DK22588D0 - PEPTIDE DERIVATIVES - Google Patents

PEPTIDE DERIVATIVES

Info

Publication number
DK22588D0
DK22588D0 DK022588A DK22588A DK22588D0 DK 22588 D0 DK22588 D0 DK 22588D0 DK 022588 A DK022588 A DK 022588A DK 22588 A DK22588 A DK 22588A DK 22588 D0 DK22588 D0 DK 22588D0
Authority
DK
Denmark
Prior art keywords
peptide derivatives
peptide
derivatives
Prior art date
Application number
DK022588A
Other languages
Danish (da)
Other versions
DK22588A (en
Inventor
Alexander Hagenbach
Rainer Metternich
Emil Pfenninger
Beat Weidmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK22588D0 publication Critical patent/DK22588D0/en
Publication of DK22588A publication Critical patent/DK22588A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK022588A 1987-01-21 1988-01-19 PEPTIDE DERIVATIVES DK22588A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3701526 1987-01-21
DE3707339 1987-03-07

Publications (2)

Publication Number Publication Date
DK22588D0 true DK22588D0 (en) 1988-01-19
DK22588A DK22588A (en) 1988-07-22

Family

ID=25851692

Family Applications (1)

Application Number Title Priority Date Filing Date
DK022588A DK22588A (en) 1987-01-21 1988-01-19 PEPTIDE DERIVATIVES

Country Status (13)

Country Link
JP (1) JPS6419053A (en)
KR (1) KR880009041A (en)
AU (1) AU1037588A (en)
BE (1) BE1002212A5 (en)
CH (1) CH676988A5 (en)
DK (1) DK22588A (en)
FR (1) FR2609716A1 (en)
GB (1) GB2200115B (en)
IL (1) IL85136A0 (en)
IT (1) IT1219811B (en)
MY (1) MY102311A (en)
NL (1) NL8800100A (en)
SE (1) SE8800169L (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
DE3732971A1 (en) * 1987-09-30 1989-04-20 Hoechst Ag RENINE INHIBITING DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE
DE3733296A1 (en) * 1987-10-02 1989-04-20 Merck Patent Gmbh AMINOSAEUREDERIVATE
EP0397779A1 (en) * 1988-02-01 1990-11-22 The Upjohn Company Renin inhibiting peptides with polar end groups
JP2524814B2 (en) * 1988-08-25 1996-08-14 キッセイ薬品工業株式会社 Method for producing α-hydroxy-β-amino acid
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
US5185284A (en) * 1989-05-22 1993-02-09 Mitsubishi Denki Kabushiki Kaisha Method of making a semiconductor memory device
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
TW225540B (en) * 1990-06-28 1994-06-21 Shionogi & Co
EP0554400B1 (en) * 1990-11-19 1997-07-23 Monsanto Company Retroviral protease inhibitors
ES2059293T3 (en) * 1990-11-19 1998-12-16 Monsanto Co RETROVIRAL PROTEASE INHIBITORS.
EP0731088B1 (en) 1990-11-19 2000-10-04 Monsanto Company Retroviral protease inhibitors
US5482947A (en) * 1990-11-19 1996-01-09 Talley; John J. Retroviral protease inhibitors
US5475027A (en) * 1990-11-19 1995-12-12 G.D. Searle & Co. Retroviral protease inhibitors
US5475013A (en) * 1990-11-19 1995-12-12 Monsanto Company Retroviral protease inhibitors
US5510487A (en) * 1990-11-19 1996-04-23 G.D. Searle & Co. Retroviral protease inhibitors
US5614522A (en) * 1990-11-19 1997-03-25 G.D. Searle & Co. Retroviral protease inhibitors
JP3492362B2 (en) * 1992-05-20 2004-02-03 ジー．ディー．サール アンド カンパニー Method for producing intermediates useful for the synthesis of retroviral protease inhibitors
ATE199545T1 (en) 1992-05-21 2001-03-15 Monsanto Co INHIBITORS OF RETROVIRAL PROTEASES
PT810209E (en) * 1992-08-25 2002-09-30 Searle & Co HYDROXYETHYLAMINO-SULFONAMIDES OF ALPHA- AND BETA-AMINOACIDOS UTEIS AS INHIBITORS OF RETROVIRAL PROTEASE
JP4091654B2 (en) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー Sulfonylalkanoylaminohydroxyethylaminosulfonamides useful as retroviral protease inhibitors
US6046190A (en) * 1992-08-25 2000-04-04 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US7141609B2 (en) 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6022994A (en) 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6743929B1 (en) 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
JP4091653B2 (en) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー N- (alkanoylamino-2-hydroxypropyl) sulfonamides useful as retroviral protease inhibitors
US5830897A (en) * 1992-08-27 1998-11-03 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (en) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl protease inhibitor of a new class of sulfonamides
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
CA2141570A1 (en) * 1992-10-30 1994-05-11 Michael L. Vazquez Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
DE69331421T2 (en) 1992-10-30 2002-08-01 Searle & Co N-substituted hydroxyethylaminosulfamic acid derivatives can be used as inhibitors of retroviral proteases
US5756498A (en) * 1992-10-30 1998-05-26 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US6337398B1 (en) 1992-10-30 2002-01-08 G.D. Searle & Co. Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
DK0885881T3 (en) * 1992-10-30 2003-07-14 Searle & Co Sulfonylalkanoylaminohydroxyethylaminosulfamic acids useful as retroviral protease inhibitors
US5578606A (en) 1992-10-30 1996-11-26 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US5514801A (en) 1992-12-29 1996-05-07 Monsanto Company Cyclic sulfone containing retroviral protease inhibitors
US5830888A (en) * 1993-04-16 1998-11-03 Monsanto Company Macrocyclic retroviral protease inhibitors
US5750648A (en) * 1993-08-20 1998-05-12 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof
US5602119A (en) * 1993-10-29 1997-02-11 Vazquez; Michael L. Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
MX9603909A (en) * 1994-03-07 1997-03-29 Vertex Pharma Sulphonamide derivatives as aspartyl protease inhibitors.
EP1059285A3 (en) * 1994-07-07 2001-10-31 Pharm-Eco Laboratories, Inc. Process for the preparation of 1,3-diamino-2-propanol and 1,3-diamino-2-propanone derivatives
US5475138A (en) * 1994-07-07 1995-12-12 Pharm-Eco Laboratories Incorporated Method preparing amino acid-derived diaminopropanols
AU693219B2 (en) * 1994-07-07 1998-06-25 Pharm-Eco Laboratories, Incorporated Amino acid-derived diaminopropanols
US5831117A (en) 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
US6143747A (en) 1995-01-20 2000-11-07 G. D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6140505A (en) 1995-03-10 2000-10-31 G. D. Searle & Co. Synthesis of benzo fused heterocyclic sulfonyl chlorides
US5985870A (en) * 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
ATE229033T1 (en) 1995-03-10 2002-12-15 Searle & Co HETEROCYCLOCARBONYL AMINO ACID HYDROXYETHYLAMINE - SULFONAMIDE INHIBITORS OF RETROVIRAL PROTEASES
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6169085B1 (en) 1995-03-10 2001-01-02 G. D. Searle & Company Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6667307B2 (en) 1997-12-19 2003-12-23 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US6063963A (en) * 1995-07-05 2000-05-16 Pharm-Eco Laboratories, Inc. Amino acid-derived diaminopropanols
US5753660A (en) * 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
JPH11324710A (en) 1998-05-20 1999-11-26 Hitachi Ltd Gas turbine power plant
EP1086076B1 (en) 1998-06-19 2004-12-22 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
US6538006B1 (en) 1998-07-08 2003-03-25 Pharmacia Corporation Retroviral protease inhibitors
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7251926B2 (en) 2001-07-26 2007-08-07 Hitachi, Ltd. Gas turbine installation
JP3888095B2 (en) 2001-07-26 2007-02-28 株式会社日立製作所 Gas turbine equipment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
JPS60163899A (en) * 1984-02-03 1985-08-26 Sankyo Co Ltd Renin-inhibiting peptide
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
EP0184855A3 (en) * 1984-12-14 1989-05-03 Abbott Laboratories Resin inhibiting compounds
KR870005013A (en) * 1985-11-29 1987-06-04 가와무라 요시부미 Lenin-inhibiting oligopeptides, methods of making and uses thereof
DE3601248A1 (en) * 1986-01-17 1987-07-23 Hoechst Ag SUBSTITUTED 4-AMINO-3-HYDROXYBUTTERIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE

Also Published As

Publication number Publication date
JPS6419053A (en) 1989-01-23
AU1037588A (en) 1988-09-01
SE8800169L (en) 1988-07-22
IL85136A0 (en) 1988-06-30
NL8800100A (en) 1988-08-16
CH676988A5 (en) 1991-03-28
MY102311A (en) 1992-05-28
BE1002212A5 (en) 1990-10-16
GB8801040D0 (en) 1988-02-17
GB2200115A (en) 1988-07-27
DK22588A (en) 1988-07-22
FR2609716A1 (en) 1988-07-22
IT1219811B (en) 1990-05-24
KR880009041A (en) 1988-09-13
GB2200115B (en) 1990-11-14
SE8800169D0 (en) 1988-01-20
IT8847556A0 (en) 1988-01-21

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment