DK630988D0 - METHOD FOR PREPARING DELTA1,4-3-KETO-21-HEMIESTER-STEROIDS - Google Patents

METHOD FOR PREPARING DELTA1,4-3-KETO-21-HEMIESTER-STEROIDS

Info

Publication number
DK630988D0
DK630988D0 DK630988A DK630988A DK630988D0 DK 630988 D0 DK630988 D0 DK 630988D0 DK 630988 A DK630988 A DK 630988A DK 630988 A DK630988 A DK 630988A DK 630988 D0 DK630988 D0 DK 630988D0
Authority
DK
Denmark
Prior art keywords
hemiester
keto
steroids
delta1
preparing
Prior art date
Application number
DK630988A
Other languages
Danish (da)
Other versions
DK630988A (en
DK175173B1 (en
Inventor
Leo A Kominek
Holly Jo Wolf
Paula S Steiert
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK630988D0 publication Critical patent/DK630988D0/en
Publication of DK630988A publication Critical patent/DK630988A/en
Application granted granted Critical
Publication of DK175173B1 publication Critical patent/DK175173B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention involves processes for 1,2-dehydrogenation of DELTA 4-3-keto C21-hemiester steroids of formula (I) <IMAGE> (I) with Arthrobacter simplex or Bacterium cyclooxydans to produce the corresponding DELTA 1,4-3-keto C21 hemiester of formula (II) <IMAGE> (II) or free alcohol thereof with improved yields. The advantage is that the processes utilize higher substrate concentrations and give shorter reaction times than previously were known.
DK198806309A 1987-03-12 1988-11-11 Process for the preparation of delta 1,4-3-keto-21-hemiester steroids DK175173B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2512787A 1987-03-12 1987-03-12
US2512787 1987-03-12
PCT/US1988/000405 WO1988007092A1 (en) 1987-03-12 1988-02-19 1,2-dehydrogenation of steroidal 21-esters with a. simplex
US8800405 1988-02-19

Publications (3)

Publication Number Publication Date
DK630988D0 true DK630988D0 (en) 1988-11-11
DK630988A DK630988A (en) 1988-11-11
DK175173B1 DK175173B1 (en) 2004-06-21

Family

ID=21824196

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806309A DK175173B1 (en) 1987-03-12 1988-11-11 Process for the preparation of delta 1,4-3-keto-21-hemiester steroids

Country Status (12)

Country Link
US (1) US5225335A (en)
EP (1) EP0350488B1 (en)
JP (1) JP2680870B2 (en)
KR (1) KR960013094B1 (en)
AT (1) ATE94212T1 (en)
AU (1) AU1340888A (en)
BG (1) BG50389A3 (en)
DE (1) DE3883973T2 (en)
DK (1) DK175173B1 (en)
HK (1) HK153896A (en)
HU (1) HU204305B (en)
WO (1) WO1988007092A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270660B (en) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa MICROBIOLOGICAL PROCEDURE FOR THE PREPARATION OF 3-OXO-4-AZASTEROIDS-17BETA-CARBOSS REPLACED AND USE OF THE PRODUCTS AS INHIBITORS OF THE 5ALPAL-REDUCED ENZYME ENZYME
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
EP1399463A1 (en) * 2001-06-18 2004-03-24 PHARMACIA &amp; UPJOHN COMPANY PROCESS TO PREPARE 11$g(b),17$g(a),21-TRIHYDROXY-6$g(a)-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
ES2744879T3 (en) 2008-05-28 2020-02-26 Reveragen Biopharma Inc Non-hormonal NF-kappaB steroid modulators for the treatment of diseases
WO2011127048A2 (en) 2010-04-05 2011-10-13 Validus Biopharma NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE
RU2480475C1 (en) * 2011-11-16 2013-04-27 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации Microbiological method of producing 21-acetoxypregna-1,4,9( 11 ),16-tetraene-3,20-dione from 21-acetoxypregna-4,9( 11 )16-triene-3,20-dione
CN103159817A (en) * 2011-12-13 2013-06-19 辽宁海思科制药有限公司 Preparation method for methylprednisolone succinate
CN104650172A (en) * 2015-03-25 2015-05-27 浙江仙琚制药股份有限公司 Method for preparing methylprednisolone hemisuccinate
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837464A (en) * 1955-01-11 1958-06-03 Schering Corp Process for production of dienes by corynebacteria
US2822318A (en) * 1956-12-07 1958-02-04 Olin Mathieson Production of 3-keto-delta pregnadienes by bacterium cyclo-oxydans
US2902411A (en) * 1957-06-28 1959-09-01 Upjohn Co Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
US2902410A (en) * 1957-09-26 1959-09-01 Upjohn Co Process for the 1,2-dehydrogenation of a steroid with septomyxa
US3360439A (en) * 1964-08-19 1967-12-26 Squibb & Sons Inc Process for preparing 1-dehydro steroids
US3770586A (en) * 1971-03-24 1973-11-06 Upjohn Co Process for the microbiological 1-dehydrogenation of certain 4,9-(11)-pregnadienes
US4524134A (en) * 1982-07-30 1985-06-18 The Upjohn Company Process for preparing 1,2-dehydro steroids
DE3322120A1 (en) * 1982-07-30 1984-02-02 The Upjohn Co., 49001 Kalamazoo, Mich. METHOD FOR CONVERTING 1,2-SATURED 3-KETOSTEROIDS IN 1,2-DEHYDROSTEROIDS
US4704358A (en) * 1982-10-25 1987-11-03 The Upjohn Company Δ1 -dehydrogenation with heat or air-dried B. cyclooxidans
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen

Also Published As

Publication number Publication date
KR890700679A (en) 1989-04-26
US5225335A (en) 1993-07-06
AU1340888A (en) 1988-10-10
JP2680870B2 (en) 1997-11-19
WO1988007092A1 (en) 1988-09-22
ATE94212T1 (en) 1993-09-15
JPH02502514A (en) 1990-08-16
DE3883973T2 (en) 1994-02-17
EP0350488B1 (en) 1993-09-08
HK153896A (en) 1996-08-16
EP0350488A1 (en) 1990-01-17
DK630988A (en) 1988-11-11
HUT50881A (en) 1990-03-28
DK175173B1 (en) 2004-06-21
KR960013094B1 (en) 1996-09-30
HU204305B (en) 1991-12-30
DE3883973D1 (en) 1993-10-14
BG50389A3 (en) 1992-07-15

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