DK2825175T3 - Rho-kinase-inhibitorer til anvendelse i behandling af amyotrofisk lateral sklerose - Google Patents

Rho-kinase-inhibitorer til anvendelse i behandling af amyotrofisk lateral sklerose

Info

Publication number
DK2825175T3
DK2825175T3 DK13708430.7T DK13708430T DK2825175T3 DK 2825175 T3 DK2825175 T3 DK 2825175T3 DK 13708430 T DK13708430 T DK 13708430T DK 2825175 T3 DK2825175 T3 DK 2825175T3
Authority
DK
Denmark
Prior art keywords
rho
treatment
kinase inhibitors
lateral sclerosis
amyotrophic lateral
Prior art date
Application number
DK13708430.7T
Other languages
English (en)
Inventor
Paul Lingor
Lars Tönges
Original Assignee
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin filed Critical Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin
Application granted granted Critical
Publication of DK2825175T3 publication Critical patent/DK2825175T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK13708430.7T 2012-03-12 2013-03-11 Rho-kinase-inhibitorer til anvendelse i behandling af amyotrofisk lateral sklerose DK2825175T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261609576P 2012-03-12 2012-03-12
PCT/EP2013/054804 WO2013135596A1 (en) 2012-03-12 2013-03-11 Rho kinase inhibitors for use in treating amyotrophic lateral sclerosis

Publications (1)

Publication Number Publication Date
DK2825175T3 true DK2825175T3 (da) 2017-11-06

Family

ID=47844328

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13708430.7T DK2825175T3 (da) 2012-03-12 2013-03-11 Rho-kinase-inhibitorer til anvendelse i behandling af amyotrofisk lateral sklerose

Country Status (5)

Country Link
US (1) US9980972B2 (da)
EP (1) EP2825175B1 (da)
DK (1) DK2825175T3 (da)
ES (1) ES2644238T3 (da)
WO (1) WO2013135596A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3037564C (en) * 2017-06-04 2022-10-11 Dun Yang Process for exploiting synthetic lethality based on overexpression of myc oncogene
US11666583B2 (en) 2020-01-09 2023-06-06 Woolsey Pharmaceuticals, Inc. Methods of treating cortical dementia associated wandering
JP2023518707A (ja) 2020-03-25 2023-05-08 ウールジー・ファーマシューティカルズ・インコーポレイテッド タンパク質症に関連する徘徊を治療する方法
EP4125910A4 (en) * 2020-03-25 2024-05-01 Woolsey Pharmaceuticals, Inc. METHODS OF USING RHO-ASSOCIATED KINASE INHIBITORS TO TREAT FRONTO-TEMPORAL DEMENTIA
CA3175183A1 (en) 2020-04-23 2021-10-28 Thomas Macallister Methods of using rho kinase inhibitors to treat alzheimer's disease
US11311553B1 (en) 2020-10-22 2022-04-26 Woolsey Pharmaceuticals, Inc. Methods of treating 4-repeat tauopathies
US11779588B2 (en) 2021-10-15 2023-10-10 Woolsey Pharmaceuticals, Inc. Method of treating amyotrophic lateral sclerosis
EP4415716A1 (en) * 2021-10-15 2024-08-21 Woolsey Pharmaceuticals, Inc. Method of treating amyotrophic lateral sclerosis
CA3236338A1 (en) * 2021-11-12 2023-05-19 Woolsey Pharmaceuticals, Inc. Method of treating amyotrophic lateral sclerosis and dosing regimen for same
CN118354769A (zh) 2021-11-29 2024-07-16 悟而喜制药公司 治疗激越和其它痴呆症相关的行为症状的方法
US20230330100A1 (en) * 2022-02-17 2023-10-19 Woolsey Pharmaceuticals, Inc. Taste-masking oral formulations of fasudil
US11944633B2 (en) 2022-02-17 2024-04-02 Woolsey Pharmaceuticals, Inc. Oral formulations of fasudil with ion exchange resin
WO2024011094A1 (en) * 2022-07-08 2024-01-11 Woolsey Pharmaceuticals, Inc. Regimen for treating amyotrophic lateral sclerosis having onset 24 months prior to treatment
WO2024011093A1 (en) * 2022-07-08 2024-01-11 Woolsey Pharmaceuticals, Inc. Treating amyotrophic lateral sclerosis having onset 24 months prior to treatment
WO2024061474A1 (en) * 2022-09-23 2024-03-28 Norwegian University Of Science And Technology (Ntnu) Combination therapy for the treatment or prevention of neurological disorders
WO2024081763A1 (en) * 2022-10-14 2024-04-18 Woolsey Pharmaceuticals, Inc. Method of treating amyotrophic lateral sclerosis by oral administration of fasudil

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
KR100236853B1 (ko) 1995-07-03 2000-02-01 야마모토 카즈모토 1-(5-이소퀴놀린술포닐)호모피페라진 염산염 수화물
CN100444843C (zh) 1998-08-10 2008-12-24 旭化成制药株式会社 法舒地尔盐酸盐缓释口服制剂
DE10153605A1 (de) * 2001-11-02 2003-05-28 Morphochem Ag Komb Chemie Verwendung von Inhibitoren der Rho-Kinasen zur Stimulation des Nervenwachstums, zur Inhibition der Narbengewebsbildung und/oder Reduktion eines Sekundärschadens
WO2005117896A1 (de) 2004-06-03 2005-12-15 Schering Aktiengesellschaft Formulierungen, die fasudil, eine matrix und einem mantel enthalten
JP2007246466A (ja) * 2006-03-17 2007-09-27 Osaka Univ 中枢神経損傷に対する嗅粘膜移植にＲｈｏキナーゼ阻害剤を用いた神経機能再建法
JP2009292782A (ja) * 2008-06-06 2009-12-17 Asahi Kasei Pharma Kk 神経新生及び／又は神経再生促進剤
CN101612157A (zh) 2008-06-26 2009-12-30 天津红日药业股份有限公司 法舒地尔诱导成年脑内源性神经干细胞再生的用途
US20120010196A1 (en) * 2010-04-02 2012-01-12 Qin Quingyu Methods of treating neurodegenerative disorders and diseases

Also Published As

Publication number Publication date
EP2825175A1 (en) 2015-01-21
WO2013135596A1 (en) 2013-09-19
EP2825175B1 (en) 2017-07-26
ES2644238T3 (es) 2017-11-28
US20150031683A1 (en) 2015-01-29
US9980972B2 (en) 2018-05-29

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