DK2047253T3 - ELECTROCHEMICAL DETECTION OF MAGNETIC PARTICLE MOBILITY - Google Patents
ELECTROCHEMICAL DETECTION OF MAGNETIC PARTICLE MOBILITY Download PDFInfo
- Publication number
- DK2047253T3 DK2047253T3 DK07766626.1T DK07766626T DK2047253T3 DK 2047253 T3 DK2047253 T3 DK 2047253T3 DK 07766626 T DK07766626 T DK 07766626T DK 2047253 T3 DK2047253 T3 DK 2047253T3
- Authority
- DK
- Denmark
- Prior art keywords
- fluid
- electrodes
- coagulation
- particles
- exemplary embodiment
- Prior art date
Links
- 239000006249 magnetic particle Substances 0.000 title claims description 16
- 238000000835 electrochemical detection Methods 0.000 title description 3
- 239000002245 particle Substances 0.000 claims description 53
- 239000012530 fluid Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 44
- 238000012544 monitoring process Methods 0.000 claims description 39
- 230000015271 coagulation Effects 0.000 claims description 25
- 238000005345 coagulation Methods 0.000 claims description 25
- 230000004044 response Effects 0.000 claims description 23
- 241000894007 species Species 0.000 claims description 21
- 230000008859 change Effects 0.000 claims description 20
- 230000005291 magnetic effect Effects 0.000 claims description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 10
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 10
- 239000003114 blood coagulation factor Substances 0.000 claims description 10
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical class [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 claims description 10
- 238000004082 amperometric method Methods 0.000 claims description 6
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims description 4
- 108010000499 Thromboplastin Proteins 0.000 claims description 4
- 102000002262 Thromboplastin Human genes 0.000 claims description 4
- 230000002950 deficient Effects 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 3
- 239000012491 analyte Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 239000003998 snake venom Substances 0.000 claims description 3
- 230000003647 oxidation Effects 0.000 claims description 2
- 238000007254 oxidation reaction Methods 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000010292 electrical insulation Methods 0.000 claims 1
- 238000012806 monitoring device Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 description 14
- 238000012360 testing method Methods 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 238000001514 detection method Methods 0.000 description 9
- 238000009792 diffusion process Methods 0.000 description 9
- 239000011324 bead Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 8
- 229960005080 warfarin Drugs 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 238000013459 approach Methods 0.000 description 6
- 230000005298 paramagnetic effect Effects 0.000 description 5
- 230000001052 transient effect Effects 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 206010053567 Coagulopathies Diseases 0.000 description 3
- 108010094028 Prothrombin Proteins 0.000 description 3
- 102100027378 Prothrombin Human genes 0.000 description 3
- 230000035602 clotting Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000005518 electrochemistry Effects 0.000 description 3
- 229940039716 prothrombin Drugs 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- DLURHXYXQYMPLT-UHFFFAOYSA-N 2-nitro-p-toluidine Chemical compound CC1=CC=C(N)C([N+]([O-])=O)=C1 DLURHXYXQYMPLT-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010067787 Coagulation factor deficiency Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 238000007820 coagulation assay Methods 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- -1 etc.) Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
- G01N2011/0086—Determining flow properties indirectly by measuring other parameters of the system magnetic properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
- G01N11/14—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
- G01N2011/147—Magnetic coupling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1027—Determining speed or velocity of a particle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83124006P | 2006-07-17 | 2006-07-17 | |
| PCT/IB2007/001990 WO2008010058A1 (en) | 2006-07-17 | 2007-07-13 | Electrochemical detection of magnetic particle mobility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2047253T3 true DK2047253T3 (en) | 2016-02-15 |
Family
ID=38956592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07766626.1T DK2047253T3 (en) | 2006-07-17 | 2007-07-13 | ELECTROCHEMICAL DETECTION OF MAGNETIC PARTICLE MOBILITY |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8974658B2 (enExample) |
| EP (1) | EP2047253B1 (enExample) |
| JP (1) | JP5309024B2 (enExample) |
| KR (1) | KR101490531B1 (enExample) |
| CN (1) | CN101627305B (enExample) |
| AU (1) | AU2007274779B2 (enExample) |
| BR (1) | BRPI0714393A2 (enExample) |
| CA (1) | CA2659152C (enExample) |
| DK (1) | DK2047253T3 (enExample) |
| HU (1) | HUE028693T2 (enExample) |
| IL (1) | IL196555A (enExample) |
| MX (1) | MX2009000544A (enExample) |
| PL (1) | PL2047253T3 (enExample) |
| PT (1) | PT2047253E (enExample) |
| SG (1) | SG173379A1 (enExample) |
| SI (1) | SI2047253T1 (enExample) |
| TW (1) | TWI449906B (enExample) |
| WO (1) | WO2008010058A1 (enExample) |
| ZA (1) | ZA200900571B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0812679D0 (en) | 2008-07-10 | 2008-08-20 | Sec Dep For Innovation Universities | Sample carrier for effecting chemical assays |
| GB0812681D0 (en) * | 2008-07-10 | 2008-08-20 | Sec Dep For Innovation Universities | Apparatus and methods for effecting chemical assays |
| WO2010119341A1 (en) * | 2009-04-17 | 2010-10-21 | Universal Biosensors Pty Ltd. | On-board control detection |
| GB201217390D0 (en) | 2012-09-28 | 2012-11-14 | Agplus Diagnostics Ltd | Test device and sample carrier |
| KR102252259B1 (ko) * | 2015-12-31 | 2021-05-14 | 주식회사 필로시스 | 혈액 응고 측정장치 |
| JP7062954B2 (ja) * | 2016-02-10 | 2022-05-09 | ソニーグループ株式会社 | 血液凝固解析装置及び血液凝固解析方法 |
| CN108614017B (zh) * | 2016-12-09 | 2021-02-09 | 广州好芝生物科技有限公司 | 一种凝血酶原时间检测方法和装置 |
| WO2018115086A1 (en) * | 2016-12-22 | 2018-06-28 | Roche Diagnostics Gmbh | Determination of local mean normal prothrombin time and of local international sensitivity index |
| CN109827891A (zh) * | 2019-02-01 | 2019-05-31 | 天津中环领先材料技术有限公司 | 一种基于sp1颗粒测试仪的cop检测方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3522098A1 (de) | 1985-06-20 | 1987-01-02 | Jung Friedrich | Vorrichtung zur bestimmung einer der erythrozytenaggregation entsprechenden me?groesse |
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| US4849340A (en) | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| FR2664981B1 (fr) * | 1990-07-20 | 1994-04-29 | Serbio | Dispositif de detection du changement de viscosite d'un electrolyte liquide par effet de depolarisation. |
| US5670329A (en) | 1993-05-28 | 1997-09-23 | Cardiovascular Diagnostics, Inc. | Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field |
| FR2756501B1 (fr) * | 1996-11-29 | 1999-02-19 | Centre Nat Rech Scient | Procede et dispositif de separation de particules ou molecules par migration a travers un ferrofluide |
| WO1998049549A1 (en) * | 1997-04-30 | 1998-11-05 | Orion Research, Inc. | Capillary electrophoretic separation system |
| US6046051A (en) * | 1997-06-27 | 2000-04-04 | Hemosense, Inc. | Method and device for measuring blood coagulation or lysis by viscosity changes |
| EP2006669A3 (en) | 1997-07-22 | 2008-12-31 | Kyoto Daiichi Kagaku Co., Ltd. | Concentration measuring apparatus and test strip for the concentration measuring apparatus |
