DOP2004000994A - SUBSTITUTED HETEROCICLIC INDANO DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA. - Google Patents
SUBSTITUTED HETEROCICLIC INDANO DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA.Info
- Publication number
- DOP2004000994A DOP2004000994A DO2004P000994A DO2004000994A DOP2004000994A DO P2004000994 A DOP2004000994 A DO P2004000994A DO 2004P000994 A DO2004P000994 A DO 2004P000994A DO 2004000994 A DO2004000994 A DO 2004000994A DO P2004000994 A DOP2004000994 A DO P2004000994A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- azithromycin
- oral
- azitromycin
- effective amount
- dosage form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
UNA FORMA DE DOSIFICACION ORAL QUE COMPRENDE AZITROMICINA Y UNA CANTIDAD EFICAZ DE UN AGENTE ALCALINIZANTE. PREFERIBLEMENTE, DICHA FORMA DE DOSIFICACION ORAL COMPRENDE UNA CANTIDAD EFICAZ DE UN AGENTE ALCALIRIIZANTE Y UN MULTIPARTICULADO DE AZITROMICINA EN EL QUE DICHO MULTIPARTICULADO COMPRENDE AZITROMICINA, UNA MEZCLA DE MONOBEHENATO DE GLICERILO, DIBEHENATO DE GLICERILO Y TRIBEHENATO DE GLICERHO Y UN POLOXAMERO. TIPICAMENTE, LA FORMA DE DOSIFICACION ORAL INCLUYE CUALQUIER MEDIO DE ADMINISTRACION ORAL ADECUADO TAL COMO UN POLVO PARA SUSPENSION ORAL, UN ENVASE O SOBRECITO DE DOSIS UNITARIA, UN COMPRIMIDO O UNA CAPSULA. EMAS SE DESCRIBE UNA SUSPENSION ORAL QUE COMPRENDE AZITROMICINA, UNA CANTIDAD EFICAZ DE UN AGENTE ALCALINIZANTE Y UN VEHICULO. PREFERIBLEMENTE, LA AZITROMICINA ESTA EN FORMA MUITIPARTICULADA EN LA QUE DICHO MULTIPARTICULADO COMPRENDE AZITROMICINA, UNA MEZCLA DE MONOBEHENATO DE GLICERILO, DIBEHENATO DE GLICERILO Y TRIBEHENATO DE GLICERILO Y UN POLOXAMERO. MBIÉN SE DESCRIBE UN PROCEDIMIENTO PARA REDUCIR LOS EFECTOS SECUNDARIOS GASTROINTESTINALES ASOCIADOS A LA ADMINISTRACION DE AZITROMICINA A UN MAMIFERO, QUE COMPRENDE LA ADMINISTRACION DE FORMA CONTIGUA DE AZITROMICINA Y UNA CANTIDAD EFICAZ DE UN AGENTE ALCALINIZANTE A DICHO MAMIFERO EN EL QUE LA FRECUENCIA DE EFECTOS SECUNDARIOS GASTROINTESTINALES ES MENOR QUE LA QUE SE EXPERIMENTA ADMINISTRANDO UNA DOSIS IGUAL DE AZITROMICINA SIN DICHO AGENTE ALCALINIZANTE. ADEMAS SE DESCRIBE UN PROCEDIMIENTO PARA TRATAR UNA INFECCION BACTERIANA O PROTOZOARIA EN UN MAMÍFERO QUE LO NECESITE QUE COMPRENDE LA MINISTRACIÓN DE FORMA CONTIGUA A DICHO MAMÍFERO DE UNA DOSIS ÚNICA DE UNA FORMA DE DOSIFICACIÓN ORAL EN LA QUE DICHA FORMA DE DOSIFICACIÓN ORAL COMPRENDE AZITROMICINA Y UNA CANTIDAD EFICAZ DE UN AGENTE ALCALINIZANTE. ICIONALMENTE SE DESCRIBEN MULTIPARTICULADOS DE AZITROMICINA QUE COMPRENDEN AZITROMICINA, UN TENSIOACTIVO; Y UN VEHÍCULO FARMACÉUTICAMENTE ACEPTABLE.AN ORAL DOSAGE FORM THAT INCLUDES AZITHROMYCIN AND AN EFFECTIVE AMOUNT OF AN ALKALINIZING AGENT. Preferably, said oral dosage form comprising an amount EFFECTIVE AND AN AGENT ALCALIRIIZANTE azithromycin multiparticulate wherein said multiparticulate comprising azithromycin, a mixture of monobehenate glyceryl dibehenate, glyceryl tribehenate GLICERHO and a poloxamer. Typically, the ORAL DOSAGE FORM INCLUDES ANY MEANS OF ADEQUATE ORAL ADMINISTRATION SUCH AS A POWDER FOR ORAL SUSPENSION, A PACKAGE OR OVERHEAD OF UNITARY DOSE, A COMPRESSED OR A CAPSULE. EMAS DESCRIBES AN ORAL SUSPENSION THAT INCLUDES AZITHROMYCIN, AN EFFECTIVE AMOUNT OF AN ALKALINIZING AGENT AND A VEHICLE. PREFERIBLY, AZYTHROMYCIN IS IN A MULTIPARTICULATED FORM IN WHICH SUCH MULTIPARTICULATE INCLUDES AZYTHROMYCIN, A MIXTURE OF GLYCERYLL MONOBEHENATE, GLYCERHYL DIBEHENATE AND A POLYXYLENE TRIBEHENATE. A PROCEDURE TO REDUCE THE GASTROINTESTINAL SECONDARY EFFECTS ASSOCIATED WITH THE ADMINISTRATION OF AZITROMYCIN IS DESCRIBED TO A MAMPHERE, WHICH UNDERSTANDS THE ADMINISTRATION IN A CONDITIONAL FORM OF AZITROMYCIN AND AN EFFECTIVE AMOUNT OF A MANUFACTURER HAS BEEN AFFECTED BY THE AGENT. IT IS LESS THAN THAT EXPERIENCED BY ADMINISTRATING AN EQUAL DOSE OF AZITHROMYCIN WITHOUT SUCH ALKALINIZING AGENT. IN ADDITION, A PROCEDURE IS DESCRIBED TO TREAT A BACTERIAL OR PROTOZOARY INFECTION IN A MAMMERE THAT NEEDS IT TO UNDERSTAND THE MINISTRATION CONCERNS SUCH MAMMER OF A SINGLE DOSE OF AN ORAL DOSAGE FORM IN WHICH DIFFERMS AN ORAL FORM EFFECTIVE AMOUNT OF AN ALKALINIZING AGENT. MULTIPARTICULATED AZITROMYCIN MULTIPARTICULATES THAT INCLUDE AZITROMYCIN, A TENSIOACTIVE, ARE DESCRIBED; AND A PHARMACEUTICALLY ACCEPTABLE VEHICLE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52708403P | 2003-12-04 | 2003-12-04 | |
US10/763,340 US6984403B2 (en) | 2003-12-04 | 2004-01-23 | Azithromycin dosage forms with reduced side effects |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2004000994A true DOP2004000994A (en) | 2005-06-30 |
Family
ID=34468055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2004P000994A DOP2004000994A (en) | 2003-12-04 | 2004-09-09 | SUBSTITUTED HETEROCICLIC INDANO DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA. |
Country Status (36)
Country | Link |
---|---|
US (4) | US6984403B2 (en) |
EP (1) | EP1537859B1 (en) |
JP (2) | JP4602711B2 (en) |
KR (1) | KR100906290B1 (en) |
AR (1) | AR045630A1 (en) |
AT (1) | ATE407663T1 (en) |
BR (1) | BRPI0403935B8 (en) |
CA (1) | CA2467611C (en) |
CL (1) | CL2004001501A1 (en) |
CR (1) | CR7500A (en) |
CY (1) | CY1108486T1 (en) |
DE (1) | DE602004016444D1 (en) |
DK (1) | DK1537859T3 (en) |
DO (1) | DOP2004000994A (en) |
EA (1) | EA010110B1 (en) |
ES (1) | ES2312929T3 (en) |
GE (1) | GEP20074056B (en) |
HK (1) | HK1080367B (en) |
HR (1) | HRP20040865A2 (en) |
IL (1) | IL164165A (en) |
IS (1) | IS2672B (en) |
MA (1) | MA27848A1 (en) |
MX (1) | MXPA04009424A (en) |
NL (1) | NL1026315C2 (en) |
NO (1) | NO20043903L (en) |
NZ (1) | NZ535464A (en) |
OA (1) | OA12858A (en) |
PA (1) | PA8611501A1 (en) |
PE (1) | PE20050573A1 (en) |
PL (2) | PL1537859T3 (en) |
PT (1) | PT1537859E (en) |
RS (1) | RS84704A (en) |
SI (1) | SI1537859T1 (en) |
TW (1) | TWI351969B (en) |
UY (1) | UY28509A1 (en) |
WO (1) | WO2005053650A1 (en) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL179910B1 (en) † | 1994-05-06 | 2000-11-30 | Pfizer | Controllable release dosing forms of azitromycin |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
PT2368553E (en) * | 2003-04-08 | 2015-03-03 | Progenics Pharm Inc | Pharmaceutical formulations containing methylnaltrexone |
PT1691787E (en) * | 2003-12-04 | 2008-09-02 | Pfizer Prod Inc | Method for making pharmaceutical multiparticulates |
WO2005053652A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
US8236349B2 (en) * | 2004-04-12 | 2012-08-07 | Bend Research Inc. | Taste-masked drugs in rupturing multiparticulates |
LT1765292T (en) | 2004-06-12 | 2018-01-10 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
JP3933683B2 (en) | 2004-07-02 | 2007-06-20 | わかもと製薬株式会社 | Azithromycin-containing aqueous pharmaceutical composition and method for preparing the same |
JP4713104B2 (en) * | 2004-08-04 | 2011-06-29 | ファイザー株式会社 | A stable composition containing azithromycins as an active ingredient and having reduced bitterness |
US20060193908A1 (en) * | 2004-11-09 | 2006-08-31 | Burnside Beth A | Extended release formulations of poorly soluble antibiotics |
CN104248763A (en) * | 2005-03-07 | 2014-12-31 | 芝加哥大学 | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
AR057325A1 (en) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | SYNTHESIS OF (S) -N-METHYLNTREXONE, PHARMACEUTICAL COMPOSITIONS AND USES |
AR057035A1 (en) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SYNTHESIS OF (R) -N-METHYLNTREXONE, PHARMACEUTICAL COMPOSITIONS AND USES |
SG2014009252A (en) * | 2005-12-22 | 2014-05-29 | Otsuka Pharma Co Ltd | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
CN101340882B (en) * | 2005-12-22 | 2015-02-11 | 大塚制药株式会社 | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
WO2007143507A2 (en) * | 2006-06-05 | 2007-12-13 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted erythromycin analogs |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
US10357462B2 (en) * | 2006-11-30 | 2019-07-23 | Ben Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
US11116728B2 (en) | 2006-11-30 | 2021-09-14 | Bend Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
JP5162134B2 (en) * | 2007-01-22 | 2013-03-13 | 愛媛県 | Method for producing functional material, functional material, sheet-like structure, and sanitary product |
ES2350029T3 (en) * | 2007-03-02 | 2011-01-17 | Farnam Companies, Inc. | SUSTAINED RELEASE PELLETS THAT INCLUDE A WAX TYPE MATERIAL. |
EP2139890B1 (en) | 2007-03-29 | 2014-06-25 | Wyeth LLC | Peripheral opioid receptor antagonists and uses thereof |
CA2865389A1 (en) * | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Crystal forms and uses thereof |
PE20090700A1 (en) * | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | HETEROCYCLIC COMPOUNDS AS ANTAGONISTS OF THE PERIPHERAL OPIOID RECEPTOR |
DE102007026550A1 (en) * | 2007-06-08 | 2008-12-11 | Bayer Healthcare Ag | Extrudates with improved taste masking |
DE102007034155A1 (en) * | 2007-07-21 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Device having at least one packaging unit with an RFID chip serving for radio frequency identification and method therefor |
CA2711807A1 (en) | 2008-01-08 | 2009-07-16 | Akthelia Pharmaceuticals | Agonists for antimicrobial peptide systems |
CN101959892B (en) | 2008-02-06 | 2014-01-08 | 普罗热尼奇制药公司 | Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone |
JP5647098B2 (en) | 2008-03-21 | 2014-12-24 | ザ ユニヴァーシティー オヴ シカゴ | Treatment with opioid antagonists and mTOR inhibitors |
RU2495662C2 (en) * | 2008-07-21 | 2013-10-20 | Отономи, Инк. | Control release antimicrobial compositions for treating ear diseases |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
US8106111B2 (en) | 2009-05-15 | 2012-01-31 | Eastman Chemical Company | Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions |
EP2314286A1 (en) * | 2009-10-21 | 2011-04-27 | Ratiopharm GmbH | Melt granulated cinacalcet |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
WO2011125075A2 (en) | 2010-04-08 | 2011-10-13 | Fdc Limited | A novel gastroretentive delivery of macrolide |
LT2673237T (en) | 2011-02-11 | 2019-05-10 | Zs Pharma, Inc | Use of a zirconium silicate for the treatment of hyperkalemia |
JP6038128B2 (en) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | A biomarker for predicting and evaluating the reactivity of thyroid and renal cancer subjects to lenvatinib compounds |
WO2013088274A1 (en) | 2011-12-14 | 2013-06-20 | Wockhardt Limited | Anhydrous amorphous azithromycin composition free of azithromycin dihydrate |
US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
EP2872148A4 (en) | 2012-07-11 | 2016-06-15 | Zs Pharma Inc | Zirconium silicate for treatment of hyperkalemia |
CA2891053C (en) | 2012-10-22 | 2020-12-01 | ZS Pharma, Inc. | Microporous zirconium silicate for treating hyperkalemia |
US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
CA2933048A1 (en) * | 2013-12-10 | 2015-06-18 | ZS Pharma, Inc. | Zirconium silicate for treating hyperkalemia without co-administering lithium |
EP3825305A1 (en) | 2014-08-28 | 2021-05-26 | Eisai R&D Management Co., Ltd. | Process for preparing lenvatinib |
PT3263106T (en) | 2015-02-25 | 2024-01-12 | Eisai R&D Man Co Ltd | Method for suppressing bitterness of quinoline derivative |
AU2016229111A1 (en) * | 2015-03-10 | 2017-09-21 | Lumos Pharma, Inc. | Cyclocreatine microsuspension |
ES2882578T3 (en) | 2015-06-10 | 2021-12-02 | Piedmont Animal Health Llc | Injectable antibiotic formulations and their use |
KR20180018695A (en) | 2015-06-16 | 2018-02-21 | 가부시키가이샤 프리즘 파마 | Anticancer drug |
KR20190008840A (en) | 2016-03-15 | 2019-01-25 | 에이서 테라퓨틱스 인크. | A taste-good composition comprising sodium phenylbutyrate and uses thereof |
WO2017222575A1 (en) | 2016-06-23 | 2017-12-28 | Collegium Pharmaceutical, Inc. | Process of making more stable abuse-deterrent oral formulations |
EP3576755A4 (en) * | 2017-02-02 | 2020-12-02 | McMaster University | Bicarbonate as a potentiator for antimicrobial agents |
WO2020024060A1 (en) | 2018-08-01 | 2020-02-06 | Mcmaster University | Methods for inhibiting microbe growth |
CN111643455A (en) * | 2020-06-22 | 2020-09-11 | 健民药业集团股份有限公司 | Azithromycin sustained-release dry suspension and preparation method thereof |
WO2022220669A1 (en) * | 2021-04-16 | 2022-10-20 | Garcia Perez Miguel Angel | Oral solid combination for the treatment of virus infection |
CN114699386B (en) * | 2022-04-14 | 2023-05-23 | 深圳职业技术学院 | Azithromycin composition and preparation method thereof |
Family Cites Families (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US190365A (en) * | 1877-05-01 | Improvement in running-gear for vehicles | ||
US25342A (en) * | 1859-09-06 | Justus k | ||
US26851A (en) * | 1860-01-17 | Improvement | ||
US228357A (en) * | 1880-06-01 | Walter m | ||
US3590A (en) * | 1844-05-17 | Rule or measure | ||
US165563A (en) * | 1875-07-13 | Improvement in snow-plows | ||
US14951A (en) * | 1856-05-27 | Boot-tree | ||
US6650A (en) * | 1849-08-14 | Edmund blunt | ||
US2955956A (en) * | 1957-05-15 | 1960-10-11 | Morton Salt Co | Process and apparatus for coating granules |
US4086346A (en) * | 1974-04-06 | 1978-04-25 | Bayer Aktiengesellschaft | Preparation of melt-sprayed spherical phenacetin granules |
US4092089A (en) * | 1974-04-06 | 1978-05-30 | Bayer Aktiengesellschaft | Apparatus for the preparation of melt-sprayed spherical phenacetin granules |
US4053264A (en) * | 1976-01-30 | 1977-10-11 | United Technologies Corporation | Apparatus for making metal powder |
US4293570A (en) * | 1979-04-02 | 1981-10-06 | Chimicasa Gmbh | Process for the preparation of sweetener containing product |
YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US4675140A (en) * | 1984-05-18 | 1987-06-23 | Washington University Technology Associates | Method for coating particles or liquid droplets |
US4874611A (en) | 1985-06-20 | 1989-10-17 | The Dow Chemical Company | Microencapsulated ant bait |
US5100592A (en) * | 1986-03-12 | 1992-03-31 | Washington University Technology Associated, Inc. | Method and apparatus for granulation and granulated product |
US5019302A (en) * | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
US5456932A (en) | 1987-04-20 | 1995-10-10 | Fuisz Technologies Ltd. | Method of converting a feedstock to a shearform product and product thereof |
US5236734A (en) * | 1987-04-20 | 1993-08-17 | Fuisz Technologies Ltd. | Method of preparing a proteinaceous food product containing a melt spun oleaginous matrix |
US5387431A (en) * | 1991-10-25 | 1995-02-07 | Fuisz Technologies Ltd. | Saccharide-based matrix |
UA27040C2 (en) * | 1987-07-09 | 2000-02-28 | Пфайзер Інк. | Crystalline azithromycin dehydrate and method for its obtaining |
WO1989002271A1 (en) | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
DE3812567A1 (en) * | 1988-04-15 | 1989-10-26 | Basf Ag | METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES |
US5064650A (en) | 1988-04-19 | 1991-11-12 | Southwest Research Institute | Controlled-release salt sensitive capsule for oral use and adhesive system |
US5024842A (en) * | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
US5160743A (en) | 1988-04-28 | 1992-11-03 | Alza Corporation | Annealed composition for pharmaceutically acceptable drug |
US4931285A (en) * | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
US5047244A (en) * | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5169645A (en) | 1989-10-31 | 1992-12-08 | Duquesne University Of The Holy Ghost | Directly compressible granules having improved flow properties |
JPH03206039A (en) * | 1990-01-08 | 1991-09-09 | Kyoto Yakuhin Kogyo Kk | Nifedipin preparation having prolonged action |
US5084287A (en) * | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
US5213810A (en) * | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
DE69111287T2 (en) * | 1990-04-18 | 1995-12-21 | Asahi Chemical Ind | Spherical nuclei, spherical granules and processes for their production. |
US5183690A (en) * | 1990-06-25 | 1993-02-02 | The United States Of America, As Represented By The Secretary Of Agriculture | Starch encapsulation of biologically active agents by a continuous process |
