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Application filed by Merck Sharp & DohmefiledCriticalMerck Sharp & Dohme
Priority to DO2002000440ApriorityCriticalpatent/DOP2002000440A/en
Publication of DOP2002000440ApublicationCriticalpatent/DOP2002000440A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Una clase de derivados de 7-fenilimidazo[l,2-b] [l,2,4jltriazina, sustitujdos en la posición meta del anillo de fenilo con un resto (ciano)(fluoro)fenilo, que son ligandos selectivos para los receptores GABAA, y que tienen en particular una buena afinidad por la subunidad ci~2 y/o c~3 de los mismos, son por consiguiente beneficiosos en el tratamiento y/o prevención de trastornos adversos del sistema nervioso central, incluyendo ansiedad y convulsiones.A class of 7-phenylimidazo [1, 2-b] [1, 2,4jltriazine derivatives, substituted at the meta position of the phenyl ring with a (cyano) (fluoro) phenyl moiety, which are selective ligands for GABAA receptors , and which in particular have a good affinity for the subunit ci ~ 2 and / oc ~ 3 thereof, are therefore beneficial in the treatment and / or prevention of adverse disorders of the central nervous system, including anxiety and seizures.
DO2002000440A2002-07-162002-07-16
IMIDAZO-TRIZINA DERIVATIVES AS LIGANDS OF GABA RECEPTORS.
DOP2002000440A
(en)
Methods for the preparation of intermediate compounds of the condensed pyrazole type for the preparation of modulators of serotonin receptors. (divisional application n ° 2384-04)
COMPOUNDS DERIVED FROM DIBENZOFURANE, CARBAZOLS, PHOSPHODESTERASE TYPE 4 INHIBITORS; PREPARATION PROCEDURE; AND ITS USE IN THE TREATMENT OF INFLAMMATORY DISORDERS AND CONDITIONS, OF THE CENTRAL NERVOUS SYSTEM AND RESISTANT INSULIN DIABETES.
SYNTHETIC METHODS AND INTERMEDIATES FOR STEREOISOMER COMPOUNDS USED FOR TREATMENT OF GASTROINTESTINAL DISORDERS AND DISORDERS IN THE CENTRAL NERVOUS SYSTEM