DK498684A - PROCEDURE FOR MANUFACTURING A MANNICH BASE. - Google Patents

PROCEDURE FOR MANUFACTURING A MANNICH BASE. Download PDF

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Publication number
DK498684A
DK498684A DK498684A DK498684A DK498684A DK 498684 A DK498684 A DK 498684A DK 498684 A DK498684 A DK 498684A DK 498684 A DK498684 A DK 498684A DK 498684 A DK498684 A DK 498684A
Authority
DK
Denmark
Prior art keywords
procedure
manufacturing
ethylamino
ylmethyl
mannich base
Prior art date
Application number
DK498684A
Other languages
Danish (da)
Other versions
DK498684D0 (en
Inventor
Brian Michael Adger
Norman John Lewis
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of DK498684D0 publication Critical patent/DK498684D0/en
Publication of DK498684A publication Critical patent/DK498684A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A process for preparing 2-(2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethylamino)-5-(2-metho xypyrid-4- ylmethyl)pyrimidin-4-one which comprises reacting 2-(2-(furan-2-ylmethylthio)ethylamino)-5-(2-methoxypyrid-4-ylmethyl)py rimidin-4- one with a organic solution of bis(dimethylamino)methane at a pH of about 1.3 to about 2.5. The product is an H2-antagonist and also is of value in forming 2-(2-(5-dimethylaminomethylfuran-2-yl-methylthio)ethylamino)-5-(2-hydr oxypyrid-4 -ylmethyl)pyrimidin-4-one by deprotecting.
DK498684A 1983-10-21 1984-10-18 PROCEDURE FOR MANUFACTURING A MANNICH BASE. DK498684A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838328240A GB8328240D0 (en) 1983-10-21 1983-10-21 Chemical process

Publications (2)

Publication Number Publication Date
DK498684D0 DK498684D0 (en) 1984-10-18
DK498684A true DK498684A (en) 1985-04-22

Family

ID=10550572

Family Applications (1)

Application Number Title Priority Date Filing Date
DK498684A DK498684A (en) 1983-10-21 1984-10-18 PROCEDURE FOR MANUFACTURING A MANNICH BASE.

Country Status (14)

Country Link
EP (1) EP0141560B1 (en)
JP (1) JPS60109588A (en)
KR (1) KR850002978A (en)
AT (1) ATE40364T1 (en)
AU (1) AU3424184A (en)
CA (1) CA1261838A (en)
DE (1) DE3476390D1 (en)
DK (1) DK498684A (en)
ES (1) ES8506305A1 (en)
GB (1) GB8328240D0 (en)
GR (1) GR80702B (en)
HU (1) HUT37422A (en)
PT (1) PT79384B (en)
ZA (1) ZA848180B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (en) * 1978-02-13 1983-03-05 Smith Kline French Lab
DE3362182D1 (en) * 1982-07-20 1986-03-27 Smith Kline French Lab A process for the preparation of 2-(2-((5-dimethyl-aminomethyl)furan-2-ylmethylthio)ethylamino)-5-(6-methylpyrid-3-ylmethyl)pyrimid-4-one

Also Published As

Publication number Publication date
DE3476390D1 (en) 1989-03-02
ES536899A0 (en) 1985-07-01
AU3424184A (en) 1985-04-26
CA1261838A (en) 1989-09-26
JPS60109588A (en) 1985-06-15
EP0141560B1 (en) 1989-01-25
PT79384A (en) 1984-11-01
DK498684D0 (en) 1984-10-18
HUT37422A (en) 1985-12-28
PT79384B (en) 1986-11-14
ES8506305A1 (en) 1985-07-01
EP0141560A2 (en) 1985-05-15
ATE40364T1 (en) 1989-02-15
EP0141560A3 (en) 1986-02-05
ZA848180B (en) 1985-08-28
KR850002978A (en) 1985-05-28
GB8328240D0 (en) 1983-11-23
GR80702B (en) 1985-02-18

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment