DOP2002000440A - IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS. - Google Patents

IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS.

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Publication number
DOP2002000440A
DOP2002000440A DO2002000440A DO2002000440A DOP2002000440A DO P2002000440 A DOP2002000440 A DO P2002000440A DO 2002000440 A DO2002000440 A DO 2002000440A DO 2002000440 A DO2002000440 A DO 2002000440A DO P2002000440 A DOP2002000440 A DO P2002000440A
Authority
DO
Dominican Republic
Prior art keywords
derivatives
ligands
trizina
imidazo
gaba receptors
Prior art date
Application number
DO2002000440A
Other languages
Spanish (es)
Inventor
William Robert Carling
David James Hallet
Michael Geoffrey Neil Russell
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Priority to DO2002000440A priority Critical patent/DOP2002000440A/en
Publication of DOP2002000440A publication Critical patent/DOP2002000440A/en

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Abstract

Una clase de derivados de 7-fenilimidazo[l,2-b] [l,2,4jltriazina, sustitujdos en la posición meta del anillo de fenilo con un resto (ciano)(fluoro)fenilo, que son ligandos selectivos para los receptores GABAA, y que tienen en particular una buena afinidad por la subunidad ci~2 y/o c~3 de los mismos, son por consiguiente beneficiosos en el tratamiento y/o prevención de trastornos adversos del sistema nervioso central, incluyendo ansiedad y convulsiones.A class of 7-phenylimidazo [1, 2-b] [1, 2,4jltriazine derivatives, substituted at the meta position of the phenyl ring with a (cyano) (fluoro) phenyl moiety, which are selective ligands for GABAA receptors , and which in particular have a good affinity for the subunit ci ~ 2 and / oc ~ 3 thereof, are therefore beneficial in the treatment and / or prevention of adverse disorders of the central nervous system, including anxiety and seizures.

DO2002000440A 2002-07-16 2002-07-16 IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS. DOP2002000440A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DO2002000440A DOP2002000440A (en) 2002-07-16 2002-07-16 IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DO2002000440A DOP2002000440A (en) 2002-07-16 2002-07-16 IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS.

Publications (1)

Publication Number Publication Date
DOP2002000440A true DOP2002000440A (en) 2003-09-15

Family

ID=44261090

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2002000440A DOP2002000440A (en) 2002-07-16 2002-07-16 IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS.

Country Status (1)

Country Link
DO (1) DOP2002000440A (en)

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