DOP2009000038A - BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES - Google Patents
BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASESInfo
- Publication number
- DOP2009000038A DOP2009000038A DO2009000038A DO2009000038A DOP2009000038A DO P2009000038 A DOP2009000038 A DO P2009000038A DO 2009000038 A DO2009000038 A DO 2009000038A DO 2009000038 A DO2009000038 A DO 2009000038A DO P2009000038 A DOP2009000038 A DO P2009000038A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- treatment
- disease
- oxazolopiridins
- benzoxazoles
- inhibitors
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuesto de benzoxazol 2.7- disustituido y oxazolo-[5,4-c[-piridina 2,4-disustituida de la fórmula I que se da más adelante, así como a sales de los mismos, a procesos para su preparación, a la aplicación de los mismos en un proceso para el tratamiento del cuerpo humano o animal, estos compuestos para utilizarse en el tratamiento (incluyendo profilaxis) del cuerpo del animal, en especial hmano (especialmente con respecto a una enfermedad proliferativa), el uso de los mismos - solos o en combinación con uno o más compuestos farmacéuticamente activos diferentes - para el tratamiento en especial de una enfermedad mediada por la cinasa de proteína tirosina (tal como una enfermedad tumoral) o para la fabricación de una preparación farmacéutica para utilizarse en el tratamiento de esta enfermedad, un método para el tratamiento de esta enfermedad y una preparación farmac?0utica para el tratamiento de una enfermedad como se menciona. Los compuestps son de fórmula I: en donde los símbolos son como se definen en la descripción. Los compuestos inhiben, por ejemplo, JAK2 y JAK3.The invention relates to benzoxazole 2.7-disubstituted and oxazolo- [5,4-c [-pyridine 2,4-disubstituted compound of the formula I below, as well as salts thereof, to processes for its preparation, to the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal's body, especially human (especially with respect to a proliferative disease), the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the special treatment of a tyrosine protein kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation for use in the treatment of this disease, a method for the treatment of this disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compuestps are of formula I: where the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2009000038A DOP2009000038A (en) | 2009-03-10 | 2009-03-10 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2009000038A DOP2009000038A (en) | 2009-03-10 | 2009-03-10 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2009000038A true DOP2009000038A (en) | 2009-03-31 |
Family
ID=44261547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2009000038A DOP2009000038A (en) | 2009-03-10 | 2009-03-10 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Country Status (1)
Country | Link |
---|---|
DO (1) | DOP2009000038A (en) |
-
2009
- 2009-03-10 DO DO2009000038A patent/DOP2009000038A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PA8748101A1 (en) | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES | |
NI201000145A (en) | DERIVATIVES OF IMIDAZINE - [1, 2-b] - PYRIDAZINE FOR THE TREATMENT OF DISEASE MEDIATED BY TYROSINE KINASE C-MET. | |
UY32302A (en) | HETEROBICYCLIC CARBOXAMIDS AS KINASE INHIBITORS | |
PA8680701A1 (en) | OXINDOL DERIVATIVES | |
PE20170666A1 (en) | 2- (MORFOLIN-4-IL) -1,7-NAPHTHYRIDINES | |
ECSP13012752A (en) | IMIDAZOPIRIDAZINAS REPLACED | |
UY29199A1 (en) | TIAZOL DERIVATIVES, COMPOSITIONS THAT CONTAIN THEM, PREPARATION PROCEDURES AND APPLICATIONS | |
BR112015028879A8 (en) | heterocyclic derivative compounds, pharmaceutical composition comprising said compounds and uses thereof | |
ECSP077324A (en) | BICYCLIC AMIDAS AS INHIBITORS OF CINASA | |
UY32462A (en) | NEW BIFENYLL DERIVATIVES FOR HEPATITIS C 644 VIRUS INFECTION TREATMENT | |
ECSP109935A (en) | PYRIMIDINE MORFOLINE DERIVATIVES USED IN DISEASES RELATED TO MTOR QUINASA AND / OR PI3K | |
UY28059A1 (en) | NEW DERIVATIVES OF DIHYDROPIRIMIDO (4,5-D) PYRIMIDONE REPLACED BY AMINO. MANUFACTURE AND USE OF THE SAME AS PHARMACEUTICAL AGENTS. | |
AR071873A1 (en) | SALTS OF 2-FLUORO-N-METHYL-4- [7- (QUINOLIN-6-IL-METIL) -IMIDAZO [1,2-B] [1,2,4] TRIAZIN-2-IL] BENZAMIDA, A HYDRATION OF SALT, A METHOD OF PREPARATION OF THE COMPOUND, A COMPOSITION THAT INCLUDES IT, A METHOD FOR INHIBITING THE ACTIVITY OF THYROSINE KINASE, A METHOD FOR TREATING A DISEASE AND A PROC | |
ECSP088828A (en) | 4-ANILINOQUINOLINA-3-CARBOXAMIDAS AS INHIBITORS OF THE QUINASE CSF-1R | |
NI200700296A (en) | IMIDAZOQUINOLINAS AS INHIBITORS OF KINASE OF LIPIDO | |
UY27234A1 (en) | NOVELTY INHIBITORS OF TYROSINE KINASE | |
ECSP088821A (en) | THIOXANTINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MPO | |
CL2009000780A1 (en) | Substituted heterocyclyl-pyran-heterocyclyl, heterocyclyl-oxepine-heterocyclyl, benzopyran-heterocyclyl and substituted benzoxepine-heterocyclyl derived compounds; pharmaceutical composition; process for preparing the composition; pharmaceutical kit; and its use in the treatment of cancer, mediated by the inhibition of pi3k. | |
SV2010003497A (en) | USEFUL HETEROCICLIC AMIDES FOR THE TREATMENT OF CANCER AND PSORIASIS | |
ECSP077235A (en) | BENZAMIDS REPLACED BY TRIFLUORO-METHYL AS QUINASE INHIBITORS | |
CO6321241A2 (en) | DERIVED FROM 1,3,4- TIADIAZOL ESPIRO CONDENSED FOR THE INHIBITION OF THE QUINESINA ACTIVITY (KSP) | |
UY32829A (en) | DERIVATIVES OF 3-HETEROARIL-METIL-IMIDAZO- [1,2-B] -PIRIDIDAZIN - 6 -ILO | |
CO2022008313A2 (en) | Chemical compounds | |
CL2022002148A1 (en) | Heterocyclic pad4 inhibitors | |
UY30862A1 (en) | PIRIDOPIRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PREPARATION PROCESSES AND APPLICATIONS |