DOP2010000403A - A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD - Google Patents
A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOODInfo
- Publication number
- DOP2010000403A DOP2010000403A DO2010000403A DO2010000403A DOP2010000403A DO P2010000403 A DOP2010000403 A DO P2010000403A DO 2010000403 A DO2010000403 A DO 2010000403A DO 2010000403 A DO2010000403 A DO 2010000403A DO P2010000403 A DOP2010000403 A DO P2010000403A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- salt
- glycinate
- hydrochloride
- exhibits
- metformin
- Prior art date
Links
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a la síntesis de una nueva sal de Glicinato 1,1- dimetilbiguanid, llamada Glicinato de Metformina diseñada para el control de la glucosa en sangre. Esta sal exhibe ventajas sobre otras sales de metformina. Estas ventajas se refieren, en primer lugar, al hecho de que el contraión exhibe efectos hipoglucemientes por sí mismos, el efecto hipoglucemiente es más pronunciado. Además esta sal exhibe una mejor absorción, alcanzando una concentración plasmática más alta que aquella producida con clorhidrato de metfromina. La síntesis se llevó a cabo a partir de clorhidrato de mefformina liberando el contraión hidrocloruro, usando una columna de intercambio iónico, la mefformina liberada se disolvió en medio acuoso y subsecuentemente se adicionó glicina a temperatura ambiente y agitación constante, el producto resultante se calienta produciendo una solución concentrada del producto, se adiciona un solvente orgánico para crear insolubilidad y favorecer la cristalización en un medio saturado, el exceso de glicina precipita y se obtiene la sal glicinato de metfromina después de filtrar y concentrar dicha sal. La sal Glicinato de Metformina presenta un efecto farmacológico más pronunciado en la reducción de los niveles de glucosa en sangre.The present invention relates to the synthesis of a new 1,1-dimethylbiguanid glycinate salt, called Metformin glycinate designed for the control of blood glucose. This salt exhibits advantages over other metformin salts. These advantages refer, first of all, to the fact that the counterion exhibits hypoglycemic effects on their own, the hypoglycemic effect is more pronounced. In addition, this salt exhibits a better absorption, reaching a higher plasma concentration than that produced with metfromine hydrochloride. The synthesis was carried out from mefformin hydrochloride releasing the hydrochloride counterion, using an ion exchange column, the released mefformin was dissolved in aqueous medium and subsequently glycine was added at room temperature and constant stirring, the resulting product was heated producing A concentrated solution of the product, an organic solvent is added to create insolubility and promote crystallization in a saturated medium, the excess glycine precipitates and the methaphromine glycinate salt is obtained after filtering and concentrating said salt. Metformin glycinate salt has a more pronounced pharmacological effect in reducing blood glucose levels.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2010000403A DOP2010000403A (en) | 2010-12-23 | 2010-12-23 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2010000403A DOP2010000403A (en) | 2010-12-23 | 2010-12-23 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2010000403A true DOP2010000403A (en) | 2011-05-15 |
Family
ID=44279252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2010000403A DOP2010000403A (en) | 2010-12-23 | 2010-12-23 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Country Status (1)
Country | Link |
---|---|
DO (1) | DOP2010000403A (en) |
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2010
- 2010-12-23 DO DO2010000403A patent/DOP2010000403A/en unknown
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