DK3639191T3 - Fremgangsmåde til træning af en deep learning-model for at opnå histopatologisk information fra billeder - Google Patents

Fremgangsmåde til træning af en deep learning-model for at opnå histopatologisk information fra billeder Download PDF

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Publication number
DK3639191T3
DK3639191T3 DK18729159.6T DK18729159T DK3639191T3 DK 3639191 T3 DK3639191 T3 DK 3639191T3 DK 18729159 T DK18729159 T DK 18729159T DK 3639191 T3 DK3639191 T3 DK 3639191T3
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training
images
learning model
deep learning
histopathological information
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DK18729159.6T
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DK3639191T4 (da
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Jeppe Thagaard
Thomas Ebstrup
Michael Grunkin
Johan Doré Hansen
Michael Friis Lippert
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Visiopharm As
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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/774—Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
    • G06V10/7753—Incorporation of unlabelled data, e.g. multiple instance learning [MIL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03—Recognition of patterns in medical or anatomical images

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  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Databases & Information Systems (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Computing Systems (AREA)
  • Artificial Intelligence (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK18729159.6T 2017-06-15 2018-06-12 Fremgangsmåde til træning af en deep learning-model for at opnå histopatologisk information fra billeder DK3639191T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17176214 2017-06-15
PCT/EP2018/065504 WO2018229052A1 (en) 2017-06-15 2018-06-12 Method for training a deep learning model to obtain histopathological information from images

Publications (2)

Publication Number Publication Date
DK3639191T3 true DK3639191T3 (da) 2021-12-06
DK3639191T4 DK3639191T4 (da) 2024-09-30

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ID=59215476

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18729159.6T DK3639191T4 (da) 2017-06-15 2018-06-12 Fremgangsmåde til træning af en deep learning-model for at opnå histopatologisk information fra billeder

Country Status (4)

Country Link
US (1) US11276165B2 (da)
EP (1) EP3639191B2 (da)
DK (1) DK3639191T4 (da)
WO (1) WO2018229052A1 (da)

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WO2019139591A1 (en) * 2018-01-11 2019-07-18 Google Llc Method for creating histopathological ground truth masks using slide restaining
CN111699510A (zh) * 2018-02-12 2020-09-22 豪夫迈·罗氏有限公司 数字病理学图像的变换
EP3608701A1 (de) * 2018-08-09 2020-02-12 Olympus Soft Imaging Solutions GmbH Verfahren zur bereitstellung wenigstens einer auswertemethode für proben
JP7090171B2 (ja) * 2018-10-09 2022-06-23 オリンパス株式会社 画像処理装置の作動方法、画像処理装置、及び画像処理装置の作動プログラム
US20220058839A1 (en) * 2018-12-31 2022-02-24 Oregon Health & Science University Translation of images of stained biological material
US11633146B2 (en) 2019-01-04 2023-04-25 Regents Of The University Of Minnesota Automated co-registration of prostate MRI data
US11631171B2 (en) * 2019-01-10 2023-04-18 Regents Of The University Of Minnesota Automated detection and annotation of prostate cancer on histopathology slides
US12094105B2 (en) * 2019-06-10 2024-09-17 Datma, Inc. System and method for automatic labeling of pathology images
EP3761032A1 (en) 2019-07-03 2021-01-06 Xyall B.V. Determining region(s) for tissue dissection in pathology slides
CN116075831A (zh) * 2020-08-18 2023-05-05 安捷伦科技有限公司 用于深度学习图像分析和虚拟染色的生物样本的组织染色和连续成像
CN112101451B (zh) * 2020-09-14 2024-01-05 北京联合大学 一种基于生成对抗网络筛选图像块的乳腺癌组织病理类型分类方法
US11321843B1 (en) * 2020-12-29 2022-05-03 Rewire Neuro, Inc. Adaptive machine learning system for image based biological sample constituent analysis
CN113256618A (zh) * 2021-06-23 2021-08-13 重庆点检生物科技有限公司 一种基于ihc染色的肿瘤识别系统及方法
US20230033075A1 (en) * 2021-07-13 2023-02-02 Nvidia Corporation Image annotation using one or more neural networks
CN113344925B (zh) * 2021-08-05 2021-12-07 深圳市瑞图生物技术有限公司 识别模型的训练方法
CN114674644B (zh) * 2021-09-07 2024-08-27 福州迈新生物技术开发有限公司 一种基于免疫组化生成训练数据的方法和存储设备
WO2024011400A1 (zh) * 2022-07-12 2024-01-18 福州迈新生物技术开发有限公司 生成用于计算浸润性乳腺癌细胞Ki-67计数的训练数据的方法、存储设备和试剂盒
CN115240000B (zh) * 2022-07-22 2023-05-02 司法鉴定科学研究院 一种用于法医鉴定的糖尿病检测装置及方法
EP4372701A1 (en) * 2022-11-17 2024-05-22 Aignostics GmbH Systems and methods for the detection and classification of biological structures
CN116883397B (zh) * 2023-09-06 2023-12-08 佳木斯大学 一种应用于解剖病理学的自动精益方法及系统

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE477558T1 (de) 2006-11-16 2010-08-15 Visiopharm As Auf merkmalen basierende registrierung von schnittbildern
US8787651B2 (en) * 2010-09-28 2014-07-22 Flagship Biosciences, LLC Methods for feature analysis on consecutive tissue sections
CN105027164B (zh) 2013-03-14 2018-05-18 文塔纳医疗系统公司 完整载片图像配准和交叉图像注释设备、系统和方法
EP3053139B1 (en) * 2013-10-01 2020-10-21 Ventana Medical Systems, Inc. Line-based image registration and cross-image annotation devices, systems and methods
AU2014333927A1 (en) 2013-10-07 2016-03-03 Ventana Medical Systems, Inc. Systems and methods for comprehensive multi-assay tissue analysis
EP3108446B1 (en) 2014-02-21 2019-03-20 Ventana Medical Systems, Inc. Medical image analysis for identifying biomarker-positive tumor cells
WO2015189264A1 (en) 2014-06-10 2015-12-17 Ventana Medical Systems, Inc. Predicting breast cancer recurrence directly from image features computed from digitized immunohistopathology tissue slides
US10572996B2 (en) 2016-06-28 2020-02-25 Contextvision Ab Method and system for detecting pathological anomalies in a digital pathology image and method for annotating a tissue slide
JP6968177B2 (ja) * 2016-12-22 2021-11-17 ベンタナ メディカル システムズ， インコーポレイテッド 一次染色および免疫組織化学画像に基づくコンピュータ採点

Also Published As

Publication number Publication date
WO2018229052A1 (en) 2018-12-20
US11276165B2 (en) 2022-03-15
US20210150701A1 (en) 2021-05-20
EP3639191A1 (en) 2020-04-22
DK3639191T4 (da) 2024-09-30
EP3639191B2 (en) 2024-07-17
EP3639191B1 (en) 2021-09-01

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