DK2288598T3 - Thiophene derivatives suitable as agents for reducing the internal pressure of the eye - Google Patents

Thiophene derivatives suitable as agents for reducing the internal pressure of the eye

Info

Publication number
DK2288598T3
DK2288598T3 DK09734043.4T DK09734043T DK2288598T3 DK 2288598 T3 DK2288598 T3 DK 2288598T3 DK 09734043 T DK09734043 T DK 09734043T DK 2288598 T3 DK2288598 T3 DK 2288598T3
Authority
DK
Denmark
Prior art keywords
eye
agents
reducing
internal pressure
thiophene derivatives
Prior art date
Application number
DK09734043.4T
Other languages
Danish (da)
Inventor
David W Old
Vinh X Ngo
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DK2288598T3 publication Critical patent/DK2288598T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/40—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, B, D, and Y are as described. Methods, compositions, and medicaments related thereto are also disclosed.
DK09734043.4T 2008-04-24 2009-04-22 Thiophene derivatives suitable as agents for reducing the internal pressure of the eye DK2288598T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4772608P 2008-04-24 2008-04-24
PCT/US2009/041387 WO2009132087A1 (en) 2008-04-24 2009-04-22 Thiophene derivatives useful as ocular hypotensive agents

Publications (1)

Publication Number Publication Date
DK2288598T3 true DK2288598T3 (en) 2012-04-23

Family

ID=40775174

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09734043.4T DK2288598T3 (en) 2008-04-24 2009-04-22 Thiophene derivatives suitable as agents for reducing the internal pressure of the eye

Country Status (8)

Country Link
US (1) US7803798B2 (en)
EP (1) EP2288598B1 (en)
AT (1) ATE550328T1 (en)
AU (1) AU2009239371B2 (en)
CA (1) CA2722312C (en)
DK (1) DK2288598T3 (en)
ES (1) ES2381435T3 (en)
WO (1) WO2009132087A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008207991B9 (en) * 2007-01-22 2014-02-27 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
ATE305463T1 (en) 2001-11-05 2005-10-15 Allergan Inc OMEGA-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGAS AS EP2 RECEPTOR AGONISTS
US7091231B2 (en) 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
JP5410271B2 (en) 2006-04-04 2014-02-05 アラーガン インコーポレイテッド Prostaglandin compounds for the treatment of glaucoma
US7439372B2 (en) 2006-05-03 2008-10-21 Allergan, Inc. Therapeutic compounds
JP2009541340A (en) 2006-06-20 2009-11-26 アラーガン インコーポレイテッド Therapeutic compounds
US7507817B2 (en) * 2006-11-17 2009-03-24 Allergan, Inc. Prostaglandin prodrugs
AU2008207991B9 (en) * 2007-01-22 2014-02-27 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents

Also Published As

Publication number Publication date
ES2381435T3 (en) 2012-05-28
CA2722312C (en) 2016-08-09
US7803798B2 (en) 2010-09-28
CA2722312A1 (en) 2009-10-29
WO2009132087A1 (en) 2009-10-29
US20090270386A1 (en) 2009-10-29
EP2288598A1 (en) 2011-03-02
AU2009239371B2 (en) 2014-05-01
EP2288598B1 (en) 2012-03-21
AU2009239371A1 (en) 2009-10-29
ATE550328T1 (en) 2012-04-15

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