DOP2017000189A - BENZOXABOROL COMPOUNDS AND USES OF THE SAME - Google Patents
BENZOXABOROL COMPOUNDS AND USES OF THE SAMEInfo
- Publication number
- DOP2017000189A DOP2017000189A DO2017000189A DO2017000189A DOP2017000189A DO P2017000189 A DOP2017000189 A DO P2017000189A DO 2017000189 A DO2017000189 A DO 2017000189A DO 2017000189 A DO2017000189 A DO 2017000189A DO P2017000189 A DOP2017000189 A DO P2017000189A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- same
- structure comprises
- whose structure
- formula iii
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Se proporcionan compuestos cuya estructura comprende la fórmula II: Fórmula II: o un compuesto cuya estructura comprende la fórmula III: Fórmula III en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, CH2CH2CH3, o -CH(CH3)2; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.Provided are compounds whose structure comprises formula II: Formula II: or a compound whose structure comprises formula III: Formula III wherein X is selected from chlorine, fluorine, bromine and iodine, R1 and R2 are each independently selected from starting from H, -CH3, -CH2CH3, -CH2CH2CH3, or -CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example, in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of these compounds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382055 | 2015-02-12 | ||
| EP15382054 | 2015-02-12 | ||
| EP15382056 | 2015-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2017000189A true DOP2017000189A (en) | 2018-02-15 |
Family
ID=55409879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2017000189A DOP2017000189A (en) | 2015-02-12 | 2017-08-10 | BENZOXABOROL COMPOUNDS AND USES OF THE SAME |
| DO2017000188A DOP2017000188A (en) | 2015-02-12 | 2017-08-10 | BENZOXABOROL 4-SUBSTITUTED COMPOUNDS AND USE OF THE SAME |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2017000188A DOP2017000188A (en) | 2015-02-12 | 2017-08-10 | BENZOXABOROL 4-SUBSTITUTED COMPOUNDS AND USE OF THE SAME |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US10774096B2 (en) |
| EP (2) | EP3256479B1 (en) |
| JP (2) | JP2018506540A (en) |
| KR (2) | KR20170117156A (en) |
| CN (2) | CN107531730B (en) |
| AU (3) | AU2016217507B2 (en) |
| BR (2) | BR112017017213A2 (en) |
| CA (2) | CA2976030C (en) |
| CL (2) | CL2017002060A1 (en) |
| CO (2) | CO2017008809A2 (en) |
| CR (2) | CR20170371A (en) |
| CY (1) | CY1123687T1 (en) |
| DK (1) | DK3256479T3 (en) |
| DO (2) | DOP2017000189A (en) |
| EA (2) | EA036516B1 (en) |
| ES (1) | ES2821951T3 (en) |
| HR (1) | HRP20201597T1 (en) |
| HU (1) | HUE051113T2 (en) |
| IL (2) | IL253865A0 (en) |
| LT (1) | LT3256479T (en) |
| MA (2) | MA41494B1 (en) |
| MX (2) | MX2017010414A (en) |
| MY (1) | MY194004A (en) |
| NZ (1) | NZ734379A (en) |
| PE (2) | PE20171348A1 (en) |
| PH (2) | PH12017501428A1 (en) |
| PL (1) | PL3256479T3 (en) |
| PT (1) | PT3256479T (en) |
| RS (1) | RS60885B1 (en) |
| SG (2) | SG11201706510YA (en) |
| SI (1) | SI3256479T1 (en) |
| TW (2) | TWI730953B (en) |
| UA (1) | UA120527C2 (en) |
| WO (2) | WO2016128949A1 (en) |
| ZA (1) | ZA201705456B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3030519T3 (en) * | 2013-08-09 | 2022-01-31 | Glaxosmithkline Ip No 2 Ltd | Tricyclic benzoxaborol compounds and uses thereof |
| AU2018265192B2 (en) * | 2017-05-08 | 2021-06-17 | Glaxosmithkline Intellectual Property Development Limited | Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection |
| US11834466B2 (en) | 2017-11-30 | 2023-12-05 | 5Metis, Inc. | Benzoxaborole compounds and formulations thereof |
| CN112867494A (en) | 2018-08-18 | 2021-05-28 | 博瑞金股份有限公司 | Solid forms of substituted benzoxaboroles and compositions thereof |
| CN110441344B (en) * | 2019-06-25 | 2020-09-29 | 北京大学 | Method for detecting RNA structure based on solid nuclear magnetic resonance technology |
| WO2023246842A1 (en) * | 2022-06-23 | 2023-12-28 | Shanghai Micurx Pharmaceutical Co., Ltd. | Prodrugs of boron compounds and their use in treating bacterial infections |
| WO2023246841A1 (en) * | 2022-06-23 | 2023-12-28 | Shanghai Micurx Pharmaceutical Co., Ltd. | Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| WO1998024753A1 (en) | 1996-12-02 | 1998-06-11 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same |
| DE60313357T2 (en) | 2002-12-02 | 2008-01-03 | Solvias Ag | METHOD FOR THE CATALYTIC HYDROGENATION OF CARBON HETEROATOM DOUBLE BINDINGS |
| SI2343304T1 (en) | 2005-02-16 | 2015-08-31 | Anacor Pharmaceuticals, Inc. | Biocidal boronophthalide compounds |
| WO2006096131A1 (en) | 2005-03-08 | 2006-09-14 | Agency For Science, Technology And Research | Chiral bisoxazoline catalysts |
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
| TWM325238U (en) * | 2006-12-29 | 2008-01-11 | Universal Scient Ind Co Ltd | Voltage regulator and voltage regulating system |
| KR100848491B1 (en) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 2-thiazolidine derivatives having beta;-amino group, pharmaceutical acceptable salts and preparation process thereof |
| JO3396B1 (en) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
| US8461364B2 (en) | 2008-12-17 | 2013-06-11 | Glaxosmithkline Llc | Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[C][1,2]oxaborol-1-OL |
| WO2011037731A1 (en) * | 2009-09-25 | 2011-03-31 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| CA2794684C (en) * | 2010-04-07 | 2018-04-24 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| SG10201507032YA (en) * | 2010-09-07 | 2015-10-29 | Anacor Pharmaceuticals Inc | Benzoxaborole derivatives for treating bacterial infections |
| WO2013093615A1 (en) | 2011-12-22 | 2013-06-27 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| CN102739587B (en) | 2012-06-16 | 2014-05-21 | 天地融科技股份有限公司 | Audio data transmission method |
| KR101636431B1 (en) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | Tricyclic benzoxaborole compound, process preparing thereof and use thereof |
| DK3030519T3 (en) | 2013-08-09 | 2022-01-31 | Glaxosmithkline Ip No 2 Ltd | Tricyclic benzoxaborol compounds and uses thereof |
-
2016
- 2016-02-11 MA MA41494A patent/MA41494B1/en unknown
- 2016-02-11 MA MA041495A patent/MA41495A/en unknown
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/en active
- 2016-02-12 SI SI201630941T patent/SI3256479T1/en unknown
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/en active Active
- 2016-02-12 CA CA2976030A patent/CA2976030C/en active Active
- 2016-02-12 PT PT167060029T patent/PT3256479T/en unknown
- 2016-02-12 EA EA201791671A patent/EA036516B1/en unknown
- 2016-02-12 CR CR20170371A patent/CR20170371A/en unknown
- 2016-02-12 ES ES16706002T patent/ES2821951T3/en active Active
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/en not_active Application Discontinuation
- 2016-02-12 RS RS20201204A patent/RS60885B1/en unknown
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/en active Pending
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/en active Active
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 PL PL16706002T patent/PL3256479T3/en unknown
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/en not_active Application Discontinuation
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/en active Pending
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/en unknown
- 2016-02-12 CA CA2976308A patent/CA2976308A1/en not_active Abandoned
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en active Active
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 MX MX2017010413A patent/MX2017010413A/en unknown
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/en unknown
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 CR CR20170372A patent/CR20170372A/en unknown
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/en active Application Filing
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/en unknown
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/en not_active Application Discontinuation
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/en active Active
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en unknown
- 2016-02-12 EA EA201791667A patent/EA201791667A1/en unknown
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/en active IP Right Grant
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/en unknown
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/en active Application Filing
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 UA UAA201708405A patent/UA120527C2/en unknown
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/en not_active Withdrawn
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/en not_active Application Discontinuation
- 2016-02-15 TW TW105104376A patent/TWI730953B/en not_active IP Right Cessation
- 2016-02-15 TW TW105104422A patent/TW201702250A/en unknown
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2017
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/en unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/en unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/en unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/en unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/en unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/en unknown
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2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en active Active
- 2020-10-07 HR HRP20201597TT patent/HRP20201597T1/en unknown
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/en unknown
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