DOP2001000184A - ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS - Google Patents

ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS

Info

Publication number
DOP2001000184A
DOP2001000184A DO2001000184A DO2001000184A DOP2001000184A DO P2001000184 A DOP2001000184 A DO P2001000184A DO 2001000184 A DO2001000184 A DO 2001000184A DO 2001000184 A DO2001000184 A DO 2001000184A DO P2001000184 A DOP2001000184 A DO P2001000184A
Authority
DO
Dominican Republic
Prior art keywords
acat
carboxialquileter
formula
inhibitor combinations
dyslipidemia
Prior art date
Application number
DO2001000184A
Other languages
Spanish (es)
Inventor
Bruce Jeffrey Auerbach
Donna Lee Zobel
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Priority to DO2001000184A priority Critical patent/DOP2001000184A/en
Publication of DOP2001000184A publication Critical patent/DOP2001000184A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención es una composicion farmaceutica que comprende un carboxialquileter que reduce trigliceridos y LDL y eleva el HDL y un inhibidor de ACAT que mejora la dislipidemia en mamiferos, dicha composicion es util para tratar la dislipidemia y sindromes isquemicos y para prevenir o retardar el comienzo de ataques cardiacos. Los carboxialquieteres tienen la formula en donde Y1 e Y2 incluyen COOH, R1, R2, R3 y R4 pueden ser alquilo, y n y m son numeros enteros de 2 a 9; y los inhibidores de ACAT tienen la formula en donde R es hidrogeno, X es 0, R1 y R2 son fenilo sustituido, e Y es alquileno.The invention is a pharmaceutical composition comprising a carboxyalkylether that reduces triglycerides and LDL and elevates HDL and an ACAT inhibitor that improves dyslipidemia in mammals, said composition is useful for treating dyslipidemia and ischemic syndromes and for preventing or delaying the onset of heart attacks. The carboxyalkieters have the formula wherein Y1 and Y2 include COOH, R1, R2, R3 and R4 can be alkyl, and n and m are whole numbers from 2 to 9; and ACAT inhibitors have the formula wherein R is hydrogen, X is 0, R1 and R2 are substituted phenyl, and Y is alkylene.

DO2001000184A 2001-06-05 2001-06-05 ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS DOP2001000184A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DO2001000184A DOP2001000184A (en) 2001-06-05 2001-06-05 ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DO2001000184A DOP2001000184A (en) 2001-06-05 2001-06-05 ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS

Publications (1)

Publication Number Publication Date
DOP2001000184A true DOP2001000184A (en) 2002-06-15

Family

ID=44261007

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2001000184A DOP2001000184A (en) 2001-06-05 2001-06-05 ACAT CARBOXIALQUILETER-INHIBITOR COMBINATIONS

Country Status (1)

Country Link
DO (1) DOP2001000184A (en)

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