DK484787D0 - BIS dioxopiperazine DERIVATIVES - Google Patents

BIS dioxopiperazine DERIVATIVES

Info

Publication number
DK484787D0
DK484787D0 DK484787A DK484787A DK484787D0 DK 484787 D0 DK484787 D0 DK 484787D0 DK 484787 A DK484787 A DK 484787A DK 484787 A DK484787 A DK 484787A DK 484787 D0 DK484787 D0 DK 484787D0
Authority
DK
Denmark
Prior art keywords
bis
dioxopiperazine derivatives
dioxopiperazine
derivatives
bis dioxopiperazine
Prior art date
Application number
DK484787A
Other languages
Danish (da)
Other versions
DK156831C (en
DK484787A (en
DK156831B (en
Inventor
Muneaki Takase
Jun-Chao Cai
Original Assignee
Zenyaku Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk
Publication of DK484787D0 publication Critical patent/DK484787D0/en
Publication of DK484787A publication Critical patent/DK484787A/en
Publication of DK156831B publication Critical patent/DK156831B/en
Application granted granted Critical
Publication of DK156831C publication Critical patent/DK156831C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK484787A 1986-02-07 1987-09-15 BIS-DIOXOPIPERAZINE DERIVATIVES WITH ANTITUMOR ACTIVITY AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK156831C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2519186 1986-02-07
JP2519186 1986-02-07
JP8700074 1987-02-05
PCT/JP1987/000074 WO1987004707A1 (en) 1986-02-07 1987-02-05 Bis-dioxopiperazine derivatives
CA536472 1987-05-06
CA000536472A CA1305484C (en) 1986-02-07 1987-05-06 Bis-dioxopiperazine derivatives and process for preparation thereof

Publications (4)

Publication Number Publication Date
DK484787D0 true DK484787D0 (en) 1987-09-15
DK484787A DK484787A (en) 1987-09-15
DK156831B DK156831B (en) 1989-10-09
DK156831C DK156831C (en) 1990-03-19

Family

ID=25671332

Family Applications (1)

Application Number Title Priority Date Filing Date
DK484787A DK156831C (en) 1986-02-07 1987-09-15 BIS-DIOXOPIPERAZINE DERIVATIVES WITH ANTITUMOR ACTIVITY AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (8)

Country Link
US (1) US4868303A (en)
EP (1) EP0256137B1 (en)
JP (1) JPH0674251B2 (en)
CA (1) CA1305484C (en)
DE (1) DE3783176T2 (en)
DK (1) DK156831C (en)
NO (1) NO173604C (en)
WO (1) WO1987004707A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU642519B2 (en) * 1990-07-04 1993-10-21 Zenyaku Kogyo Kabushiki Kaisha Water-soluble bis-dioxopiperazine derivative
AU681337B2 (en) * 1991-10-23 1997-08-28 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
EP2941423B1 (en) 2013-01-07 2021-06-09 University of Southern California Deoxyuridine triphosphatase inhibitors
CA2935717C (en) 2014-01-03 2022-06-21 University Of Southern California Uracil isostere and pharmaceutical compositions thereof useful as deoxyuridine triphosphatase inhibitors
CA2991468A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2017006283A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
WO2018098206A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US11174271B2 (en) 2016-11-23 2021-11-16 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018128720A1 (en) 2017-01-05 2018-07-12 Cv6 Therapeutics (Ni) Limited Uracil containing compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1240700B (en) * 1960-10-31 1967-05-18 Eastman Kodak Co Jet fuels
NL273692A (en) * 1961-01-19 1900-01-01
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
NL163957C (en) * 1968-07-02 1980-11-17 Nat Res Dev METHOD FOR PREPARING A MEDICINE AGAINST CANCER, AND METHOD FOR PREPARING A 1,2-DI (3,5-DIOXOPIPERAZINOALCANE COMPOUND).
DE2511891A1 (en) * 1975-03-19 1976-10-07 Gruenenthal Chemie Anti-thrombotic dioxo-piperazine derivs - prepd. e.g. by cyclising N,N,N',N'-1,2-alkylene-diamine-tetraacetic acids with amines
US4404381A (en) * 1981-06-19 1983-09-13 The Dow Chemical Company Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides
US4737497A (en) * 1983-04-12 1988-04-12 Zenyaki Kogyo Kabushiki Kaisha Bis-dioxopiperazine derivatives, antitumor agents comprising them and compositions containing them
JPS6097963A (en) * 1983-10-31 1985-05-31 Zenyaku Kogyo Kk Bis-dioxopiperazine derivative, its production and antitumor agent composed thereof
US4536564A (en) * 1983-12-09 1985-08-20 The Dow Chemical Company Polyamide from bis-carboxy containing 3,5,3',5'-tetraoxo-1,2-dipiperazine compound and diamine
JPS60152660A (en) * 1984-01-23 1985-08-10 Nisshin Steel Co Ltd Precipitation hardening martensitic stainless steel
JPS61152660A (en) * 1984-12-26 1986-07-11 Zenyaku Kogyo Kk Bis-dioxopiperazine derivative
JPH0676392B2 (en) * 1985-06-26 1994-09-28 全薬工業株式会社 Bis-dioxopiperazine derivative and antitumor agent comprising the same
US4764614A (en) * 1987-03-23 1988-08-16 Monsanto Company Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
JPH0697963A (en) * 1992-07-02 1994-04-08 Oki Electric Ind Co Ltd Packet switching system

Also Published As

Publication number Publication date
WO1987004707A1 (en) 1987-08-13
EP0256137B1 (en) 1992-12-23
CA1305484C (en) 1992-07-21
JPS62281870A (en) 1987-12-07
DK156831C (en) 1990-03-19
EP0256137A4 (en) 1989-01-19
DE3783176D1 (en) 1993-02-04
AU7025587A (en) 1987-08-25
NO173604B (en) 1993-09-27
NO173604C (en) 1994-01-05
NO874197D0 (en) 1987-10-07
NO874197L (en) 1987-12-07
DK484787A (en) 1987-09-15
JPH0674251B2 (en) 1994-09-21
DK156831B (en) 1989-10-09
AU602332B2 (en) 1990-10-11
US4868303A (en) 1989-09-19
EP0256137A1 (en) 1988-02-24
DE3783176T2 (en) 1993-04-22

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Legal Events

Date Code Title Description
PBP Patent lapsed