DK336589D0 - benzodiazepine - Google Patents

benzodiazepine

Info

Publication number
DK336589D0
DK336589D0 DK336589A DK336589A DK336589D0 DK 336589 D0 DK336589 D0 DK 336589D0 DK 336589 A DK336589 A DK 336589A DK 336589 A DK336589 A DK 336589A DK 336589 D0 DK336589 D0 DK 336589D0
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
carboxy
halogen
amino
Prior art date
Application number
DK336589A
Other languages
Danish (da)
Other versions
DK336589A (en
Inventor
Yoshinari Sato
Teruaki Matuo
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888816207A external-priority patent/GB8816207D0/en
Priority claimed from GB888820560A external-priority patent/GB8820560D0/en
Priority claimed from GB888823660A external-priority patent/GB8823660D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of DK336589D0 publication Critical patent/DK336589D0/en
Publication of DK336589A publication Critical patent/DK336589A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A compound of the formula : <CHEM> wherein R<1> is halogen, heterocyclic group which may have one or more suitable substituent(s), aryl which may have one or more suitable substituent(s), -NH-R<5> (in which R<5> is hydrogen, lower alkanoyl or hydroxy(lower)alkyl), -S-R<6> (in which R<6> is lower alkyl, lower alkyl substituted with carboxy and amino, lower alkyl substituted with protected carboxy and protected amino, or pyridyl), -O-R<7> (in which R<7> is hydrogen, hydroxy protective group, lower alkyl, lower alkenyl, ar(lower)alkyl, halo(lower)alkyl, amino(loweralkyl, protected amino(lower)alkyl, or piperazinyl(lower)alkyl which may have lower alkyl), -CONH-R<8> (in which R<8> is cyano, carbamoyl(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or lower alkyl substituted with carbamoyl and aryl ), or -Z-R<9> [in which R<9> is hydrogen or lower alkyl, and Z is <CHEM> (wherein is hydroxy, lower alkoxy or amino) or <CHEM> (wherein R<1><1> is carboxy or protected carboxy and R<1><2> is hydrogen; or R<1><1> is halogen and R<1><2> is halogen)], R<2> is aryl which may have one or more suitable substituent(s), R<3> is hydrogen or halogen, R<4> is hydrogen, halogen or lower alkoxy and A is lower alkylene, and a pharmaceutically acceptable salt thereof, processes for the preparation and pharmaceutical compositions comprising them as an active ingredient
DK336589A 1988-07-07 1989-07-06 benzodiazepine DK336589A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888816207A GB8816207D0 (en) 1988-07-07 1988-07-07 Benzodiazepine derivatives
GB888820560A GB8820560D0 (en) 1988-08-31 1988-08-31 Benzodiazepine derivatives
GB888823660A GB8823660D0 (en) 1988-10-07 1988-10-07 Benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
DK336589D0 true DK336589D0 (en) 1989-07-06
DK336589A DK336589A (en) 1990-01-08

Family

ID=27263983

Family Applications (1)

Application Number Title Priority Date Filing Date
DK336589A DK336589A (en) 1988-07-07 1989-07-06 benzodiazepine

Country Status (17)

Country Link
US (1) US4970207A (en)
EP (1) EP0349949B1 (en)
JP (2) JP2536160B2 (en)
KR (1) KR900001688A (en)
CN (1) CN1041941A (en)
AT (1) ATE147403T1 (en)
AU (1) AU3785989A (en)
CA (1) CA1334589C (en)
DE (1) DE68927620T2 (en)
DK (1) DK336589A (en)
ES (1) ES2095833T3 (en)
FI (1) FI95699C (en)
GR (1) GR3022239T3 (en)
HU (1) HUT50331A (en)
IL (1) IL90830A (en)
NO (1) NO173014C (en)
PT (1) PT91092B (en)

Families Citing this family (57)

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JPH01211939A (en) * 1988-02-18 1989-08-25 Nec Kyushu Ltd Ion-implantation device
US5264433A (en) * 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
GB9015879D0 (en) * 1990-07-19 1990-09-05 Fujisawa Pharmaceutical Co Benzodiazepine derivatives
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
CA2071181A1 (en) * 1991-06-14 1992-12-15 Roger M. Freidinger Benzodiazepine analogs
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
AU5975094A (en) * 1993-02-03 1994-08-29 Fisons Corporation 1,2,4-triazinone derivatives and their use in therapy
US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
CA2196062A1 (en) * 1994-07-29 1996-02-15 Yoshinari Sato Benzodiazepine derivatives
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) * 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
AU722110B2 (en) * 1996-06-28 2000-07-20 Merck & Co., Inc. Pharmaceutical preparation
WO1998000406A1 (en) * 1996-07-02 1998-01-08 Merck & Co., Inc. Method for the treatment of preterm labor
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
ES2239788T3 (en) * 1996-12-06 2005-10-01 Vertex Pharmaceuticals Incorporated INHIBITORS OF THE CONVERSION ENZYME OF INTERLEUQUINA-1-BETA.
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
ES2214273T3 (en) * 1999-04-30 2004-09-16 The Regents Of The University Of Michigan USE OF BENZODIAZEPINS FOR THE TREATMENT OF AUTOIMMUNE DISEASES INDUCED BY APOPTOSIS.
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
US6558690B2 (en) 2000-12-15 2003-05-06 Pacific Health Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
US7196079B2 (en) * 2003-06-26 2007-03-27 Merck & Co, Inc. Benzodiazepine CGRP receptor antagonists
JP2008528448A (en) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Compositions and methods relating to novel compounds and targets thereof
JP2008545757A (en) 2005-06-01 2008-12-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Unsolvated benzodiazepine compositions and methods
JP5241501B2 (en) 2005-11-01 2013-07-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
EP2139331B1 (en) 2007-03-09 2013-02-20 The Regents of the University of Michigan Compositions and methods relating to novel compounds and targets thereof
CN101855203B (en) 2007-09-14 2014-03-19 密执安州立大学董事会 F1F0-ATPase inhibitors and related methods
CA2703005A1 (en) 2007-11-06 2009-05-14 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
WO2010030891A2 (en) 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Aryl guanidine f1f0-atpase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CU20090172A7 (en) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM
JP5856064B2 (en) 2009-11-17 2016-02-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 1,4-Benzodiazepine-2,5-dione and related compounds having therapeutic properties
CA2915237C (en) 2009-11-17 2017-10-10 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
JP6486837B2 (en) 2013-02-05 2019-03-20 ラドウィッグ ストッカー ホフフェイステレイ ゲーエムベーハー Use of microorganisms for the prevention and treatment of bowel disease

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines

Also Published As

Publication number Publication date
NO173014C (en) 1993-10-13
HUT50331A (en) 1990-01-29
US4970207A (en) 1990-11-13
PT91092B (en) 1995-05-04
IL90830A0 (en) 1990-01-18
PT91092A (en) 1990-02-08
FI893226A0 (en) 1989-07-03
KR900001688A (en) 1990-02-27
EP0349949A2 (en) 1990-01-10
CN1041941A (en) 1990-05-09
NO173014B (en) 1993-07-05
CA1334589C (en) 1995-02-28
FI95699C (en) 1996-03-11
JP2536160B2 (en) 1996-09-18
AU3785989A (en) 1990-01-11
DE68927620D1 (en) 1997-02-20
ATE147403T1 (en) 1997-01-15
JPH07224060A (en) 1995-08-22
NO892799L (en) 1990-01-08
EP0349949A3 (en) 1991-09-04
ES2095833T3 (en) 1997-03-01
FI893226A (en) 1990-01-08
DE68927620T2 (en) 1997-04-24
EP0349949B1 (en) 1997-01-08
NO892799D0 (en) 1989-07-06
IL90830A (en) 1995-06-29
FI95699B (en) 1995-11-30
DK336589A (en) 1990-01-08
GR3022239T3 (en) 1997-04-30
JPH0256481A (en) 1990-02-26

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Legal Events

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AHB Application shelved due to non-payment