GB9014646D0 (en) | 1990-07-02 | 1990-08-22 | Courtaulds Coatings Holdings | Coating compositions |
US5194262A (en) * | 1990-10-22 | 1993-03-16 | Revlon Consumer Products Corporation | Encapsulated antiperspirant salts and deodorant/antiperspirants |
US5196199A (en) * | 1990-12-14 | 1993-03-23 | Fuisz Technologies Ltd. | Hydrophilic form of perfluoro compounds and method of manufacture |
US5292657A (en) * | 1990-12-31 | 1994-03-08 | Pioneer Hi-Bred International, Inc. | Process for preparing rotary disc fatty acid microspheres of microorganisms |
US5143662A (en) * | 1991-02-12 | 1992-09-01 | United States Surgical Corporation | Process for preparing particles of bioabsorbable polymer |
US5707546A (en) * | 1991-06-17 | 1998-01-13 | Rio Linda Chemical Co., Inc. | Generation and storage of chlorine dioxide in a non-aqueous medium |
US5405617A (en) * | 1991-11-07 | 1995-04-11 | Mcneil-Ppc, Inc. | Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals |
GB9201857D0 (en) * | 1992-01-29 | 1992-03-18 | Smithkline Beecham Plc | Novel compound |
JP3265680B2 (en) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | Oral pharmaceutical composition |
DE4214272A1 (en) * | 1992-05-04 | 1993-11-11 | Nukem Gmbh | Method and device for producing microspheres |
CA2095776C (en) * | 1992-05-12 | 2007-07-10 | Richard C. Fuisz | Rapidly dispersable compositions containing polydextrose |
EP0641195B1 (en) * | 1992-05-22 | 1996-04-10 | Gödecke Aktiengesellschaft | Process for preparing delayed-action medicinal compositions |
US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
TW271400B (en) * | 1992-07-30 | 1996-03-01 | Pfizer | |
US5348758A (en) * | 1992-10-20 | 1994-09-20 | Fuisz Technologies Ltd. | Controlled melting point matrix formed with admixtures of a shearform matrix material and an oleaginous material |
US5380473A (en) * | 1992-10-23 | 1995-01-10 | Fuisz Technologies Ltd. | Process for making shearform matrix |
GB9224855D0 (en) * | 1992-11-27 | 1993-01-13 | Smithkline Beecham Plc | Pharmaceutical compositions |
US5569467A (en) | 1993-05-15 | 1996-10-29 | Societe De Conseils De Recherches Et D'applications (S.C.R.A.S.) | Process for the preparation of microballs and microballs thus obtained |
US5690959A (en) | 1993-05-29 | 1997-11-25 | Smithkline Beecham Corporation | Pharmaceutical thermal infusion process |
US5851553A (en) | 1993-09-10 | 1998-12-22 | Fuisz Technologies, Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
US5935600A (en) * | 1993-09-10 | 1999-08-10 | Fuisz Technologies Ltd. | Process for forming chewable quickly dispersing comestible unit and product therefrom |
US5597416A (en) * | 1993-10-07 | 1997-01-28 | Fuisz Technologies Ltd. | Method of making crystalline sugar and products resulting therefrom |
US5433951A (en) * | 1993-10-13 | 1995-07-18 | Bristol-Myers Squibb Company | Sustained release formulation containing captopril and method |
AT401871B (en) * | 1994-01-28 | 1996-12-27 | Gebro Broschek Gmbh | METHOD FOR THE PRODUCTION OF S (+) - IBUPROFEN PARTICLES WITH IMPROVED FLOW PROPERTIES AND THE USE THEREOF FOR THE PRODUCTION OF MEDICINAL PRODUCTS |
GB9402203D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
DE69535127T2 (en) * | 1994-03-18 | 2007-02-15 | Supernus Pharmaceuticals, Inc. | EMULSIFIED DRUG DISPENSING SYSTEMS |
US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
PL179910B1 (en) * | 1994-05-06 | 2000-11-30 | Pfizer | Controllable release dosing forms of azitromycin |
DE19509807A1 (en) * | 1995-03-21 | 1996-09-26 | Basf Ag | Process for the preparation of active substance preparations in the form of a solid solution of the active substance in a polymer matrix, and active substance preparations produced using this method |
US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
US5582855A (en) | 1994-07-01 | 1996-12-10 | Fuisz Technologies Ltd. | Flash flow formed solloid delivery systems |
US5556652A (en) * | 1994-08-05 | 1996-09-17 | Fuisz Technologies Ltd. | Comestibles containing stabilized highly odorous flavor component delivery systems |
