DK2800762T3 - Native og agonistiske ctl-epitoper af muc1-tumor-antigenet - Google Patents
Native og agonistiske ctl-epitoper af muc1-tumor-antigenet Download PDFInfo
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- DK2800762T3 DK2800762T3 DK13700352.1T DK13700352T DK2800762T3 DK 2800762 T3 DK2800762 T3 DK 2800762T3 DK 13700352 T DK13700352 T DK 13700352T DK 2800762 T3 DK2800762 T3 DK 2800762T3
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 108010035534 tyrosyl-leucyl-alanine Proteins 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 108010036320 valylleucine Proteins 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4622—Antigen presenting cells
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
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- A61K9/10—Dispersions; Emulsions
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/49—Breast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/54—Pancreas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- A—HUMAN NECESSITIES
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-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (12)
15. Sammensætning ifølge et hvilket som helst af kravene 8-14 til anvendelse ved forøgelse af en immunrespons i et individ.
16. Lymfocytter der er stimuleret med sammensætningen ifølge et hvilket som helst af kravene 8-14 ex vivo til anvendelse i behandlingen af MUC1-udtrykkende cancer hos et individ.
17. Dendritiske celler der er behandlet med sammensætningen ifølge et hvilket som helst af kravene 8-14 ex vivo til anvendelse i behandlingen af MUCl-udtrykkende cancer hos et individ.
18. Adoptivt overførte T-celler der er stimuleret in vitro med sammensætningen ifølge et hvilket som helst af kravene 8-14 til anvendelse i behandlingen af MUCl-udtrykkende cancer hos et individ.
19. Kit til anvendelse til at inhibere en MUC-l-udtrykkende cancer hos et individ, hvilket kit omfatter: a) en første rekombinant vektor der omfatter en nukleinsyre, som koder for et peptid der omfatter SEQ ID NO: 2; og b) en anden rekombinant vektor der omfatter en nukleinsyre, som koder for et peptid der omfatter SEQ ID NO: 2.
20. Kittet ifølge krav 19, hvor den første og den anden rekombinante vektor omfatter hver især en nukleinsyre, der koder for mindst et af SEQ ID NO: 5, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 29 eller SEQ ID NO: 32.
21. Kit ifølge krav 19 eller 20, hvor den første og den anden rekombinante vektor hver yderligere omfatter en nukleinsyre, der koder for et CEA-antigen.
22. Kit ifølge et hvilket som helst af kravene 19-21, hvor hver rekombinante vektor er en rekombinant poxvirusvektor, fortrinsvis er den rekombinante poxvirusvektor valgt fra gruppen der består af orthopox, avipox, capripox og suipox, fortrinsvis er den rekombinante vektor eller rekombinante poxvirusvektor af den første sammensætning forskellig fra den rekombinante vektor eller rekombinante poxvirusvektor af den anden sammensætning.
23. En første sammensætning og en anden sammensætning til anvendelse til at inhibere en MUC-l-udtrykkende cancer i et individ, hvilken første sammensætning og anden sammensætning hver omfatter en rekombinant vektor, der omfatter en nukleinsyre, som koder for en peptid der omfatter SEQ ID NO: 2, hvor den første sammensætning indgives til individet som en priming-vaccination, og den anden sammensætning indgives til individet som en eller flere efterfølgende booster-vaccinationer.
24. Den første sammensætning og den anden sammensætning til anvendelse ifølge krav 23, hvor hver rekombinante vektor yderligere omfatter en nukleinsyre, der koder for mindst et af SEQ ID NO: 5, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 29 eller SEQ ID NO: 32.
25. Den første sammensætning og den anden sammensætning til anvendelse ifølge krav 23 eller 24, hvor hver rekombinante vektor yderligere omfatter en nukleinsyre, der koder for et CEA-antigen.
26. Den første sammensætning og den anden sammensætning til anvendelse ifølge et hvilket som helst af kravene 23-25, hvor hver rekombinante vektor er en rekombinant poxvirusvektor, fortrinsvis er den rekombinante poxvirusvektor valgt fra gruppen, som består af orthopox, avipox, capripox og suipox, fortrinsvis er den rekombinante vektor eller rekombinante poxvirusvektor af den første sammensætning forskellig fra den rekombinante vektor eller rekombinante poxvirusvektor af den anden sammensætning.
