DK328289D0 - USE OF DINITRO-TRINITROPHENYL - Google Patents

USE OF DINITRO-TRINITROPHENYL

Info

Publication number
DK328289D0
DK328289D0 DK328289A DK328289A DK328289D0 DK 328289 D0 DK328289 D0 DK 328289D0 DK 328289 A DK328289 A DK 328289A DK 328289 A DK328289 A DK 328289A DK 328289 D0 DK328289 D0 DK 328289D0
Authority
DK
Denmark
Prior art keywords
antibodies
interaction
host
cells
trinitrophenyl
Prior art date
Application number
DK328289A
Other languages
Danish (da)
Other versions
DK328289A (en
Inventor
Eustrate-Stratis Avrameas
Pamaupta Matsiota-Bernard
Therese Ternynck
Marie-Francoise Saron
Jean-Claude Guillon
Luc Montagnier
Denise Guetard
Veronique Favier
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Publication of DK328289A publication Critical patent/DK328289A/en
Publication of DK328289D0 publication Critical patent/DK328289D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

In a process for modifying the conditions of interaction between the target cells of a living host and a pathogenic agent to the host, said cells are placed in contact with anti-NP antibodies or with NP molecules chemically modified by means of a covalent bond at the C1 position of the phenyl ring or its phenol position, by a chemical group which neutralizes the in vivo toxic properties of NP without, however, affecting its capacity to be recognized by anti-NP antibodies, in particular by dosing the anti-NP antibodies or detoxified NPs in function of the desired degree of modulation of said interaction.
DK328289A 1987-10-30 1989-06-30 USE OF DINITRO-TRINITROPHENYL DK328289D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8715126A FR2622444B1 (en) 1987-10-30 1987-10-30 APPLICATION OF DINITRO-TRINITROPHENYL AND ITS DERIVATIVES OR ANTI-NITROPHENYL ANTIBODIES TO MODIFYING THE INTERACTION BETWEEN HOST SENSITIVE CELLS AND A PATHOGENIC AGENT
PCT/FR1988/000533 WO1989003690A1 (en) 1987-10-30 1988-10-28 Application of dinitro-trinitrophenyl and its derivatives or of anti-nitrophenyl antibodies to the modification of the interaction between the target cellules of a host and a pathogenic agent

Publications (2)

Publication Number Publication Date
DK328289A DK328289A (en) 1989-06-30
DK328289D0 true DK328289D0 (en) 1989-06-30

Family

ID=9356378

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328289A DK328289D0 (en) 1987-10-30 1989-06-30 USE OF DINITRO-TRINITROPHENYL

Country Status (8)

Country Link
EP (1) EP0316212B1 (en)
JP (1) JPH02501932A (en)
AT (1) ATE119397T1 (en)
DE (1) DE3853261D1 (en)
DK (1) DK328289D0 (en)
FR (1) FR2622444B1 (en)
PT (1) PT88889B (en)
WO (1) WO1989003690A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1453792A (en) * 1991-02-27 1992-10-06 Regents Of The University Of California, The Targeting complex mediated immunogenicity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2963410D1 (en) * 1978-08-10 1982-09-16 Schering Ag Process for obtaining murine immunglobulin-e antibodies, hybrid cell lines used in the process and the process for preparing them, application of the immunglobulin-e antibodies so obtained
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4673691A (en) * 1984-11-05 1987-06-16 Nicholas Bachynsky Human weight loss inducing method

Also Published As

Publication number Publication date
DK328289A (en) 1989-06-30
FR2622444A1 (en) 1989-05-05
EP0316212A1 (en) 1989-05-17
FR2622444B1 (en) 1990-08-03
WO1989003690A1 (en) 1989-05-05
JPH02501932A (en) 1990-06-28
ATE119397T1 (en) 1995-03-15
EP0316212B1 (en) 1995-03-08
PT88889B (en) 1993-05-31
PT88889A (en) 1989-07-31
DE3853261D1 (en) 1995-04-13

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment