DK351087A - NEW PROPAN-1,3-DIOL DERIVATIVES, THEIR PREPARATION AND USE - Google Patents

Abstract

A derivative of 2-methylenepropane-1,3-diol of the general formula I <IMAGE> where O-A1 and O-A2, which can be identical or different, each represents O, O-C(O), O-C(O)NH, O-C(S)NH or O-C(O)O, R1 denotes an alkyl or alkenyl group having 10-22 carbon atoms, n is an integer from 1 to 11, B+ denotes a quaternary ammonium group, either N+R4R5R6 or N+(Het), where R4, R5 and R6 are identical or different alkyl groups having 1-4 carbon atoms, or two or all of R4, R5 and R6 can enter into a cyclic or bicyclic structure which can contain additional heteroatoms; X- denotes the anion of a pharmaceutically acceptable inorganic or organic acid; and R2 and R3 are identical or different and denote hydrogen or alkyl groups having 1-4 carbon atoms. The present compounds have been found to possess a PAF- antagonistic effect and an inhibitory effect on the growth of tumour cells and are consequently valuable in human and veterinary practice as inhibitors of blood platelet aggregation, as agents against thromboses, asthma, allergy, inflammation, hypotension, gastric ulcer, psoriasis and transplant rejection, and as anti- conception and anti-tumour agents.