DOP2010000137A - 1,2,3-TRIAZOL DERIVATIVES AS INHIBITORS FROM ESTEAROIL-COENZIMA TO DESATURASA - Google Patents

1,2,3-TRIAZOL DERIVATIVES AS INHIBITORS FROM ESTEAROIL-COENZIMA TO DESATURASA

Info

Publication number
DOP2010000137A
DOP2010000137A DO2010000137A DO2010000137A DOP2010000137A DO P2010000137 A DOP2010000137 A DO P2010000137A DO 2010000137 A DO2010000137 A DO 2010000137A DO 2010000137 A DO2010000137 A DO 2010000137A DO P2010000137 A DOP2010000137 A DO P2010000137A
Authority
DO
Dominican Republic
Prior art keywords
desaturasa
coenzima
estearoil
inhibitors
triazol derivatives
Prior art date
Application number
DO2010000137A
Other languages
Spanish (es)
Inventor
Anne Marie Jeanne Bouillot
Alain Laroze
Lionel Trottet
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of DOP2010000137A publication Critical patent/DOP2010000137A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The present invention relates to substituted triazole compounds of the formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.
DO2010000137A 2007-11-09 2010-05-07 1,2,3-TRIAZOL DERIVATIVES AS INHIBITORS FROM ESTEAROIL-COENZIMA TO DESATURASA DOP2010000137A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0722077.5A GB0722077D0 (en) 2007-11-09 2007-11-09 Compounds

Publications (1)

Publication Number Publication Date
DOP2010000137A true DOP2010000137A (en) 2010-08-15

Family

ID=38858481

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000137A DOP2010000137A (en) 2007-11-09 2010-05-07 1,2,3-TRIAZOL DERIVATIVES AS INHIBITORS FROM ESTEAROIL-COENZIMA TO DESATURASA

Country Status (32)

Country Link
US (2) US8486977B2 (en)
EP (2) EP2207770B1 (en)
JP (1) JP5491407B2 (en)
KR (1) KR101577080B1 (en)
CN (1) CN101918376B (en)
AT (1) ATE512140T1 (en)
AU (1) AU2008324172B2 (en)
BR (1) BRPI0820471A2 (en)
CA (1) CA2705113C (en)
CO (1) CO6270331A2 (en)
CR (1) CR11482A (en)
CY (2) CY1112233T1 (en)
DK (2) DK2207770T3 (en)
DO (1) DOP2010000137A (en)
EA (1) EA016621B1 (en)
ES (2) ES2366422T3 (en)
GB (1) GB0722077D0 (en)
HK (2) HK1141528A1 (en)
HR (2) HRP20110552T1 (en)
IL (1) IL205152A (en)
MA (1) MA31801B1 (en)
ME (1) ME01962B (en)
MX (1) MX2010005187A (en)
MY (1) MY163126A (en)
NZ (1) NZ584725A (en)
PL (2) PL2207770T3 (en)
PT (2) PT2368887E (en)
RS (2) RS51918B (en)
SI (2) SI2207770T1 (en)
UA (1) UA107324C2 (en)
WO (1) WO2009060053A1 (en)
ZA (1) ZA201002596B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0722075D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0722077D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
CN102159605B (en) * 2008-09-15 2014-01-08 大金工业株式会社 Aqueous polymer dispersion composition and surface treatment agent
BRPI0920237A2 (en) * 2008-10-21 2015-12-29 Metabolex Inc aril gpr120 receptor agonists and their respective uses
FR2974089B1 (en) * 2011-04-18 2014-04-25 Univ Nice Sophia Antipolis ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS COMPRISING THEM, THEIR THERAPEUTIC USES AND METHODS OF SYNTHESIS.
US9233102B2 (en) 2012-03-07 2016-01-12 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
ES2605632T3 (en) * 2012-09-17 2017-03-15 F. Hoffmann-La Roche Ag Triazole carboxamide derivatives
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Anti-aging compositions comprising bile acid and fatty acid conjugates
JP6728198B2 (en) 2015-01-30 2020-07-22 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Substituted triazoles and methods relating thereto
KR20180036318A (en) * 2016-09-30 2018-04-09 경북대학교 산학협력단 Composition for preventing or treating neurodegenerative disease comprising derivatives of 2-amino-2-(1-dodecyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol
CN110099898B (en) 2016-10-24 2023-07-25 优曼尼蒂治疗公司 Compounds and uses thereof
IL304017A (en) * 2017-01-06 2023-08-01 Yumanity Therapeutics Inc Methods for the treatment of neurological disorders
KR102292989B1 (en) 2017-03-29 2021-08-26 재단법인 아산사회복지재단 Composition for preventing and treating nonalcoholic steatohepatitis by targeting S1PR4
EP3700934A4 (en) 2017-10-24 2021-10-27 Yumanity Therapeutics, Inc. Compounds and uses thereof
EP3784234A1 (en) 2018-04-25 2021-03-03 Yumanity Therapeutics, Inc. Compounds and uses thereof
KR102017324B1 (en) * 2018-04-30 2019-09-02 경북대학교 산학협력단 Novel ASM direct inhibition compound 2-amino-2-(1,2,3-triazol-4-yl)propane-1,3-diol derivatives and uses thereof
CA3127791A1 (en) 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Compounds and uses thereof
CN114656414B (en) * 2022-05-24 2022-08-23 常熟华虞环境科技有限公司 Triazole modified titanium dioxide photocatalyst and preparation method thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722941A (en) 1978-06-07 1988-02-02 Kali-Chemie Pharma Gmbh Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof
US4460372A (en) 1981-02-17 1984-07-17 Alza Corporation Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer
US4573996A (en) 1984-01-03 1986-03-04 Jonergin, Inc. Device for the administration of an active agent to the skin or mucosa
US4624665A (en) 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US5223261A (en) 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US20070087363A1 (en) 1998-12-22 2007-04-19 Myriad Genetics, Incorporated Therapeutic methods, compounds and compositions
US6987001B2 (en) 2000-02-24 2006-01-17 Xenon Pharmaceuticals Inc. Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
US7232662B2 (en) 2000-09-26 2007-06-19 Xenon Pharmaceuticals Inc. Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5
PE20040600A1 (en) * 2002-04-26 2004-09-15 Lilly Co Eli TRIAZOLE DERIVATIVES AS ANTAGONISTS OF THE TACHYCININ RECEPTOR
US20060160794A1 (en) * 2003-06-12 2006-07-20 Amegadzie Albert K Tachykinin receptor antagonists
ATE532772T1 (en) * 2003-07-30 2011-11-15 Xenon Pharmaceuticals Inc PIPERAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
KR20060037410A (en) 2003-07-30 2006-05-03 제논 파마슈티칼스 인크. Pyridazine derivatives and their use as therapeutic agents
WO2007046867A2 (en) 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Piperidine derivatives and their uses as therapeutic agents
WO2007046868A2 (en) 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Thiazolidine derivatives and their uses as therapeutic agents
WO2008073461A2 (en) * 2006-12-11 2008-06-19 Wyeth Ion channel modulators
GB0625604D0 (en) * 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
GB0625654D0 (en) * 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
GB0625605D0 (en) * 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
WO2008104524A1 (en) * 2007-02-28 2008-09-04 Smithkline Beecham Corporation Thiadiazole derivatives, inhibitors of stearoyl-coa desaturase
US20100137312A1 (en) * 2007-05-15 2010-06-03 Neurosearch A/S Novel aromatic heterocyclic carboxylic acid amide derivatives useful as potassium channel modulators
GB0714129D0 (en) 2007-07-19 2007-08-29 Smithkline Beecham Corp compounds
GB0715055D0 (en) 2007-08-02 2007-09-12 Smithkline Beecham Corp Compounds
GB0721419D0 (en) 2007-10-31 2007-12-12 Smithkline Beecham Corp Compounds
GB0722075D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0722077D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
GB0810913D0 (en) 2008-06-13 2008-07-23 Smithkline Beecham Corp Comppounds