US5601761A (en) * | 1994-09-26 | 1997-02-11 | The Dow Chemical Company | Encapsulated active materials and method for preparing same |
US5493044A (en) * | 1994-10-20 | 1996-02-20 | Fmc Corporation | Process for preparing alkylsilyl or arylsilyl ethers |
US5965164A (en) | 1994-10-28 | 1999-10-12 | Fuisz Technologies Ltd. | Recipient-dosage delivery system |
US5683720A (en) | 1994-10-28 | 1997-11-04 | Fuisz Technologies Ltd. | Liquiflash particles and method of making same |
US6083430A (en) * | 1994-10-28 | 2000-07-04 | Fuisz Technologies Ltd. | Method of preparing a dosage unit by direct tableting and product therefrom |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
FR2732621B1 (en) * | 1995-04-10 | 1997-06-06 | Rhone Poulenc Chimie | PEARLS OF A PRODUCT HAVING THE SURFUSION PHENOMENON AND THEIR PRODUCTION METHOD |
ES2279519T3 (en) | 1995-05-02 | 2007-08-16 | Taisho Pharmaceutical Co. Ltd | COMPOSITION FOR ADMINISTRATION BY ORAL ROUTE. |
US5883103A (en) * | 1995-06-07 | 1999-03-16 | Shire Laboratories Inc. | Oral acyclovir delivery |
US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
AU6403196A (en) * | 1995-06-30 | 1997-02-05 | Baylor University | Polyester/carboxylic acid composite materials |
EP0784933A3 (en) * | 1995-10-16 | 1997-11-26 | Leaf, Inc. | Extended release of additives in comestible products |
US5919489A (en) * | 1995-11-01 | 1999-07-06 | Abbott Laboratories | Process for aqueous granulation of clarithromycin |
US5705190A (en) * | 1995-12-19 | 1998-01-06 | Abbott Laboratories | Controlled release formulation for poorly soluble basic drugs |
US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
DE19629753A1 (en) * | 1996-07-23 | 1998-01-29 | Basf Ag | Process for the production of solid dosage forms |
US6139872A (en) | 1996-08-14 | 2000-10-31 | Henkel Corporation | Method of producing a vitamin product |
HRP970485A2 (en) * | 1996-09-13 | 1998-08-31 | Joerg Rosenberg | Process for producing solid pharmaceutical forms |
US8828432B2 (en) * | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
DE19652257A1 (en) * | 1996-12-16 | 1998-06-18 | Lohmann Therapie Syst Lts | Individually dosed, film-like dosage form that quickly disintegrates on contact with liquid and contains active ingredients and especially flavorings |
US5948407A (en) * | 1997-03-19 | 1999-09-07 | Shire Laboratories Inc. | Oral induction of tolerance to parenterally administered non-autologous polypeptides |
US6551616B1 (en) * | 1997-04-11 | 2003-04-22 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
US6010718A (en) * | 1997-04-11 | 2000-01-04 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
DE19729487A1 (en) * | 1997-07-10 | 1999-01-14 | Dresden Arzneimittel | Process for the preparation of active ingredient preparations with controlled release from a matrix |
SI9700186B (en) * | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Novel pharmaceutical preparation with controlled release of active healing substances |
US5851555A (en) | 1997-08-15 | 1998-12-22 | Fuisz Technologies Ltd. | Controlled release dosage forms containing water soluble drugs |
US5869098A (en) * | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
US5840334A (en) | 1997-08-20 | 1998-11-24 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
US5980941A (en) | 1997-08-20 | 1999-11-09 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
IT1294760B1 (en) * | 1997-09-03 | 1999-04-12 | Jagotec Ag | PROCEDURE FOR THE PREPARATION OF PHARMACEUTICAL TABLETS ABLE TO RELEASE, ACCORDING TO PREDETERMINABLE SCHEMES, LITTLE ACTIVE INGREDIENTS |
US6692767B2 (en) * | 1997-09-19 | 2004-02-17 | Shire Laboratories Inc. | Solid solution beadlet |
US6013280A (en) * | 1997-10-07 | 2000-01-11 | Fuisz Technologies Ltd. | Immediate release dosage forms containing microspheres |
IE970731A1 (en) * | 1997-10-07 | 2000-10-04 | Fuisz Internat Ltd | Product and method for the treatment of hyperlipidemia |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
US6328993B1 (en) * | 1997-12-08 | 2001-12-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for an acid liable active proton pump inhibitor |
US6270804B1 (en) * | 1998-04-03 | 2001-08-07 | Biovail Technologies Ltd. | Sachet formulations |
US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
JPH11335300A (en) * | 1998-05-20 | 1999-12-07 | Sumitomo Pharmaceut Co Ltd | Sustained release preparation using glycerol fatty acid ester |
FR2779651B1 (en) * | 1998-06-16 | 2001-04-20 | Gattefosse Ets Sa | PROCESS FOR THE MANUFACTURE OF SUSTAINED RELEASE TABLETS OF ACTIVE INGREDIENT (S) HAVING ZERO-SIZE DISSOLUTION KINETICS |
US6117452A (en) * | 1998-08-12 | 2000-09-12 | Fuisz Technologies Ltd. | Fatty ester combinations |
US6086920A (en) * | 1998-08-12 | 2000-07-11 | Fuisz Technologies Ltd. | Disintegratable microspheres |
CA2245398C (en) * | 1998-08-21 | 2002-01-29 | Apotex Inc. | Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
US6165512A (en) | 1998-10-30 | 2000-12-26 | Fuisz Technologies Ltd. | Dosage forms containing taste masked active agents |
EP1152765B1 (en) * | 1998-11-30 | 2004-10-13 | Teva Pharmaceutical Industries Ltd. | Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof |
DE19901683B4 (en) * | 1999-01-18 | 2005-07-21 | Grünenthal GmbH | Controlled-release analgesic |
DE60042352D1 (en) * | 1999-02-10 | 2009-07-23 | Pfizer Prod Inc | Osmotic system for administering active substances containing solid amorphous dispersions |
US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6291013B1 (en) * | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
WO2001022937A1 (en) * | 1999-09-27 | 2001-04-05 | Sonus Pharmaceuticals, Inc. | Compositions of tocol-soluble therapeutics |
IL141438A0 (en) * | 2000-02-23 | 2002-03-10 | Pfizer Prod Inc | Method of increasing the bioavailability and tissue penetration of azithromycin |
AR030557A1 (en) * | 2000-04-14 | 2003-08-27 | Jagotec Ag | A TABLET IN MULTI-MAP OF CONTROLLED RELEASE AND TREATMENT METHOD |
IL161259A0 (en) * | 2001-12-21 | 2004-09-27 | Pfizer Prod Inc | Methods for wet granulating azithromycin |
MXPA04005105A (en) * | 2001-12-21 | 2004-08-19 | Pfizer Prod Inc | Directly compressible formulations of azithromycin. |
US6682759B2 (en) * | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
AU2003201146B2 (en) * | 2002-02-01 | 2008-04-17 | Pfizer Products Inc. | Dry granulated formulations of azithromycin |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
WO2005009447A1 (en) * | 2003-07-24 | 2005-02-03 | Pliva - Research And Development Ltd. | Single dose fast dissolving azithromycin |
-
2004
- 2004-01-23 US US10/763,340 patent/US6984403B2/en not_active Expired - Lifetime
- 2004-05-06 ES ES04252643T patent/ES2312929T3/en not_active Expired - Lifetime
- 2004-05-06 DK DK04252643T patent/DK1537859T3/en active
- 2004-05-06 PT PT04252643T patent/PT1537859E/en unknown
- 2004-05-06 AT AT04252643T patent/ATE407663T1/en active
- 2004-05-06 SI SI200430865T patent/SI1537859T1/en unknown
- 2004-05-06 DE DE602004016444T patent/DE602004016444D1/en not_active Expired - Lifetime
- 2004-05-06 EP EP04252643A patent/EP1537859B1/en not_active Expired - Lifetime
- 2004-05-06 PL PL04252643T patent/PL1537859T3/en unknown
- 2004-05-14 NZ NZ535464A patent/NZ535464A/en unknown
- 2004-05-14 RS YUP-847/04A patent/RS84704A/en unknown
- 2004-05-14 WO PCT/IB2004/001654 patent/WO2005053650A1/en active Application Filing
- 2004-05-14 PL PL379984A patent/PL379984A1/en not_active Application Discontinuation
- 2004-05-14 MX MXPA04009424A patent/MXPA04009424A/en active IP Right Grant
- 2004-05-14 EA EA200401216A patent/EA010110B1/en not_active IP Right Cessation
- 2004-05-14 GE GEAP8414A patent/GEP20074056B/en unknown
- 2004-05-14 OA OA1200400253A patent/OA12858A/en unknown
- 2004-05-14 BR BRPI0403935A patent/BRPI0403935B8/en active IP Right Grant
- 2004-05-18 CA CA2467611A patent/CA2467611C/en not_active Expired - Lifetime
- 2004-06-02 NL NL1026315A patent/NL1026315C2/en not_active IP Right Cessation