Applications Claiming Priority (2)
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| US201261582723P | 2012-01-03 | 2012-01-03 | |
| PCT/US2013/020058 WO2013103658A1 (en) | 2012-01-03 | 2013-01-03 | Native and agonist ctl epitopes of the muc1 tumor antigen |
Publications (1)
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| DK2800762T3 true DK2800762T3 (da) | 2018-04-16 |
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| DK13700352.1T DK2800762T3 (da) | 2012-01-03 | 2013-01-03 | Native og agonistiske ctl-epitoper af muc1-tumor-antigenet |
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| EP (1) | EP2800762B1 (da) |
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| AU (1) | AU2013206896B2 (da) |
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| DK (1) | DK2800762T3 (da) |
| ES (1) | ES2664325T3 (da) |
| WO (1) | WO2013103658A1 (da) |
Families Citing this family (10)
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| US9090673B2 (en) * | 2003-12-12 | 2015-07-28 | City Of Hope | Synthetic conjugate of CpG DNA and T-help/CTL peptide |
| ES2918452T3 (es) | 2007-02-19 | 2022-07-15 | Marine Polymer Tech Inc | Composiciones hemostáticas y regímenes terapéuticos |
| WO2015061416A2 (en) | 2013-10-23 | 2015-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
| RU2756534C2 (ru) | 2016-09-28 | 2021-10-01 | Бавариан Нордик А/С | Композиции и способы для повышения стабильности трансгенов в поксвирусах |
| EP3542814B1 (en) * | 2018-03-21 | 2022-08-24 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Novel peptide-based compounds for use in the prevention, treatment and/or detection of cancer |
| JP2022512595A (ja) | 2018-10-05 | 2022-02-07 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
| CA3119503A1 (en) | 2018-11-20 | 2020-05-28 | Bavarian Nordic A/S | Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l |
| JP2023503857A (ja) | 2019-11-20 | 2023-02-01 | バヴァリアン・ノルディック・アクティーゼルスカブ | がんを治療するための腫瘍内及び／または静脈内投与用組み換えｍｖａウイルス |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| WO2023140412A1 (ko) * | 2022-01-24 | 2023-07-27 | 싸이런테라퓨틱스 주식회사 | Muc-1에 특이적으로 결합하는 항체 및 이의 용도 |
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| US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
| US4885172A (en) | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| IE912535A1 (en) | 1990-07-27 | 1992-01-29 | Res Dev Foundation | Liposomes that Provide Thymic Dependent Help to Weak Vaccine¹Antigens |
| US5744144A (en) | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
| US5643599A (en) | 1995-06-07 | 1997-07-01 | President And Fellows Of Harvard College | Intracellular delivery of macromolecules |
| ATE394474T1 (de) | 1997-05-08 | 2008-05-15 | Biomira Inc | Verfahren zur gewinnung von aktivierten t-zellen und mit antigen inkubierten antigenpräsentierenden zellen |
| US20090004212A1 (en) * | 1997-12-30 | 2009-01-01 | Franz-Georg Hanisch | Tumour vaccines for MUC1-positive carcinomas |
| IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
| DE60030450T2 (de) * | 1999-09-08 | 2007-08-30 | Transgene S.A. | Von MUC-1 abgeleitete Peptide |
| JP5052893B2 (ja) | 2003-02-20 | 2012-10-17 | アメリカ合衆国 | ポックスベクターにおける新規の挿入部位 |
| US7696306B2 (en) | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| CA2545164C (en) | 2003-11-12 | 2016-11-29 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Recombinant vectors expressing mucin and carcinoembryoinic antigen |
| AU2004289368B2 (en) | 2003-11-12 | 2010-08-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Custom vectors for treating and preventing pancreatic cancer |
| EP1697399B1 (en) * | 2003-12-12 | 2016-11-23 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS | A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1 |
| WO2008011672A1 (en) * | 2006-07-25 | 2008-01-31 | 4G Vaccines Pty Ltd | A cancer vaccine comprising a mucin 1 (muc1) t cell epitope-derived peptide |
| US20110318380A1 (en) * | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| KR102049928B1 (ko) * | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
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| AU2013206896A1 (en) | 2014-07-24 |
| ES2664325T3 (es) | 2018-04-19 |
| EP2800762B1 (en) | 2018-01-03 |
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| JP2015504071A (ja) | 2015-02-05 |
| WO2013103658A1 (en) | 2013-07-11 |
| EP2800762A1 (en) | 2014-11-12 |
| AU2013206896B2 (en) | 2017-05-25 |
| US10138271B2 (en) | 2018-11-27 |
| JP6523685B2 (ja) | 2019-06-05 |
| US20140363495A1 (en) | 2014-12-11 |
| CA2860599A1 (en) | 2013-07-11 |
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