DK3347050T3 - PCSK9-antistofpræparater til afgivelse i et lumen i mave-tarmkanalen ved hjælp af en indtagelig enhed til afgivelse af lægemiddel - Google Patents
PCSK9-antistofpræparater til afgivelse i et lumen i mave-tarmkanalen ved hjælp af en indtagelig enhed til afgivelse af lægemiddel Download PDFInfo
- Publication number
- DK3347050T3 DK3347050T3 DK16845073.2T DK16845073T DK3347050T3 DK 3347050 T3 DK3347050 T3 DK 3347050T3 DK 16845073 T DK16845073 T DK 16845073T DK 3347050 T3 DK3347050 T3 DK 3347050T3
- Authority
- DK
- Denmark
- Prior art keywords
- lumen
- gastrointestinal tract
- antibody compositions
- pcsk9 antibody
- delivery device
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562215586P | 2015-09-08 | 2015-09-08 | |
| US15/150,379 US11548940B2 (en) | 2014-05-15 | 2016-05-09 | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| PCT/US2016/050832 WO2017044665A1 (en) | 2015-09-08 | 2016-09-08 | Pcsk9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3347050T3 true DK3347050T3 (da) | 2025-04-14 |
Family
ID=58240088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16845073.2T DK3347050T3 (da) | 2015-09-08 | 2016-09-08 | PCSK9-antistofpræparater til afgivelse i et lumen i mave-tarmkanalen ved hjælp af en indtagelig enhed til afgivelse af lægemiddel |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3347050B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2018526403A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108401419A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016320867B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2997958A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3347050T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017044665A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10220076B2 (en) | 2014-05-15 | 2019-03-05 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins |
| US10689460B2 (en) | 2014-05-15 | 2020-06-23 | Incube Labs, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US11207272B2 (en) | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| AU2019269636A1 (en) | 2018-05-17 | 2020-11-19 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US12128133B2 (en) | 2018-09-25 | 2024-10-29 | Rani Therapeutics, Llc | Ingestible device with expandable enclosure |
| US20200206132A1 (en) * | 2018-12-31 | 2020-07-02 | Incube Labs, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| EP3917598B1 (en) | 2019-02-01 | 2025-10-29 | Massachusetts Institute of Technology | Systems for liquid injection |
| KR20220004148A (ko) * | 2019-05-03 | 2022-01-11 | 라니 테라퓨틱스, 엘엘씨 | 삼킬 수 있는 약물 전달 장치를 사용하여 장관 조직으로 전달하기 위한 응고인자 제제 |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102905753B (zh) * | 2009-12-24 | 2016-06-29 | 因卡伯实验室有限责任公司 | 可吞咽式药剂递送装置和药剂递送方法 |
| US8759284B2 (en) * | 2009-12-24 | 2014-06-24 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) * | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| PL2726091T3 (pl) * | 2011-06-29 | 2020-08-10 | Rani Therapeutics, Llc | Preparaty lecznicze dostarczane do kanału przewodu jelitowego za pomocą połykalnego urządzenia dostarczającego lek |
| EP3653223B1 (en) * | 2011-06-29 | 2021-08-25 | Rani Therapeutics, LLC | Device for the oral delivery of therapeutic compounds |
| BR112014000392A2 (pt) * | 2011-07-14 | 2017-02-21 | Pfizer | tratamento com anticorpos anti-pcsk9 |
| EA201691320A1 (ru) * | 2014-02-14 | 2016-11-30 | Ридженерон Фармасьютикалз, Инк. | Способы лечения пациентов с гиперхолестеринемией, которая устойчива к терапии умеренными дозами статинов |
| EP3294273A4 (en) * | 2015-05-08 | 2018-12-05 | Incube Labs, LLC | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
-
2016
- 2016-09-08 DK DK16845073.2T patent/DK3347050T3/da active
- 2016-09-08 JP JP2018512407A patent/JP2018526403A/ja not_active Withdrawn
- 2016-09-08 WO PCT/US2016/050832 patent/WO2017044665A1/en not_active Ceased
- 2016-09-08 CA CA2997958A patent/CA2997958A1/en active Pending
- 2016-09-08 AU AU2016320867A patent/AU2016320867B2/en not_active Ceased
- 2016-09-08 CN CN201680065019.1A patent/CN108401419A/zh active Pending
- 2016-09-08 EP EP16845073.2A patent/EP3347050B1/en active Active
-
2021
- 2021-07-30 JP JP2021125408A patent/JP2021169530A/ja active Pending
-
2023
- 2023-05-23 JP JP2023084891A patent/JP2023104992A/ja active Pending
- 2023-06-29 AU AU2023204153A patent/AU2023204153A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023104992A (ja) | 2023-07-28 |
| AU2016320867B2 (en) | 2023-03-30 |
| AU2016320867A1 (en) | 2018-04-05 |
| JP2021169530A (ja) | 2021-10-28 |
| WO2017044665A1 (en) | 2017-03-16 |
| EP3347050A1 (en) | 2018-07-18 |
| AU2023204153A1 (en) | 2023-07-20 |
| JP2018526403A (ja) | 2018-09-13 |
| EP3347050A4 (en) | 2019-05-22 |
| CN108401419A (zh) | 2018-08-14 |
| EP3347050B1 (en) | 2025-01-15 |
| CA2997958A1 (en) | 2017-03-16 |
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