DK990A - L-FUCOSE ANALOGS, PROCEDURES FOR PREPARING THEREOF, USING THE ANALOGS FOR PREPARING UNKNOWN GLYCALS, ANTHRACYCLINES OBTAINED BY USING THE GLYCALS AND USING THE USE OF ANY USE - Google Patents

L-FUCOSE ANALOGS, PROCEDURES FOR PREPARING THEREOF, USING THE ANALOGS FOR PREPARING UNKNOWN GLYCALS, ANTHRACYCLINES OBTAINED BY USING THE GLYCALS AND USING THE USE OF ANY USE Download PDF

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Publication number
DK990A
DK990A DK000990A DK990A DK990A DK 990 A DK990 A DK 990A DK 000990 A DK000990 A DK 000990A DK 990 A DK990 A DK 990A DK 990 A DK990 A DK 990A
Authority
DK
Denmark
Prior art keywords
glycals
preparing
analogs
anthracyclines
procedures
Prior art date
Application number
DK000990A
Other languages
Danish (da)
Other versions
DK990D0 (en
Inventor
Jean-Pierre Gesson
Patricia Petit
Martine Mondon
Jean-Claude Jacquesy
Hans Peter Kraemer
Original Assignee
Hoechst Lab
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Lab, Behringwerke Ag filed Critical Hoechst Lab
Publication of DK990D0 publication Critical patent/DK990D0/en
Publication of DK990A publication Critical patent/DK990A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Feed For Specific Animals (AREA)
DK000990A 1988-05-04 1990-01-03 L-FUCOSE ANALOGS, PROCEDURES FOR PREPARING THEREOF, USING THE ANALOGS FOR PREPARING UNKNOWN GLYCALS, ANTHRACYCLINES OBTAINED BY USING THE GLYCALS AND USING THE USE OF ANY USE DK990A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8805969A FR2630914A1 (en) 1988-05-04 1988-05-04 NOVEL ANALOGUES OF L-FUCOSE, PROCESS FOR THE PREPARATION THEREOF, APPLICATION OF THESE ANALOGUES TO THE PREPARATION OF NOVEL GLYCALS, ANTHRACYCLINES OBTAINED BY SAID GLYCALS AND USE OF SAID ANTHRACYCLINS AS MEDICAMENTS
PCT/FR1989/000217 WO1989010929A2 (en) 1988-05-04 1989-05-03 New l-fucose analogs, method of preparation, application of such analogs to the preparation of new glycals, anthracyclines obtained with said glycals and utilization of said anthracyclines as drugs

Publications (2)

Publication Number Publication Date
DK990D0 DK990D0 (en) 1990-01-03
DK990A true DK990A (en) 1990-03-05

Family

ID=9365971

Family Applications (1)

Application Number Title Priority Date Filing Date
DK000990A DK990A (en) 1988-05-04 1990-01-03 L-FUCOSE ANALOGS, PROCEDURES FOR PREPARING THEREOF, USING THE ANALOGS FOR PREPARING UNKNOWN GLYCALS, ANTHRACYCLINES OBTAINED BY USING THE GLYCALS AND USING THE USE OF ANY USE

Country Status (9)

Country Link
EP (1) EP0341154A3 (en)
JP (1) JPH02504153A (en)
KR (1) KR900701805A (en)
AU (1) AU3563089A (en)
DK (1) DK990A (en)
FI (1) FI900051A0 (en)
FR (1) FR2630914A1 (en)
PT (1) PT90446A (en)
WO (1) WO1989010929A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300683A (en) * 1988-09-28 1994-04-05 Exfluor Research Corporation Fluorination of acetals, ketals and orthoesters
CA2723197C (en) 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US9504702B2 (en) 2010-08-05 2016-11-29 Seattle Genetics, Inc. Methods of inhibition of protein fucosylation in vivo using fucose analogs
MX363385B (en) 2012-08-23 2019-03-20 Seattle Genetics Inc Treatment of sickle cell disease and inflammatory conditions.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4301276A (en) * 1980-03-07 1981-11-17 Purdue University Synthesis of daunosamine hydrochloride and intermediates used in its preparation
US4302449A (en) * 1980-09-02 1981-11-24 Board Of Control Of Michigan Technological University Carminomycin analogue
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
DE3712350A1 (en) * 1987-04-11 1988-10-20 Behringwerke Ag SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Also Published As

Publication number Publication date
PT90446A (en) 1989-11-30
AU3563089A (en) 1989-11-29
DK990D0 (en) 1990-01-03
KR900701805A (en) 1990-12-04
JPH02504153A (en) 1990-11-29
EP0341154A2 (en) 1989-11-08
FI900051A (en) 1990-01-04
FI900051A0 (en) 1990-01-04
WO1989010929A3 (en) 1990-02-22
FR2630914A1 (en) 1989-11-10
EP0341154A3 (en) 1991-10-02
WO1989010929A2 (en) 1989-11-16

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