EA028963B1 - Применение альфа-1-микроглобулина для защиты митохондриальной структуры и/или митохондриальной продукции атф - Google Patents
Применение альфа-1-микроглобулина для защиты митохондриальной структуры и/или митохондриальной продукции атф Download PDFInfo
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- 108010031403 zeaxanthin epoxidase Proteins 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1722—Plasma globulins, lactoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Hematology (AREA)
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- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201270538 | 2012-09-05 | ||
| DKPA201270557 | 2012-09-12 | ||
| PCT/EP2013/068270 WO2014037390A1 (en) | 2012-09-05 | 2013-09-04 | Alpha-1-microglobulin for use in the treatment of mitochondria-related diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590503A1 EA201590503A1 (ru) | 2015-06-30 |
| EA028963B1 true EA028963B1 (ru) | 2018-01-31 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590503A EA028963B1 (ru) | 2012-09-05 | 2013-09-04 | Применение альфа-1-микроглобулина для защиты митохондриальной структуры и/или митохондриальной продукции атф |
Country Status (21)
| Country | Link |
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| US (1) | US10226507B2 (enFirst) |
| EP (1) | EP2900254B1 (enFirst) |
| JP (2) | JP2015533790A (enFirst) |
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| CN (1) | CN104661673A (enFirst) |
| AU (1) | AU2013311714C1 (enFirst) |
| BR (1) | BR112015003957A2 (enFirst) |
| CA (1) | CA2881321A1 (enFirst) |
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| HU (1) | HUE030559T2 (enFirst) |
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| NZ (1) | NZ629621A (enFirst) |
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| PT (1) | PT2900254T (enFirst) |
| SG (1) | SG11201500669SA (enFirst) |
| WO (1) | WO2014037390A1 (enFirst) |
| ZA (1) | ZA201500547B (enFirst) |
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| JP2016204360A (ja) * | 2015-02-25 | 2016-12-08 | エー１エム ファーマ エービーＡ１Ｍ Ｐｈａｒｍａ ＡＢ | 放射性核種療法における腎臓の保護に用いるためのアルファ−１−ミクログロブリン |
| WO2017144674A1 (en) * | 2016-02-25 | 2017-08-31 | A1M Pharma Ab | Alpha-1-microglobulin for use in the protection of kidneys in connection with use of contrast media |
| SG11201807352XA (en) * | 2016-03-18 | 2018-09-27 | A1M Pharma Ab | Novel alpha-1-microglobulin derived proteins and their use |
| GB2566516A (en) | 2017-09-15 | 2019-03-20 | Univ Oxford Innovation Ltd | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria |
| CN109867717A (zh) * | 2019-04-01 | 2019-06-11 | 山西瑞亚力生物技术有限公司 | 一种血浆中α1微球蛋白的提取方法 |
| CN110452980B (zh) * | 2019-09-23 | 2023-07-28 | 武汉儿童医院 | 一种线粒体脑肌病诊断试剂盒及应用 |
| US20220362293A1 (en) * | 2019-09-25 | 2022-11-17 | Cytegen Corp. | Treatment of Mitochondrial Deficits and Age-Related Diseases Using Blood Products |
| CN115575646B (zh) * | 2022-11-21 | 2023-04-28 | 四川大学华西医院 | 一种代谢标志物组在制备预测癫痫发作的试剂盒中的用途 |
Citations (1)
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| WO2010006809A2 (en) * | 2008-07-18 | 2010-01-21 | Akerstroem Bo | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin |
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| WO2005051379A1 (en) * | 2003-11-26 | 2005-06-09 | Sanofi-Aventis Deutschland Gmbh | Tubular proteinuria as an indicator for elevated cardiovascular risk |
| NZ578077A (en) * | 2007-02-12 | 2012-04-27 | Stefan Hansson | Diagnosis of preeclampsia using free foetal haemoglobin |
| EP2300614B1 (en) * | 2008-02-04 | 2015-10-28 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods and compositions for treatment of mitochondrial disorders |
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2013
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- 2013-09-04 BR BR112015003957A patent/BR112015003957A2/pt not_active Application Discontinuation
- 2013-09-04 MX MX2015002604A patent/MX357656B/es active IP Right Grant
- 2013-09-04 AU AU2013311714A patent/AU2013311714C1/en not_active Ceased
- 2013-09-04 SG SG11201500669SA patent/SG11201500669SA/en unknown
- 2013-09-04 KR KR1020157005748A patent/KR20150047510A/ko not_active Ceased
- 2013-09-04 HR HRP20161364TT patent/HRP20161364T1/hr unknown
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- 2013-09-04 CA CA2881321A patent/CA2881321A1/en not_active Abandoned
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- 2013-09-04 EA EA201590503A patent/EA028963B1/ru not_active IP Right Cessation
- 2013-09-04 US US14/423,260 patent/US10226507B2/en not_active Expired - Fee Related
- 2013-09-04 CN CN201380043567.0A patent/CN104661673A/zh active Pending
- 2013-09-04 DK DK13759995.7T patent/DK2900254T3/en active
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010006809A2 (en) * | 2008-07-18 | 2010-01-21 | Akerstroem Bo | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin |
Non-Patent Citations (5)
| Title |
|---|
| ÂKERSTRÖM BO ET AL.: "The lipocalin alpha1-microglobulin has radical scavenging properties", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 282, 1 January 2007 (2007-01-01), pages 31493-31503, XP002516419, ISSN: 0021-9258, DOI: 10.1074/JBC.M702624200 [retrieved on 2007-08-31], abstract * |
| MAY K. ET AL.: "Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by-microglobulin", PLACENTA, W.B. SAUNDERS, GB, vol. 32, no. 4, 31 January 2011 (2011-01-31), pages 323-332, XP028165366, ISSN: 0143-4004, DOI: 10.1016/J.PLACENTA.2011.01.017 [retrieved on 2011-02-07], cited in the application, abstract * |
| OLSSON M.G. ET AL.: "THE LIPOCALIN ALPHA1-MICROGLOBULIN PROTECTS ERYTHROID K562 CELLS AGAINST OXIDATIVE DAMAGE INDUCED BY HEME AND REACTIVE OXYGEN SPECIES", FREE RADICAL RESEARCH, YVERDON, CH, vol. 42, no. 8, 1 August 2008 (2008-08-01), pages 725-736, XP008102557, ISSN: 1071-5762, DOI: 10.1080/10715760802337265, cited in the application, abstract * |
| OLSSON MAGNUS G. ET AL.: "Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for [alpha](1)-microglobulin", 1 September 2012 (2012-09-01), ANTIOXIDANTS & REDOX SIGNALING 1 SEP 2012, VOL. 17, NR. 5, Pages 813-846, XP002696478, ISSN: 1557-7716, cited in the application, the whole document * |
| OLSSON MAGNUS G. ET AL.: "The Radical-Binding Lipocalin A1M Binds to a Complex I Subunit and Protects Mitochondrial Structure and Function", 4 January 2013 (2013-01-04), ANTIOXIDANTS & REDOX SIGNALING, 1 JUN 2013, Vol. 18, NR. 16, Pages 2017-2028, XP002696477, ISSN: 1557-7716, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2900254T3 (en) | 2016-08-29 |
| KR20150047510A (ko) | 2015-05-04 |
| AU2013311714C1 (en) | 2018-01-25 |
| MX357656B (es) | 2018-07-18 |
| CN104661673A (zh) | 2015-05-27 |
| HUE030559T2 (en) | 2017-05-29 |
| US10226507B2 (en) | 2019-03-12 |
| EA201590503A1 (ru) | 2015-06-30 |
| SG11201500669SA (en) | 2015-02-27 |
| JP2018203756A (ja) | 2018-12-27 |
| BR112015003957A2 (pt) | 2017-08-08 |
| NZ629621A (en) | 2015-09-25 |
| HK1210585A1 (en) | 2016-04-29 |
| US20150258171A1 (en) | 2015-09-17 |
| PL2900254T3 (pl) | 2017-02-28 |
| ES2599034T3 (es) | 2017-01-31 |
| ZA201500547B (en) | 2017-09-27 |
| CA2881321A1 (en) | 2014-03-13 |
| PT2900254T (pt) | 2016-10-18 |
| MX2015002604A (es) | 2015-06-10 |
| WO2014037390A1 (en) | 2014-03-13 |
| EP2900254B1 (en) | 2016-08-03 |
| JP2015533790A (ja) | 2015-11-26 |
| IN2015DN00515A (enFirst) | 2015-06-26 |
| AU2013311714B2 (en) | 2017-10-12 |
| HRP20161364T1 (hr) | 2016-12-16 |
| EP2900254A1 (en) | 2015-08-05 |
| AU2013311714A1 (en) | 2015-03-12 |
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