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Application filed by Aventis Pharma SafiledCriticalAventis Pharma Sa
Priority to DO2007000012ApriorityCriticalpatent/DOP2007000012A/en
Publication of DOP2007000012ApublicationCriticalpatent/DOP2007000012A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La invencion se refiere a nuevos productos de formula (I): en la que X1 Y X2 representan: ya sea el uno al hidrogeno y el otro al alquilo; ya sea el uno a -OCF3 0 -SCF3 y el otro a NH-CO-alquil-R3; ya sea X1 Y X2 forman con el radical fenil al que estan unidos un radical di-hidroindol opcionalmente sustituido; R representa piridilo o pirimidinilo sustituidos por NR1R2, representando R, hidrogeno o alquilo, y representando R2 alquilo opcionalmente sustituido, cicloalquilo, heterocicloalquilo, fenilo, pirimidinilo, piridilo, y CO-R3 con R3 que representa principalmente amina, alcoxi, heterocicloalquilo, arilo, ariloxi y heteroarilo; estando todos estos radicales opcionalmente sustituidos; y sus sales.The invention relates to new products of formula (I): in which X1 and X2 represent: either one to hydrogen and the other to alkyl; either one at -OCF3 0 -SCF3 and the other at NH-CO-alkyl-R3; either X1 and X2 form with the phenyl radical to which an optionally substituted dihydroindole radical is attached; R represents pyridyl or pyrimidinyl substituted by NR1R2, representing R, hydrogen or alkyl, and representing R2 optionally substituted alkyl, cycloalkyl, heterocycloalkyl, phenyl, pyrimidinyl, pyridyl, and CO-R3 with R3 primarily representing amine, alkoxy, heterocycloalkyl, aryl, aryloxy and heteroaryl; all these radicals being optionally substituted; And its salts.
DO2007000012A2007-01-122007-01-12
NEW DERIVATIVES OF UREA CICLICA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS INHIBITORS OF KINASES
DOP2007000012A
(en)
NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS
NEW IMIDAZO DERIVATIVES (1,2-A) PIRIDINA, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW USE IN PARTICULARLY AS MET INHIBITORS
NEW DERIVATIVES OF TRIAZOLO (4,3-A) PIRIDINA, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW USE IN PARTICULARLY AS MET INHIBITORS
NEW DERIVATIVES OF IMIDAZO [1,2-a] PYRIMIDINE, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW USE, PARTICULARLY AS AN INHIBITOR OF MET.