DK3270686T3 - Preparation of ingenol, ingenol esters and / or tiglian-3-one derivatives by Euphorbiaceae plant cell suspension cultures - Google Patents

Preparation of ingenol, ingenol esters and / or tiglian-3-one derivatives by Euphorbiaceae plant cell suspension cultures Download PDF

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Publication number
DK3270686T3
DK3270686T3 DK16713341.2T DK16713341T DK3270686T3 DK 3270686 T3 DK3270686 T3 DK 3270686T3 DK 16713341 T DK16713341 T DK 16713341T DK 3270686 T3 DK3270686 T3 DK 3270686T3
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DK
Denmark
Prior art keywords
ingenol
tiglian
derivatives
preparation
plant cell
Prior art date
Application number
DK16713341.2T
Other languages
Danish (da)
Inventor
Yantree Devi Sankar-Thomas
Thomas Selge
Thomas Leibold
Harald Heckenmüller
Gilbert Gorr
David Alexander Ullisch
Original Assignee
Phyton Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phyton Holdings Llc filed Critical Phyton Holdings Llc
Application granted granted Critical
Publication of DK3270686T3 publication Critical patent/DK3270686T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/002—Culture media for tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16713341.2T 2015-03-20 2016-03-18 Preparation of ingenol, ingenol esters and / or tiglian-3-one derivatives by Euphorbiaceae plant cell suspension cultures DK3270686T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15160160 2015-03-20
EP16156907 2016-02-23
PCT/EP2016/055989 WO2016150860A1 (en) 2015-03-20 2016-03-18 Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures

Publications (1)

Publication Number Publication Date
DK3270686T3 true DK3270686T3 (en) 2020-03-09

Family

ID=55646546

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16713341.2T DK3270686T3 (en) 2015-03-20 2016-03-18 Preparation of ingenol, ingenol esters and / or tiglian-3-one derivatives by Euphorbiaceae plant cell suspension cultures

Country Status (6)

Country Link
US (1) US10172306B2 (en)
EP (1) EP3270686B1 (en)
AU (1) AU2016236309B2 (en)
DK (1) DK3270686T3 (en)
ES (1) ES2770769T3 (en)
WO (1) WO2016150860A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111454153B (en) * 2019-01-18 2023-01-31 南开大学 Five ent-tisane diterpene compounds from euphorbia humifusa and preparation method and application thereof
CN110178728B (en) * 2019-05-16 2022-04-08 四川农业大学 Tissue culture and rapid propagation method for salvia miltiorrhiza bunge
CN110551676B (en) * 2019-09-07 2023-06-20 江苏省中国科学院植物研究所 Suspension culture method for euphorbia lathyris callus cells capable of extracting and obtaining ingenol
CN111034616B (en) * 2019-12-25 2022-05-06 甘肃农业大学 Broccoli hairy root high sulforaphane glycoside and sulforaphane synthesis release culture method
CN113277934B (en) * 2021-05-25 2022-07-15 中国科学院成都生物研究所 Euphorbia lathyris diterpene derivatives with MDR reversion activity and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0954596T3 (en) 1996-05-24 2006-05-15 Phyton Inc Increased production of taxanes by taxus cell culture
JP2007527713A (en) 2004-02-13 2007-10-04 フィトン バイオテック インコーポレイテッド Use of indanoylamide to stimulate secondary metabolism in yew species (Taxussp.)
EP1971588B1 (en) 2005-12-23 2012-07-11 QBiotics Limited Tiglien-3-one derivatives
CN102126941B (en) 2010-12-20 2013-04-10 南京春秋生物工程有限公司 Preparation method of euphorbia peplus plant extract for preparing antitumor medicament
ES2408507B1 (en) 2011-10-04 2014-04-21 Vivacell Biotechnology España, S.L INGENOL INSULATION METHOD.

Also Published As

Publication number Publication date
US20180042194A1 (en) 2018-02-15
ES2770769T3 (en) 2020-07-03
AU2016236309A1 (en) 2017-11-02
EP3270686A1 (en) 2018-01-24
WO2016150860A1 (en) 2016-09-29
EP3270686B1 (en) 2019-12-18
AU2016236309B2 (en) 2020-10-29
US10172306B2 (en) 2019-01-08

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