Also Published As

Publication number Publication date
US8486977B2 (en) 2013-07-16
AU2008324172B2 (en) 2012-03-15
PT2368887E (en) 2014-05-15
EP2368887B1 (en) 2014-02-26
KR20100095574A (en) 2010-08-31
EP2207770B1 (en) 2011-06-08
BRPI0820471A2 (en) 2015-06-16
CA2705113C (en) 2016-01-05
HRP20110552T1 (en) 2011-09-30
ES2457521T3 (en) 2014-04-28
IL205152A0 (en) 2010-11-30
NZ584725A (en) 2012-05-25
RS53294B (en) 2014-08-29
PT2207770E (en) 2011-09-01
CR11482A (en) 2010-07-09
PL2207770T3 (en) 2011-10-31
DK2368887T3 (en) 2014-04-14
CY1115058T1 (en) 2016-12-14
KR101577080B1 (en) 2015-12-11
ATE512140T1 (en) 2011-06-15
AU2008324172A1 (en) 2009-05-14
MA31801B1 (en) 2010-10-01
CY1112233T1 (en) 2015-12-09
UA107324C2 (en) 2014-12-25
SI2207770T1 (en) 2011-09-30
HK1160467A1 (en) 2012-08-17
EA016621B1 (en) 2012-06-29
WO2009060053A1 (en) 2009-05-14
ES2366422T3 (en) 2011-10-20
HRP20140346T1 (en) 2014-05-09
ZA201002596B (en) 2010-12-29
DK2207770T3 (en) 2011-09-12
RS51918B (en) 2012-02-29
CO6270331A2 (en) 2011-04-20
US20130281499A1 (en) 2013-10-24
GB0722077D0 (en) 2007-12-19
EA201070588A1 (en) 2010-10-29
EP2368887B8 (en) 2014-04-16
EP2368887A1 (en) 2011-09-28
EP2207770A1 (en) 2010-07-21
JP5491407B2 (en) 2014-05-14
MX2010005187A (en) 2010-05-27
CA2705113A1 (en) 2009-05-14
US20100297054A1 (en) 2010-11-25
PL2368887T3 (en) 2014-07-31
CN101918376B (en) 2013-11-06
SI2368887T1 (en) 2014-05-30
MY163126A (en) 2017-08-15
US9051281B2 (en) 2015-06-09
JP2011503031A (en) 2011-01-27
HK1141528A1 (en) 2010-11-12
CN101918376A (en) 2010-12-15
ME01962B (en) 2012-02-29
IL205152A (en) 2013-10-31

Similar Documents

Publication Publication Date Title
DOP2010000137A (en) 1,2,3-TRIAZOL DERIVATIVES AS INHIBITORS FROM ESTEAROIL-COENZIMA TO DESATURASA
WO2008074824A3 (en) Isoquinolinecarboxamides as inhibitors of stearoyl-coa desaturase (scd)
GEP20125487B (en) Organic compounds and their use
WO2008074834A3 (en) Isoquinolinecarboxamides as inhibitors of stearoyl-coa desaturase (scd)
CY1112429T1 (en) Substituted Sulfonamide Derivatives
SV2011004077A (en) AMINOBUTIRIC DERIVATIVES REPLACED AS NEPRILISINE INHIBITORS
MX2009011997A (en) Pyrrolopyrimidin-7-one derivatives and their use as pharmaceuticals.
NO20076197L (en) New 2-azetidinone derivatives useful in the treatment of hyperlipidemic conditions
TW200626158A (en) Naphthaline derivatives
WO2008074832A3 (en) Isoquinolinecarboxamides as inhibitors of stearoyl-coa desaturase ( scd)
MX2009013501A (en) Piperidine compounds and uses thereof.
DOP2011000134A (en) WE REACT AS BETA SECRETASA INHIBITORS
DE602004008959D1 (en) BENZOÄBÜÄ1,4ÜDIOXEPINDERIVATE
WO2008074833A3 (en) Compounds
MX2008012093A (en) New therapeutic combinations for the treatment or prevention of psychotic disorders.
TW200800993A (en) Organic compounds
MX2009005242A (en) 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof.
GEP20125640B (en) Phenanthrenone compounds, compositions containing them and use thereof