DK355489A - USE OF SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES FOR THE PREPARATION OF A MEDICINE AGAINST OBSTRUCTIVE FUNCTIONAL DISORDERS OF THE LUNGS AND / OR DISORDERS OF THE URINARY ROADS - Google Patents

USE OF SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES FOR THE PREPARATION OF A MEDICINE AGAINST OBSTRUCTIVE FUNCTIONAL DISORDERS OF THE LUNGS AND / OR DISORDERS OF THE URINARY ROADS Download PDF

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Publication number
DK355489A
DK355489A DK355489A DK355489A DK355489A DK 355489 A DK355489 A DK 355489A DK 355489 A DK355489 A DK 355489A DK 355489 A DK355489 A DK 355489A DK 355489 A DK355489 A DK 355489A
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DK
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Prior art keywords
disorders
alkyl
dihydro
substituted
urinary
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DK355489A
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Danish (da)
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DK171782B1 (en
DK355489D0 (en
Inventor
Heinrich Christian Englert
Erik Klaus
Dieter Mania
Bernward Schoelkens
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Hoechst Ag
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Publication of DK355489D0 publication Critical patent/DK355489D0/en
Publication of DK355489A publication Critical patent/DK355489A/en
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Publication of DK171782B1 publication Critical patent/DK171782B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrane Compounds (AREA)

Abstract

The use of 3,4-dihydro-2H-benzo[b]pyrans of the formula I <IMAGE> in which R<1> is H, OH, (C1-C2)-alkoxy, (C1-C2)-alkyl or NR<4>R<5>, where R<4> and R<5> are identical or different and are H, (C1-C2)-alkyl or (C1-C3)-alkylcarbonyl, R<2> and R<3> are identical or different and are alkyl with 1-4 C atoms, Ar is an aromatic or heteroaromatic system which is unsubstituted or substituted by 1 to 3 identical or different radicals (C1-C2)-alkyl, (C1-C2)-alkoxy, halogen, trifluoromethyl, CN, NO2, CO-(C1-C2)-alkyl or SOm-(C1-C2)-alkyl with m = 1 or 2, n is 1 or 2, X is a chain (CH2)r which can be interrupted by a heteroatom O, S or NR<6> where R<6> is H or (C1-C4)-alkyl and r is the numbers 2, 3, 4 or 5, for the production of a medicament for urinary tract disorders.
DK355489A 1988-07-19 1989-07-18 Use of 3,4-dihydro-2H-benzo [b] pyrans for the manufacture of a drug against obstructive pulmonary dysfunction DK171782B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3824446A DE3824446A1 (en) 1988-07-19 1988-07-19 USE OF SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANE AS A MEDICINE AGAINST OBSTRUCTIVE FUNCTIONAL DISORDERS OF THE LUNG AND / OR DISORDERS OF THE LEADING URINE PATHS
DE3824446 1988-07-19

Publications (3)

Publication Number Publication Date
DK355489D0 DK355489D0 (en) 1989-07-18
DK355489A true DK355489A (en) 1990-01-20
DK171782B1 DK171782B1 (en) 1997-05-26

Family

ID=6359009

Family Applications (1)

Application Number Title Priority Date Filing Date
DK355489A DK171782B1 (en) 1988-07-19 1989-07-18 Use of 3,4-dihydro-2H-benzo [b] pyrans for the manufacture of a drug against obstructive pulmonary dysfunction

Country Status (18)

Country Link
EP (2) EP0351720B1 (en)
JP (1) JPH0273015A (en)
KR (1) KR900001367A (en)
AT (1) ATE110270T1 (en)
AU (1) AU621388B2 (en)
CA (1) CA1336891C (en)
CZ (1) CZ417091A3 (en)
DE (2) DE3824446A1 (en)
DK (1) DK171782B1 (en)
ES (1) ES2061816T3 (en)
FI (1) FI893460A (en)
HU (1) HU210149B (en)
IE (1) IE63872B1 (en)
IL (1) IL91015A (en)
NZ (1) NZ229961A (en)
PH (1) PH26696A (en)
PT (1) PT91197B (en)
ZA (1) ZA895459B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW244350B (en) * 1991-12-14 1995-04-01 Hoechst Ag
TW316850B (en) * 1992-02-28 1997-10-01 Takeda Pharm Industry Co Ltd
HUT72741A (en) * 1992-12-19 1996-05-28 Alkaloida Vegyeszeti Gyar Method for producing benzopyrane derivatives and pharmaceutical compositions containing them
GB9316111D0 (en) * 1993-08-04 1993-09-22 Pfizer Ltd Benzopyrans
WO2001047491A1 (en) 1999-12-23 2001-07-05 Coifman Robert E Methods and formulations for the efficient delivery of water-insoluble drugs by nebulizer
KR100475147B1 (en) * 2002-09-09 2005-03-10 정의상 Remove noxious gas deodorant composite of alumina dust
US7306789B2 (en) 2002-11-12 2007-12-11 Warner-Lambert Company, Llc Method of stimulating hair growth using benzopyrans

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3364734D1 (en) * 1982-10-19 1986-08-28 Beecham Group Plc Novel chromans and chromenes
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3881714D1 (en) * 1987-02-04 1993-07-22 Hoechst Ag ALKYL-SUBSTITUTED N-BENZOPYRANYLLACTAME, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS.
DE3703227A1 (en) * 1987-02-04 1988-08-18 Hoechst Ag SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS

Also Published As

Publication number Publication date
HUT55988A (en) 1991-07-29
ES2061816T3 (en) 1994-12-16
JPH0273015A (en) 1990-03-13
AU3818989A (en) 1990-01-25
ZA895459B (en) 1990-03-28
NZ229961A (en) 1991-11-26
IE892323L (en) 1990-01-19
ATE110270T1 (en) 1994-09-15
DK171782B1 (en) 1997-05-26
PT91197B (en) 1995-07-18
IL91015A (en) 1994-11-28
EP0351720B1 (en) 1994-08-24
CZ417091A3 (en) 1993-02-17
DK355489D0 (en) 1989-07-18
PH26696A (en) 1992-09-15
AU621388B2 (en) 1992-03-12
FI893460A0 (en) 1989-07-17
EP0351720A3 (en) 1992-01-02
IE63872B1 (en) 1995-06-14
FI893460A (en) 1990-01-20
PT91197A (en) 1990-02-08
EP0560399A1 (en) 1993-09-15
KR900001367A (en) 1990-02-27
DE58908228D1 (en) 1994-09-29
CA1336891C (en) 1995-09-05
HU210149B (en) 1995-02-28
EP0351720A2 (en) 1990-01-24
DE3824446A1 (en) 1990-01-25

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