DOP2009000038A - BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES - Google Patents

BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES

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Publication number
DOP2009000038A
DOP2009000038A DO2009000038A DO2009000038A DOP2009000038A DO P2009000038 A DOP2009000038 A DO P2009000038A DO 2009000038 A DO2009000038 A DO 2009000038A DO 2009000038 A DO2009000038 A DO 2009000038A DO P2009000038 A DOP2009000038 A DO P2009000038A
Authority
DO
Dominican Republic
Prior art keywords
treatment
disease
oxazolopiridins
benzoxazoles
inhibitors
Prior art date
Application number
DO2009000038A
Other languages
Spanish (es)
Inventor
Marc Gerspacher
Pascal Furet
Eric Vangrevelinghe
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority to DO2009000038A priority Critical patent/DOP2009000038A/en
Publication of DOP2009000038A publication Critical patent/DOP2009000038A/en

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Abstract

La invención se refiere a compuesto de benzoxazol 2.7- disustituido y oxazolo-[5,4-c[-piridina 2,4-disustituida de la fórmula I que se da más adelante, así como a sales de los mismos, a procesos para su preparación, a la aplicación de los mismos en un proceso para el tratamiento del cuerpo humano o animal, estos compuestos para utilizarse en el tratamiento (incluyendo profilaxis) del cuerpo del animal, en especial hmano (especialmente con respecto a una enfermedad proliferativa), el uso de los mismos - solos o en combinación con uno o más compuestos farmacéuticamente activos diferentes - para el tratamiento en especial de una enfermedad mediada por la cinasa de proteína tirosina (tal como una enfermedad tumoral) o para la fabricación de una preparación farmacéutica para utilizarse en el tratamiento de esta enfermedad, un método para el tratamiento de esta enfermedad y una preparación farmac?0utica para el tratamiento de una enfermedad como se menciona. Los compuestps son de fórmula I: en donde los símbolos son como se definen en la descripción. Los compuestos inhiben, por ejemplo, JAK2 y JAK3.The invention relates to benzoxazole 2.7-disubstituted and oxazolo- [5,4-c [-pyridine 2,4-disubstituted compound of the formula I below, as well as salts thereof, to processes for its preparation, to the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal's body, especially human (especially with respect to a proliferative disease), the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the special treatment of a tyrosine protein kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation for use in the treatment of this disease, a method for the treatment of this disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compuestps are of formula I: where the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.

DO2009000038A 2009-03-10 2009-03-10 BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES DOP2009000038A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DO2009000038A DOP2009000038A (en) 2009-03-10 2009-03-10 BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DO2009000038A DOP2009000038A (en) 2009-03-10 2009-03-10 BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES

Publications (1)

Publication Number Publication Date
DOP2009000038A true DOP2009000038A (en) 2009-03-31

Family

ID=44261547

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2009000038A DOP2009000038A (en) 2009-03-10 2009-03-10 BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES

Country Status (1)

Country Link
DO (1) DOP2009000038A (en)

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