EA020148B1 - Solid dosage form having a choleretic effect (variants) - Google Patents

Abstract

The invention relates to the pharmaceutical industry and medicine and can be used in the creation and administration of solid dosage forms having a choleretic effect. The present invention is aimed at creating an effective solid dosage form having a choleretic effect. In the description, two variants of the invention are claimed which solve the problem of interest in that the solid dosage form contains dried bile, mineral substances and a pharmaceutically acceptable carbon-containing additional substance with carbonC isotopes. The invention achieves the technical results of a greater and more rapid therapeutic effect in the treatment of liver and gall bladder diseases without decreasing the duration of said therapeutic effect or increasing the concentration of bile.

Description

The invention relates to the field of pharmaceutical industry and medicine and can be used in the creation and use of solid dosage forms with choleretic action.

Background of the Related Art

An important problem of modern medicine is the creation of new drugs for the treatment of diseases of the gastrointestinal tract, the proportion of which from all diseases in the country is growing steadily.

The solution to this problem is to create synthetic drugs, or to create drugs that include extracts of plant or animal origin, including dietary supplements. To date, many such preparations have been patented in Russia (see RF patents No. 2445965, publ. 03/27/2012, No. 2442595, publ. 02/20/2012, No. 2423993, publ. 06/10/2011, No. 2287335, publ. 20.11.2006, No. 2281008, published on 08/10/2006, No. 2260440, published on 09/20/2005, etc.).

Studies show that one of the ways to solve this problem is the creation of dosage forms based on bile.

So, it is known choleretic agent Allochol, made in the form of coated tablets containing animal bile, dry garlic extract, nettle extract, activated charcoal and excipients (Mashkovsky M.D. Medicines, vol. 1, M. 2000) .

The invention claims two variants of a solid dosage form.

An analogue to each variant of the solid dosage form is a solid dosage form containing bile, described in the method for producing Allohol in the form of tablets (RF patent No. 2260440, publ. September 20, 2005). The method describes the technology for the preparation of Allohol tablets, which consists in mixing components, such as bile, plant products: nettle extract, garlic, potato starch, activated carbon, flavoring agents, forming a dosage form by granulation, drying, dusting, while dried garlic is mixed , nettle leaves, polyvinylpyrrolidone (PVP) medium molecular weight and separately prepare a mixture of dry bile with a particle size of 0.6-1.0 mm with aerosil, talc and polyvinylpyrrolidone medium molecular weight m, and thereto are added dry granulate and the mixture is tabletted, moistened with 70% sugar syrup containing 0.35-0.40% PVP middle molecular form a shell with powder dusted basic magnesium carbonate.

From other sources, the following is known about Allochol tablets.

The solid dosage form Allochol has a choleretic effect, made in the form of a tablet (yyr: //ar1eke.sot.ia/bgid8/a11osyo1_og8siadou8kuusrr.rir).

The composition of the tablet includes the main (active) and excipients.

Main substances: dry bile (in terms of anhydrous substance) - 80 mg, dried garlic - 40 mg, nettle leaves - 5 mg, activated carbon - 25 mg.

Excipients: magnesium oxide, potato starch, aerosil, calcium stearate, sugar, povidone, basic magnesium carbonate, titanium dioxide, talc, tropeolin O or tartrazine, beeswax, vaseline oil.

Tablets belong to choleretic drugs.

Tablets are used for the following diseases - chronic hepatitis, cholangitis, cholecystitis, atonic constipation.

The Allochol tablet improves the secretory function of the liver cells, causing a moderate choleretic effect. Stimulates the synthesis of bile acids; increases the osmotic gradient between bile and blood, which leads to increased filtration into the bile capillaries of water and electrolytes; accelerates the flow of bile along the bile ducts, prevents the spread of ascending infection and reduces the intensity of the inflammatory process; reduces the chance of cholesterol precipitation with subsequent formation of stones. The process of cholate formation occurs mainly due to taurocholic and deoxycholic acids entering dry bile. An increase in the output of bile into the intestinal lumen promotes a reflex increase in the secretory and motor activity of the digestive tract, improves emulsification of dietary fats and, in general, digestion processes. Elements of garlic, which are part of the drug, contribute to the inhibition of fermentation in the intestines, reducing flatulence.

The drug is well absorbed in the intestine, quickly entering the hepatoduodenal circulation.

Allochol is used in the treatment of the following diseases: chronic cholecystitis, uncomplicated gallstone disease, gallbladder dyskinesia, postcholicystectomy syndrome, constipation, intestinal hypotension, uncomplicated gallbladder cholesterosis.

The disadvantage of the analogue is the relatively low speed of the onset of the therapeutic effect.

In addition, there is an analogue (RF patent No. 2156087, publ. 09/20/2000). The patent describes a dietary supplement (BAA) for food, including potassium (4-380 mg / l), magnesium (1-510 mg / l), iron (12100 mg / l), zinc (1-1240 mg / l) and an additional 29 different minerals and drugs. The patent claims that the dietary supplement has various medicinal properties. The dietary supplement described in the patent by known technologies can be made in the form of a solid form.

- 1 020148

However, in the dietary supplement there is no bile and dietary supplement does not have a choleretic effect.

A known method for the prevention and treatment of pathologies caused by an increased and / or low content of physiologically necessary macro- and microelements in the human body, including laboratory analysis of human substrates, the identification of excess and / or lack of macro- and microelements and the selection of medicines (RF patent No. 2238749, publ. 10/27/2004).

So, with an excess of nickel in the human body, aralia manchurian plants (root) are selected - 20.0 g;

marsh rosemary (aerial parts) - 20.0 g;

three-leaf watch (sheet) - 40.0 g;

and another 17 plants containing biological nickel antagonists, mainly iron, calcium, magnesium, cobalt, manganese, zinc, copper, with a biological accumulation coefficient above 1.0 and contributing to the neutralization and elimination of nickel from the body.

With an excess of lithium in the human body, Chinese lemongrass plants (leaf) are selected - 40.0 g;

May birch (leaf) - 20.0 g;

and 11 more plants containing biological lithium antagonists, mainly iron, sodium, potassium, iodine, with a biological accumulation coefficient above 1.0 and contributing to the neutralization and elimination of lithium from the body.

There is also known a method for the prevention and treatment of pathologies caused by increased or decreased levels of physiologically necessary or potentially toxic macro- and microelements in the human body (RF patent No. 2263511, publ. 10.11.2005).

In the method, when there is an excess of macro- and micronutrients in the body, phyto-collections from medicinal plants are used as medicines, which help to neutralize and remove from the body an excess of these macro- or micronutrients and containing the maximum concentration of antagonists of the detected excess macro- or microelements. So, with an excess of aluminum - plants containing the maximum concentration of its antagonists such as iron, boron, silicon, phosphorus, magnesium, calcium; with an excess of cobalt - its antagonists: manganese, iron, nickel. Herbal marshmallow (root), warty birch (leaf), or drooping birch (leaf), three-leaved watch (leaf), and other medicinal plants are included in the phytosborder.

In the above two patents, the content of minerals in plants has not been investigated or indicated. It will be indicated below that the amount of mineral substances in a particular plant depends on their content in the soil and on the mineral nutrition of plants and can range from 0.00001 to 0.7% by weight of a dry plant.

In the invention, the authors enrich the solid dosage form on the basis of bile with mineral substances at a content exceeding by one or two orders of magnitude the content of mineral substances in all medicinal plants, including those described in Russian patents No. 2263511 and 2238749.

In the process of conducting research, the effect of small concentrations of mineral substances on the achievement of technical results was verified. It has been established, as will be indicated below, that the mineral substances in the concentrations in which they are found in the studied plants and phytochemicals do not affect the achievement of the technical results indicated in the application.

The authors conducted studies to determine the content of minerals in Allohol tablets of various manufacturers (Moskhimpharmpreparaty named after N. Semashko, CJSC Scientific Production Center Borshchagovsky Chemical and Pharmaceutical Plant).

Mineral substances in tablets are contained in the following elements: garlic, nettle leaves, magnesium oxide, aerosil, calcium stearate, basic magnesium carbonate, titanium dioxide, talc, tropeolin (tartrazine).

The concentration of mineral substances was determined by the atomic absorption method for the determination of sodium, potassium, calcium, magnesium, iron, manganese, copper, zinc, lead, cadmium, cobalt, nickel, and chromium. Clause 1.3.2.1 of the source (Guidance on methods for monitoring the quality and safety of biologically active food additives. - M: Federal Center for Sanitary and Epidemiological Supervision of the Ministry of Health of Russia, 2004, 240 pp.).

The quantitative composition of minerals in the studied tablets is given in table. 1. No other minerals were found.

In addition, the authors conducted a mineral analysis of various plants, including medicinal plants, and phyto-collections for the content of mineral substances.

Investigated: hops (cones), chamomile (flowers), flea plantain (leaf), shepherd’s bag (aerial part), common dandelion (root and leaf), marshmallow (root), birch (leaf), field horsetail (root) , odorous celery (herb), calendula officinalis (flowers), wormwood (herb), etc.

The studied plants contain minerals: potassium, calcium, magnesium, iron, manganese, copper, zinc, cobalt, etc. It is established that the content by weight of potassium, calcium, magnesium in plants is high - from 0.0001 to 0.7%. So calcium contains 0.01-0.1%, potassium - 0.003-0.7%, magnesium - 0.0001-2 020148

0.01%

The content by weight of iron, manganese, copper, zinc, cobalt, chromium is low - from 0.00003 to 0.0001%. The molybdenum content is 0.00001%.

The experiments also examined dried nettle leaves and garlic heads.

In nettle and garlic, the content of minerals in milligrams per kilogram of dry nettle leaves and dried garlic (mg / kg) calcium - 110 - 150;

magnesium - 120-130;

sodium - 25 - 27.

No other minerals were found.

The amount of mineral substances in a particular plant depends on the mineral content in the soil and on the mineral nutrition of the plants.

The prototype of the invention is a solid dosage form (1i1p: // | sGopb.gi / gi / 51a1 / 2-agNc1c5 / 30ds1c111). possessing a choleretic effect, made in the form of a tablet containing dried bile, mineral substances in the following ratio of components in mg / kg:

dried bile - 25 10 ³ - 625'10 ³ ;

sodium - 1550.0 - 105000.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0.

These features of the prototype coincide with the features of both variants of the invention. The dimension mg / kg indicates the content of an element (in particular, dried bile or sodium) in milligrams per kilogram of solid dosage form (in kilogram of solid dosage form).

The disadvantages of the prototype are the relatively low speed of the onset of the therapeutic effect, not sufficiently large therapeutic effect, low stability during the expiration date.

In the invention, the disadvantages of the prototype are eliminated by introducing into the tablet a strictly defined amount of additional mineral substances. Also considered is the option of partial replacement of carbon isotopes ¹² C with carbon isotopes ¹³ C.

SUMMARY OF THE INVENTION

Let us define the terms.

Solid dosage forms are: tablets, powders (including capsules), granules.

Tablets are a solid dosage form (Lp: //1cGopb.gi/gi/51a1/2-agIs1e5/33-de1sy). Tablets are made by compressing drugs. Tablets are of various shapes, in particular in the form of cylinders, balls, flattened balls. Tablets are prescribed for oral administration. In some cases, tablets are used for the preparation of solutions, including injection, as well as for subcutaneous implantation (Esperal).

Powders are a solid dosage form with the property of flowability. In some cases, powders are placed in capsules. Capsules are coatings for metered-dose powdered drugs used internally.

Granules are a solid dosage form in the form of grains (grains) of a round, cylindrical or other shape.

Shelf life - the period during which the solid dosage form retains its properties to the extent that ensures its intended use.

Extract - extract, concentrated extraction of active principle from medicinal raw materials. Depending on the extractant, aqueous, alcoholic, ethereal and other extracts are distinguished. According to the degree of condensation after evaporation, it is a liquid, thick (not more than 20-25% moisture) and dry (up to 5% moisture) extract. The invention contemplates a solid dosage form with a thick or dry extract of medicinal plants.

Bile is a biological fluid produced by the liver. Dried bile may contain up to 25% moisture (0 to 25% moisture).

Starch (С ₆ Н ₁₀ О ₅ ) _p - polysaccharides of amylose and amylopectin, the monomer of which is α-glucose. Starch, synthesized by different plants in chloroplasts, under the influence of light during photosynthesis, differs somewhat in the structure of grains, the degree of polymerization of molecules, the structure of polymer chains and physicochemical properties.

Aerosil - colloidal silicon dioxide (8ίΘ _2), light mikronizirovenny powder with pronounced adsorption properties. Technical name - pyrogenic silicon dioxide.

Magnesium oxide is a chemical compound with the formula MdO, colorless crystals, insoluble in water.

Calcium stearate is a mixture of calcium salts of stearic and a mixture of stearic and synthetic fatty acids, obtained by the reaction of neutralization of acids with calcium hydroxide. It is used as a plasticizer. The empirical formula C ₃₆ H _7S1 O4Sa.

- 3 020148

Magnesium carbonate - magnesium carbonate, MdCO ₃ , magnesium salt of carbonic acid.

Titanium oxide (titanium dioxide, titanium dioxide) T1O ₂ is an amphoteric tetravalent titanium oxide.

Talc - Md ₃ 81 ₄ About ₁₀ (OH) ₂ - crystalline substance. It is a crumbly powder of white (occasionally green) color.

Tropeolin is a coloring matter. It is a sodium salt of Na8O ₃ .C ₆ .H ₄ .M: KK.

Tartrazine is a synthetic azo dye. It is described by the formula C ₁₆ H9K ₄ Ca ₃ O ₉ 8 ₂ .

An object of the present invention is to provide an effective solid dosage form having a choleretic effect.

In the description claimed two variants of the invention.

In the first embodiment of the invention, the problem is solved due to the fact that the solid dosage form having a choleretic effect is made in the form of a tablet, contains dried bile, mineral substances in the following ratio of components in mg / kg:

dried bile - 25 10 ³ - 625 10 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium 1350.0-63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper - 0.1 - 21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0.

From the prototype, the first embodiment of the invention is distinguished by the following set of features:

potassium - 320.0-15300.0;

iron - 1.0-135.0;

Manganese -0.3 - 35.0;

zinc 1.0-320.0;

copper - 0.1 - 21.0;

chrome 0.015-6.5;

molybdenum - 0.01 - 5.0.

In the second embodiment of the invention, the problem is solved due to the fact that the solid dosage form having a choleretic effect is made in the form of a tablet, contains dried bile, mineral substances in the following ratio of components in mg / kg:

dried bile - 25 10 ³ - 625 1 0 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chrome -0.015-6.5;

molybdenum - 0.01 - 5.0;

and the solid dosage form contains a pharmaceutically acceptable carbon-containing additional substance with ¹³ C carbon isotopes, and the ratio of ¹³ C carbon isotopes to total carbon (to total carbon isotopes) in the solid dosage form is from 0.003 to 0.75.

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The second embodiment of the invention differs from the prototype in the following set of features: potassium - 320.0-15300.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper - 0.1 -21.0;

chrome -0.015-6.5;

molybdenum - 0.01 - 5.0, and the solid dosage form contains a pharmaceutically acceptable carbon-containing additional substance with ¹³ C carbon isotopes, and the ratio of ¹³ C carbon isotopes to total carbon (to total carbon isotopes) in solid dosage form is from 0.003 up to 0.75.

In the particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be set in a narrower range of values, mg / kg

sodium - 1550.0 105000 potassium - 320.0 15300.0 calcium - 725.0 41500.0 magnesium - 1350.0 63150.0 iron - 1.0 135.0 Manganese - 0.3 35.0 zinc- 1.0 320.0 copper - 0.1 21.0 chrome - 0.015 6.5 molybdenum - 0.01 5.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 1550.0 90,000 potassium - 320.0 10000.0 calcium - 725.0 30500.0 magnesium - 1350.0 40050.0 iron - 1.0 105.0 Manganese - 0.3 25.0 zinc- 1.0 250.0 copper - 0.1 15.0 chrome - 0.015 5.5 molybdenum - 0.01 4.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 1550.0 60,000 potassium - 320.0 8000.0 calcium - 725.0 25000.0 magnesium - 1350.0 35000.0 iron - 1.0 80.0 Manganese - 0.3 15.0 zinc - 1.0 150.0 copper - 0.1 11.0 chrome - 0.015 3.5 molybdenum - 0.01 - 2.0

In another particular case of the implementation of the first and second variants of the invention, the content of mine

- 5 020148 solid substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 1550.0 41000 potassium - 320.0 6500.0 calcium - 725.0 21000.0 magnesium - 1350.0 32000.0 iron - 1.0 70.0 Manganese - 0.3 10.0 zinc - 1.0 70.0 copper - 0.1 8.0 chrome - 0.015 - 1.5 molybdenum - 0.01 - 1.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 15050.0 90,000 potassium - 1500.0 10000.0 calcium - 3555.0 30500.0 magnesium - 7000.0 40050.0 iron - 10.0 105.0 Manganese - 1.0 25.0 zinc- 5.0 250.0 copper - 1.0 15.0 chrome - 0.15 5.5 molybdenum - 0. 1 4.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 25050.0 90,000 potassium - 2500.0 10000.0 calcium - 15955.0 30500.0 magnesium - 15000.0 40050.0 iron - 20.0 105.0 Manganese - 1.5 25.0 zinc- 10.0 250.0 copper - 2.0 15.0 chromium 0.25 5.5 molybdenum - 0.2 4.0

- 6 020148

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 30050.0 90,000 potassium - 3000.0 10000.0 calcium - 16000.0 30500.0 magnesium - 20000.0 40050.0 iron - 30.0 105.0 Manganese - 1.5 25.0 zinc - 20.0 250.0 copper - 2.5 15.0 chrome - 0.35 5.5 molybdenum - 0.27 4.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 15050.0 41000 potassium - 1500.0 6500.0 calcium - 3555.0 21000.0 magnesium - 7000.0 32000.0 iron - 10.0 70.0 Manganese - 1.0 10.0 zinc - 5.0 70.0 copper - 1.0 8.0 chrome - 0.15 1.5 molybdenum - 0. 1 1.0

In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium - 25050.0 41000 potassium - 2500.0 6500.0 calcium - 15955.0 21000.0 magnesium - 15000.0 32000.0 iron - 20.0 70.0 Manganese - 1.5 10.0 zinc - 10.0 70.0 copper - 2.0 8.0 chrome - 0.25 1.5 molybdenum - 0.2 1.0

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In another particular case of the implementation of the first and second variants of the invention, the content of mineral substances in solid dosage form can be specified in narrower ranges of values, mg / kg

sodium 30050.0 - 41000 potassium - 3000.0 - 6500.0 calcium - 16000.0 - 21000.0 magnesium - 20000.0 - 32000.0 iron - 30.0 - 70.0 Manganese - 1.5 10.0 zinc - 20,0 70.0 copper - 2.5 8.0 chrome - 0.35 1.5 molybdenum - 0.27 1.0

In the particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 25-10 ³ -505-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be set in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 25-10 ³ -425-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 25-10 ³ -325-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 25-10 ³ -300-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 70-10 ³ -625-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 150-10 ³ -625-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 180-10 ³ -625-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 70-10 ³ -325-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 150-10 ³ -325-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 180-10 ³ -325-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be specified in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 70-10 ³ -300-10 ³ .

In another particular case of the implementation of the first and second variants of the invention, the content of bile in

- 8 020148 solid dosage form can be specified in narrower ranges of values: solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 150 · 10 ³ -300- 10 ³ . In another particular case of the implementation of the first and second variants of the invention, the content of bile in a solid dosage form can be set in narrower ranges of values: a solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, in the following ratio of components in mg / kg: dried bile - 180 · 10 ³ -300 · 10 ³ .

The narrower ranges of the values of minerals and bile given above can be selected for various groups of patients (children, pregnant women, etc.).

This ensures the achievement of the claimed technical results of the invention: increasing the speed of the onset of the therapeutic effect (reducing the time of onset of the therapeutic effect) while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder;

an increase in the therapeutic effect while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder.

It is advisable to increase the content of carbon in the tablet to increase the content of activated carbon in the tablet and / or to use a pharmaceutically acceptable carbon-containing additional substance or substances, and / or a pharmaceutically acceptable carbon-containing excipient. In this case, the amount of ¹³ C carbon isotopes in solid dosage form can be increased.

Further in the application (to simplify the description and streamlining of terms) bile, dry or dried bile - the main active substance. All other substances in the solid dosage form are pharmaceutically acceptable additional substances.

A pharmaceutically acceptable adjuvant may be a pharmaceutically acceptable excipient;

a pharmaceutically acceptable carbonaceous excipient; a pharmaceutically acceptable carbonaceous adjuvant;

carbon, in particular activated carbon; medicinal plants, in particular dried garlic, nettle leaves; metal oxides (in particular magnesium oxide, titanium dioxide);

potato starch;

aerosil;

calcium stearate;

sugar;

povidone;

magnesium basic carbonate;

talc;

tropeolin O or tartrazine;

beeswax;

petroleum jelly;

minerals (in particular, sodium, calcium), etc.

If the substance is a pharmaceutically unacceptable substance for the solid dosage form in question, then such a substance is not used in the dosage form.

In the particular case of the invention, the solid dosage form having a choleretic effect can be made in the form of a tablet containing dried bile, a pharmaceutically acceptable additional substance with mineral substances, or pharmaceutically acceptable additional substance with mineral substances in the following ratio of components in mg / kg:

- 9 020148 dried bile - 25 1 0 ³ - 625 1 0 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0 -15300.0;

calcium-725.0-41500.0;

magnesium - 1350.0 - 63150.0;

iron - 1.0 -135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0.

As a pharmaceutically acceptable additional substance can use dry garlic extract, dry nettle extract, activated carbon.

In the particular case of the invention, the solid dosage form having a choleretic effect can be made in the form of a tablet containing dried bile, pharmaceutically acceptable additional substances with mineral substances, in the following ratio of components in mg / kg:

dried bile - 25-10 ³ -625-10 ³ ;

pharmaceutically acceptable additional substances - the rest;

while the content of mineral substances in solid dosage form (or in pharmaceutically acceptable additional substances), mg / kg sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0-41500.0;

magnesium - 1350.0 - 63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

honey. - 0.1 - 21.0;

chrome -0.015-6.5;

molybdenum - 0.01 - 5.0.

In the particular case of the invention, the solid dosage form having a choleretic effect can be made in the form of a tablet containing dried bile, pharmaceutically acceptable additional substances with mineral substances and a carbon-containing substance or with carbon-containing substances, in the following ratio of components in mg / kg:

dried bile - 25-10 ³ -625-10 ³ ;

pharmaceutically acceptable additional substances - the rest;

while the content of mineral substances in solid dosage form (or in pharmaceutically acceptable additional substances), mg / kg sodium - 1550.0 - 105000.0;

potassium - 320.0 - 15300.0;

calcium -725.0-41500.0;

magnesium - 1350.0 - 63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chromium - 0.015 -6.5;

molybdenum - 0.01 - 5.0;

and the total carbon content is 8 10 ³ - 62 1 0 ³ mg / kg.

For the task set in the invention, the main active substance (or simply the main substance) is dry (dried) bile in terms of anhydrous substance - 25-10 ³ -625-10 ³ mg / mg; a pharmaceutically acceptable additional substance may be dried garlic - 10-10 ³ -3 25-10 ³ mg / mg; nettle leaves - 1.5-10 ³ -62.5-10 ³ mg / mg; activated carbon - 2.5-10 ³ -45-10 ³ mg / mg.

- 10 020148

In addition, pharmaceutically acceptable additional substances may include magnesium oxide, potato starch, aerosil, calcium stearate, sugar, povidone, basic magnesium carbonate, titanium dioxide, talc, tropeolin O or tartrazine, beeswax, paraffin oil.

Mineral substances (Ei, Cu, Ζη, etc.) in solid dosage form are contained in pharmaceutically acceptable oxides, pharmaceutically acceptable salts, for example, succinates, chlorides, carbonates or sulfates, as well as in various pharmaceutically acceptable complex compounds.

Pharmaceutically acceptable additional substances (which include minerals) can be various pharmaceutically acceptable oxides, various pharmaceutically acceptable salts, various pharmaceutically acceptable complex compounds.

In the particular case of the invention, the solid dosage form can be made in such a way that tropeolin and / or tartrazine and / or calcium stearate and / or magnesium carbonate are used as a pharmaceutically acceptable carbon-containing additional substance.

The dimension mg / kg relating to the elements of the solid dosage form means their content (in milligrams) in kilogram of solid dosage form.

A solid dosage form in the form of a tablet may contain a shell. The shell can be made using the following substances: Opadry II white, talc, titanium dioxide, polyvinyl alcohol or other pharmaceutically acceptable substances.

Technical results for all variants of the invention are:

an increase in the speed of the onset of the therapeutic effect (a decrease in the time of the onset of the therapeutic effect) while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder;

an increase in the therapeutic effect while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder.

The developed solid dosage form can be used in the treatment of the same diseases for the treatment of which the drug Allohol is used.

An additional technical result may be an increase in the stability of the solid dosage form with bile during the expiration date, which was established experimentally.

Currently, an increase in the speed of the onset of the therapeutic effect is provided by: the dosage of the drug and the time of its exposure;

the introduction into the dosage form of an auxiliary ingredient - an accelerator of the speed of exposure (a special case of a regulator of the speed of exposure);

proactive (preventive) use of the drug.

Here are some examples.

Known dosage form (application of the Russian Federation No. 94015245, publ. 12/27/1995), in which as a regulator of the speed of exposure using a 5-10% solution of hyaluronic acid.

Known pacemaker drug (RF patent No. 2068697, publ. 10.11.1996) containing green toad poison, chlorobutane dihydrate, sodium chloride and water. To increase the onset of the pacemaker effect (while maintaining the duration of action) provided by the specified poison, up to 95% ethyl alcohol is introduced into the drug. Alcohol due to osmotic phenomena causes pain and local negative reaction, which accelerates the effect of the drug.

Biologically active additives are known which, when introduced together with the active principle, increase the pharmacological activity of therapeutic drugs by optimizing the rate of assimilation of the active principle. So, polyvinylpyrrolidone and sorbic acid are additionally introduced into the antitumor agent (USSR author's certificate No. 1683190, publ. 20.04.1995). These components increase the antitumor activity of the active principle.

A known method of preventing the development of the disease using the extract of the herb marshmallow medicinal (RF patent No. 2380108, publ. 27.01.2010).

In the invention, an increase in the speed of the onset of the therapeutic effect is achieved while maintaining the duration of action without increasing the concentration of the active substance due to the introduction of mineral substances into the solid dosage form.

Below is the well-known information about minerals.

Minerals are subdivided into macro- and microelements.

Macronutrients include calcium, phosphorus, magnesium, potassium, sodium, chlorine and sulfur.

Trace elements: iron, copper, manganese, zinc, cobalt, iodine, fluorine, chromium, molybdenum, vanadium, nickel, strontium, silicon, selenium are recognized as essential for human and animal life.

Macronutrients regulate water-salt metabolism, maintain the osmotic pressure in cells and intercellular fluids, which is necessary for the movement of nutrients and drugs between them. Blood formation processes occur with the participation of iron, copper, manganese, calcium and other mineral substances (elements). Minerals (trace elements) activate the action of enzymes, hormones, participate in all types of metabolism.

Minerals in solid dosage form are pharmaceutically

- 11 020148 volatile oxides, pharmaceutically acceptable salts, for example, succinates, chlorides, carbonates or sulfates, as well as in various pharmaceutically acceptable complex compounds.

Minerals have an antimicrobial effect by inactivating the enzymes necessary for the functioning of microorganisms. Enzyme inactivation occurs through the interaction of metal ions with sulfhydryl groups of enzymes.

Metals have a pronounced local effect on the mucous membranes. At the concentrations of mineral substances considered in the application, the local action of these substances may be astringent or irritating.

The mechanism of local action of metals is due to their ability to react with tissue proteins. As a result of this interaction, proteins coagulate and form albuminates with metal ions. Moreover, if partial coagulation of proteins occurs only in the surface layers of tissues, an astringent or irritating effect is observed that is reversible.

The studies, when developing this application for the invention, showed that the mineral substances that make up the solid dosage form enhance its therapeutic effect, i.e. enhance the therapeutic effect of the use of the active substance.

For all variants of solid dosage forms considered in the invention, the rational ranges of the values of the content of mineral substances are as follows, mg / kg:

sodium - 1550.0 - 105000.0;

potassium - 320.0 - 15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0.

When developing the invention, it was found that an increase in the speed of the onset of the therapeutic effect, an increase in the therapeutic effect without increasing the concentration of the main active substance (bile) in the solid dosage form, is provided by the introduction of certain minerals (a certain combination of minerals) in a quantity strictly defined for each mineral into the solid dosage form. As a result of the research, a weight range in solid dosage form was established for each mineral.

The use of less than indicated in the range, the amount of mineral substance does not lead to the achievement of technical results. The use of more than indicated in the range, the amount of mineral substance not only does not lead to the achievement of technical results, but, in some cases, worsens the therapeutic effect of the action of bile. It was found that with an increase in the concentration of mineral substances in solid dosage form (above the stated ranges), they suppress the action of bile, i.e. the healing effect of bile disappears.

An additional increase in the speed of the onset of the therapeutic effect, an increase in the therapeutic effect without increasing the concentration of the main active substance in solid dosage form is ensured by the partial replacement in the solid dosage form of carbon isotopes ¹² C with carbon isotopes ¹³ C.

List of figures, drawings and other materials

In FIG. 1 shows the dependence of the change in the volume of bile in samples on time when the mineral composition in solid dosage forms with a bile content of 267 g / kg changes.

In FIG. 2 shows the dependence of changes in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 25 g / kg changes.

In FIG. 3 shows the dependence of the change in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 267 g / kg changes.

In FIG. 4 shows the dependence of the change in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 625 g / kg changes.

In FIG. 5 is a diagram of a cavitation reactor for isotopic enrichment of various mixtures.

In FIG. 6 shows a cross section of a cavitation reactor.

In FIG. 7 is a diagram of an isotope enrichment plant.

- 12 020148

Information confirming the possibility of carrying out the invention

The invention is illustrated by the examples below.

Example 1 - a method of introducing minerals into water.

Example 2 - a method of obtaining a solid dosage form and verification of stability.

Example 3 - tests of solid dosage forms for general toxicity.

Examples 4-6 illustrate the choleretic effect of the claimed solid dosage forms.

Example 1

The introduction of mineral substances into the solution (in water) was carried out according to the method described in (Guidelines on methods for monitoring the quality and safety of biologically active food additives. - M .: Federal Center for Sanitary and Epidemiological Supervision of the Ministry of Health of Russia, 2004, 240 pp.).

It should be noted that there are other ways of introducing mineral substances into the solution.

Solutions were prepared from pure metals using pharmaceutically acceptable solvents to ensure storage stability of the solutions.

