DK450584D0 - EXPRESSION VECTORS AND ITS USE FOR PREPARING A PROTEIN WITH THE ACTIVITY OF HUMAN ANTITRYPSIN-ALFA1 - Google Patents

EXPRESSION VECTORS AND ITS USE FOR PREPARING A PROTEIN WITH THE ACTIVITY OF HUMAN ANTITRYPSIN-ALFA1

Info

Publication number
DK450584D0
DK450584D0 DK450584A DK450584A DK450584D0 DK 450584 D0 DK450584 D0 DK 450584D0 DK 450584 A DK450584 A DK 450584A DK 450584 A DK450584 A DK 450584A DK 450584 D0 DK450584 D0 DK 450584D0
Authority
DK
Denmark
Prior art keywords
alfa1
protein
preparing
activity
expression vectors
Prior art date
Application number
DK450584A
Other languages
Danish (da)
Other versions
DK450584A (en
Inventor
Michael Courtney
Anne Buchwalder
Luc-Henri Tessier
Michael Jaye
Richard Lathe
Paul Tolstoshev
Jean-Pierre Lecocq
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8300909A external-priority patent/FR2539758B1/en
Priority claimed from FR8311594A external-priority patent/FR2549082B2/en
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of DK450584A publication Critical patent/DK450584A/en
Publication of DK450584D0 publication Critical patent/DK450584D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK450584A 1983-01-21 1984-09-20 EXPRESSION VECTORS AND ITS USE FOR PREPARING A PROTEIN WITH THE ACTIVITY OF HUMAN ANTITRYPSIN-ALFA1 DK450584D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8300909A FR2539758B1 (en) 1983-01-21 1983-01-21 NOVEL EXPRESSION VECTORS AND THEIR APPLICATION TO THE PREPARATION OF A PROTEIN HAVING THE ACTIVITY OF HUMAN ANTITRYPSIN-A1
FR8311594A FR2549082B2 (en) 1983-07-12 1983-07-12 IMPROVED PROTEIN EXPRESSION VECTORS HAVING HUMAN ANTITRYPSIN-A1 ACTIVITY
PCT/FR1984/000014 WO1984002918A1 (en) 1983-01-21 1984-01-20 NEW EXPRESSION VECTORS AND APPLICATION THEREOF TO THE PREPARATION OF A PROTEIN HAVING THE ACTIVITY OF HUMAN ANTITRYPSIN-alpha1

Publications (2)

Publication Number Publication Date
DK450584A DK450584A (en) 1984-09-20
DK450584D0 true DK450584D0 (en) 1984-09-20

Family

ID=26223249

Family Applications (1)

Application Number Title Priority Date Filing Date
DK450584A DK450584D0 (en) 1983-01-21 1984-09-20 EXPRESSION VECTORS AND ITS USE FOR PREPARING A PROTEIN WITH THE ACTIVITY OF HUMAN ANTITRYPSIN-ALFA1

Country Status (5)

Country Link
EP (1) EP0114777B1 (en)
CA (1) CA1303530C (en)
DE (1) DE3482840D1 (en)
DK (1) DK450584D0 (en)
WO (1) WO1984002918A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304971B1 (en) * 1982-08-13 1998-02-04 ZymoGenetics, Inc. A method of producing a polypeptide having the protease inhibition activity of mammalian alpha-1-antitrypsin
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
BE895961A (en) * 1983-02-21 1983-06-16 Wallone Region PROCESS FOR THE PREPARATION OF A BACTERIAL CLONE PRODUCING HUMAN ALPHA 1-ANTITRYPSIN
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
JPS60186290A (en) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド Development of alpha-1-antitrypsin by bacteria
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US4766066A (en) * 1984-09-27 1988-08-23 Eli Lilly And Company Method of using bacteriophage lambda p1 promoter to produce a functional polypeptide in streptomyces
AU6469886A (en) * 1985-11-08 1987-05-14 Smithkline Beckman Corporation Mutant alpha-1-antitryosin and dna sequence therefor
FR2594845B1 (en) * 1986-02-21 1989-12-01 Genetica MICROBIOLOGICAL PREPARATION OF THE HUMAN PLASMINOGEN TISSUE ACTIVATOR (T-PA) AND CONVERSION OF THE ENZYME SO OBTAINED IN ITS ACTIVE FORM
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
FR2601033B1 (en) * 1986-07-02 1990-01-19 Transgene Sa VARIANTS OF GLYCOSYLATED HUMAN ALPHA-ANTITRYSPIN AND PROCESS FOR THE PREPARATION
US4839283A (en) * 1986-12-30 1989-06-13 Zymogenetics, Inc. Method of expressing alpha-1-antitrypsin in yeast
AU782051B2 (en) * 1996-06-03 2005-06-30 Case Western Reserve University Enhanced delivery via serpin enzyme complex receptor
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AU2354801A (en) * 1999-11-08 2001-06-06 Ipf Pharmaceuticals Gmbh Peptide (virip) which inhibits a circulating virus in humans and the use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1431678A (en) * 1963-06-12 1966-03-18 Behringwerke Ag Method for the isolation of alpha1-antitrypsin
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
BR8101972A (en) * 1980-06-06 1982-08-17 Biogen Nv VECTOR, PROCESS FOR ITS PRODUCTION, PROCESS TO PRODUCE A RECOMBINANT DNA MOLECULE, AND PROCESS TO PRODUCE A POLYPEPTIDE
FR2526661B1 (en) * 1982-05-13 1986-02-21 Transgene Sa NOVEL VECTORS FOR THE EXPRESSION OF THE ANTIGENIC PROTEIN OF RABIES AND THEIR APPLICATION TO THE PREPARATION OF VACCINES
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression

Also Published As

Publication number Publication date
WO1984002918A1 (en) 1984-08-02
DK450584A (en) 1984-09-20
DE3482840D1 (en) 1990-09-06
CA1303530C (en) 1992-06-16
EP0114777A3 (en) 1985-06-05
EP0114777A2 (en) 1984-08-01
EP0114777B1 (en) 1990-08-01

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