DK3426641T3 - Immunoproteasominhibitoranaloger - Google Patents

Immunoproteasominhibitoranaloger Download PDF

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Publication number
DK3426641T3
DK3426641T3 DK17764239.4T DK17764239T DK3426641T3 DK 3426641 T3 DK3426641 T3 DK 3426641T3 DK 17764239 T DK17764239 T DK 17764239T DK 3426641 T3 DK3426641 T3 DK 3426641T3
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DK
Denmark
Prior art keywords
immunoproteasominhibitor
analogs
immunoproteasominhibitor analogs
Prior art date
Application number
DK17764239.4T
Other languages
English (en)
Inventor
Michael C Pirrung
Nicole A Bakas
Andre Bachmann
Original Assignee
Univ Michigan State
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan State, Univ California filed Critical Univ Michigan State
Application granted granted Critical
Publication of DK3426641T3 publication Critical patent/DK3426641T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052Val-amino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK17764239.4T 2016-03-11 2017-03-10 Immunoproteasominhibitoranaloger DK3426641T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662307370P 2016-03-11 2016-03-11
US201662307433P 2016-03-12 2016-03-12
PCT/US2017/021931 WO2017156471A1 (en) 2016-03-11 2017-03-10 Immunoproteasome inhibitor analogs

Publications (1)

Publication Number Publication Date
DK3426641T3 true DK3426641T3 (da) 2022-01-17

Family

ID=59789857

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20196268.5T DK3778578T3 (da) 2016-03-11 2017-03-10 Immunoproteasominhibitoranaloger til behandling af inflammatoriske sygdomme
DK17764239.4T DK3426641T3 (da) 2016-03-11 2017-03-10 Immunoproteasominhibitoranaloger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK20196268.5T DK3778578T3 (da) 2016-03-11 2017-03-10 Immunoproteasominhibitoranaloger til behandling af inflammatoriske sygdomme

Country Status (4)

Country Link
US (1) US10584105B2 (da)
EP (2) EP3778578B1 (da)
DK (2) DK3778578T3 (da)
WO (1) WO2017156471A1 (da)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210881A1 (en) * 2009-01-14 2010-07-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Derivatives of syringolin A
US9221772B2 (en) 2009-12-03 2015-12-29 The Regents Of The University Of California Synthesis of syrbactin proteasome inhibitors
EP2861565B1 (en) * 2012-06-15 2016-12-21 The Regents of the University of California Syringolin and glidobactin analogs as proteasome inhibitors for the treatment of cancer
WO2014008204A2 (en) * 2012-07-02 2014-01-09 Pono Corporation Structures of proteasome inhibitors and methods for synthesizing and use thereof
WO2014183015A1 (en) 2013-05-09 2014-11-13 Brown University Macrocyclic proteasome inhibitors
DK3172213T3 (da) 2014-07-21 2021-12-13 Dana Farber Cancer Inst Inc Makrocykliske kinasehæmmere og anvendelser deraf

Also Published As

Publication number Publication date
US10584105B2 (en) 2020-03-10
DK3778578T3 (da) 2022-06-20
EP3778578A1 (en) 2021-02-17
US20190047969A1 (en) 2019-02-14
WO2017156471A1 (en) 2017-09-14
EP3426641A4 (en) 2019-10-02
EP3778578B1 (en) 2022-05-04
EP3426641A1 (en) 2019-01-16
EP3426641B1 (en) 2021-11-24

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