particular, variable and can decrease with the use of the applicator, in particular with the advance of the plunger (to displace at least part of the liquid). In this document, the advancement of the plunger to reduce the storage space refers in particular to the translational movement of the plunger along the longitudinal axis of the storage space, in particular towards the valve. Therefore, at least the first part of the container wall is formed adjacent to the storage space, that is, in particular, contacts the storage space (with the liquid in the space). The second part of the container wall may not be located adjacent to the storage space, in particular when the plunger is advancing. Said second part of the container wall, in particular, may be adjacent to the system for advancing the plunger and, in particular, may not be in contact with the liquid. During the advancement of the plunger, the ratio of the (area) of the first part of the container wall to (area) of the second part of the container wall can decrease, which, in particular, also provides a reduction in the variable storage space.

The longitudinal axis of the container portion may define the longitudinal axis of the storage space. In particular, they may be the same.

In particular, the plunger contacts the container wall to seal with at least a portion of the peripheral wall (plunger). As the plunger moves in, fluid can move towards the valve. Gradually, some of the liquid can be squeezed out of the applicator through the tip.

As used herein, the term hermetically sealed in terms of contacting to ensure hermetic sealing and the like may refer in particular to (substantially) preventing liquid from passing (through the zone of such sealed contact). Liquid may not (substantially) pass by the peripheral wall (plunger) (as the plunger moves). However, the plunger may nevertheless be movable relative to the container wall, in particular in a direction substantially parallel to the threaded rod (see below). Consequently, the plunger is particularly movable relative to the container wall in a direction substantially parallel to the axis of the main body of the device. The plunger is particularly movable relative to the container wall in a direction substantially parallel to the longitudinal axis of the storage space and / or to the peripheral wall.

The surface of the plunger is substantially defined by a peripheral wall, a first end, and a second end (opposite the first end). The peripheral wall can in particular connect the first end and the second end. The longitudinal axis of the plunger has, in particular, a first end and a second end. The term peripheral wall refers in particular to the wall (plunger) defining the periphery of the plunger. In embodiments, the peripheral wall has an annular shape. The specified periphery does not have to be a circular periphery. In additional embodiments, the implementation of the specified wall may have a non-circular shape, such as a rectangular shape or an oval shape.

The container may have a circular cross-sectional area (or cross-section) of the container perpendicular (s) to the longitudinal axis of the storage space (in particular, the inner cross-sectional area does not include the container wall). The cross-sectional area of the container (also) does not need to be circular. The container cross-sectional area (container cross-section) can have any arbitrary shape. In embodiments, the cross-section of the container has a rectangular shape, such as a square shape. In additional embodiments, the cross-section of the container is oval in shape. The shape of the peripheral wall (plunger) substantially matches the shape (in particular, the shape) of the cross-section of the container to provide a tight / sealed contact between the plunger and the wall of the container. The cross-section of the container, in particular, is circular, and the peripheral wall (plunger), in

- 5 038326 in particular has a round shape.

The shape of the plunger and the shape of the peripheral wall in particular are similar. In addition, the plunger can have a cylindrical shape, in particular it can have a round shape. Alternatively or additionally, the plunger may have a conical shape (forming a round shape).

It has been experimentally found that embodiments comprising a cylindrical plunger in which the cross-sectional area of the plunger is substantially constant along the longitudinal axis of the plunger may nevertheless allow small amounts of liquid to leak along the peripheral wall of the plunger. In addition, it has been found that by choosing a plunger having a tapered shape, in particular a double taper shape, such leakage was prevented.

The term double-cone shape refers particularly to a configuration comprising a first tapered portion optionally forming a first plunger end and a second tapering portion optionally forming a second plunger end. The cross section of the first tapered portion in the area closer to the second tapered portion is in particular smaller than the cross section (first tapered portion) in the area closer to the first end. The cross section of the second tapered portion in the area closer to the first tapered portion, in particular (also) smaller than the cross section (second tapered portion) in the area closer to the second end. As used herein, the term cross-section of the (first or second) tapered portion refers in particular to a cross-section perpendicular to the longitudinal axis of the plunger. The cross-section of the plunger may be smallest at the location between the first end and the second end. In particular, the first tapered portion and / or the second tapered portion includes a cylindrical portion. Such a plunger may (also) comprise a peripheral wall with a concave shape (such as a fitted shape). Such a concave shape can be formed by the first and second tapered portions.

In further preferred embodiments, at least one of the first and second ends of the plunger (also) may have a concave shape. In embodiments, the plunger is reinforced adjacent to at least one of the first end and the second end of the plunger. The plunger can be strengthened, for example, by providing the peripheral wall with a greater thickness near the end of the plunger (compared to places on the peripheral wall between the ends). The peripheral wall forms, in particular, a concave peripheral wall. In this document, the term concave can refer to a gradually changing shape. The specified term can also refer to a more discretely varying shape, in particular, forming a generally concave shape.

In embodiments, the plunger comprises one or more (polymeric) materials selected from the group consisting of PP (polypropylene) and EVA (ethylene vinyl acetate), in particular ethylene vinyl acetate. Ethylene vinyl acetate can be flexible and make tight contact with the container wall. In addition, EVA can be resistant to certain fluids, such as one containing trichloroacetic acid. In embodiments, the plunger, in particular the peripheral wall, may further comprise a coating and / or a seal, such as an O-ring. In embodiments, the plunger comprises ethylene vinyl acetate, in particular (substantially) ethylene vinyl acetate.

In particular, the plunger has a two-taper shape and, in addition, contains, in particular, EVA.

The plunger advancement system contains a polymer material (polymer). In particular, the plunger advancement system further comprises a second spring material. In embodiments, the polymeric material comprises polypropylene and ethylene vinyl acetate. In particular, the polymeric material essentially contains only polypropylene and ethylene vinyl acetate, while, in particular, the remainder of the polymeric material contains polypropylene, in particular consists of polypropylene. In further embodiments, the second spring material and in particular also the first spring material comprises 316 stainless steel, in particular 316 stainless steel.

The plunger advancement system is located, in particular, outside the storage space. Thus, a liquid, in particular a corrosive liquid (that is, incompatible with the materials with which it comes in contact), may in particular not come into contact with the plunger advancement system. However, surprisingly, it has been found that the plunger advance system (in particular, the elements (see below) of the plunger advance system) can (nevertheless) undergo wear in a relatively short period (for example, a couple of months) when using corrosive liquids (such as liquids containing trichloroacetic acid in higher concentrations, as described in this document). Even when no corrosive fluid is leaking, it has been observed that at least a portion of the ram advance system can wear out over time. Surprisingly, it turned out that this problem can only be solved by using certain combinations of materials.

However, the applicator according to the invention is configured to contain the liquid previously described, in particular trichloroacetic acid, and the applicator may (almost) not degrade over time (see below). In particular, the applicator can be durable and can function properly for a period of at least one year, such as at least 2 years.

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The plunger advancement system is essentially configured to actuate the plunger, in particular to advance the plunger, in particular to reduce storage space, in particular for fluid displacement (for treatment / care). In embodiments, the plunger advancement system comprises a plunger stem (operatively coupled to the plunger) for actuating the plunger. The application device can be used for a longer period, and the liquid, in particular, is not expelled at one time. Therefore, the plunger advancement system is particularly configured to displace a predetermined amount of treatment / care fluid. The plunger advancement system is in particular configured to (regularly) displace an adjustable dose of liquid (for treatment / care).

In additional embodiments, the plunger advancement system comprises a spindle system. In particular, the spindle system comprises a screw-driven spindle system. Such a spindle system can comprise a threaded rod and a screw base. A screw base (having a (internal) screw thread) can be positioned around the threaded rod. The screw thread (thread) of the threaded rod and the screw base thread, in particular, are connected / come into contact with each other (see further below). The threaded rod can be rotated (in the screw base) relative to the screw base. This rotation can, in particular, provide a translational movement of the threaded rod relative to the screw base. The threaded rod can be circular (cylindrical) in shape. In additional embodiments, the implementation of the threaded rod has a flat shape (see also below) on the outer surface. In particular, at least part of the outer surface contains threads. In particular, a thread is formed on two opposite sides of the outer surface (such a threaded rod with flat surfaces), the longitudinal axis of the threaded rod being in particular between said opposite sides. In embodiments, the threaded rod has a cross-section (perpendicular to the longitudinal axis of the threaded rod) having a rectangular shape, in particular having threads on two opposite sides of the cross-section with a rectangular shape. In additional embodiments, the implementation of the specified cross-section has an oval shape. In other additional embodiments, the cross-section is circular.

As used herein, the term cross-sectional area, such as the cross-sectional area of a threaded rod, can also refer to a plurality of (different) cross-sections. Therefore, the cross-sectional area of the threaded rod can vary along the longitudinal axis of the threaded rod.

The axis of the main body of the device may form the longitudinal axis of the threaded rod. In particular, the axis of the main body and the longitudinal axis of the threaded rod are the same. In addition, in particular, the longitudinal axis of the plunger is substantially parallel to the longitudinal axis of the threaded rod.

The threaded rod can be functionally connected to the plunger. The threaded rod, in particular, is physically connected to the plunger. The threaded rod can be physically connected to the plunger at a location within the plunger. The threaded rod can pass through (only) one of the ends of the plug. The threaded rod is in particular fixed in the plunger. In embodiments, the plunger is pivotable relative to the threaded rod.

The screw base can be formed in the container part, whereby, in particular, the movement of the screw base is substantially prevented. The screw base, in particular, is configured to prevent its movement in the direction along the longitudinal axis of the container part and, in particular, to prevent its rotation relative to the container wall. Consequently, the rotation of the threaded rod can be converted (by means of the screw cap) into a translational movement of the threaded rod (relative to the screw cap). In particular, such a rotation with respect to the screw cap is also a rotation with respect to the plunger. In additional embodiments, the implementation of the screw base can be configured to prevent movement in the direction along the longitudinal axis of the container part and, in particular, does not allow rotation about (about) the longitudinal axis. In particular, in such an embodiment, the threaded rod can move in translation and, in particular, not pivot (when actuated).

The application device may further comprise an end cap. The end cap is in particular directly or indirectly operatively connected to the threaded rod. In embodiments, the drive element is located around the threaded rod. The drive element can in particular comprise an opening, the opening being configured to correspond to the cross-section of the threaded rod. The drive element can rotate the threaded rod (relative to the screw base). The end cap can be functionally connected to the drive element. In embodiments, the end cap comprises a drive element. In additional embodiments, the end cap and the actuator are not in contact with each other. The end cap is in particular positioned to drive the threaded rod. In embodiments, rotation of the end cap (relative to the screw cap) rotates the threaded rod. In embodiments, the rotation of the end cap directly provides such rotation of the threaded rod. In particular,

- 7 038326 angular displacement of the end cap provides angular displacement of the threaded rod to the same extent. In other embodiments, pivoting the end cap indirectly pivots the threaded rod. In embodiments, the angular displacement of the end cap and the angular displacement of the threaded rod are not the same. In particular, the rotation of the end cap is proportional to the rotation of the threaded rod (relative to the screw cap).

In other embodiments, the end cap can be (directly or indirectly) connected to the screw base, and the rotation of the end cap can, in particular, rotate the screw base. In embodiments, the pivoting of the screw cap provides translational movement of the threaded rod.

In additional embodiments, translational movement of the end cap (relative to the screw cap) rotates the threaded rod. In particular, in such embodiments, the end cap can be functionally and / or physically connected (in particular by means of a drive element) to the threaded rod by means of a conversion element that converts translational movement into rotation. In particular, such an end cap may be a click-and-click end cap. In particular, the application device can be configured to displace a predetermined amount of liquid each time it is clicked on the end cap. In other further embodiments, translational movement of the end cap rotates the screw base (allowing, in particular, translational movement of the threaded rod).

Therefore, in embodiments, the application device may further comprise an end cap operatively connected to a threaded rod, wherein the application device is configured to rotate the threaded rod (i) based on translational movement of the end cap relative to the screw cap, or (ii) based on rotation of the end cap. cap relative to the screw base.

In other embodiments, the plunger advancement system comprises a spindle system comprising a threaded rod, a screw cap, and a unidirectional ratchet system, wherein the plunger advancement system is configured to move the plunger toward the valve based on rotation of the screw cap. In particular, such embodiments may further comprise an end cap operably coupled to the screw cap, the application device being configured to rotate the screw cap (i) based on translational movement of the end cap relative to the screw cap, or (ii) based on rotation of the end cap relative to the plunger, in particular relative to the container wall.

The spindle system may further comprise a ratchet system. Therefore, in embodiments, the plunger advancement system comprises a spindle system that includes a ratchet system. In embodiments, the ratchet system comprises a unidirectional ratchet system. Such ratchet systems are known to the person skilled in the art and may comprise, for example, a male element and a female element which enable rotation in one direction and prevent any rotation in the opposite direction. The ratchet system is, in particular, a unidirectional ratchet system. The ratchet system can provide the ability to rotate the threaded rod in one direction. In embodiments, pivoting the end cap in the first direction may rotate the threaded rod, particularly in the same direction (and translate the threaded rod). In other embodiments, pivoting the end cap in the first direction may rotate the screw cap, in particular in the same direction (and translate the threaded rod). Rotating the end cap in the opposite direction cannot rotate the threaded rod or screw base. In additional embodiments, the ratchet system is configured to prevent the end cap from rotating in the opposite direction. In particular, one of the (male and female) elements is rigidly connected in the container part to the wall of the container part. In embodiments, the end cap may physically contact another member (male and female). In further embodiments, the implementation, including, in particular, the end cap that yields with a click with a click, this other element can contact with the actuator element. Therefore, the ratchet system can comprise a first element and a (complementary) second element, which, in particular, can contact / engage with each other.

Therefore, in embodiments, the plunger advancement system comprises a spindle system comprising a threaded rod, a screw cap, and a unidirectional ratchet system, and the plunger advancement system is particularly configured to move the plunger towards the valve based on rotation of the threaded rod.

The plunger advancement system contains the material of the plunger advancement system. The material of the plunger advancement system consists in particular of a polymeric material. In additional embodiments, the material of the plunger advancement system is metal. Metal can also

- 8 038326 contain, in particular, a metal alloy. In another further embodiment, the material of the plunger advancement system is comprised of a ceramic material.

The material of the plunger advancement system may in particular contain polypropylene. In additional embodiments, the plunger advancement system material comprises chlorotrifluoroethylene ethylene. In other additional embodiments, the plunger advancement system material comprises polyoxymethylene. In particular, the plunger advancement system contains polypropylene, in particular consists of polypropylene.

In particular, the spindle system contains the material of the plunger advancement system.

In embodiments, the spindle system comprises polypropylene. In embodiments, the threaded rod is comprised of polypropylene. In additional embodiments, the implementation of the ratchet system (also) consists of polypropylene.

In other further embodiments, the screw base is comprised of polypropylene.

As used herein, the term material, such as plunger advancement system material, can also refer to more than one material (different materials), for example, more than one material (different materials) of the plunger advancement system. The plunger advancement system can contain polypropylene, in particular it can consist of polypropylene. In additional embodiments, the implementation of the spindle system contains polypropylene, in particular, consists of polypropylene.

In embodiments, the applicator, in particular the plunger advancement system, comprises a second spring system. The second spring system can be formed at the location between the end cap and the ratchet system so that it, in particular, brings the elements of the ratchet system into contact with each other. In particular, the second spring system is a means for bringing the male and female elements of the ratchet system into contact with each other, in particular their engagement with each other. In certain embodiments, the plunger advancement system comprises a spindle system comprising a ratchet system that includes a first element and a second element, the second spring system being configured to engage / engage the first element and the second element with each other. The second spring system may additionally provide (directly or indirectly) feedback to the user of the applicator when the applicator is actuated (in particular when the end cap is rotated or when the end cap is “pressed” with a click), in particular tactile feedback and / or audio feedback. Such audible feedback can be provided by means of a ratchet system, in particular providing an indication of the incremental rotation of the screw cap.

Therefore, the plunger advancement system may comprise a second spring system, the second spring system in particular located adjacent to the side of the plunger opposite to the storage space. As used herein, the plunger side and the opposite plunger side refer specifically to the first end and the second end of the plunger. In particular, one of the first end and the second end of the plunger may be in contact with liquid, while the other side may not be in contact with liquid. In particular, the second spring system is not in contact with liquid (stored in the storage space).

In other further specific embodiments, the second spring system is configured to provide tactile and / or audible feedback during translation of the plunger relative to the valve.

In embodiments, the second spring system comprises an opening, namely a through hole, in the center of the second spring system. In further embodiments, the implementation of the ratchet system includes an opening, in particular a through hole, in the center of the ratchet mechanism. These openings or through openings are formed, in particular, parallel to the longitudinal axis of the container part. In embodiments containing one or more of these through holes, the threaded rod may be located in the through holes (which are). The threaded rod can hold one or more of the ratchet system and the second spring system in a predetermined position. In particular, the threaded rod can define the location of one or more of the ratchet system and the second spring system.

In particular, the second spring system is made with certain characteristics such as dimensions (length, width, etc.) and physical characteristics such as spring stiffness. These characteristics can be attributed to the material of the second spring. In particular, such characteristics can be adjusted by selecting a spring material containing a metal, such as spring steel. Surprisingly, however, it has been found that in embodiments, application devices comprising a spring material comprised of (standard) spring steel were short-lived (see further below).

Therefore, in embodiments, the second spring system comprises a second spring material selected from the group of stainless steel types containing molybdenum, in particular at least 0.1 wt% molybdenum, for example at least 0.5 wt% molybdenum. In particular, the content of molybdenum is equal to or less than 7 wt.%, For example equal to or less than 5 wt.% Such types of stainless steels are known and include, for example, types 316, 316L, 317, 317L stainless steels and super-austenitic stainless steels. such as Allegheny Ludlum AL-6XN and 254SMO. Stainless steel type 316 (SS316) and type 316L (SS316L) may contain, for example, about 2-3 wt.% Molybdenum. Stainless steel type 317 (SS317) and type 317L (SS317L) may contain 3-4 wt% molybdenum. The content of molybdenum in the second spring material, in particular, exceeds 0 wt.% In embodiments, the content of molybdenum in the second spring material is less than or equal to 3 wt.% In other embodiments, the content of molybdenum in the second spring material is equal to or more than 3 wt.%

In additional embodiments, the second spring material is comprised of polypropylene. In other additional embodiments, the implementation of the second spring material consists of a noble metal. The second spring material may be composed of one or more noble metals selected from the group consisting of ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, titanium, and gold. In particular, the second spring material may comprise titanium or (a) a titanium alloy, even more particularly a titanium alloy containing at least 0.1 wt% ruthenium. These (noble) metals and / or titanium can provide corrosion resistance. However, such metals can be difficult to obtain and difficult to process in a viable mass-produced commodity. Such metals can be used, in particular, in specific embodiments. The second spring material consists in particular of stainless steel, in particular of molybdenum-containing stainless steel, for example stainless steel of the SS316 type.

In the application device, the valve is adapted in particular to prevent a spontaneous flow of liquid from the application device. The valve can, in particular, prevent fluid leakage. The valve can (also) prevent air from entering the container (through the tip). Allowing air to come into contact with the liquid in the container may adversely affect the quality of the liquid. The valve in particular contains a check valve. In embodiments, the valve comprises a duck nose (check) valve. In embodiments, the valve may comprise a ball check valve.

In embodiments, the valve comprises polypropylene (PP). In additional embodiments, the valve comprises chlorotrifluoroethylene ethylene (ECTFE). In embodiments, the ball check valve may, for example, comprise a PP ball or an ECTFE ball. In addition, the valve may contain polybutylene terephthalate (PBT). In additional embodiments, the ball is comprised of a metal selected from the group consisting of noble metal and 316 stainless steel. In particular, the ball check valve comprises a glass ball (a ball composed of glass). The valve, in particular a ball check valve, may further comprise a first spring system. Such a spring system can be configured to bias the ball in the direction of the plunger, in particular when the valve is closed, and in particular to prevent (together with this) the entry of air into the container through the valve and / or the spontaneous flow of liquid from the container through the valve. ...

In embodiments, the first spring system comprises a first spring material selected from the group of stainless steel types containing molybdenum, in particular at least 0.1 wt% molybdenum, for example at least 0.5 wt% molybdenum. In particular, the content of molybdenum in the first spring material is equal to or less than 7 wt%, for example equal to or less than 5 wt% The content of molybdenum in the first spring material, in particular, exceeds 0 wt% In embodiments, the content of molybdenum in the first spring material is less or equal to 3 wt.% In other embodiments, the content of molybdenum in the first spring material is equal to or greater than 3 wt.% In embodiments in which the application device comprises a (first) spring system, the first spring material (also), in particular, consists of molybdenum-containing stainless steel (for example, stainless steel material containing molybdenum), in particular SS316.

In additional embodiments, the first spring material is comprised of polypropylene. In other additional embodiments, the implementation of the first spring material consists of a noble metal or titanium alloy, similar to those described above (in connection with the second spring material).

The spring material for these one or more spring systems can be selected based in particular on the material of the plunger advancement system.

A number of materials have been tested. Surprisingly, it turned out that even when the elements were not in contact with the acidic liquid, the materials appeared to degrade over time. For example, metal parts not in contact with acid will wear out over time. In addition, it turned out that this wear / tear process was significantly less in the case of materials described herein as the first spring material and the second spring material, such as steel, in particular, like SS316 steel. Surprisingly, the experimental results showed that although the second spring did not substantially contact the liquid in the experiments, embodiments having (corrosive) liquids containing trichloroacetic acid in the storage space and having a second spring made from conventional

- 10 038326 spring steel were not very durable. Despite the fact that the second spring was not in contact with liquid, over time the second spring was negatively affected. Without being limited by theory, it is hypothesized that negligible amounts of gaseous trichloroacetic acid may have been present on the side of the plunger opposite to the storage space, in particular in the contact area with the second spring. Due to the negative charge of trichloroacetic acid and the positive charge of the steel spring, ionization can occur, and the chloroform generated from the trichloroacetic acid can corrode the spring material. While it is known (eg, from reference books) that 304 stainless steel has very good chloroform compatibility, embodiments containing SS304 also showed poor durability during durability tests. Springs made from SS304 could show discoloration and / or corrosion in durability tests, which ultimately adversely affect the plunger advance system or even cause it to break and, in particular, prevent the displacement of the controlled dose (or any dose) liquids (for treatment / care). However, when tested with second springs made from molybdenum-containing stainless steel, such as type 316 stainless steel, the spring material was not adversely affected when the storage space contained a liquid containing trichloroacetic acid.

Likewise, it turned out that some components made of polymer, in particular the plunger advancement system, even when not in contact with the acidic liquid, showed deterioration over time.

In addition, the combination of the spring materials referred to in this document and PP, ECTFE or POM, in particular PP, turned out to give the best results in terms of stability, while other spring materials and / or other polymers were chosen, the device had a relatively short lifespan. The required properties of the polymeric material may depend on the characteristics of the fluid. Durability tests have shown that embodiments comprising, in particular, a polypropylene container, and in particular also a plunger advance system comprising polypropylene, can reliably continue to function when tested also in the case of liquids having high concentrations of trichloroacetic acid (for example, equal or greater than 30 wt%, for example equal to or greater than 40 wt%, for example equal to or less than 60 wt%). Upon exposure to trichloroacetic acid (at high concentrations), some of the resilience / stiffness properties of polypropylene may change. However, this did not adversely affect the usability and safety of the application device. However, in particular during durability tests at high concentrations of trichloroacetic acid, parts of the application device made of polyethylene, polyoxymethylene showed partial dissolution and / or degradation, which, in particular, adversely affected the usability and safety of the application device. ... Additional tests performed on a polymeric material containing PEEK or PVDF also did not show great durability. In addition, high concentrations of trichloroacetic acid did not appear to adversely affect elements made from ethylene vinyl acetate (TCA) (see also below).

In embodiments, the implementation of the application device may be configured to contain trichloroacetic acid at a concentration equal to or greater than 40 wt.% In additional embodiments, the implementation of the application device may be configured to contain trichloroacetic acid at a concentration equal to or less than 40 wt. .%, however, is, in particular, at least 0.5 wt.%, for example, at least 1 wt.% In embodiments, the implementation of the device can be configured to contain trichloroacetic acid with a concentration selected in the range 5-40 wt.% In embodiments, the device contains trichloroacetic acid at a concentration selected in the range of 0.5-40 wt.% In additional embodiments, the applicator is configured to contain trichloroacetic acid at a concentration selected in the range 15-25 wt. .% In particular, the liquid contains trichloroacetic acid at the above-described concentration centration. The fluid can also be called a treatment / care fluid. Liquid can also be indicated as composition.

In particular, the applicator is configured such that the rotation of the threaded rod can move the plunger, in particular towards the valve, in particular to displace at least a portion of the liquid. The rotation of the threaded rod can in particular be a step rotation. The stepwise rotation of the threaded rod can provide a stepwise translational movement of the threaded rod, and this can, in particular, displace the incremental amount of liquid. The specified threads may contain metric threads. Said threads may also include other types of standard threads known in the art, such as uniform threads, rectangular threads, trapezoidal threads, American special uniform threads (UTS), or American trapezoidal threads (ACME). In particular, the screw thread

- 11 038326 of the base / plinth corresponds to the thread of the threaded rod, which makes it possible to connect these two threads to each other. In embodiments, the connection of two threads (female thread of the screw cap and male thread of the threaded rod) is defined by international standards such as the metric standard. In additional embodiments, the threads of the threaded rod are changed from the standard. In embodiments, the shape of the male thread crest and / or female thread root is smoothed (s), in particular rounded (s). In embodiments, the first female thread angle may be different from the first male thread angle and / or the second female thread angle may be different from the second male thread angle. Such (first and second) angle can be formed by a turn (surface of a turn) of the thread and a plane perpendicular to the longitudinal axis of the threaded rod (or the longitudinal axis of the screw cap). Such an angle can refer to the angle of inclination of the thread, in particular the angle of inclination on the first side (lateral surface of the profile) and / or the angle of inclination on the second side (lateral surface of the profile) of the thread. For example, for a triangular type thread, all of these angles (for both external and internal threads) can be substantially equal to 30 °. In embodiments, the difference between said first angles and / or the difference between said second angles is selected in the range of 1-15 °, for example 1-10 °, in particular 1-5 °. In embodiments, the threads are substantially symmetrical. In particular, the angle of inclination of the first side of the thread is substantially equal to the angle of inclination of the second side of the thread. The first side (side surface of the profile) of the thread can be made mirror-symmetric with respect to the second side (side surface of the profile) of the thread (relative to the axis of symmetry). In additional embodiments, the first side and the second side of the thread are not mirror-symmetrical. In particular, the external thread is not mirror-symmetrical. In particular, the angle of inclination on the first side (side surface of the profile) of the external thread is not equal to the angle of inclination on the second side (side surface of the profile) of the thread. In threaded rod embodiments, the selected second angle is greater than the first angle. In embodiments, the first angle is selected in the range of 10-45 °, for example 10-40 °, in particular 10-20 °, while the second angle is 1-30 °, for example 120 °, in particular 3-15 °, greater than the first corner. Surprisingly, it has been found that in such (non-symmetrical) embodiments, the polypropylene threaded rod and the polypropylene screw base can be more easily rotated (relative to each other) compared to embodiments having mirror-symmetrical threads. In particular, such an embodiment can be more durable and, in particular, can be subject to less wear.

Such an embodiment can provide, in particular, a reduced resistance to rotation of the threaded rod in the screw base. Such an embodiment may comprise, in particular, a polypropylene screw base and a polypropylene threaded rod. In addition, the threaded rod may contain a flat surface (see also above). The threaded rod can, for example, have a rectangular cross-section, with the thread located on a part of the periphery of the cross-section, in particular on two opposite sides of the periphery. This configuration can, in particular, further reduce the turning resistance (and wear). Embodiments comprising a polypropylene screw cap and a polypropylene threaded rod that include standard type internal and external threads, such as metric threads or trapezoidal threads, may require heavy load bearing elements in the plunger advancement system to provide a durable and efficient applicator. In particular, the thread of the standard type may be a mirror-symmetrical thread. Therefore, in embodiments, the internal thread is a standard type (standardized) thread, while the external thread is a modified (standardized) thread, in particular, said thread is not mirror-symmetric. In other embodiments, the external thread is a standard type (standardized) thread and the internal thread is the specified modified thread. In addition, in further embodiments, both threads are modified, in particular with a slight difference, to provide reduced resistance to turning. As used herein, a mirror-symmetric thread is a thread having a first flank and a second flank, the first angle between the first flank and a plane perpendicular to the longitudinal axis of the thread (such as the longitudinal axis of a bolt or nut) is substantially equal to the second the angle between the second side surface and the specified plane.

In embodiments, said angles of the internal thread (screw cap) are selected in the range of 45-30 °, in particular in the range of 30-40 °, even more particularly in the range of 33-37 °. In further embodiments, the angles of the external thread (threaded rod) are also selected in the range of 45-30 °, in particular in the range of 30-40 °, even more particularly in the range of 33-37 °. In addition, in additional embodiments, the first angle between the first flank of the external thread (threaded rod) and a plane perpendicular to the longitudinal axis of the threaded rod is selected in the range of 20-24 °, in particular in the range of 21-23 °, and the second angle between the second flank surface of the external thread and the specified plane is selected in the range of 13-17 °, in particular in the range of 14-16 °. In particular, the sum of the specified first angle and the specified second angle (threads of the threaded rod) is given

- 12 038326 equal to approximately 37 ± 2 °.

The threads of the threaded rod have a pitch length that can be substantially constant over the length of the threaded rod. The step length can also vary along the length of the threaded rod. In embodiments, the step length gradually increases from the side of the rod closest to the plunger to the side of the rod farthest from the plunger.

The applicator may further comprise a tip base. The base for the tip is in particular adapted to hold an application tip therein. The base for the tip may be positioned to provide a fluid connection between the container portion and the application tip. The base for the tip, in particular, contains a central cavity for allowing fluid to drain from the container portion into the tip. The base for the tip, in particular, is sealed to the container part. In embodiments, the base for the tip comprises an application tip. In particular, in such an embodiment, the liquid can be supplied (eg, to the skin) through an opening in the base for the tip. The application device may further comprise a fluid delivery member containing an application tip. In particular, the base in the applicator is adapted to hold the fluid delivery device (including the application tip). In addition, in embodiments, the base in the applicator may function as a fluid delivery device.

The configuration of the fluid delivery member (or no such member as such) can be selected (o) depending, for example, on the application, dispensing (mode) and / or use of the pen applicator member. In particular, an application tip is contained in a hole in the base for the tip. The fluid delivery member may include a brush (fluid delivery member). In additional embodiments, the fluid delivery member comprises a barbed protrusion. In additional embodiments, the fluid delivery member comprises a tubular tip having a fluid channel and an opening in the tubular tip.

The fluid delivery element (eg, tubular tip) may be circular in shape. The end device can also be oval in shape. In other additional embodiments, the fluid delivery member is rectangular in shape. The liquid supply element can have essentially any arbitrary shape. In particular, the shape of the application tip matches the shape of the fluid delivery member (or tip base). The liquid delivery element, in particular in the region of the application tip, can have a characteristic dimension such as diameter or width. In particular, such a characteristic size can be selected in the range of 0.5-10 mm, for example 0.5-5 mm, in particular 1-5 mm. The applicator is particularly adapted to replace the fluid delivery element. In embodiments, the applicator comprises a retaining locating ring for aligning the end fixture, in particular the fluid delivery member. The retaining locating ring can function as a base for the automatic fill line elements. On such a filling line, the fluid delivery element can be automatically centered and can be positioned in the container portion by means of a simple pressing tool. In particular, the fluid delivery member comprises a brush. In embodiments, the brush comprises fibers. The fibers are held together, in particular by the resin. In embodiments, the brush (fluid delivery device) contains polybutylene terephthalate. In other embodiments, the fluid delivery member comprises polypropylene.

In particular, an application tip, in particular a fluid delivery member, comprises a fluid delivery member with a precisely adjusted dose (at the application tip). In embodiments, the finely adjusted dose fluid delivery member is a tube. The tubular tip contains, in particular, one hole (for displacing the liquid).

The applicator may further comprise a closure cap. The closure cap can cover, in particular, the liquid delivery element and / or the base for the tip. The closure cap can additionally cover a portion of the container. Such a closure cap may be configured to prevent leakage from the applicator. In addition, the closure cap may be configured to prevent any loss of treatment / withdrawal fluid from the applicator due to evaporation. Such a closure cap can be configured to prevent the applicator from drying out. Such a closure cap can prevent the end device from drying out, in particular the spike or tassel. Such a closure cap can further prevent oxidation of the liquid in the liquid delivery member and / or in the rest of the applicator. For example, the air surrounding the applicator (otherwise) can cause oxidation of the fluid in the fluid delivery element and / or in the base for the tip and other parts of the applicator. In embodiments, the closure cap comprises a closure system within the closure cap, in particular adapted to fit snugly against the base for the tip and / or the fluid delivery elements. In an embodiment, the closure cap is a child-safe closure cap. In particular, the closure cap and tip base and / or container may include guards to prevent a child from separating the closure cap from the rest of the applicator. In additional embodiments, the implementation of the closure cap and container include visual indicators, in particular arrows, which must be aligned to remove the closure cap.

In a particular embodiment, the application device includes an application tip and a container portion, wherein the container portion comprises (i) a container comprising a container wall, a valve, and a plunger, wherein the container wall, valve, and plunger jointly define a storage space for retaining liquid, the plunger contains a peripheral wall in contact with the container wall to ensure tightness; and (ii) a plunger advancement system operatively coupled to the plunger and configured to allow the plunger advancement to reduce storage space for displacing at least a portion of the liquid through said valve into said tip, the plunger advancement system being located outside the storage space; wherein (iii) the following applies: (a) the valve comprises a first spring system comprising a first spring material comprising stainless steel material and having a molybdenum content selected in the range of 0.5-7 wt%, and (b) the plunger advancement system comprises a second spring system containing a second spring material containing a material that is stainless steel and having a molybdenum content selected in the range of 0.5-7 wt%; and (iv) the plunger advancement system comprises a polymer selected from the group consisting of polypropylene, ethylene chlorotrifluoroethylene and polyoxymethylene (in particular polypropylene), and wherein the plunger advancement system comprises a spindle system comprising a ratchet system that contains a first element and a second element , while the second spring system is made (located) with the possibility of contacting / engaging the first element and the second element with each other.

In addition, according to the invention, there is provided a treatment / care liquid, in particular for treating a wart (or corn). In a specific embodiment, the formulation may further comprise vitamin A. In yet another further embodiment, the treatment / care fluid further comprises vitamin A. The acid in the treatment / care fluid is used, in particular, to exfoliate the skin or mucous membranes, in particular the skin, whereby the cells of the skin or mucous membrane can be renewed.

The applicator or treatment / care fluid can be used for several types of lesions. The applicator or treatment / care liquid can be used for medical and / or non-medical uses such as cosmetic applications. As used herein, the term treatment / care fluid refers to fluid. The liquid may contain an acid, in particular trichloroacetic acid, and optionally one or more other components.

According to a further aspect of the invention, there is provided, in particular, the use of an applicator as defined herein for cosmetic care. In embodiments, the use relates to the cosmetic treatment of a local injury selected from the group consisting of warty epidermodysplasia, HPV (human papillomavirus) skin damage, acne, scar, wrinkle, tattoo, eyelid xanthelasma, age pigment spot, senile lentigo, sun lentigo, melasma, warts on the arm, horny warts, calluses, ingrown toenails, nail dystrophy, nail fungus, mucosal damage, stomatitis. The term wart can refer, for example, to one or more of a simple wart and a plantar wart. The healing fluid is especially suitable for treating one (one) or more of the wart and callus. Likewise, the treatment / care liquid can be used on its own. The use in particular relates to one or more treatments selected from the group consisting of skin care, nail care, oral care, ear care (ear treatment), eyelid care (eyelid / eye treatment). The term oral care can refer to treating oral ulcers, brushing children's teeth, whitening teeth, and ingrown nails. Ear care can include, for example, treating an ear infection, blocked ears, and cleaning your ears. Eyelid / eye care can be associated with, for example, dry eyes, eye irritation and reddened eyes.

Therefore, in another additional aspect of the invention, there is also provided the use of a treatment / care fluid as defined herein for the cosmetic care (or treatment) of a local injury selected from the group consisting of epidermodysplasia warty, HPV (human papillomavirus) -induced skin damage , acne, scar, wrinkles, tattoos, eyelid xanthelasma, age pigment spot, senile lentigo, solar lentigo, melasma, wart on the arm, horny wart, callus, ingrown toenail, mucosal damage.

The term topical treatment / topical care refers in particular to the treatment of a body surface such as skin, nail or mucous membrane, in particular human skin, with a treatment / care fluid.

In embodiments, grooming specifically refers to nail or oral care.

The treatment / care fluid, in particular an acid, may contain one or more acids selected from the group consisting of trichloroacetic acid, salicylic acid, formic acid, glycolic acid, dichloroacetic acid, monochloroacetic acid, boric acid, nitric acid, sulfuric acid, phosphoric acid, oxalic acid, lactic acid, hydrochloric / hydrochloric acid. Even more specifically, the treatment / care fluid contains at least trichloroacetic acid (TCA). Therefore, the acid can also contain a combination of two or more different acids.

Of course, the treatment / care fluid may contain one or more other ingredients, including one or more other active ingredients, as needed. The composition described herein may contain other ingredients commonly used in cosmetic and pharmaceutical products, such as one or more of a surfactant, a colorant, and a perfume.

Trichloroacetic acid (TCA) in the treatment / care fluid described in this document has been shown to be effective against a variety of skin lesions, in particular warts, calluses and growths, water warts (molluscum contagiosum), acne, skin hyperpigmentation, actinic keratosis as well as damage to nails, including ingrown toenails and onychomycosis, and damage to mucous membranes, such as oral ulcers and herpes of the lips. The use of trichloroacetic acid is especially effective against genital warts, and in particular against anogenital warts, which has been investigated in comparative trials in which its effectiveness was compared with other therapies intended for the elimination of warts. In addition, the use of trichloroacetic acid has been effective in various other skin lesions, in particular epidermodysplasia warty, skin damage also caused by the HPV virus, acne, in the removal of acne scars and wrinkles, tattoo removal, eyelid xanthelasma, age spots, senile lentigo and solar lentigo, melasma.

In a specific embodiment, the acid contains one or more acids selected from the group consisting of trichloroacetic acid, salicylic acid, glycolic acid, dichloroacetic acid, monochloroacetic acid, boric acid, nitric acid, sulfuric acid, phosphoric acid, oxalic acid, and lactic acid.

As a supplement or alternative, the treatment / care fluid can contain one or more of formic acid and salicylic acid, which alone or in combination can also provide a good result. Therefore, in an embodiment, the treatment / care fluid contains trichloroacetic acid and optionally formic acid, and in another embodiment, the treatment / care fluid contains formic acid and optionally trichloroacetic acid.

Salicylic acid has a beneficial effect on skin and nail care. In addition, salicylic acid provides a mild pain relieving effect. Salicylic acid in combination with trichloacetic acid has been shown to act synergistically against skin damage and nail damage. Another advantage is that the use of a combination of salicylic acid and trichloroacetic acid allows the use of a formulation with a relatively low concentration of each of salicylic acid and trichloroacetic acid with an effect similar to formulations using only trichloroacetic acid or only salicylic acid. The use of relatively low concentrations of trichloroacetic acid and salicylic acid reduces the likelihood of skin irritation caused by any of these ingredients. In addition, salicylic acid reduced the discomforting burning sensation on skin and nails sometimes experienced by people treated with products containing significant amounts of trichloroacetic acid.

Thus, the treatment / care liquid can be used, inter alia, for a treatment to exfoliate dead skin cells, for the treatment or cosmetic treatment of a skin lesion selected from the group consisting of warts, corns and skin growths, and for the care of nails, including ingrown toenails. The proposed mechanism of action is that the formulation containing trichloroacetic acid or another acid softens the skin or nail and allows the damage to the skin or nail to be released. Serious damage may require many treatments. Both cosmetic care and treatment can be carried out by means of the compositions according to the invention. Other active ingredients may be added to aid in the treatment of injury. For example, salicylic acid (see also above) is another component that is effective against skin or nails and can be used as an additional active ingredient in combination with trichloroacetic acid.

Therefore, the invention further provides the use of a treatment / care liquid for cosmetic care of human skin. The composition is particularly used for a treatment for exfoliating dead skin cells or for treating skin damage selected from

- 15 038326 of a group consisting of warts, corns and skin growths. The formulations are particularly effective against warts and related lesions, including simple warts, congenital warts, and watery warts (molluscum contagiosum). This treatment is generally viewed as a cosmetic treatment rather than a treatment. The invention also provides the use of the composition described herein for cosmetic nail care. In particular, effective treatment of nail deformities (eg, due to onychomycosis) and ingrown toenails can be provided.

In addition, the invention provides the use of a treatment / care liquid or a treatment / care composition described herein for treating mucosal lesions, in particular oral ulcers and herpes labialis. In addition, the invention provides the use of a care liquid or care composition described herein for the cosmetic treatment of superficial lesions selected from the group consisting of simple warts, congenital warts, water warts (molluscum contagiosum), corns and skin growths, age spots, solar lentigo, senile lentigo, acne, oral ulcers (ulcerative stomatitis) and ingrown toenails.

The treatment / care liquid contains, in particular, an aqueous liquid such as water, and an acid. The total amount of other components in a treatment / care fluid other than an acid and a fluid such as an aqueous fluid is less than 10% by weight, in particular less than 5% by weight, with examples of other compounds such as a colorant and a perfume mentioned above. The treatment / care fluid contains in particular an acid with a concentration of up to 40% by weight, for example a maximum of 35% by weight, even more particularly a maximum of 20% by weight Higher acid concentrations can lead to undesirable topological effects and / or can be unsafe , for example, in the case of use for children or certain places of application, like the mucous membrane. In a specific embodiment, the treatment / care fluid contains an acid in the range of 1-10 wt%. Concentrations less than 1 wt% may not be effective enough. In particular, the concentration of acid in the treatment / care fluid is at least 2% by weight, even more particularly at least 3% by weight.

In embodiments, the applicator can be configured, in particular, with the possibility of dispensing a single dose not exceeding 1 ml, for example, in particular not exceeding 0.75 ml, for example 0.10.5 ml, for example 0.1-0.2 ml or less than 0.2 ml. As known to the person skilled in the art, this can be adjusted by, inter alia, the dimensions of the fluid delivery element, such as the dimensions of the brush, the angular offset, the pitch of the threaded rod. A metering valve or metering application can be used to control that the target dose is substantially always met.

As indicated above, polypropylene, in particular, can be used for one or more elements of the application device. The application device may comprise a polymeric material and a metallic material, in particular it may consist essentially of a polymeric material and a metallic material (for example, for a spring system), and in addition some additional elements containing other material, such as a glass ball in a valve. In embodiments, the polymeric material comprises polypropylene and ethylene vinyl acetate, the metallic material in particular comprising molybdenum-containing stainless steel, in particular SS316. In additional embodiments, only the plunger contains ethylene vinyl acetate. In embodiments, the first spring material, and in particular also the second spring material, is a molybdenum steel such as SS316. In specific embodiments, the application device comprises a polymeric material and a metallic material, the polymeric material being composed of polypropylene and ethylene vinyl acetate, the plunger comprising ethylene vinyl acetate (consisting of ethylene vinyl acetate), and the metallic material being composed of molybdenum steel, in particular SS316.

In a particular embodiment, the container wall and the spindle system comprise polypropylene, in particular polypropylene, wherein the plunger in particular comprises ethylene vinyl acetate, in particular consists of ethylene vinyl acetate, and wherein in particular the first spring material and the second spring material comprise molybdenum steels, in particular, consist of molybdenum steel, in particular SS316.

The propylene polymer can be selected from, for example, homopolymer, random copolymer, and block copolymer. Typically a copolymer with ethylene is used. Likewise, the ethylene polymer can be selected from, for example, homopolymer, random copolymer, and block copolymer.

In an embodiment, the treatment / care fluid may further comprise vitamin A. Vitamin A is a retinoid that can act to act on HPV-induced damage to prevent virus recurrence. Vitamin A can induce or enhance immunity to warts, and therefore, in the case of the described composition, the treatment may be more effective with the inclusion of vitamin A. Therefore, vitamin A can accelerate healing and / or prevent

- 16 038326 to reduce the recurrence of skin damage, in particular warts.

The term essentially / generally in this document, for example in the expression essentially consists, will be understood by a person skilled in the art. The term as such can also encompass embodiments with the whole, the whole, the whole, etc. Therefore, in embodiments, a term essentially having an adjective function may also be omitted. Where applicable, the term essentially can also refer to 90% or more, for example 95% or more, in particular 99% or more, even more specifically 99.5% or more, including 100%. The term contain also encompasses embodiments in which the term contains means consists of. The term and / or specifically refers to one or more of the objects mentioned before and after and / or. For example, the expression object 1 and / or object 2 and similar expressions may refer to one or more of object 1 and object 2. In an embodiment, the term containing may refer to consisting of, but in another embodiment may also refer to containing at least certain types / objects / substances and, if necessary, one / one or more other types / objects / substances.

In addition, the terms first, second, third, and the like in the specification and claims are used to distinguish between like elements and not necessarily to describe sequential or chronological order. It should be understood that the terms used in this manner are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operating in sequences other than those described or illustrated herein.

The devices in this document are described, among other things, during operation. As will be clear to a person skilled in the art, the invention is not limited to methods of operation or devices in operation.

It should be noted that the aforementioned embodiments are illustrative and not limiting of the invention and that those skilled in the art will be able to create many alternative embodiments without departing from the scope of the appended claims. In the claims, any reference numbers in parentheses should not be construed as limiting the claims. The use of the verb contain and the forms of its conjugation does not exclude the presence of elements or stages other than those given in the claim. The use of the singular does not exclude the plural. The invention can be implemented using technical means containing several separate elements, and by means of a computer programmed accordingly. In the claim on the device, which lists several means, some of these means can be implemented by means of the same object of technical means. The mere fact that certain measures are given in different dependent claims does not mean that a combination of these measures cannot be used successfully.

In addition, the invention is applicable to a device comprising one or more of the features described in the description and / or shown in the accompanying drawings. In addition, the invention relates to a method or process comprising one or more of the features described in the description and / or shown in the accompanying drawings.

The various aspects discussed in this patent can be combined to provide additional benefits. In addition, some of the features can form the basis for one or more dedicated applications.

Brief Description of Drawings

Embodiments of the invention will now be described, by way of example only, with reference to the accompanying schematic drawings, in which respective reference numerals designate respective components, and in which FIG. 1 and 2 schematically show embodiments of an applicator;

fig. 3A and B schematically show embodiments of a plunger; and FIG. 4 shows schematically some additional features of the spindle system. The drawings are not necessarily to scale.

Detailed Description of Embodiments

FIG. 1 schematically shows an embodiment of an application device 1. The embodiment shown in FIG. 1 is an embodiment in which the applicator 1 can be actuated by rotating the end cap 360. The embodiment shown in FIG. 2 can be actuated by translational movement of end cap 360. Applicator 1 includes an application tip 100 and a container portion 200. Specifically, the application tip 100 indicates the end point of the applicator 1 when the cap 500 is removed. In addition, the figures show the axis 19 of the main body of the device.

The container portion 200 comprises a container 210 specifically for containing the treatment / care fluid 10 in the storage space 250. In this document, the term composition can also be used to refer to a liquid 10. The container portion 200 has a design

- 17 038326 longitudinal axle 299 or axle 299 of the main part. The storage space 250 is a variable storage space 250 and is delimited by the container wall 211, the valve 220, and the plunger 230. Note: FIG. 2 only shows the location of valve 220, valve 220 is not explicitly shown. The translational movement of the plunger 230 (along the longitudinal axis 259 of the storage space 250) towards the valve 220 may be provided by a plunger advance system 300 operatively coupled to the plunger 230, whereby the storage space 250 is reduced and at least a portion of the liquid 10 ( if contained in container 210) can be forced out of storage space 250 through valve 220.

In both embodiments of FIG. 1 and 2, the plunger advancement system 300 is located outside the storage space 250 and therefore does not in particular come into contact with the liquid 10. The applicator 1 is configured such that when the plunger 230 moves, no liquid 10 can also pass by the peripheral plunger walls 235. This peripheral wall 235 contacts the container wall 211 to provide a seal. Plunger 230 may contain polypropylene (PP) or ethylene vinyl acetate (EVA). In particular, the plunger 230 contains ethylene vinyl acetate (EVA). FIG. 1 further shows a plunger 230 having a bicone shape, the plunger wall 235 having a particularly concave shape. In addition, in an embodiment, the plunger 230 includes a concave first end 231 and a concave second end 232 (see also FIGS. 3A, B). The plunger advancement system 300 includes, in particular, a spindle system 350 comprising a ratchet system 353 that includes a first element 355 and a second element 356, which can be forcibly brought closer to each other by means of the second spring system 325 (allowing them to engage).

The illustrated embodiments comprise a ratchet system 353 comprising two members 355, 356 (both male and female members). Both embodiments comprise a second spring system 325 configured in particular to force the elements 355, 356 of the ratchet system 353 towards each other, thereby allowing one element 356 to engage with another element 355. Male and female contact / engagement of the elements 355, 356, rotation (threaded rod 351) in one direction can be prevented and can be enabled, in particular, to rotate in the opposite direction. In embodiments, the second spring system 326 comprises a second spring material 326, such as a noble metal or stainless steel material having a molybdenum content selected in the range of 0.5-7 wt.% In certain embodiments, the second spring material 326 comprises a molybdenum stainless steel such as 316 stainless steel (SS316) or the like. In the illustrated embodiments, the second spring system 325 is positioned adjacent to the side of the plunger 230 opposite to the storage space 250. Consequently, in particular, the liquid 10 cannot contact the second spring system 325. The second spring system 325 can be configured to provide (directly and / or indirectly) tactile and / or audible feedback when actuating the applicator 1, in particular plunger 230. Audible feedback can be directly provided by the elements 355, 356 of the ratchet system 353. When the applicator is actuated, the plunger 230 can translate relative to the valve 220.

FIG. 1 further shows an embodiment comprising a first spring system 225 comprising a first spring material 226. In embodiments, the first spring material 226 (also) comprises, in particular, SS316. In this embodiment, valve 220 comprises a ball check valve 221 containing a first spring system 225. Ball check valve 221 further comprises a ball, such as a glass ball 223. Valve 220 has a particularly closed position (shown in FIG. 1) when wherein the application tip 100 is in a state in which the fluid connection between it and the storage space 250 is closed, and an open position in which the application tip 100 is in fluid communication with the storage space 250 (the fluid connection is open). As the plunger 230 translates, the force on the ball valve from the treatment / care fluid 10 may exceed the (opposing) resilient force from the spring system 225 and the valve 220 may assume an open position.

The plunger advance system 300 of FIG. 1 and 2 contains a spindle system 350 containing a threaded rod 351 having a longitudinal axis 359, a screw base 352 and a unidirectional ratchet system 353 containing a female (or first) and male (or second) elements 355, 356, and, if necessary, a drive element 358 (see further below). The plunger advancement system 300 may comprise polymer 310, such as polymer 310 selected from the group consisting of polypropylene (PP), polyoxymethylene (POM), and ethylene vinyl acetate (EVA). In particular, one or more of the above elements 351, 352, 353, and 358 of the plunger advancement system 300 comprise polymer 310. In embodiments, at least one of these elements 351, 352, 353, 358, in particular all elements 351, 352, 353 and optionally 358, consist of polypropylene. In further 18,038,326 embodiments, at least one of these elements 351, 352, 353, 358 is composed of ethylene vinyl acetate. In further embodiments, the container 210, in particular the container wall 211, also comprises polypropylene, in particular polypropylene. In particular, all elements 351, 352, 353 and optionally 358 are composed of ethylene vinyl acetate.

The plunger advancement system 300 is particularly adapted to move the plunger 230 towards the valve 220 based on the rotation of the threaded rod 351, in particular to move the liquid 10 towards the tip 100.

The application devices 1 shown in FIG. 1 and 2 further comprise an end cap 360 that is operatively connected to a threaded rod 351. The embodiment shown in FIG. 1 is configured to rotate the threaded rod 351 based on the rotation of the end cap 360 relative to the screw cap 352. The embodiment shown in FIG. 2 is a click-to-press embodiment where the rotation of the threaded rod 351 is dependent on the translational movement of the end cap 360 relative to the screw cap 352. The screw cap 352 may be attached to the wall of the container portion and may not move (translationally move or rotate ) relative to the specified wall. Therefore, the rotation of the threaded rod 351 can be converted by the screw cap 352 into translational movement of the threaded rod 351 relative to the screw cap 352.

The action on the end cap 360 can be converted to action on the threaded rod 351 by means of a drive member 358 that is disposed around the threaded rod 351. Such a drive member 358 can rotate the threaded rod 351 by rotating it itself. In the embodiment of FIG. 1, end cap 360 includes an actuator 358. In the embodiment of FIG. 2, which provides a click-to-press function, element 356 of ratchet system 353 may engage with actuator 358 when acting on end cap 360.

Applicator 1 may further comprise a fluid delivery member 150. Such a fluid delivery member 150 may provide fluid 10 to the area to be treated, such as the skin or nail. The fluid delivery member may, for example, comprise a tubular tip 120, a brush 110, or a pointed projection. The fluid delivery member 150 may include an application tip 100.

The applicators shown in FIG. 1 and 2 have an elongated shape, in particular have the shape of a handle. In such embodiments, the main body axis 19, the longitudinal axis 259 of the storage space 250, the longitudinal axis 359 of the threaded rod 351, and the longitudinal axis 299 of the container portion 200, also referred to herein as the container body axis 299, may be the same.

FIG. 3A and B show embodiments of a plunger 230. The figures show different embodiments of a plunger 230 having a double cone shape, in particular, the peripheral wall 235 of the plunger has a concave shape. Plunger 230 includes a concave first end 231 and a concave second end 232. In embodiments, the first and second ends 231, 232 are reinforced by providing a thicker peripheral wall 235 at 236 at the ends 231, 232.

FIG. 4 schematically shows a feature of a spindle system containing modified threads. The figure shows a part of a screw cap 352 having an internal thread 3521 and a part of a threaded rod 351 having an external thread 3511. In a standardized thread, the first angle α1 between the first side surface 3512 of the external thread 3511 and a plane 3591 perpendicular to the longitudinal axis 359 of the threaded rod 351 may be equal to the second angle α2 between the second flank 3513 of the external thread 3511 and plane 3591. Similarly, the first corresponding angle β1 between the first mating flank 3522 of the internal thread 3531 and the corresponding plane 3528 perpendicular to the longitudinal axis 3529 of the screw cap 352 and a second corresponding angle β2 between the second mating flank 3523 of the female thread 3521 and the corresponding plane 3528. In particular, the first angle α1 and the first corresponding angle β1 may be substantially equal. In particular, the second angle α2 and the second corresponding angle β2 (also) may be substantially equal.

In the modified thread, the first angle α1 and / or the second angle α2 can be changed (adapted), the first angle α1 being greater than the second angle α2, or the second angle α2 being greater than the first angle α1. Alternatively or additionally, the first corresponding angle β1 and / or the second corresponding angle β2 can be changed such that the first corresponding angle β1 is greater than the second corresponding angle β2 or the second corresponding angle β2 is greater than the first corresponding angle β1.

In the embodiments (first and second), the respective angles β1 and β2 are substantially equal. In embodiments, the respective angles β1 and β2 are selected in the range of 45-30 °, in particular in the range of 30-40 °, even more particularly in the range of 33-37 °. In additional embodiments

- 19,038326 (first and second) angles are selected in the range of 45-30 °, in particular in the range of 30-40 °, even more particularly in the range of 33-37 °. In addition, in additional embodiments, the first angle α1 (between the first flank 3512 of the external thread 3511 and the plane 3591) is selected in the range of 20-24 °, in particular in the range of 21-23 °, and the second angle α2 (between the second flank 3513 of the profile of the external thread 3511 and plane 3591) is selected in the range of 13-17 °, in particular in the range of 14-16 °. In particular, the sum of the first angle α1 and the second angle α2 is approximately 37 ± 2 °. In particular, the sum of the first corresponding angle β1 and the second corresponding angle β2 is approximately 70 ± 2 °.

The figure also further shows some of the flattened / rounded tops 3526 and troughs 3525.

The application device 1 according to an embodiment can in particular be configured to contain trichloroacetic acid (TCA) with a concentration equal to or less than 40 wt% The applicator can be used for (cosmetic) care, for example, for skin care , nail care, oral care, or ear care (ear treatments) and eye care (eye treatments).

In addition, due to the strong exfoliating power of the treatment / care fluid in combination with the applicator, the applicator can also be advantageously applied for precise correction to remove tattoos, soft warts / senile fibroids / skin growths, or other skin-related adjustments.

Claims (15)

CLAIM 1. An application device (1) comprising an application tip (100) and a container portion (200), wherein the container portion (200) comprises (i) a container (210) containing a container wall (211), a valve (220) and a plunger (230), while the wall (211) of the container, the valve (220) and the plunger (230) jointly define the storage space (250) intended for holding the therapeutic fluid, while the plunger (230) contains a peripheral wall (235), hermetically in contact with the container wall (211); (ii) a plunger advancement system (300) operatively connected to the plunger (230) and configured to advance the plunger (230) to reduce the storage space (250) for displacing at least a portion of the treatment fluid through said valve (220) into said a tip (100), wherein the plunger advancement system (300) is located outside the storage space (250); wherein (a) the valve (220) comprises a first spring system (225) comprising a first spring material (226) comprising a stainless steel material having a molybdenum content selected in the range of 0.5-7 wt%, and (b) the plunger advancement system (300) comprises a second spring system (325) containing a second spring material (326) containing stainless steel material and having a molybdenum content selected in the range of 0.5-7 wt%; and the plunger advancement system (300) comprises a polymer (310) selected from the group consisting of polypropylene (PP), ethylene chlorotrifluoroethylene (ECTFE) and polyoxymethylene (POM), and wherein the plunger advancement system (300) comprises a spindle system (350) containing a ratchet system (353), which contains the first element (355) and the second element (356), while the second spring system (325) is configured to provide contact interaction of the first element (355) and the second element (356) with each other ... 2. An application device (1) according to claim 1, wherein when the valve (220) is open, the application tip (100) is fluidly connected to the storage space (250), while when the valve (220) is closed, said connection is fluid interrupted. 3. An application device (1) according to any one of the preceding claims, wherein the plunger (230) comprises ethylene vinyl acetate (EVA), the plunger advancement system (300) comprises polypropylene, and wherein the container wall (211) comprises polypropylene. 4. An application device (1) according to any one of the preceding claims, in which the spindle system (350) further comprises a threaded rod (351), a screw base (352) and a unidirectional ratchet system (353), and wherein the plunger advancement system (300) made with the possibility of moving the plunger (230) towards the valve (220) based on the rotation of the threaded rod (351). 5. The application device (1) according to claim 4, further comprising an end cap (360) functionally connected to the threaded rod (351), wherein the application device (1) is configured to rotate the threaded rod based on (i) the translation of the end cap (360) relative to the screw cap (352) or based on (ii) the rotational movement of the end cap (360) relative to the screw cap (352). 6. Application device (1) according to any one of the preceding claims, in which the second strand - 20 038326 The material (326) consists of 316 stainless steel. 7. An application device (1) according to any one of the preceding claims, wherein the second spring system (325) is configured to provide tactile and / or audible feedback during translation of the plunger (230). 8. An application device according to any one of the preceding claims, wherein the first spring material (226) is comprised of Type 316 stainless steel. 9. An application device according to any of the preceding claims, wherein the valve (220) comprises a ball check valve (221). 10. An application device (1) according to claim 9, wherein the ball check valve (221) comprises a glass bead (223). 11. An application device (1) according to any one of the preceding claims, wherein the peripheral wall (235) is concave in shape. 12. An application device (1) according to claim 11, wherein the plunger (230) comprises a concave first end (231) and a concave second end (232). 13. Application device (1) according to any one of the preceding claims, containing trichloroacetic acid (TCA) at a concentration selected from the range of 0.5 to 40 wt% 14. An application device (1) according to any one of the preceding claims, wherein the treatment fluid contains a gel, in particular, the treatment fluid contains trichloroacetic acid and carbopol. 15. Use of the application device (1) according to any one of the preceding claims for cosmetic care.