DOP2003000758A - DERMIC ADMINISTRATION OF A WATER SOLUBLE SELECTIVE CYCLLOXYGENASA-2 INHIBITOR - Google Patents
DERMIC ADMINISTRATION OF A WATER SOLUBLE SELECTIVE CYCLLOXYGENASA-2 INHIBITORInfo
- Publication number
- DOP2003000758A DOP2003000758A DO2003000758A DO2003000758A DOP2003000758A DO P2003000758 A DOP2003000758 A DO P2003000758A DO 2003000758 A DO2003000758 A DO 2003000758A DO 2003000758 A DO2003000758 A DO 2003000758A DO P2003000758 A DOP2003000758 A DO P2003000758A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- active agent
- composition
- subject
- administration
- skin
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacautica para aplicación a un area de piel de un sujeto para el tratamiento local y/o sistémico de un trastomo mediado por COX 2, que comprende una lamina de soporte que puede conformarse de forma flexible al area de piel, teniendo la lamina de soporte superficies enfrentadas que estan respectivamente distal y proximal a la piel cuando se aplica; y un recubrimiento sobre la superficie proximal de la lamina de soporte, que comprende (a) un adhesivo y (b) un agente activo soluble en agua seleccionado de farmacos o profarmacos o sus sales inhibidores de COX-2 selectivos, estando el agente activo en una cantidad total terapéuticamente efectiva y disperso en una matriz que comprende de cero a menos de una cantidad efectiva para solubilizar el agente activo en total de uno o mas disolventes distintos del adhesivo. Un procedimiento de tratamiento local de un sitio de dolor y/o inflamación que comprende aplicar la composición a una superficie de piel del sujeto, preferiblemente en una localización por encima o adyacente al sitio de dolor y/o inflamación, y dejar la composición colocada durante un periodo de tiempo efectivo para permitir la administración de una cantidad localmente terapeutica del agente activo. Un procedimiento de tratamiento sistemico de un sujeto que tiene un trastorno mediado por COX-2, que comprende aplicar la composición a una superficie de piel del sujeto, y dejar la composición colocada durante un periodo de tiempo efectivo para permitir la administración transdarmica de una cantidad terapéutica del agente activo.A pharmaceutical composition for application to a skin area of a subject for the local and / or systemic treatment of a COX 2-mediated disorder, comprising a support sheet that can flexibly conform to the skin area, the sheet having support facing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the support sheet, comprising (a) an adhesive and (b) a water soluble active agent selected from drugs or prodrugs or their selective COX-2 inhibiting salts, the active agent being in a therapeutically effective total amount and dispersed in a matrix comprising from zero to less than an amount effective to solubilize the active agent in total from one or more solvents other than the adhesive. A method of local treatment of a site of pain and / or inflammation comprising applying the composition to a skin surface of the subject, preferably at a location above or adjacent to the site of pain and / or inflammation, and leaving the composition placed during an effective period of time to allow the administration of a locally therapeutic amount of the active agent. A method of systematic treatment of a subject having a COX-2 mediated disorder, which comprises applying the composition to a skin surface of the subject, and leaving the composition in place for an effective period of time to allow transdarmic administration of an amount Therapeutics of the active agent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2003000758A DOP2003000758A (en) | 2003-11-20 | 2003-11-20 | DERMIC ADMINISTRATION OF A WATER SOLUBLE SELECTIVE CYCLLOXYGENASA-2 INHIBITOR |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2003000758A DOP2003000758A (en) | 2003-11-20 | 2003-11-20 | DERMIC ADMINISTRATION OF A WATER SOLUBLE SELECTIVE CYCLLOXYGENASA-2 INHIBITOR |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2003000758A true DOP2003000758A (en) | 2004-05-31 |
Family
ID=44261253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2003000758A DOP2003000758A (en) | 2003-11-20 | 2003-11-20 | DERMIC ADMINISTRATION OF A WATER SOLUBLE SELECTIVE CYCLLOXYGENASA-2 INHIBITOR |
Country Status (1)
Country | Link |
---|---|
DO (1) | DOP2003000758A (en) |
-
2003
- 2003-11-20 DO DO2003000758A patent/DOP2003000758A/en unknown
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