- 2004-06-04 TW TW093116207A patent/TWI351969B/en active
- 2004-06-16 CL CL200401501A patent/CL2004001501A1/en unknown
- 2004-08-04 JP JP2004228455A patent/JP4602711B2/en active Active
- 2004-09-07 PE PE2004000861A patent/PE20050573A1/en not_active Application Discontinuation
- 2004-09-08 PA PA20048611501A patent/PA8611501A1/en unknown
- 2004-09-09 DO DO2004P000994A patent/DOP2004000994A/en unknown
- 2004-09-10 AR ARP040103256A patent/AR045630A1/en not_active Application Discontinuation
- 2004-09-13 UY UY28509A patent/UY28509A1/en not_active Application Discontinuation
- 2004-09-17 NO NO20043903A patent/NO20043903L/en not_active Application Discontinuation
- 2004-09-20 IS IS7464A patent/IS2672B/en unknown
- 2004-09-20 HR HR20040865A patent/HRP20040865A2/en not_active Application Discontinuation
- 2004-09-20 IL IL164165A patent/IL164165A/en active IP Right Grant
- 2004-09-29 CR CR7500A patent/CR7500A/en unknown
- 2004-10-11 KR KR1020047016213A patent/KR100906290B1/en active IP Right Grant
-
2005
- 2005-08-25 US US11/212,433 patent/US20060029677A1/en not_active Abandoned
- 2005-10-26 US US11/259,839 patent/US20060039988A1/en not_active Abandoned
- 2005-12-08 MA MA28638A patent/MA27848A1/en unknown
-
2006
- 2006-01-05 HK HK06100226.0A patent/HK1080367B/en not_active IP Right Cessation
-
2007
- 2007-07-18 US US11/779,489 patent/US20080015343A1/en not_active Abandoned
-
2008
- 2008-11-06 CY CY20081101264T patent/CY1108486T1/en unknown
-
2010
- 2010-03-01 JP JP2010044743A patent/JP2010132700A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2004000994A (en) | SUBSTITUTED HETEROCICLIC INDANO DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA. | |
RU2011117203A (en) | SYSTEM TREATMENT OF BLOOD-DRYING PARASITES AND BLOOD CONSUMPULAR PARASITES BY Oral Administration of ANTI-PARASITIC AGENT | |
AR048431A1 (en) | GALENIC FORMULATIONS OF ORGANIC COMPOUNDS | |
MX2007006212A (en) | Oral medicament for the modified release of at least one active principle, in multimicrocapsule form. | |
UY27533A1 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING OXIBUTININE | |
PE20160195A1 (en) | USE OF PRIDOPIDINE IN HIGH DOSES FOR THE TREATMENT OF HUNTINGTON DISEASE | |
ES2088312T3 (en) | CONTROLLED RELEASE FORMULATION CONTAINING TRAMADOL. | |
ECSP099350A (en) | TETRAHYDROCICLOPENTA COMPOUNDS [b] INDOL AS MODULATORS | |
CR9662A (en) | ACTIVE CANABINOID PHARMACEUTICAL INGREDIENT FOR IMPROVED DOSE FORMS | |
ES2570401T3 (en) | Methods of treatment using single doses of oritavancin | |
WO2009026473A3 (en) | Stabilized therapeutic compositions and formulations | |
RU2008119454A (en) | MEDICINE FOR PROTECTION OF MOTOR NEURON IN PATIENTS WITH LATERAL AMYOTROPHIC SCLEROSIS | |
PA8616201A1 (en) | PHARMACEUTICAL COMPOSITIONS OF SUSTAINED LIBERATION | |
WO2007038428A3 (en) | Prevention and treatment of gastrointestinal and bladder disorders using active vitamin d compounds | |
BR0311414A (en) | Therapeutic agent for an overactive bladder | |
AR047469A1 (en) | ANTIMICROBIAL PRESERVANTS TO ACHIEVE A MULTIPLE DOSE FORMULATION USING BETA CYCLODEXTRINES FOR LIQUID DOSAGE FORMS | |
ECSP045351A (en) | DOSAGE FORMS OF AZITHROMYCIN WITH REDUCED SIDE EFFECTS | |
PT1656131E (en) | Use of betaine for treating intermittent claudication | |
PE20040706A1 (en) | SPECIFIC DERIVATIVE OF AMINE CYCLIC AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS INVOLVED IN THE PREVENTION OF HEART FAILURE | |
ES2182504T3 (en) | BIFENILSULFONILCIANAMIDAS, PROCEDURE FOR ITS PREPARATION AND ITS USE AS A MEDICINAL PRODUCT. | |
UY26459A1 (en) | 3,4-DIHIDROQUINAZOLINES 5,6-DISSTITUTED | |
AR036009A1 (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF VISCERAL PAIN AND GASTROINTESTINAL DISORDERS THAT INCLUDE A BICYCLIC AMINO ACID COMPOUND AND USE OF THIS LAST TO MANUFACTURE SUCH PHARMACEUTICAL COMPOSITION | |
PA8483301A1 (en) | SERTRALINA ORAL CONCENTRATE | |
AR037543A1 (en) | METHOD FOR CANCER THERAPY AND PHARMACEUTICAL COMPOSITION | |
KR920700626A (en) | Drugs for the treatment of toxoplasma disease |