DK2928477T3 - USE OF TELETOMERASE INHIBITOR IMETELSTAT TO TREAT MYELOFIBROSIS - Google Patents

USE OF TELETOMERASE INHIBITOR IMETELSTAT TO TREAT MYELOFIBROSIS Download PDF

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Publication number
DK2928477T3
DK2928477T3 DK13861008.4T DK13861008T DK2928477T3 DK 2928477 T3 DK2928477 T3 DK 2928477T3 DK 13861008 T DK13861008 T DK 13861008T DK 2928477 T3 DK2928477 T3 DK 2928477T3
Authority
DK
Denmark
Prior art keywords
teletomerase
treat myelofibrosis
imetelstat
inhibitor
inhibitor imetelstat
Prior art date
Application number
DK13861008.4T
Other languages
Danish (da)
Inventor
Stephen Kelsey
Monic J Stuart
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of DK2928477T3 publication Critical patent/DK2928477T3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
DK13861008.4T 2012-12-07 2013-11-15 USE OF TELETOMERASE INHIBITOR IMETELSTAT TO TREAT MYELOFIBROSIS DK2928477T3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
PCT/US2013/070437 WO2014088785A1 (en) 2012-12-07 2013-11-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms

Publications (1)

Publication Number Publication Date
DK2928477T3 true DK2928477T3 (en) 2019-10-07

Family

ID=50883867

Family Applications (2)

Application Number Title Priority Date Filing Date
DK13861008.4T DK2928477T3 (en) 2012-12-07 2013-11-15 USE OF TELETOMERASE INHIBITOR IMETELSTAT TO TREAT MYELOFIBROSIS
DK18196690.4T DK3456333T3 (en) 2012-12-07 2013-11-15 APPLICATION OF TELETOMERASE INHIBITOR IMETELSTAT FOR TREATMENT OF MYELODYSOPLASTIC SYNDROME

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK18196690.4T DK3456333T3 (en) 2012-12-07 2013-11-15 APPLICATION OF TELETOMERASE INHIBITOR IMETELSTAT FOR TREATMENT OF MYELODYSOPLASTIC SYNDROME

Country Status (33)

Country Link
EP (3) EP2928477B1 (en)
JP (5) JP6433911B2 (en)
KR (2) KR20230028590A (en)
CN (2) CN111617252A (en)
AP (1) AP2015008504A0 (en)
AU (3) AU2013356533B2 (en)
BR (1) BR112015013260A2 (en)
CA (2) CA2892907C (en)
CL (2) CL2015001530A1 (en)
CY (2) CY1122169T1 (en)
DK (2) DK2928477T3 (en)
EA (1) EA032973B1 (en)
ES (2) ES2789176T3 (en)
HK (2) HK1210940A1 (en)
HR (2) HRP20191784T1 (en)
HU (2) HUE049858T2 (en)
IL (2) IL239266B (en)
LT (2) LT2928477T (en)
MA (2) MA38193B1 (en)
ME (1) ME03538B (en)
MX (3) MX2015007169A (en)
MY (1) MY180634A (en)
NZ (1) NZ708920A (en)
PH (1) PH12015501282A1 (en)
PL (2) PL2928477T3 (en)
PT (2) PT3456333T (en)
RS (2) RS59363B1 (en)
SG (3) SG11201504383TA (en)
SI (2) SI2928477T1 (en)
TN (1) TN2015000249A1 (en)
UA (2) UA126015C2 (en)
WO (1) WO2014088785A1 (en)
ZA (2) ZA201504124B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT1778711T (en) 2004-07-02 2017-10-25 Geron Corporation Synthesis of protected 3`-amino nucleoside monomers
HUE042792T2 (en) * 2013-11-06 2019-07-29 Mayo Found Medical Education & Res Methods and materials for treating hematological malignancies
MY187804A (en) * 2015-04-23 2021-10-26 Geron Corp Methods of polynucleotide preparation using multivalent cation salt compositions
EP3318276A1 (en) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
CN110944646A (en) * 2017-07-28 2020-03-31 美国杰龙生物医药公司 Methods of treating myelodysplastic syndrome
TWI741286B (en) * 2018-04-30 2021-10-01 美商卡托斯醫療公司 Methods of treating cancer
CN115666588A (en) * 2019-11-04 2023-01-31 美国杰龙生物医药公司 Use of Janus kinase inhibitors and telomerase inhibitors for treating myeloproliferative tumors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
JP2001507229A (en) 1996-12-20 2001-06-05 ジェロン コーポレイション Methods for detecting and inhibiting the telomerase RNA component
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
AU2004209428A1 (en) * 2003-01-31 2004-08-19 Jessie L.-S. Au Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (en) * 2003-07-11 2006-03-08 暨南大学 Antisense nucleic acid having inhibiting leukemid cell telomerase activity and its application
ES2662196T3 (en) 2003-09-09 2018-04-05 Geron Corporation Modified oligonucleotides for telomerase inhibition
US20050282893A1 (en) * 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
LT1778711T (en) 2004-07-02 2017-10-25 Geron Corporation Synthesis of protected 3`-amino nucleoside monomers
FR2877013A1 (en) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris INDENTIFICATION OF A JAK2 MUTATION INVOLVED IN THE VAQUEZ POLYGLOBULIA
US20060166221A1 (en) 2005-01-21 2006-07-27 Bahou Wadie F Methods of diagnosing essential thrombocythemia
WO2006113470A2 (en) 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
WO2006113426A2 (en) * 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of telomerase and tubulin activities
US20070224598A1 (en) 2006-03-15 2007-09-27 The Methodist Hospital Research Institute System and method for detection of mutations in JAK2 polynucleotides
US20080021013A1 (en) 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
CN101220044B (en) * 2008-01-21 2010-06-02 中国药科大学 Telomerase inhibitor, preparation method and application thereof

Also Published As

Publication number Publication date
EA032973B1 (en) 2019-08-30
MX2020003276A (en) 2020-07-20
EP3646876B1 (en) 2024-02-14
AP2015008504A0 (en) 2015-06-30
KR20210107906A (en) 2021-09-01
JP7288098B2 (en) 2023-06-06
HK1212226A1 (en) 2016-06-10
PL2928477T3 (en) 2020-03-31
LT2928477T (en) 2019-10-10
CA2892907C (en) 2023-03-21
PT3456333T (en) 2020-06-01
ZA201504124B (en) 2017-05-31
LT3456333T (en) 2020-06-25
WO2014088785A1 (en) 2014-06-12
KR20230028590A (en) 2023-02-28
RS59363B1 (en) 2019-11-29
EP3456333B1 (en) 2020-04-01
KR20150091130A (en) 2015-08-07
HRP20191784T1 (en) 2019-12-27
SG11201504383TA (en) 2015-07-30
MA45504B1 (en) 2021-10-29
EP3456333B8 (en) 2020-05-13
HRP20200993T1 (en) 2020-11-27
HUE045098T2 (en) 2019-12-30
IL280144A (en) 2021-03-01
CA3188494A1 (en) 2014-06-12
JP2022179684A (en) 2022-12-02
AU2013356533A1 (en) 2014-06-12
MA38193B1 (en) 2018-12-31
NZ748134A (en) 2020-10-30
NZ708920A (en) 2020-08-28
MA45504A1 (en) 2020-05-29
CL2015001530A1 (en) 2016-03-28
EA201590878A1 (en) 2016-04-29
CY1122169T1 (en) 2020-11-25
JP6998191B2 (en) 2022-02-04
PL3456333T3 (en) 2020-09-21
DK3456333T3 (en) 2020-05-18
PH12015501282B1 (en) 2015-08-24
SI2928477T1 (en) 2019-11-29
AU2013356533B2 (en) 2018-09-27
CY1123206T1 (en) 2021-10-29
ES2744790T3 (en) 2020-02-26
HUE049858T2 (en) 2020-11-30
JP2020041001A (en) 2020-03-19
WO2014088785A8 (en) 2015-07-16
EP2928477A4 (en) 2016-09-21
AU2020267142A1 (en) 2020-12-03
MY180634A (en) 2020-12-03
UA126015C2 (en) 2022-08-03
TN2015000249A1 (en) 2016-10-03
IL239266B (en) 2019-11-28
EP3646876A1 (en) 2020-05-06
JP2022050537A (en) 2022-03-30
EP2928477B1 (en) 2019-07-24
SG10201802926XA (en) 2018-05-30
RS60401B1 (en) 2020-07-31
IL239266A0 (en) 2015-07-30
SI3456333T1 (en) 2020-10-30
UA117116C2 (en) 2018-06-25
BR112015013260A2 (en) 2018-02-06
KR102294819B1 (en) 2021-09-01
ES2789176T3 (en) 2020-10-26
ZA202108991B (en) 2023-05-31
MA38193A1 (en) 2017-12-29
EP3456333A1 (en) 2019-03-20
JP2018035196A (en) 2018-03-08
CA2892907A1 (en) 2014-06-12
HK1210940A1 (en) 2016-05-13
PH12015501282A1 (en) 2015-08-24
ME03538B (en) 2020-07-20
PT2928477T (en) 2019-10-25
CL2017002156A1 (en) 2018-05-04
MX2022015437A (en) 2023-01-11
SG10202103341SA (en) 2021-05-28
CN104936602B (en) 2020-07-17
CN104936602A (en) 2015-09-23
AU2018282364A1 (en) 2019-05-23
JP2016504307A (en) 2016-02-12
MX2015007169A (en) 2016-03-31
CN111617252A (en) 2020-09-04
EP2928477A1 (en) 2015-10-14
JP6433911B2 (en) 2018-12-05

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