For in-depth studies, when developing an application for an invention, the concentration of metals in solid dosage form was provided in the following ranges, mg / kg:

sodium - 1550.0 - 105000.0;

potassium - 320.0 - 15300.0;

calcium - 725.0 - 41500.0;

magnesium 1350.0-63150.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chromium 0.015-6.5;

molybdenum - 0.01 - 5.0.

In addition, studies have been conducted on the extremely high content of minerals in solid dosage form. These studies will be written below.

The concentration of metals in solutions was controlled by the atomic absorption method for determining the contents of sodium, potassium, calcium, magnesium, iron, manganese, copper, zinc, lead, cadmium, cobalt, nickel, and chromium. Clause 1.3.2.1 of the source (Guidance on methods for monitoring the quality and safety of biologically active food additives. - M: Federal Center for Sanitary and Epidemiological Supervision of the Ministry of Health of Russia, 2004, 240 pp.).

Example 2

The claimed solid dosage form (tablet) is made by compressing a tableted mixture - the main active substance and the pharmaceutically acceptable (s) additional (s) substance (c).

To impart additional properties, the desired shape and weight, pharmaceutically acceptable additional substances, in particular mineral substances, potato starch, aerosil, sugar, a pharmaceutically acceptable excipient, in particular talc, beeswax, vaseline oil, etc., can be introduced into the tablet.

Excipients affect the rate of release, the rate and completeness of absorption of the main active ingredient and other pharmaceutically acceptable additional substances.

For example, we describe the preparation of one solid dosage form with mineral substances of a given concentration, mg / kg sodium -1550.0;

potassium - 320.0;

calcium - 725.0;

magnesium - 1350.0;

iron -1.0;

Manganese - 0.3;

zinc - 1.0;

copper -0.1;

chromium - 0.015;

molybdenum - 0.01.

8 l of distilled water are poured into a stirred reactor. Then, dried bile - 250 g, is loaded into the reactor, and solutions with mineral substances are poured with constant stirring.

- 13 020148 research institutes.

Then pharmaceutically acceptable additional substances are added to the solution: activated carbon - 190 g, starch - 57 g. The resulting solution is brought to a volume of 10 l with water, stirred and passed through a filter.

Then carry out the evaporation, molding (pressing) and drying of the solid (solid) dosage form.

The control showed high-quality performance of the solid dosage form.

Similarly, other solid dosage forms with minerals and dried bile, described in the application, were obtained.

Studies of stability (shelf life) showed that the solid dosage forms obtained in this way are stable and retain their initial values for 3.5–4 years.

Thus, it provides increased stability of the solid dosage form over the expiration date.

Example 3

Tests for general toxicity were carried out by intraperitoneal administration of a solution (2 ml), obtained from a solid dosage form based on dried bile and minerals, to rats. In solid dosage form, a 75% carbon isotope content of ¹³ C. was provided.

For studies of the concentration of mineral substances in solid dosage form selected, mg / kg sodium -105000.0;

potassium - 15300.0;

calcium -41500.0;

magnesium - 63150.0;

iron - 135.0;

Manganese - 35.0;

zinc - 320.0;

copper-21.0;

chrome - 6.5;

Molybdenum - 5.0.

LI ₅₀ is up to 3000 mg / kg, which makes it possible to attribute the claimed solid dosage forms to non-toxic substances.

With prolonged use of a solid dosage form based on dried bile and minerals in rats, no changes in the organs and tissues of the body were detected.

Example 4

Verification of the effectiveness of the claimed solid dosage forms.

The authors conducted studies on the effect of Allohol tablets on bile formation in the liver of animals. The bile-forming function of the liver (with the introduction of Allohol into the stomach and without the introduction of Allohol) was studied in a chronic experiment on dogs. During the experiments, the volume of bile in the samples, the content of taurocholic acid, and the temperature of the liver were measured. In addition, the content of mixtures of various bile acids, in particular mixtures of taurochenodeoxycholic and taurodeoxycholic acids, was evaluated. The studies were carried out jointly with scientists of the Institute of Veterinary Medicine of the National Academy of Agrarian Sciences of Ukraine (Kiev) and according to their methods.

The experimental conditions were as follows. The number of dogs is 25 (of which 15 dogs are the control group not exposed to the action of the drug Allohol) weighing from 13 to 17 kg. The catheter is installed in the common bile duct. The design of the catheter allows you to make samples of bile, and outside the experiment ensures the passage of bile into the duodenum. Dogs were fed once a day at 3 p.m. Experimental measurements were performed on hungry dogs from 11 a.m. to 15 p.m. In the experiments, the amount of bile secreted by the liver every 30 minutes for 4 hours of the experiment was taken into account. The drug Allohol was administered at 10 am orally at the rate of 1 tablet per 3 kg of animal weight (or 0.027 g of dry bile per 1 kg of animal weight).

The effects of the drug Allochol on bile formation in the liver of animals are conveniently evaluated by a change in the volume of bile in the samples.

In FIG. 3 shows the dependence of changes in bile volume in samples on time. The time moment of 0 min is characterized by the fact that Allohol was orally administered to the animal an hour before it. On the ordinate axis - bile content in the sample. The abscissa is time.

Curve 34 (see Fig. 3) is the change in the volume of bile in the control group of animals that did not receive the drug Allohol.

Curve 38 is the change in bile volume (upper bound of values) in animals treated with Allochol.

- 14 020148

Curve 40 is the change in the volume of bile (lower bound of values) in animals that received the drug Allohol.

All curves of changes in the volume of bile in animals treated with Allochol pass through region 39 (the shaded region between curves 38 and 40).

A comparison of curves 34, 38 and 40 shows that Allochol stimulates bile formation.

In experiments, an increase in the acid content in bile, in particular taurocholic acid, was also established (graph 2 in the source of ННр: // | сГоп0.гі / ги / 51а1 / 2-ар11с1с5 / 30-дс1сН1).

In the experiments, the choleretic effect of only dry (dried) bile was also evaluated (tablets consisted only of dry pressed bile weighing 80 mg). In FIG. 3, the curves of the effect of dry bile on bile formation from time to time pass along curve 34 and through region 39.

In studies, the content of bile and minerals in the preparation was reduced and increased. The mineral composition (quantitative and qualitative) was changed due to changes in the amount of the following elements: garlic, nettle leaves, magnesium oxide, aerosil, calcium stearate, povidone, basic magnesium carbonate, titanium dioxide, talc, tropeolin (tartrazine). This or that element was introduced into a tablet or removed from a tablet.

For example, tablets were formed without silicon and titanium. That is, tablets were made without aerosil, titanium dioxide and talc.

The experiments did not establish the effect of an increase (decrease) in the content of sodium, calcium, magnesium on the dynamics of bile formation. However, the authors' experience with the use of mineral substances to increase the effectiveness of the active substance suggests that an increase in the amount of mineral substances in a dosage form with dried bile can affect its effectiveness.

Given this, the authors conducted studies to increase the number of mineral substances and their quantitative composition in solid dosage form. The aim of the research was to achieve a significant increase in bile formation.

In addition to the minerals already existing in Allochol (sodium, calcium, magnesium), potassium, iron, manganese, zinc, copper, cobalt, chromium, and molybdenum were introduced into the solid dosage form.

In FIG. 1 shows the dependence of the change in the volume of bile in samples on time when the mineral composition in solid dosage forms with a bile content of 267 g / kg changes.

Curve 53 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium - 36187.0;

calcium - 18900.0;

magnesium - 27600.0;

potassium 4817.0;

iron - 56.0.

Curve 54 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium-36187.0;

calcium-18900.0;

magnesium - 27600.0;

potassium - 4817.0;

iron - 56.0.

Curve 54 differs from curve 53 in that curve 54 reflects the effect of using ¹³ C isotopes on the effectiveness of the solid dosage form. Here, the ¹³ C isotope content was 15% of the total carbon (of all carbon isotopes) in the dosage form.

Curve 55 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium -36187.0;

calcium -18900.0;

magnesium - 27600.0;

potassium - 4817.0;

iron - 56.0;

Manganese - 3.2.

- 15 020148

Curve 56 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium-36187.0;

calcium -18900.0;

magnesium - 27600.0;

potassium 4817.0;

iron - 56.0;

Manganese - 3.2;

zinc - 48.5.

Curve 57 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium -36187.0;

calcium -18900.0;

magnesium - 27600.0;

potassium - 4817.0;

iron - 56.0;

Manganese - 3.2;

zinc - 48.5;

copper - 5.0.

Curve 58 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium - 36187.0;

calcium -18900.0;

magnesium - 27600.0;

potassium 4817.0;

iron - 56.0;

manganese -3.2;

zinc - 48.5;

copper - 5.0;

cobalt - 0.31.

Curve 59 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium -36187.0;

calcium - 18900.0;

magnesium - 27600.0;

potassium - 4817.0;

iron - 56.0;

manganese -3.2;

zinc - 48.5;

copper-5.0;

cobalt - 0.31;

chromium 0.7;

molybdenum - 0.44.

- 16 020148

Curve 60 is characterized by the content of dried bile (267 g / kg) and the content of minerals, mg / kg sodium - 36187.0;

calcium -18900.0;

magnesium - 27600.0;

potassium - 4817.0;

iron - 56.0;

Manganese - 3.2;

zinc - 48.5;

copper-5.0;

cobalt -0.31;

chromium 0.7;

molybdenum - 0.44.

Curve 59 differs from curve 60 in that curve 60 reflects the effect of using ¹³ C isotopes on the effectiveness of the solid dosage form. Here, the ¹³ C isotope content was 15% of the total carbon (of all carbon isotopes) in the dosage form.

An analysis of the above research results (curves 38, 53-60) led to the conclusion that it is advisable to conduct in-depth studies on the use of mineral substances and ¹³ C isotopes to increase the choleretic effect of solid dosage forms based on dried bile.

Below are the results of in-depth studies on the use of mineral substances and ¹³ C isotopes to increase the choleretic effect of solid dosage forms.

The studied pharmaceutical compositions are given in table. 2-10.

In carrying out the work, they were guided by the recommendations given in the source (Guidelines for the experimental (preclinical) study of new pharmacological substances. Edited by Khabriev R.U. - Moscow: Ministry of Health of the Russian Federation, 2005).

Below we describe the choleretic effect of the claimed solid dosage forms with a bile content of 25 g / kg.

In FIG. 2 shows the dependence of changes in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 25 g / kg changes.

In experiments it was found that the claimed solid dosage forms based on dried bile and minerals have a pronounced choleretic effect. The experimental results are shown in FIG. 2.

The experimental conditions were similar to the experimental conditions with Allohol:

1) 15 dogs weighing 13 to 17 kg - a control group not exposed to the claimed solid dosage forms;

2) bile-forming (choleretic) function of the liver (with the introduction of the claimed solid dosage forms into the stomach) was investigated in a chronic experiment on dogs. The studies were carried out on 6-10 dogs weighing 13 to 17 kg for each of the dosage forms (No. 1-72), that is, 6-10 experiments were conducted for each dosage form.

Curve 34 (see Fig. 2) is the change in the volume of bile in the control group (15 dogs) of animals that did not receive a choleretic drug (tablets).

Curve 35 is the change in bile volume (upper bound of values) in animals (6-10 dogs) that received a choleretic drug - 0.0027 g of dry bile per 1 kg of animal weight.

Curve 37 is the change in bile volume (lower bound of values) in animals that received a choleretic drug - 0.0027 g of dry bile per 1 kg of animal weight.

All curves of changes in the volume of bile in animals treated with a choleretic drug pass through region 36 (the shaded area between curves 35 and 37).

Curve 34 and through region 44 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 2.

Curve 34 and through region 45 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 4.

Curve 34 and through region 46 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 5.

Curves of changes in the volume of bile in animals treated with choleretic solid dosage forms No. 1, are significantly lower than area 44. Solid dosage form No. 1 (see table. 2) practically does not exceed the effect of dry bile in its action. Therefore this solid drug

- 17 020148 it is not advisable to use the new form in practice.

Solid dosage form No. 6 (see table. 2) in its effect practically does not exceed the effect of solid dosage form No. 5. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 7 (see table. 2) in its effect is equal to the action of solid dosage form No. 2. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 8 (see table. 2) in its effect is inferior (by 10-15%) to the action of solid dosage form No. 2. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 44 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 10 (see table. 3).

Curve 34 and through region 45 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 12.

Curve 34 and through region 46 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 13.

Curves of changes in the volume of bile in animals treated with choleretic solid dosage forms No. 9 are significantly lower than area 44. Solid dosage form No. 9 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 14 in its effect practically does not exceed the effect of solid dosage form No. 13. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 15 in its effect is equal to the action of solid dosage form No. 10. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 16 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 10. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 44 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 18 (see table 4).

Curve 34 and through region 45 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 20.

Curve 34 and through region 46 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 21.

Curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 17, are significantly lower than area 44. Solid dosage form No. 17 in its effect practically does not exceed the effect of dry bile. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 22 in its effect practically does not exceed the effect of solid dosage form No. 21. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 23 in its effect is equal to the action of solid dosage form No. 18. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 24 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 18. Therefore, this solid dosage form is not practical to use.

Example 5

We describe the choleretic effect of the claimed solid dosage forms with a bile content of 267 g / kg.

In FIG. 3 shows the dependence of the change in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 267 g / kg changes.

In experiments it was found that the claimed solid dosage forms based on dried bile and minerals have a pronounced choleretic effect. The experimental results are shown in FIG. 3.

Curve 34 (see Fig. 3) is the change in the volume of bile in the control group (15 dogs) of animals that did not receive a choleretic drug (tablets).

Curve 38 is the change in bile volume (upper bound of values) in animals (6-10 dogs) that received a choleretic drug - 0.027 g of dry bile per 1 kg of animal weight.

- 18 020148

Curve 40 is the change in the volume of bile (lower bound of values) in animals that received a choleretic drug - 0.027 g of dry bile per 1 kg of animal weight.

All curves of changes in the volume of bile in animals treated with a choleretic drug pass through region 39 (the shaded region between curves 38 and 40).

Curve 34 and through region 47 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 26 (see Table 5).

Curve 34 and through region 48 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 28.

Curve 34 and through region 49 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 29.

Curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 25 pass significantly below area 47. Solid dosage form No. 25 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 30 in its effect practically does not exceed the effect of solid dosage form No. 29. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 31 in its effect is equal to the action of solid dosage form No. 26. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 32 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 26. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 47 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 34 (see table. 6).

Curve 34 and through region 48 are curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 36.

Curve 34 and through region 49 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 37.

Curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 33 pass significantly below area 47. Solid dosage form No. 33 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 38 in its effect practically does not exceed the effect of solid dosage form No. 37. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 39 in its effect is equal to the action of solid dosage form No. 34. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 40 is inferior (by 10-15%) to the action of solid dosage form No. 34. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 47 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 42 (see table. 7).

Curve 34 and through region 48 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 44.

Curve 34 and through region 49 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 45.

Curves of changes in the volume of bile in animals treated with choleretic solid dosage forms No. 41 are significantly lower than area 47. Solid dosage form No. 41 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 46 in its effect practically does not exceed the effect of solid dosage form No. 45. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 47 in its effect is equal to the action of solid dosage form No. 42. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 48 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 42. Therefore, this solid dosage form is not practical to use.

- 19 020148

Example 6

We describe the choleretic effect of the claimed solid dosage forms with a bile content of 625 g / kg.

In FIG. 4 shows the dependence of the change in the volume of bile in samples on time when the content of mineral substances in solid dosage forms with a bile content of 625 g / kg changes.

In experiments it was found that the claimed solid dosage forms based on dried bile and minerals have a pronounced choleretic effect. The experimental results are shown in FIG. 4.

Curve 34 (see Fig. 4) is the change in bile volume in the control group of animals that did not receive the choleretic drug.

Curve 41 is the change in bile volume (upper bound of values) in animals (6-10 dogs) that received a choleretic drug - 0.063 g of dry bile per 1 kg of animal weight.

Curve 43 is the change in the volume of bile (lower bound of values) in animals that received a choleretic drug - 0.063 g of dry bile per 1 kg of animal weight.

All curves of changes in the volume of bile in animals treated with a choleretic drug pass through region 42 (the shaded region between curves 41 and 43).

Curve 34 and through region 50 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 50 (see table. 8).

Curve 34 and through region 51 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 52.

Curve 34 and through region 52 (near the lower boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 53.

Curves of changes in the volume of bile in animals treated with choleretic solid dosage forms No. 49 pass significantly below area 50. Solid dosage form No. 49 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 54 in its effect practically does not exceed the effect of solid dosage form No. 53. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 55 in its effect is equal to the action of solid dosage form No. 50. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 56 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 50. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 50 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 58 (see table. 9).

Curve 34 and through area 51 are the curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 60.

Curve 34 and through region 52 pass curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 61.

Curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 57 pass below area 50. Solid dosage form No. 57 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 62 in its effect practically does not exceed the effect of solid dosage form No. 61. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 63 in its effect is equal to the action of solid dosage form No. 58. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 64 is inferior (by 10-15%) to the action of solid dosage form No. 58. Therefore, this solid dosage form is not practical to use.

Curve 34 and through region 50 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 66 (see Table 10).

Curve 34 and through region 51 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 68.

Curve 34 and through region 52 (near the upper boundary of the region and along the upper boundary of the region) show curves of changes in the volume of bile in animals that received choleretic solid dosage forms No. 69.

- 20 020148

Curves of changes in the volume of bile in animals treated with choleretic solid dosage forms No. 65 pass below area 50. Solid dosage form No. 65 practically does not exceed the effect of dry bile in its action. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 70 in its effect practically does not exceed the effect of solid dosage form No. 69. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 71 in its effect is equal to the action of solid dosage form No. 66. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 72 in its effect is inferior (by 10-15%) to the action of solid dosage form No. 66. Therefore, this solid dosage form is not practical to use.

Solid dosage form No. 3 in its choleretic effect occupies an intermediate position between solid dosage forms No. 2 and 4.

Solid dosage form No. 11 in its choleretic action position between solid dosage forms No. 10 and 12.

Solid dosage form No. 19 in its choleretic action, the position between solid dosage forms No. 18 and 20.

Solid dosage form No. 27 in its choleretic effect, the position between solid dosage forms No. 26 and 28.

Solid dosage form No. 35 in its choleretic effect, the position between solid dosage forms No. 34 and 36.

Solid dosage form No. 43 in its choleretic effect, the position between solid dosage forms No. 42 and 44.

Solid dosage form No. 51 in its choleretic action, the position between solid dosage forms No. 50 and 52.

Solid dosage form No. 59 in its choleretic action, the position between solid dosage forms No. 58 and 60.

Solid dosage form No. 67 in its choleretic action, the position between solid dosage forms No. 66 and 68.

Experiments have shown that partial replacement of ¹² C carbon isotopes in solid dosage form with ¹³ C carbon isotopes can increase the therapeutic effect of dried bile with minerals in a number of dosage forms by 5% or more.

Numerous experiments have proved that if the dosage form has a choleretic effect, then it is possible, with a high degree of probability, to argue that the dosage form can be successfully used in the treatment of diseases of the liver and gall bladder.

Thus, in practice, it is advisable to use solid dosage forms No. 2-5, 1013, 18-21, 26-29, 34-37, 42-45, 50-53, 58-61, 66-69. A joint analysis of the graphs in FIG. 1-4 allows us to conclude that the use of the claimed solid dosage forms provides an increase in the rate of onset of the therapeutic effect (decrease in the time of onset of the therapeutic effect) while maintaining the duration of action without increasing the concentration of dried bile, which can be used in the treatment of diseases of the liver and gall bladder.

An increase in the therapeutic effect was also confirmed while maintaining the duration of action without increasing the concentration of dried bile, which can be used in the treatment of diseases of the liver and gall bladder.

Thus, the application is described and technical results are confirmed when using solid dosage forms No. 1 and 2, which can be described as follows.

Solid dosage form No. 1.

takes takes takes takes takes takes intermediate intermediate intermediate intermediate intermediate intermediate intermediate intermediate

- 21 020148

A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances in the following ratio of components in mg / kg:

dried bile - 25'10 ³ - 625 10 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper - 0.1 - 21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0.

It was found that in addition to the above mineral substances in solid dosage form No. 1, cobalt, mg / kg can be added: cobalt - 0.03-5.3.

Moreover, the total content of all components included in the solid dosage form is 1000 g / kg.

Studies of solid dosage form No. 2 with an expanded content of minerals have been carried out.

It was found that in addition to the above mineral substances in solid dosage form No. 2, any of the following mineral substances can be added or can be added, mg / kg: cobalt - 0.03-5.3.

Moreover, the total content of all components included in the solid dosage form is 1000 g / kg.

At present, ¹³ C carbon isotopes in the world are widely used in biochemistry and medicine for diagnostics. The application presents the results of our own studies on the effect of carbon ¹³ C isotopes on the effectiveness of solid dosage forms based on dried bile.

Studies of solid dosage form No. 2 with an expanded content of minerals have been carried out.

It was found that in addition to the above mineral substances in solid dosage form No. 2, any of the following mineral substances may be added or may be added, mg / kg sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0 - 63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

cobalt-0.03 -5.3;

chromium 0.015-6.5;

molybdenum - 0.01 - 5.0.

At present, ¹³ C carbon isotopes in the world are widely used in biochemistry and medicine for diagnostics. The application presents the results of our own studies on the effect of carbon ¹³ C isotopes on the effectiveness of solid dosage forms based on dried bile.

It was also found to increase the stability of the claimed solid dosage forms over the shelf life by replacing (from 0.3 to 75%) the carbon isotopes of ¹² C with carbon isotopes of ¹³ C. It was found that carbon isotopes of ¹³ C in the dosage form slow down the reactions occurring in the dosage form form stronger covalent bonds than carbon isotopes ¹² C.

Carbon isotopes ¹³ C increase the resistance of molecules to the oxidative effects of radicals.

Carbon isotopes ¹³ C are not toxic. The experiments show that feeding mice, rats and guinea pigs with foods enriched with 75% ¹³ C carbon does not lead to side effects and poor health.

- 22 020148

In the process of experimental verification of the claimed solid dosage forms enriched in carbon ¹³ C isotopes, it was found that they have increased stability, they are non-toxic and, in addition, have an increased expectorant, local enveloping and anti-inflammatory effect compared to a solid dosage form in which there are no carbon isotopes ¹³ C.

Methods for the production of a stable highly enriched non-radioactive ¹³ C isotope are widely used in Russian and world industry. Well-developed methods for producing the ¹³ C isotope by gas diffusion through porous septa, vapor diffusion, thermal diffusion, as well as by distillation, isotope exchange, centrifugation, electrolysis, genetic engineering, etc. A brief description of these methods is given in the source (Isotope Separation. Physical Encyclopedia. L1R: // Tens.asayet1.s.GiM1s.p8G/eps_yu8U8/1071/ISOTOPES).

At the Moscow State Academy of Fine Chemical Technology. Lomonosova M.V. They are working out modern nanotechnologies for producing and incorporating atoms of stable carbon ¹³ C isotopes into molecules of various structures. At the academy, molecules of isotopically labeled compounds with various levels of isotope enrichment are obtained - from fractions of a percent to one hundred percent of isotopes in a substance. The work is in the interests of medical diagnosis. In the source (Nanotechnology and the incorporation of 2 13 15 18 atoms of deuterium H, carbon C, nitrogen N and oxygen O into amino acid and protein molecules. from \\ '<1e) 1ep] a211g1G.51it1) 165 references to foreign sources of information on the isotopic enrichment of various substances are given.

In turn, the authors actively participated in the work on the isotopic enrichment of hydrocarbons, as well as reagents for the production of various drugs. The reagents were enriched with ¹³ C carbon isotope (replacing ¹² C carbon isotopes with ¹³ C carbon isotopes) in a cavitation reactor designed by Professor V. I. Kormilitsyn. (Moscow Energy Institute - Technical University).

The reactor was manufactured according to the methodology given in the source (Ganiev R.F., Kormilitsyn V.I., Ukrainian L.I. Wave technology for the preparation of alternative types of fuels and the efficiency of their combustion. - M .: Scientific and Publishing Center Regular and chaotic dynamics , 2008 .-- 116 p.). The flow velocity in the reactor, along the length of the channel, varied from 10 to 50 m / s.

In FIG. 5 is a diagram cavitation reactor for isotopic enrichment of various mixtures, in particular the reagents for the preparation of solid dosage forms based on the dried bile enriched with carbon isotope ¹³ C. The reactor is located in a plant which comprises 6NK-6x pump 1 that provides the maximum flow of 90 m ³ / h, a pressure of 125 m with an electric motor power of 75 kW, a rotational speed of an electric motor rotor and a pump wheel of 2950 rpm. Additionally, the installation contains tanks for reagents and measuring instruments.

The installation diagram is shown in FIG. 7.

The cavitation reactor 1 (see Fig. 5) is made in the form of a flat Laval nozzle with cavitation bodies 2–9 in channel 10.

In FIG. 6 shows a cross section of a cavitation reactor. The reactor channel in the area of cavitation bodies is divided into several channels. For example, cavitation bodies 5 and 6 divide the channel into smaller channels 13, 14 and 15. Outside, the channel is limited by walls 16 and 17, as well as two covers 11 and 12.

In FIG. 5, arrows 18 show the direction of movement of the reagent at the inlet to the reactor, arrow 19 shows the direction of movement of the reagent at the outlet of the reactor.

In the wall 16, channels 24 and 25 are made for supplying carbon dioxide and nitrogen to the cavitation zones.

Installation works as follows. The hydrocarbon reagent from the tank 28 is pumped through the reactor 27 through the pump 27 and enters the tank 28. The pressure drop in the reactor is controlled by pressure gauges 29 and 30. The temperature of the reactant is monitored by thermometer 31. The reagent is heated in the tank by a heater 32.

When the reactor is operating, the hydrocarbon reagent moves along the cavitator channel in direction 18. When flowing around cavitation bodies, the stream is divided into several streams. Beyond the cavitation bodies, cavitation areas arise. In particular, behind the bodies (if you look in the direction of movement of the reagent) cavitation 2, 3, and 4 are cavitation zones 20, 21, 22, and 23. Upon entering the cavitation region, the reagent boils, cavitation bubbles appear, and cavitation bubbles collapse when leaving the cavitation region . Moreover, in the area (in place) of the collapse of the cavitation bubble, an increase in pressure to several thousand atmospheres and an increase in temperature to a thousand degrees Celsius are observed. Through channels 24 and 25, carbon dioxide is supplied to the stream so that the gas enters the cavitation zone.

The gas-vapor mixture obtained in the reactor, together with the liquid reagent, enters the vessel 28. Next, the gas-vapor mixture is passed through a pipe 33 to a separator with a porous partition, where the gas-vapor mixtures with ¹³ C and ¹² C are separated.

In the experiments, the reactor worked from several hours to several days. A direct dependence of the degree of enrichment of a gas-vapor mixture and a reagent with a ¹³ C isotope ^{on the} operating time of cavit is established.

- 23 020148 reactor.

The amount of ¹³ C carbon isotopes was controlled by high resolution mass spectroscopy.

As a result of the experiments, the reagent was enriched in the ¹³ C carbon isotope from 0.3 to 75%.

Thus, solutions (reagents) were obtained, and solid dosage forms based on dried bile with a content of ¹³ C carbon isotopes from 0.3 to 75% of all carbon in solid dosage form were obtained from solutions.

In the claimed solid dosage forms, the active substance is dried bile. The dried bile content is from 25 · 10 ³ to 625 · 10 ³ mg / kg. Values close to the left border for children and pregnant women. Values close to the right border are for adults and animals.

In the research process, a solid dosage form was created in the form of a tablet with the possibility of separation into parts.

In a formalized form, a tablet, which can be divided into parts, is described as follows.

A solid dosage form made in the form of a tablet contains an active substance and a pharmaceutically acceptable additional substance, and the tablet is made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (O1 + 02) / O = 0.9 + 1.0;

B = | O1-02 | / O = 0 + 0.1, where K is an indicator that indicates that during the separation two main parts are obtained, and they can also receive more than two parts, however, at the same time, two of the obtained parts are the largest in size ;

B is an indicator that indicates that during separation two parts are obtained, the weight of which can differ by no more than 10%;

- the weight of the first part of the solid dosage form after separation of the solid dosage form;

- the weight of the second part of the solid dosage form after separation of the solid dosage form;

- the weight of the solid dosage form before separation.

In addition, work was carried out to create a solid dosage form with the possibility of dividing it into parts and obtaining two parts with different indicators. So, a specific indicator (for example, activated carbon content, mineral content, bile content, etc.) in the first part of the solid dosage form differs from the corresponding indicator in the second part of the solid dosage form.

Another example.

A solid dosage form was prepared with the possibility of dividing into parts and obtaining two parts for which the dried bile content in the first part of the solid dosage form differs from the dried bile content in the second part of the solid dosage form by 10%.

A solid dosage form made with the possibility of separation into parts with different indicators is called a hybrid solid dosage form. A solid dosage form made with the possibility of separation, for example, into two parts was made by pressing two prefabricated half-tablets.

This embodiment of the solid dosage form expands the possibilities of using the dosage form.

In the table. 11 and 12 show some field proven hybrid solid dosage forms.

Hybrid solid dosage forms can be described in various ways. Below are a few formal descriptions of these dosage forms.

1. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a tablet made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01 + 02) / O = 0.9 + 1.0;

B = | O1 - 02 I / 0 = 0 + 0.1, where K is an indicator that indicates that during the separation two main parts are obtained, and they can also receive more than two parts, however, at the same time, two of the obtained parts are the largest in size ;

B is an indicator that indicates that during separation two parts are obtained, the weight of which can differ by no more than 10%;

- the weight of the first part of the solid dosage form after separation of the solid dosage form;

- the weight of the second part of the solid dosage form after separation of the solid dosage form;

- the weight of the solid dosage form before separation, and the dried bile content in the first part of the solid dosage form is different from the dried bile content in the second part of the solid dosage form.

- 24 020148

2. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a tablet made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01+ 62) / 6 = 0.9 + 1.0;

B = I 01 - 021/0 = 0 + 0.1, and the content of dried bile in the first part of the solid dosage form is different from the content of dried bile in the second part of the solid dosage form and the content of components in the first part of the solid dosage form, mg / kg dried bile - 25 1 0 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc - 1.0-320.0;

copper-0.1 -21.0;

chrome -0.015-6.5; molybdenum - 0.01 - 5.0;

and the content of the components in the second part of the solid dosage form, mg / kg dried bile - 625 10 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0 - 15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0-135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0.

3. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a tablet made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (61 + 62) / 6 = 0.9 + 1.0;

B = | 61-62 | / 6 = 0 + 0.1, and the content of dried bile in the first part of the solid dosage form is different from the content of dried bile in the second part of the solid dosage form and the content of components in the first part of the solid dosage form, mg / kg dried bile - 25 1 0 ³ - 325 1 0 ³ ;

sodium - 1550.0 - 105000.0;

potassium - 320.0 - 15300.0;

calcium - 725.0 - 41500.0;

magnesium - 1350.0-63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper - 0.1 - 21.0;

chrome - 0.015 - 6.5;

molybdenum - 0.01 - 5.0, and the content of the components in the second part of the solid dosage form, mg / kg

- 25 020148 dried bile - 325.01 1О ³ - 625 10 ³ ;

sodium-1550.0-105000.0;

potassium - 320.0-15300.0;

calcium - 725.0 - 41500.0;

magnesium -1350.0-63150.0;

iron - 1.0 - 135.0;

Manganese - 0.3 - 35.0;

zinc 1.0-320.0;

copper-0.1 -21.0;

chromium 0.015-6.5;

molybdenum - 0.01 - 5.0.

4. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a tablet made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (O1 + (32) / (3 = 0.9-1.0;

B = | O1-02 | / (3 = 0-4) .1, and the content of the components in the first part of the solid dosage form, mg / kg dried bile - 25 10 ³ - 625 10 ³ ;

sodium - 1550.0;

potassium - 320.0;

calcium -725.0;

magnesium -1350.0;

iron - 1.0;

Manganese -0.3;

zinc 1.0;

copper -0.1;

chromium 0.015;

molybdenum - 0.01, and the content of the components in the second part of the solid dosage form, mg / kg dried bile - 25'10 ³ - 625 1 0 ³ ;

sodium -105000.0;

potassium - 15300.0;

calcium -41500.0;

magnesium -63150.0;

iron -135.0;

manganese -35.0;

zinc - 320.0;

copper-21.0;

chromium -6.5;

molybdenum -5.0.

5. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (O1 + 02) / St = 0.9 + 1.0;

B = | O1 - 02) / 0 = 0 + 0.1, while the sodium content in the first part of the solid dosage form is chosen so that it differs from the sodium content in the second part of the solid dosage form.

6. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, a mineral substance or minerals, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

- 26 020148

wherein the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is different from the sodium content in the second part of the solid dosage form;

and / or the solid dosage form contains potassium, and the potassium content in the first part of the solid dosage form is different from the potassium content in the second part of the solid dosage form;

and / or the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is different from the calcium content in the second part of the solid dosage form;

and / or the solid dosage form contains magnesium, and the magnesium content in the first part of the solid dosage form is different from the magnesium content in the second part of the solid dosage form;

and / or the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is different from the iron content in the second part of the solid dosage form;

and / or the solid dosage form contains manganese, and the manganese content in the first part of the solid dosage form is different from the manganese content in the second part of the solid dosage form;

and / or the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is different from the zinc content in the second part of the solid dosage form;

and / or the solid dosage form contains copper, and the copper content in the first part of the solid dosage form is different from the copper content in the second part of the solid dosage form;

and / or the solid dosage form contains cobalt, and the cobalt content in the first part of the solid dosage form is different from the cobalt content in the second part of the solid dosage form;

and / or the solid dosage form contains chromium, and the chromium content in the first part of the solid dosage form is different from the chromium content in the second part of the solid dosage form;

and / or the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is different from the molybdenum content in the second part of the solid dosage form.

7. A solid dosage form having a choleretic effect, made in the form of a tablet, containing dried bile, a pharmaceutically acceptable carbon-containing additional substance, or pharmaceutically acceptable carbon-containing additional substances, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01+ 02) / O = 0.9 + 1.0;

B =] O1-02 5/0 = 0 + 0.1, while the content of carbon isotopes ¹³ C in the first part of the solid dosage form differs from the content of carbon isotopes ¹³ C in the second part of the solid dosage form.

8. A solid dosage form having a choleretic effect, made in the form of a tablet, containing dried bile, a pharmaceutically acceptable carbon-containing additional substance or pharmaceutically acceptable carbon-containing additional substances, a mineral substance or mineral substances, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which conditions are met

K = (01 + 02) / O = 0.9 1.0;

B = | 01-02 | / O = 0-0.1, wherein the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is different from the sodium content in the second part of the solid dosage form;

and / or the solid dosage form contains potassium, and the potassium content in the first part of the solid dosage form is different from the potassium content in the second part of the solid dosage form;

and / or the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is different from the calcium content in the second part of the solid dosage form;

and / or the solid dosage form contains magnesium, and the magnesium content in the first part of the solid dosage form is different from the magnesium content in the second part of the solid dosage form;

and / or the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is different from the iron content in the second part of the solid dosage form;

and / or the solid dosage form contains manganese, and the manganese content in the first part of the solid dosage form is different from the manganese content in the second part of the solid dosage form;

- 27 020148 and / or the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is different from the zinc content in the second part of the solid dosage form;

and / or the solid dosage form contains copper, and the copper content in the first part of the solid dosage form is different from the copper content in the second part of the solid dosage form;

and / or the solid dosage form contains cobalt, and the cobalt content in the first part of the solid dosage form is different from the cobalt content in the second part of the solid dosage form;

and / or the solid dosage form contains chromium, and the chromium content in the first part of the solid dosage form is different from the chromium content in the second part of the solid dosage form;

and / or the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is different from the molybdenum content in the second part of the solid dosage form;

and the content of carbon isotopes ¹³ C in the first part of the solid dosage form is different from the content of carbon isotopes ¹³ C in the second part of the solid dosage form.

9. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (O1 + (32) / (3 = 0.9-1.0;

B = | 01 - 02 | / O = 0-0.1, wherein the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is 1.001-10 times greater than the sodium content in the second part of the solid dosage form;

and / or the solid dosage form contains potassium, and the potassium content in the first part of the solid dosage form is 1.00110 times greater than the potassium content in the second part of the solid dosage form;

and / or the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is 1.001-10 times greater than the calcium content in the second part of the solid dosage form;

and / or the solid dosage form contains magnesium, and the magnesium content in the first part of the solid dosage form is 1.001-10 times higher than the magnesium content in the second part of the solid dosage form;

and / or the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is 1.00110 times greater than the iron content in the second part of the solid dosage form;

and / or the solid dosage form contains manganese, and the manganese content in the first part of the solid dosage form is 1.001-10 times greater than the manganese content in the second part of the solid dosage form;

and / or the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is 1.001-10 times higher than the zinc content in the second part of the solid dosage form;

and / or the solid dosage form contains copper, and the copper content in the first part of the solid dosage form is 1.001-10 times greater than the copper content in the second part of the solid dosage form;

and / or the cobalt content in the first part of the solid dosage form is more than 1.001-10 times greater than the cobalt content in the second part of the solid dosage form;

and / or the solid dosage form contains chromium, and the chromium content in the first part of the solid dosage form is 1.001-10 times greater than the chromium content in the second part of the solid dosage form;

and / or the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is 1.001-10 times greater than the molybdenum content in the second part of the solid dosage form.

10. A solid dosage form having a choleretic effect, made in the form of a tablet, containing dried bile, pharmaceutically acceptable carbon-containing (s) additional substance (s), mineral substances, and a solid dosage form made with the possibility of separation into parts with the receipt of two parts for which the conditions are met

K = (61 + 62) / 6 = 0.9-1.0;

B = | O1 - 62 | / 6 = 0-0.1, while the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is 1.001-10 times higher than the sodium content in the second part of the solid dosage form;

and / or the solid dosage form contains potassium, and the potassium content in the first part of the solid

- 28 020148 dosage forms more than the potassium content in the second part of the solid dosage form 1.00110 times;

and / or the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is 1.001-10 times greater than the calcium content in the second part of the solid dosage form;

and / or the solid dosage form contains magnesium, and the magnesium content in the first part of the solid dosage form is 1.001-10 times higher than the magnesium content in the second part of the solid dosage form;

and / or the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is 1.00110 times greater than the iron content in the second part of the solid dosage form;

and / or the solid dosage form contains manganese, and the manganese content in the first part of the solid dosage form is 1.001-10 times greater than the manganese content in the second part of the solid dosage form;

and / or the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is 1.001-10 times higher than the zinc content in the second part of the solid dosage form;

and / or the solid dosage form contains copper, and the copper content in the first part of the solid dosage form is 1.001-10 times greater than the copper content in the second part of the solid dosage form;

and / or the cobalt content in the first part of the solid dosage form is more than 1.001-10 times greater than the cobalt content in the second part of the solid dosage form;

and / or the solid dosage form contains chromium, and the chromium content in the first part of the solid dosage form is 1.001-10 times greater than the chromium content in the second part of the solid dosage form;

and / or the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is more than 1.001-10 times higher than the molybdenum content in the second part of the solid dosage form;

and the content of carbon isotopes ¹³ C in the first part of the solid dosage form is greater than the content of carbon isotopes ¹³ C in the second part of the solid dosage form 1.001-10 times.

11. A solid dosage form having a choleretic effect, made in the form of a tablet, containing dried bile, pharmaceutically acceptable carbon-containing (s) additional substance (s), mineral substances, and a solid dosage form made with the possibility of separation into parts with the receipt of two parts for which the conditions are met

K = (O1 + 02) / 0 = 0.94.0;

B = | O1-02 I /0=04.1, wherein the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is 1.001-10 times higher than the sodium content in the second part of the solid dosage form;

and / or the solid dosage form contains potassium, and the potassium content in the first part of the solid dosage form is 1.00110 times greater than the potassium content in the second part of the solid dosage form;

and / or the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is 1.001-10 times greater than the calcium content in the second part of the solid dosage form;

and / or the solid dosage form contains magnesium, and the magnesium content in the first part of the solid dosage form is 1.001-10 times higher than the magnesium content in the second part of the solid dosage form;

and / or the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is 1.00140 times greater than the iron content in the second part of the solid dosage form;

and / or the solid dosage form contains manganese, and the manganese content in the first part of the solid dosage form is 1.001-10 times greater than the manganese content in the second part of the solid dosage form;

and / or the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is 1.001-10 times higher than the zinc content in the second part of the solid dosage form;

and / or the solid dosage form contains copper, and the copper content in the first part of the solid dosage form is 1.001-10 times greater than the copper content in the second part of the solid dosage form;

and / or the cobalt content in the first part of the solid dosage form is greater than the co

- 29 020148 balts in the second part of the solid dosage form 1.001-10 times;

and / or the solid dosage form contains chromium, and the chromium content in the first part of the solid dosage form is 1.001-10 times greater than the chromium content in the second part of the solid dosage form;

and / or the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is more than 1.001-10 times higher than the molybdenum content in the second part of the solid dosage form;

and the content of carbon isotopes ¹³ C in the first part of the solid dosage form is less than the content of carbon isotopes ¹³ C in the second part of the solid dosage form 1.001-10 times.

12. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01 + 02) / O = 0.9-1.0;

B = | O1-02 | / 0 = 0-0.1, while the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is 1.001-10 times higher than the sodium content in the second part of the solid dosage form;

and the solid dosage form contains potassium, and the potassium content in the first part of the solid dosage form is less than 1.001-10 times less than the potassium content in the second part of the solid dosage form.

13. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01 + 02) / O = 0.9 + 1.0;

B = | O1 - 02 | / 0 = 0 + 0.1, while the solid dosage form contains sodium, and the sodium content in the first part of the solid dosage form is 1.001-10 times higher than the sodium content in the second part of the solid dosage form;

and the solid dosage form contains calcium, and the calcium content in the first part of the solid dosage form is less than 1.001-10 times lower than the calcium content in the second part of the solid dosage form.

14. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (01+ 02) / O = 0.9-1.0;

B = | O1-021/0 = 0 + 0.1, while the solid dosage form contains iron, and the iron content in the first part of the solid dosage form is 1.001-10 times greater than the iron content in the second part of the solid dosage form;

and the solid dosage form contains zinc, and the zinc content in the first part of the solid dosage form is 1.001-10 times lower than the zinc content in the second part of the solid dosage form.

15. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, minerals, and a solid dosage form made with the possibility of separation into parts to obtain two parts for which the conditions are met

K = (O1 + 02) / O = 0.9-1.0;

B = | O1-02 | / 0 = 0 + 0.1, while the solid dosage form contains cobalt, and the cobalt content in the first part of the solid dosage form is 1.001-10 times greater than the cobalt content in the second part of the solid dosage form;

and the solid dosage form contains molybdenum, and the molybdenum content in the first part of the solid dosage form is less than 1.001-10 times lower than the molybdenum content in the second part of the solid dosage form.

Thus, the implementation of the claimed solid dosage forms provides: an increase in the rate of onset of the therapeutic effect (decrease in the onset of the therapeutic effect) while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder;

an increase in the therapeutic effect while maintaining the duration of action without increasing the concentration of bile in the treatment of diseases of the liver and gall bladder.

- 30 020148

Table 1. The mineral composition of Allochol tablets of various manufacturers

Minerals Mineral content (in milligrams) per kilogram of solid dosage form (mg / kg) sodium, mg / kg 41256.0 *) calcium, mg / kg 21340.0 magnesium, mg / kg 31680.0 silicon, mg / kg 159.0 titanium, mg / kg 27.0

*) the average value after studies of Allohol tablets from 26 different packs. The scatter of values ranged from 0.1 to 4%.

Table 2. Solid dosage form with dried bile and minerals

Minerals mg / kg The serial number of the solid dosage form with 25 grams of dried bile and minerals, mg / kg G " 2 3 4 5 6 7 8 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 10 56 135 195 231 310 manganese 0.03 0.3 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molybdenum 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

*) the numbering of solid dosage forms is through.

Table 3. A solid dosage form with dried bile, minerals and a ratio of ¹³ C carbon isotopes to the total amount of carbon (carbon isotopes) in solid dosage form is 0.003

Minerals mg / kg The serial number of the solid dosage form with 25 grams of dried bile and minerals, mg / kg nine 10 eleven 12 thirteen 14 fifteen sixteen sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molyb den 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

- 31 020148

Table 4. A solid dosage form with dried bile, minerals and a ratio of ¹³ C carbon isotopes to the total amount of carbon (carbon isotopes) in solid dosage form is 0.75

Minerals mg / kg The serial number of the solid dosage form with 25 grams of dried bile and minerals, mg / kg 17 eighteen nineteen twenty 21 22 23 24 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molyb den 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

Table 5. Solid dosage form with dried bile and minerals

Minerals mg / kg The serial number of the solid dosage form with 267 grams of dried bile and minerals, mg / kg 25 26 27 28 29th thirty 31 32 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molyb den 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

- 32 020148

Table 6. A solid dosage form with dried bile, minerals, and a ratio of ¹³ C carbon isotopes to total carbon (carbon isotopes) in solid dosage form is 0.003

Minerals mg / kg The serial number of the solid dosage form with 267 grams of dried bile and minerals, mg / kg 33 34 35 36 37 38 39 40 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molyb den 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

Table 7. A solid dosage form with dried bile, minerals and a ratio of ¹³ C carbon isotopes to the total carbon (carbon isotopes) in solid dosage form is 0.75

Minerals mg / kg The serial number of the solid dosage form with 267 grams of dried bile and minerals, mg / kg 41 42 43 44 45 46 47 48 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molybdenum 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

- 33 020148

Table 8. Solid dosage form with dried bile and minerals

Minerals mg / kg The serial number of the solid dosage form with 625 grams of dried bile and minerals, mg / kg 49 fifty 51 52 53 54 55 56 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molyb den 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

Table 9. A solid dosage form with dried bile, minerals and a ratio of ¹³ C carbon isotopes to the total amount of carbon (carbon isotopes) in solid dosage form is 0.003

Minerals mg / kg The serial number of the solid dosage form with 625 grams of dried bile and minerals, mg / kg 57 58 59 60 61 62 63 64 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molybdenum 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

- 34 020148

Table 10. A solid dosage form with dried bile, minerals and a ratio of ¹³ C carbon isotopes to the total carbon (carbon isotopes) in solid dosage form is 0.75

Mine- Serial number of solid dosage form with 625 grams of dried dried bile and minerals, mg / kg

substances mg / kg 65 66 67 68 69 70 71 72 sodium 1050 1550 10,000 36187 105000 120,000 130 100 140,000 potassium 120 320 1200 4817 15300 17050 19030 20000 calcium 550 725 2300 18900 41500 52500 61350 67000 magnesium 970 1350 10050 27600 63150 75,000 83340 95000 iron 0.3 one 10 56 135 195 231 310 manganese 0.03 0.3 one 3.2 35 55 73.8 95 zinc 0.35 one 5 48.5 320 380 571 670 copper 0.035 0.1 one 5.0 21 42 65.1 75 cobalt chromium 0.008 0.015 0.5 0.7 6.5 9.7 11.59 fifteen molybdenum 0.007 0.01 0.1 0.44 5 8.5 14.45 nineteen

Table 11. Hybrid (with the possibility of separation into two parts) solid dosage form with dried bile, minerals and carbon isotopes ¹³ C equal

Components of the solid dosage form, mg / kg Hybrid Solid Dosage Form Number G1 G2 GZ G4 G1-1 G1-2 G2-1 G2-2 GZ-1 GZ-2 G4-1 G4-2 dried bile 2510 ³ 2510 ³ 62510 ³ 625 10 ³ 25 10 ³ “625Ϊ0 ³ ” 25 10 ³ 3510 ³ sodium 1550 105000 1550 105000 1550 105000 1550 100,000 potassium 320 15300 320 15300 320 15300 320 15,000 calcium 725 41500 725 41500 725 41500 725 40500 magnesium 1350 63150 1350 63150 1350 63150 1350 62050 iron one 135 one 135 one 135 one 125 manganese 0.3 35 0.3 35 0.3 35 0.3 25 zinc one 320 one 320 one 320 one 320 copper 0.1 21 0.1 21 0.1 21 0.1 twenty cobalt chromium 0.015 6.5 0.015 6.5 0.015 6.5 0.015 6.0 molybdenum 0.01 5 0.01 5 0.01 5 0.01 5.9 ^H S.% 75 75 fifty 75 75 75 75 10

Note.

G1 is the serial number of the hybrid solid dosage form. G1-1 is the serial number of the first part of the hybrid solid dosage form. G1-2 - serial number of the second part of the hybrid solid dosage form.

- 35 020148

Table 12. Hybrid (with the possibility of separation into two parts) solid dosage form with dried bile, minerals and carbon isotopes ¹³ With equal

Components of the solid dosage form, mg / kg Hybrid Solid Dosage Form Number G5 GB G7 G8 G5-1 G5-2 GB-1 GB-2 G7-1 G7-2 G8-1 G8-2 dried bile 25 10 ³ 25 10 ³ 62510 ³ 625 10 ³ 62510 ³ 625 10 ³ 8510 ³ 3510 ³ sodium 1550 1555 104200 105000 1550 1650 1550 100,000 potassium 320 330 15,000 15300 320 360 320 15,000 calcium 725 735 41000 41500 725 825 725 40500 magnesium 1350 1370 63100 63150 1350 1550 1350 62050 iron one 10.6 130 135 one 1.9 one 125 manganese 0.3 0.9 thirty 35 0.3 0.8 0.3 25 zinc one 1.8 300 320 one 1.9 one 320 copper 0.1 0.9 twenty 21 0.1 0.18 0.1 twenty cobalt chromium 0.015 0. 15 6.0 6.5 0.015 0.15 0.015 6.0 molybdenum 0.01 0.1 4.5 5 0.01 0.1 0.01 5.9 ¹³ C,% 75 70 55 75 55 75 fifteen 10

CLAIM

Claims (2)

1. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances in the following ratio of components in mg / kg: dried bile - 25 I O ³ - 625 10 ³ ; sodium - 1550.0 - 105000.0; potassium - 320.0-15300.0; calcium-725.0-41500.0; magnesium -1350.0-63150.0; iron - 1.0 - 135.0; Manganese - 0.3 - 35.0; zinc 1.0-320.0; copper-0.1 -21.0; chromium 0.015-6.5; molybdenum - 0.01 - 5.0. 2. A solid dosage form having a choleretic effect, made in the form of a tablet containing dried bile, mineral substances in the following ratio of components in mg / kg: - 36 020148 dried bile - 25 10 ³ - 625 1 0 ³ ; sodium - 1550.0 - 105000.0; potassium - 320.0-15300.0; calcium - 725.0 - 41500.0; magnesium - 1350.0 - 63150.0; iron - 1.0-135.0; Manganese - 0.3 - 35.0; zinc 1.0-320.0; copper - 0.1 - 21.0; chromium -0.015 -6.5; molybdenum is 0.01 - 5.0, and the solid dosage form contains ¹³ C carbon isotopes, and the ratio of ¹³ C carbon isotopes to the total carbon in the solid dosage form is from 0.003 to 0.75.