DK3662053T3 - Kryptiske metabolitter og fremgangsmåde til aktivering af stille biosyntetiske genklynger i forskellige mikroorganismer - Google Patents
Kryptiske metabolitter og fremgangsmåde til aktivering af stille biosyntetiske genklynger i forskellige mikroorganismer Download PDFInfo
- Publication number
- DK3662053T3 DK3662053T3 DK18841482.5T DK18841482T DK3662053T3 DK 3662053 T3 DK3662053 T3 DK 3662053T3 DK 18841482 T DK18841482 T DK 18841482T DK 3662053 T3 DK3662053 T3 DK 3662053T3
- Authority
- DK
- Denmark
- Prior art keywords
- regeneration
- various microorganisms
- biosynthetic
- activating
- cryptic metabolites
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539263P | 2017-07-31 | 2017-07-31 | |
| PCT/US2018/044328 WO2019027877A1 (en) | 2017-07-31 | 2018-07-30 | CRYPTIC METABOLITES AND METHOD FOR ACTIVATION OF SILENT BIOSYNTHETIC GENE GROUPS IN VARIOUS MICROORGANISMS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3662053T3 true DK3662053T3 (da) | 2025-01-06 |
Family
ID=65234047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18841482.5T DK3662053T3 (da) | 2017-07-31 | 2018-07-30 | Kryptiske metabolitter og fremgangsmåde til aktivering af stille biosyntetiske genklynger i forskellige mikroorganismer |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11549950B2 (da) |
| EP (2) | EP3662053B1 (da) |
| CN (1) | CN111164202B (da) |
| DK (1) | DK3662053T3 (da) |
| WO (1) | WO2019027877A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112147211B (zh) * | 2020-09-23 | 2021-08-17 | 中国科学院青岛生物能源与过程研究所 | 原位分析微生物菌落中角鲨烯含量的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100285446A1 (en) | 2007-07-20 | 2010-11-11 | Akos Vertes | Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry |
| WO2013022763A1 (en) * | 2011-08-05 | 2013-02-14 | The Scripps Research Institute | Glycopeptide antibiotic analogs effective against vancomycin-resistant bacterial strains |
| US9596861B2 (en) | 2013-12-24 | 2017-03-21 | Sami Labs Limited | Method of producing partially purified extracellular metabolite products from Bacillus coagulans and biological applications thereof |
| WO2015138442A1 (en) * | 2014-03-10 | 2015-09-17 | The Trustees Of Princeton University | Method for awakening silent gene clusters in bacteria and discovery of cryptic metabolites |
| CN106497981B (zh) * | 2016-10-31 | 2020-07-07 | 广东省微生物研究所 | 一种激活微生物隐性次级代谢产物生物合成基因簇表达的方法 |
-
2018
- 2018-07-30 EP EP18841482.5A patent/EP3662053B1/en active Active
- 2018-07-30 DK DK18841482.5T patent/DK3662053T3/da active
- 2018-07-30 WO PCT/US2018/044328 patent/WO2019027877A1/en not_active Ceased
- 2018-07-30 CN CN201880063706.9A patent/CN111164202B/zh active Active
- 2018-07-30 EP EP24202193.9A patent/EP4462125A3/en active Pending
- 2018-07-30 US US16/634,388 patent/US11549950B2/en active Active
-
2022
- 2022-12-01 US US18/072,800 patent/US20230123785A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3662053B1 (en) | 2024-09-25 |
| EP3662053A4 (en) | 2021-12-29 |
| US20230123785A1 (en) | 2023-04-20 |
| WO2019027877A1 (en) | 2019-02-07 |
| US20210041452A1 (en) | 2021-02-11 |
| EP3662053A1 (en) | 2020-06-10 |
| CN111164202A (zh) | 2020-05-15 |
| EP4462125A2 (en) | 2024-11-13 |
| EP4462125A3 (en) | 2025-02-12 |
| US11549950B2 (en) | 2023-01-10 |
| CN111164202B (zh) | 2023-12-29 |
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