DK633187A - METHOD OF PREPARING QUINOLINCARBOXYL ACID - Google Patents

METHOD OF PREPARING QUINOLINCARBOXYL ACID

Info

Publication number
DK633187A
DK633187A DK633187A DK633187A DK633187A DK 633187 A DK633187 A DK 633187A DK 633187 A DK633187 A DK 633187A DK 633187 A DK633187 A DK 633187A DK 633187 A DK633187 A DK 633187A
Authority
DK
Denmark
Prior art keywords
quinolincarboxyl
preparing
acid
agents
esters
Prior art date
Application number
DK633187A
Other languages
Danish (da)
Other versions
DK633187D0 (en
DK174929B1 (en
Inventor
Michael Preiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK633187D0 publication Critical patent/DK633187D0/en
Publication of DK633187A publication Critical patent/DK633187A/en
Application granted granted Critical
Publication of DK174929B1 publication Critical patent/DK174929B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A process for the preparation of quinolinecarboxylic acids of the formula (I) <IMAGE> in which R<1>, R<2> and R<3>, X and A have the meaning given in the description, which are used as such or in the form of their esters, salts, prodrugs etc. as antibacterial agents in human and veterinary medicine and as agents stimulating the immune defence.
DK198706331A 1986-12-03 1987-12-02 Process for the preparation of quinoline carboxylic acids or derivatives thereof DK174929B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863641312 DE3641312A1 (en) 1986-12-03 1986-12-03 METHOD FOR PRODUCING CHINOLINE CARBONIC ACIDS
DE3641312 1986-12-03

Publications (3)

Publication Number Publication Date
DK633187D0 DK633187D0 (en) 1987-12-02
DK633187A true DK633187A (en) 1988-06-04
DK174929B1 DK174929B1 (en) 2004-03-01

Family

ID=6315377

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198706331A DK174929B1 (en) 1986-12-03 1987-12-02 Process for the preparation of quinoline carboxylic acids or derivatives thereof

Country Status (25)

Country Link
EP (1) EP0274033B1 (en)
JP (1) JPS63145268A (en)
KR (1) KR970005191B1 (en)
CN (1) CN87107230A (en)
AT (1) ATE73446T1 (en)
AU (1) AU593961B2 (en)
CS (1) CS270577B2 (en)
DD (1) DD270904A5 (en)
DE (2) DE3641312A1 (en)
DK (1) DK174929B1 (en)
ES (1) ES2038156T3 (en)
FI (1) FI875289A (en)
GR (1) GR3004301T3 (en)
HU (1) HU199823B (en)
IE (1) IE64261B1 (en)
IL (1) IL84627A (en)
NO (1) NO174199C (en)
NZ (1) NZ222736A (en)
PH (1) PH24489A (en)
PL (1) PL158614B1 (en)
PT (1) PT86252B (en)
SU (1) SU1482526A3 (en)
UA (1) UA8017A1 (en)
YU (1) YU45049B (en)
ZA (1) ZA879040B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (en) * 1985-09-18 1990-05-05 Pfizer
EP0470252A4 (en) * 1989-04-28 1992-12-02 Daiichi Pharmaceutical Co., Ltd. Anti-hiv drug
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
JP2613139B2 (en) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 Quinolonecarboxylic acid derivatives
ES2050613B1 (en) * 1992-10-16 1996-03-16 Iteve S A NEW PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THE ACID 1-CICLOPROPIL-3-QUINOLINCARBOXILICO.
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
AU6421898A (en) * 1997-03-25 1998-10-20 Sankyo Company Limited Anti-fiv agent
KR100454750B1 (en) * 2002-06-20 2004-11-03 삼성에스디아이 주식회사 Blue light-emitting compound for organic electroluminescent device and organic electroluminescent device using the same
BRPI0413964B8 (en) 2003-09-10 2021-05-25 Kyorin Seiyaku Kk quinolone carboxylic acid derivative acid, its composition and antibacterial agent
JP5322927B2 (en) 2007-05-24 2013-10-23 杏林製薬株式会社 A mutilin derivative having a heteroaromatic carboxylic acid structure at the 14-position substituent.
CN101671302B (en) * 2008-12-30 2011-03-30 广东海康兽药有限公司 Production process of enrofloxacin antibacterial drug for fowl and livestock
CN101899044B (en) * 2010-08-16 2012-07-18 常州市勇毅生物药业有限公司 Method for synthesizing Gemifloxacin main ring compound
CN113912540A (en) * 2021-12-15 2022-01-11 山东国邦药业有限公司 Synthesis method of 1-cyclopropyl-6, 7-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
DE2656574A1 (en) * 1976-12-10 1978-06-15 Schering Ag 1-Alkyl-4-oxo-1,4-di:hydro-1,6-naphthyridine-3-carboxylic acid derivs. - with antibacterial activity esp. effective in the urinary tract
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5845426B2 (en) * 1978-09-29 1983-10-08 杏林製薬株式会社 Substituted quinoline carboxylic acid derivatives
DE3142854A1 (en) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
DE3318145A1 (en) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3420743A1 (en) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIHALOGEN-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
JPS61205258A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd Quinolonecarboxylic acid derivative and production thereof

Also Published As

Publication number Publication date
JPS63145268A (en) 1988-06-17
PH24489A (en) 1990-07-18
KR880007472A (en) 1988-08-27
UA8017A1 (en) 1995-12-26
NO174199B (en) 1993-12-20
FI875289A0 (en) 1987-12-01
ATE73446T1 (en) 1992-03-15
DK633187D0 (en) 1987-12-02
DK174929B1 (en) 2004-03-01
DE3777370D1 (en) 1992-04-16
CN87107230A (en) 1988-07-06
NZ222736A (en) 1990-08-28
PT86252B (en) 1990-11-07
DD270904A5 (en) 1989-08-16
IE873279L (en) 1988-06-03
NO874788D0 (en) 1987-11-17
PL269185A1 (en) 1989-01-05
IL84627A (en) 1992-01-15
CS868887A2 (en) 1989-11-14
NO174199C (en) 1994-04-06
PL158614B1 (en) 1992-09-30
ZA879040B (en) 1988-05-26
IE64261B1 (en) 1995-07-26
EP0274033B1 (en) 1992-03-11
NO874788L (en) 1988-06-06
YU45049B (en) 1991-06-30
SU1482526A3 (en) 1989-05-23
AU8217787A (en) 1988-06-09
EP0274033A1 (en) 1988-07-13
ES2038156T3 (en) 1993-07-16
CS270577B2 (en) 1990-07-12
HU199823B (en) 1990-03-28
HUT45521A (en) 1988-07-28
KR970005191B1 (en) 1997-04-14
YU215687A (en) 1988-10-31
IL84627A0 (en) 1988-04-29
FI875289A (en) 1988-06-04
PT86252A (en) 1988-01-01
DE3641312A1 (en) 1988-06-09
AU593961B2 (en) 1990-02-22
GR3004301T3 (en) 1993-03-31

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