DK3100026T3 - Fremgangsmåde, anordning og system til automatiseret bestemmelse af optiske tætheder eller ændring af optiske tætheder af reaktionsblandinger i omrørte reaktorer - Google Patents

Fremgangsmåde, anordning og system til automatiseret bestemmelse af optiske tætheder eller ændring af optiske tætheder af reaktionsblandinger i omrørte reaktorer Download PDF

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Publication number
DK3100026T3
DK3100026T3 DK15711054.5T DK15711054T DK3100026T3 DK 3100026 T3 DK3100026 T3 DK 3100026T3 DK 15711054 T DK15711054 T DK 15711054T DK 3100026 T3 DK3100026 T3 DK 3100026T3
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Denmark
Prior art keywords
optical densities
change
reaction mixtures
stirred reactors
automated determination
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Application number
DK15711054.5T
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English (en)
Inventor
David Frank
Konrad Herzog
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aquila biolabs GmbH
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Publication of DK3100026T3 publication Critical patent/DK3100026T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/82Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16Vibrating; Shaking; Tilting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06Investigating concentration of particle suspensions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06Investigating concentration of particle suspensions
    • G01N15/075Investigating concentration of particle suspensions by optical means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042Investigating dispersion of solids
    • G01N2015/0046Investigating dispersion of solids in gas, e.g. smoke
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042Investigating dispersion of solids
    • G01N2015/0053Investigating dispersion of solids in liquids, e.g. trouble
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • G01N21/5907Densitometers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DK15711054.5T 2014-02-01 2015-01-30 Fremgangsmåde, anordning og system til automatiseret bestemmelse af optiske tætheder eller ændring af optiske tætheder af reaktionsblandinger i omrørte reaktorer DK3100026T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014001284.0A DE102014001284B3 (de) 2014-02-01 2014-02-01 Verfahren, Vorrichtung und System zur automatisierten Bestimmung optischer Dichten oder der Veränderung optischer Dichten von Reaktionsgemischen in geschüttelten Reaktoren
PCT/EP2015/051911 WO2015114083A1 (de) 2014-02-01 2015-01-30 Verfahren, vorrichtung und system zur automatisierten bestimmung optischer dichten oder der veränderung optischer dichten von reaktionsgemischen in geschüttelten reaktoren

Publications (1)

Publication Number Publication Date
DK3100026T3 true DK3100026T3 (da) 2023-06-12

Family

ID=52131630

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15711054.5T DK3100026T3 (da) 2014-02-01 2015-01-30 Fremgangsmåde, anordning og system til automatiseret bestemmelse af optiske tætheder eller ændring af optiske tætheder af reaktionsblandinger i omrørte reaktorer

Country Status (5)

Country Link
US (1) US10533950B2 (da)
EP (1) EP3100026B1 (da)
DE (1) DE102014001284B3 (da)
DK (1) DK3100026T3 (da)
WO (1) WO2015114083A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2983806C (en) 2015-04-28 2023-06-13 Aterica Inc. Portable organic molecular sensing device and related systems and methods
WO2016176622A1 (en) * 2015-04-29 2016-11-03 University Of Virginia Patent Foundation Optical density system and related method thereof
DE102017012186B4 (de) 2017-02-17 2018-10-18 aquila biolabs GmbH Verfahren und Vorrichtung zur Abstimmung optischer Messungen an kontinuierlich durchmischten Reaktoren
DE102017001588B4 (de) 2017-02-17 2018-09-06 aquila biolabs GmbH Verfahren und Vorrichtung zur Abstimmung optischer Messungen an kontinuierlich durchmischten Reaktoren
DE102017107033A1 (de) 2017-03-31 2018-11-22 Presens Precision Sensing Gmbh Vorrichtung, verfahren und system zur parallelisierten erfassung mindestens einer veränderlichen während eines biologisch / chemischen prozesses
JP2021518146A (ja) * 2018-03-23 2021-08-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 透明なバッグ内での培地の溶解および/または細菌の増殖の観察用システム
DE102018003910B8 (de) * 2018-05-16 2019-09-05 aquila biolabs GmbH Vorrichtung und Verfahren zur Kultivierung von Zellen im Schüttelbetrieb
DE102018112895B4 (de) 2018-05-30 2024-05-08 Presens Precision Sensing Gmbh System, Vorrichtung und Verfahren zur Erfassung mindestens einer Veränderlichen während eines biologisch / chemischen Prozesses
CN112100821B (zh) * 2020-08-26 2022-03-22 西北工业大学 光伏电池的稳健性优化设计方法
RU2756373C1 (ru) * 2020-11-25 2021-09-29 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") Способ исследования оптической плотности текущей жидкости
CN113522117B (zh) * 2021-07-13 2022-07-26 知弗(上海)科技股份有限公司 一种用于高分子化学材料成分分析装置
EP4341683A1 (de) * 2022-06-13 2024-03-27 Aquila Biolabs GmbH Verfahren und vorrichtung zur überwachung des inhalts durchmischter reaktoren
CN117233055B (zh) * 2023-11-14 2024-02-09 芯视界(北京)科技有限公司 泥沙含量测量方法及装置、电子设备和存储介质

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1309719B2 (en) * 2000-08-14 2022-09-07 University of Maryland at Baltimore County Bioreactor and bioprocessing technique
DE10125600A1 (de) * 2001-05-25 2002-12-05 Schindler Heinz Verfahren und Vorrichtung zur Charakterisierung und Identifizierung von Mikroorganismenstämmen und Zellinien
US20050219526A1 (en) * 2003-01-17 2005-10-06 Hong Peng Method and apparatus for monitoring biological substance
DE102004017039A1 (de) * 2004-04-02 2005-11-03 Rwth Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern von Reaktionsflüssigkeiten in mehreren geschüttelten Mikroreaktoren
US8603772B2 (en) * 2007-07-28 2013-12-10 Bug Lab LLC Particle sensor with wide linear range
US8405033B2 (en) * 2010-07-30 2013-03-26 Buglab Llc Optical sensor for rapid determination of particulate concentration
JP5774352B2 (ja) * 2011-04-13 2015-09-09 タイテック株式会社 培養中の試料の増殖を非接触で連続測定する方法

Also Published As

Publication number Publication date
EP3100026B1 (de) 2023-05-10
EP3100026A1 (de) 2016-12-07
DE102014001284B3 (de) 2015-01-22
WO2015114083A1 (de) 2015-08-06
US20180011027A1 (en) 2018-01-11
US10533950B2 (en) 2020-01-14

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