EA033181B1 - Stable dosage form of etidronate-cytarabine conjugate, and use thereof - Google Patents
Stable dosage form of etidronate-cytarabine conjugate, and use thereofInfo
- Publication number
- EA033181B1 EA033181B1 EA201501157A EA201501157A EA033181B1 EA 033181 B1 EA033181 B1 EA 033181B1 EA 201501157 A EA201501157 A EA 201501157A EA 201501157 A EA201501157 A EA 201501157A EA 033181 B1 EA033181 B1 EA 033181B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- conjugate
- etidronate
- dosage form
- parenteral administration
- stable dosage
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the field of medicine and pharmaceuticals and particularly to a stable lyophilizate for preparing a solution for parenteral administration for the treatment of primary bone cancer or bone lesion caused by a malignant neoplasm, and to a method for the preparation thereof. The stable lyophilizate comprises a trisodium salt of an etidronate-cytarabine conjugate and a stabilizer which is magnesium chloride in a molar ratio of 1:1 to 12:1. Such form ensures the hydrolytic and physical stability of the conjugate during long-term storage, and the stability of solutions of the conjugate for parenteral administration during clinical use.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201501157A EA033181B1 (en) | 2015-12-09 | 2015-12-09 | Stable dosage form of etidronate-cytarabine conjugate, and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA201501157A EA033181B1 (en) | 2015-12-09 | 2015-12-09 | Stable dosage form of etidronate-cytarabine conjugate, and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201501157A1 EA201501157A1 (en) | 2017-06-30 |
EA033181B1 true EA033181B1 (en) | 2019-09-30 |
Family
ID=59206013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201501157A EA033181B1 (en) | 2015-12-09 | 2015-12-09 | Stable dosage form of etidronate-cytarabine conjugate, and use thereof |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA033181B1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2068262C1 (en) * | 1992-03-06 | 1996-10-27 | Научно-исследовательский институт клинической и экспериментальной иммунологии | Antileukosis medicinal preparation |
CA2376258A1 (en) * | 1999-06-02 | 2000-12-14 | The Procter & Gamble Company | Oral preparations of etidronate disodium |
RU2002121643A (en) * | 2000-01-20 | 2004-04-10 | Ф.Хоффманн-Ля Рош Аг | PHARMACEUTICAL PARENTERAL COMPOSITION CONTAINING BIPHOSPHONATE |
WO2012008845A1 (en) * | 2010-07-13 | 2012-01-19 | Clavis Pharma Asa | Parenteral formulations of elacytarabine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
-
2015
- 2015-12-09 EA EA201501157A patent/EA033181B1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2068262C1 (en) * | 1992-03-06 | 1996-10-27 | Научно-исследовательский институт клинической и экспериментальной иммунологии | Antileukosis medicinal preparation |
CA2376258A1 (en) * | 1999-06-02 | 2000-12-14 | The Procter & Gamble Company | Oral preparations of etidronate disodium |
RU2002121643A (en) * | 2000-01-20 | 2004-04-10 | Ф.Хоффманн-Ля Рош Аг | PHARMACEUTICAL PARENTERAL COMPOSITION CONTAINING BIPHOSPHONATE |
WO2012008845A1 (en) * | 2010-07-13 | 2012-01-19 | Clavis Pharma Asa | Parenteral formulations of elacytarabine derivatives |
Non-Patent Citations (2)
Title |
---|
SCHENKEIN D.P. et al. Accelerated bone formation causing profound hypocalcemia in acute leukemia. Ann Intern Med, 1986 Sep; 105(3): 375-8, реферат * |
Описание. Osteros Biomedica, 2012-2013 [он-лайн] [найдено 2016-05-23]. Найдено из Интернет: <URL: http://www.osteros.ru/ru/content/%D0%BE%D0%BF%D0%B8%D1%81%D0%B0%D0%BD%D0%B8%D0%B5> * |
Also Published As
Publication number | Publication date |
---|---|
EA201501157A1 (en) | 2017-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |