DK362688A - FLUORABLE POLYPEPTIDES AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVE MEDICINES - Google Patents

FLUORABLE POLYPEPTIDES AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVE MEDICINES

Info

Publication number
DK362688A
DK362688A DK362688A DK362688A DK362688A DK 362688 A DK362688 A DK 362688A DK 362688 A DK362688 A DK 362688A DK 362688 A DK362688 A DK 362688A DK 362688 A DK362688 A DK 362688A
Authority
DK
Denmark
Prior art keywords
fluorable
polypeptides
preparation
chem
antihypertensive medicines
Prior art date
Application number
DK362688A
Other languages
Danish (da)
Other versions
DK362688D0 (en
Inventor
Dennis Jay Hoover
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK362688D0 publication Critical patent/DK362688D0/en
Publication of DK362688A publication Critical patent/DK362688A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Renin inhibitors, useful as antihypertensives, of the formula:- <CHEM> or a pharmaceutically acceptable salt thereof, wherein X is O or NH; R1 is alkyl having one to six carbon atoms, imidazol-4-ylmethyl or methylthiomethyl; Y is <CHEM> and R2 is CF2CONHCH3, CF3 or <CHEM> C
DK362688A 1987-07-01 1988-06-30 FLUORABLE POLYPEPTIDES AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVE MEDICINES DK362688A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6898987A 1987-07-01 1987-07-01

Publications (2)

Publication Number Publication Date
DK362688D0 DK362688D0 (en) 1988-06-30
DK362688A true DK362688A (en) 1989-02-14

Family

ID=22085994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK362688A DK362688A (en) 1987-07-01 1988-06-30 FLUORABLE POLYPEPTIDES AND THEIR USE FOR THE PREPARATION OF ANTIHYPERTENSIVE MEDICINES

Country Status (9)

Country Link
EP (1) EP0297815B1 (en)
JP (1) JPH0757759B2 (en)
AT (1) ATE109157T1 (en)
CA (1) CA1322075C (en)
DE (1) DE3850818T2 (en)
DK (1) DK362688A (en)
ES (1) ES2056930T3 (en)
FI (1) FI883134A (en)
PT (1) PT87867B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
DE4126485A1 (en) * 1991-08-10 1993-02-11 Bayer Ag TRIFLUOROMETHYL-CONTAINING PSEUDOPEPTIDE
JP2005259307A (en) * 2004-03-15 2005-09-22 Sony Corp Optical pickup and disk driver
US7964690B2 (en) 2005-11-24 2011-06-21 Asahi Kasei Chemicals Corporation Methacrylic resin and process for producing thererof
TWI490240B (en) 2009-10-22 2015-07-01 Asahi Kasei Chemicals Corp Forming body

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3538749A1 (en) * 1985-10-31 1987-05-07 Merck Patent Gmbh PEPTIDE

Also Published As

Publication number Publication date
FI883134A (en) 1989-01-02
DK362688D0 (en) 1988-06-30
DE3850818T2 (en) 1994-11-17
PT87867A (en) 1989-06-30
EP0297815A2 (en) 1989-01-04
JPS6422865A (en) 1989-01-25
CA1322075C (en) 1993-09-07
EP0297815A3 (en) 1990-06-06
ES2056930T3 (en) 1994-10-16
PT87867B (en) 1995-05-04
EP0297815B1 (en) 1994-07-27
FI883134A0 (en) 1988-06-30
DE3850818D1 (en) 1994-09-01
ATE109157T1 (en) 1994-08-15
JPH0757759B2 (en) 1995-06-21

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment