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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Priority to DO2003000634ApriorityCriticalpatent/DOP2003000634A/en
Publication of DOP2003000634ApublicationCriticalpatent/DOP2003000634A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La presente invención se refiere a inhibidores de metaloproteinasa de triaril-oxiaril-espiro-pirimidina-2, 4, 6-triona de formula en la que el anillo x es un anillo heterocíclido de 5-7 miembros, y donde a, y, b, g y w son tal y como se han definido en la memoria descriptiva; y a composiciones farmacéuticas y procedimientos de tratamiento de la inflamación, cánceres y otros trastornos.The present invention relates to triaryl-oxyaryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors of the formula in which the x-ring is a 5-7 membered heterocyclic ring, and wherein a, y, b , gyw are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancers and other disorders.
NEW DERIVATIVES (HETEROCICLO - TETRAHIDRO - PIRIDIN) - (PIPERAZINIL) - 1 - ALCANONE AND (HETEROCICLO - DIHIDRO - PIRROLIDIN) - (PIPERAZINIL) - 1 - ALCANONA AND ITS USE AS INHIBITORS OF p75