| SE9800590D0 (sv) * | 1998-02-26 | 1998-02-26 | Global Hemostasis Inst Mgr Ab | Determination of polymerization/coagulation in a fluid |
| EP1482296B1 (en) * | 1998-07-29 | 2008-06-25 | Hemosense, Inc. | Method and device for measuring blood coagulating or lysis by viscosity changes |
| US6620310B1 (en) | 2000-12-13 | 2003-09-16 | Lifescan, Inc. | Electrochemical coagulation assay and device |
| US7144495B2 (en) | 2000-12-13 | 2006-12-05 | Lifescan, Inc. | Electrochemical test strip with an integrated micro-needle and associated methods |
| GB0030929D0 (en) * | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
| KR100442822B1 (ko) * | 2001-10-23 | 2004-08-02 | 삼성전자주식회사 | 전단응력 측정을 이용한 생분자들간의 결합 여부 검출 방법 |
| US6746872B2 (en) * | 2002-01-16 | 2004-06-08 | Lifescan, Inc. | Control compositions and methods of use for coagulation tests |
| US7010432B2 (en) | 2002-08-30 | 2006-03-07 | Lifescan, Inc. | Method and system for determining the acceptability of signal data collected from a prothrombin time test strip |
| EP1544596B1 (de) * | 2003-12-17 | 2016-11-23 | Boehringer Ingelheim microParts GmbH | Verfahren und Vorrichtung zur Bestimmung der Viskosität |
| US20080026476A1 (en) * | 2004-05-20 | 2008-01-31 | Steven Howell | Device and Method for Detecting Blood Coagulation |
-
2007
- 2007-07-13 CN CN200780028935.9A patent/CN101627305B/zh not_active Expired - Fee Related
- 2007-07-13 AU AU2007274779A patent/AU2007274779B2/en not_active Ceased
- 2007-07-13 SI SI200731740T patent/SI2047253T1/sl unknown
- 2007-07-13 PL PL07766626T patent/PL2047253T3/pl unknown
- 2007-07-13 SG SG2011051497A patent/SG173379A1/en unknown
- 2007-07-13 US US12/374,276 patent/US8974658B2/en active Active
- 2007-07-13 HU HUE07766626A patent/HUE028693T2/en unknown
- 2007-07-13 WO PCT/IB2007/001990 patent/WO2008010058A1/en not_active Ceased
- 2007-07-13 MX MX2009000544A patent/MX2009000544A/es active IP Right Grant
- 2007-07-13 KR KR20097003086A patent/KR101490531B1/ko not_active Expired - Fee Related
- 2007-07-13 PT PT77666261T patent/PT2047253E/pt unknown
- 2007-07-13 EP EP07766626.1A patent/EP2047253B1/en not_active Not-in-force
- 2007-07-13 JP JP2009520067A patent/JP5309024B2/ja not_active Expired - Fee Related
- 2007-07-13 CA CA2659152A patent/CA2659152C/en not_active Expired - Fee Related
- 2007-07-13 BR BRPI0714393-1A patent/BRPI0714393A2/pt not_active Application Discontinuation
- 2007-07-13 DK DK07766626.1T patent/DK2047253T3/en active
- 2007-07-17 TW TW096126052A patent/TWI449906B/zh not_active IP Right Cessation
-
2009
- 2009-01-15 IL IL196555A patent/IL196555A/en active IP Right Grant
- 2009-01-26 ZA ZA200900571A patent/ZA200900571B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008010058A1 (en) | 2008-01-24 |
| SI2047253T1 (sl) | 2016-04-29 |
| TW200806982A (en) | 2008-02-01 |
| KR101490531B1 (ko) | 2015-02-05 |
| HK1128765A1 (zh) | 2009-11-06 |
| CA2659152A1 (en) | 2008-01-24 |
| US20090301901A1 (en) | 2009-12-10 |
| EP2047253A4 (en) | 2010-07-07 |
| HUE028693T2 (en) | 2016-12-28 |
| US8974658B2 (en) | 2015-03-10 |
| PT2047253E (pt) | 2016-03-11 |
| IL196555A0 (en) | 2009-11-18 |
| ZA200900571B (en) | 2009-11-25 |
| AU2007274779A1 (en) | 2008-01-24 |
| BRPI0714393A2 (pt) | 2013-03-26 |
| CN101627305B (zh) | 2015-03-04 |
| EP2047253A1 (en) | 2009-04-15 |
| CA2659152C (en) | 2015-11-03 |
| PL2047253T3 (pl) | 2016-06-30 |
| TWI449906B (zh) | 2014-08-21 |
| IL196555A (en) | 2015-03-31 |
| JP2009544031A (ja) | 2009-12-10 |
| JP5309024B2 (ja) | 2013-10-09 |
| EP2047253B1 (en) | 2015-11-04 |
| KR20090033268A (ko) | 2009-04-01 |
| AU2007274779B2 (en) | 2013-05-09 |
| SG173379A1 (en) | 2011-08-29 |
| MX2009000544A (es) | 2009-05-28 |
| CN101627305A (zh) | 2010-01-13 |
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