DK200501310A - The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults - Google Patents

The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults Download PDF

Info

Publication number
DK200501310A
DK200501310A DK200501310A DKPA200501310A DK200501310A DK 200501310 A DK200501310 A DK 200501310A DK 200501310 A DK200501310 A DK 200501310A DK PA200501310 A DKPA200501310 A DK PA200501310A DK 200501310 A DK200501310 A DK 200501310A
Authority
DK
Denmark
Prior art keywords
treatment
diabetes
adults
antagonist
prevention
Prior art date
Application number
DK200501310A
Other languages
Danish (da)
Inventor
Skak Kresten
Lundsgaard Dorthe
Hansen Lars
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK200501310A priority Critical patent/DK200501310A/en
Publication of DK200501310A publication Critical patent/DK200501310A/en

Links

Description

CLAIMS 1. Use of an IL-21 antagonist for the manufacture of a medicament for the treatment of latent autoimmune diabetes in adults. 2. Use of an IL-21 antagonist for the manufacture of a medicament for prolonging the remission phase in patients with newly diagnosed type 1 diabetes. 3. Use of an IL-21 antagonist for the manufacture of a medicament for reducing the secondary failure rate of treatment with orally active hypoglycaemic agents and/or postponing the need for insulin therapy in islet cell antibody (ICA), insulin antibody-, heat shock protein (hsp) 60 antibody- and/or GAD antibody-positive patients with type 2 diabetes; 4. A pharmaceutical composition comprising an IL-21 antagonist in combination with another agent that suppress immune responses and/or promotes the generation of regulatory immune responses. 5. The use of an IL-21 antagonist for the manufacture of a medicament for the treatment of autoimmune diseases administered in combination with another agent that suppress immune responses and/or promotes the generation of regulatory immune responses 6. The use according to claim 5 wherein the autoimmune diseases are Type 1 Diabetes and LADA. 7. The use according to claim 5 wherein the compounds that suppress immune responses and/or promote regulatory immune responses are CD3 antagonists, hereunder OKT3, CD25 antagonists, CTLA-4 agonists, IL-2 antagonists, IL-2R antagonists, thiazolidin-diones (TZDs). 8. The use of an IL-21 antagonist for the manufacture of a medicament for the treatment of autoimmune diseases including T1D and LADA administered in combination with one or more agents that stimulates the regeneration or neoformation of β-cells, 9. The use according to claim 8 wherein the compounds that promote regeneration and/or neoformation of β-cells are selected from gastrin, gastrin analogues, epidermal growth factor (EGF), EGF-R agonists, fibroblast growth factor (FGF), FGF-R agonists, Keratinocyte growth factor, growth hormone (GH), Ghrelin, glucagon-like peptide (GLP)-1, GLP-1 analogues, hereunder Liraglutide; 10. The use of an? One or more? antagonist of IL-21 for the manufacture of a medicament for the treatment of complications and disorders resulting from or associated with obesity administered together with one or more antidiabetics, antiobesity agents, antihypertensive agents, and/or agents for the treatment of complications resulting from or associated with diabetes. 11. A pharmaceutical composition comprising an antagonist of IL-21 together with one or more compounds that suppress immune responses and/or promote regulatory immune responses. 12. A pharmaceutical composition comprising an antagonist of IL-21 together with one or more agents that stimulate the regeneration or neoformation of β-cells. 13. A pharmaceutical composition comprising an antagonist of IL-21 together with antidiabetics, antiobesity agents, antihypertensive agents, and/or agents for the treatment of complications resulting from or associated with diabetes. 14. A method for the treatment of latent autoimmune diabetes in the adults by administering an effective amount of an antagonist of IL-21; 15. A method for prolonging the remission phase in patients with newly diagnosed type 1 diabetes by administering an effective amount of an antagonist of IL-21; 16. A method for reducing the secondary failure rate of treatment with orally active hypoglycaemic agents and/or postponing the need for insulin therapy in islet cell antibody (ICA), insulin antibody, heat shock protein (hsp) 60 antibody and/or GAD antibody positive patients with type 2 diabetes by administering an effective amount of an antagonist of IL-21.CLAIMS 1. Use of an IL-21 antagonist for the manufacture of a medicament for the treatment of latent autoimmune diabetes in adults. Use of an IL-21 antagonist for the manufacture of a medicament for prolonging the remission phase in patients with newly diagnosed type 1 diabetes. Use of an IL-21 antagonist for the manufacture of a medicament for reducing the secondary failure rate of treatment with orally active hypoglycaemic agents and / or postponing the need for insulin therapy in islet cell antibody (ICA), insulin antibody-, heat shock protein (hsp) 60 antibody- and / or GAD antibody-positive patients with type 2 diabetes; A pharmaceutical composition comprising an IL-21 antagonist in combination with another agent that suppresses immune responses and / or promotes the generation of regulatory immune responses. 5. The use of an IL-21 antagonist for the manufacture of a medicament for the treatment of autoimmune diseases administered in combination with another agent that suppresses immune responses and / or promotes the generation of regulatory immune responses 6. The use according to claim 5 where the autoimmune diseases are Type 1 Diabetes and LADA. The use according to claim 5 wherein the compounds that suppress immune responses and / or promote regulatory immune responses are CD3 antagonists, hereunder OKT3, CD25 antagonists, CTLA-4 agonists, IL-2 antagonists, IL-2R antagonists, thiazolidin-diones (TZDs). 8. The use of an IL-21 antagonist for the manufacture of a medicament for the treatment of autoimmune diseases including T1D and LADA administered in combination with one or more agents that stimulates the regeneration or neoformation of β-cells, 9. The use according to claim 8 wherein the compounds that promote regeneration and / or neoformation of β-cells are selected from gastrin, gastrin analogues, epidermal growth factor (EGF), EGF-R agonists, fibroblast growth factor (FGF), FGF-R agonists, Keratinocyte growth factor, growth hormone (GH), Ghrelin, glucagon-like peptide (GLP) -1, GLP-1 analogues, including Liraglutide; 10. The use of an? One or more? antagonist of IL-21 for the manufacture of a medicament for the treatment of complications and disorders resulting from or associated with obesity administered together with one or more antidiabetics, antiobesity agents, antihypertensive agents, and / or agents for the treatment of complications resulting from or associated with diabetes. 11. A pharmaceutical composition comprising an antagonist of IL-21 together with one or more compounds that suppress immune responses and / or promote regulatory immune responses. 12. A pharmaceutical composition comprising an antagonist of IL-21 together with one or more agents that stimulate the regeneration or neoformation of β-cells. 13. A pharmaceutical composition comprising an antagonist of IL-21 together with antidiabetics, antiobesity agents, antihypertensive agents, and / or agents for the treatment of complications resulting from or associated with diabetes. 14. A method for the treatment of latent autoimmune diabetes in the adults by administering an effective amount of an antagonist of IL-21; 15. A method for prolonging the remission phase in patients with newly diagnosed type 1 diabetes by administering an effective amount of an antagonist of IL-21; 16. A method for reducing the secondary failure rate of treatment with orally active hypoglycaemic agents and / or postponing the need for insulin therapy in islet cell antibody (ICA), insulin antibody, heat shock protein (hsp) 60 antibody and / or GAD antibody positive patients with type 2 diabetes by administering an effective amount of an antagonist of IL-21.

DK200501310A 2005-09-21 2005-09-21 The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults DK200501310A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200501310A DK200501310A (en) 2005-09-21 2005-09-21 The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK200501310A DK200501310A (en) 2005-09-21 2005-09-21 The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults

Publications (1)

Publication Number Publication Date
DK200501310A true DK200501310A (en) 2005-10-01

Family

ID=35229545

Family Applications (1)

Application Number Title Priority Date Filing Date
DK200501310A DK200501310A (en) 2005-09-21 2005-09-21 The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults

Country Status (1)

Country Link
DK (1) DK200501310A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010055366A3 (en) * 2007-12-07 2010-10-21 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
US9388241B2 (en) 2005-11-28 2016-07-12 Zymogenetics, Inc. Anti-human IL-21 antibodies

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388241B2 (en) 2005-11-28 2016-07-12 Zymogenetics, Inc. Anti-human IL-21 antibodies
WO2010055366A3 (en) * 2007-12-07 2010-10-21 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
EP2426146A3 (en) * 2007-12-07 2012-05-30 ZymoGenetics, Inc. Anti-human IL-21 monoclonal antibodies
US8226948B1 (en) 2007-12-07 2012-07-24 Zymogenetics, Inc. Anti-human IL-21 monoclonal antibodies
US8361470B2 (en) 2007-12-07 2013-01-29 Zymogenetics, Inc. Methods of treatment using anti-human IL-21 monoclonal antibodies
EP3103813A1 (en) * 2007-12-07 2016-12-14 ZymoGenetics, Inc. Anti-human il-21 monoclonal antibodies

Similar Documents

Publication Publication Date Title
CN112512633A (en) Methods of treatment using GIP/GLP1 co-agonists
Apovian Naltrexone/bupropion for the treatment of obesity and obesity with Type 2 diabetes
US20080213288A1 (en) Combined Use Of A Modulator Of CD3 And A GLP-1 Compound
RU2015101826A (en) APPLICATION OF LONG-TERM GLP-1 PEPTIDES
AU2017361539A1 (en) Buffered formulations of exendin (9-39)
Cao et al. The clinical application of linagliptin in Asians
CA3049034A1 (en) Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
MX2022009149A (en) Gip/glp1 co-agonist compounds.
Provilus et al. Weight gain associated with antidiabetic medications
DK200501310A (en) The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults
Cariou et al. Liraglutide in whole-pancreas transplant patients with impaired glucose homoeostasis: A case series
WO2006130769A3 (en) Methods for treatment of growth disorders
US20150065535A1 (en) Method of restoring the incretin effect
Ankem et al. Risperidone-induced priapism
JP2022513351A (en) Avexide for the treatment of hyperinsulinemia hypoglycemia
Gallwitz GLP-1 Receptor Agonists in Type 2 Diabetes and Beyond–New Insights 2015
Chaplin Semaglutide: a new GLP‐1 analogue for type 2 diabetes
Repas Next-generation GLP-1 therapy: an introduction to liraglutide
Scheen et al. Liraglutide (Victoza): human glucagon-like peptide-1 used in once daily injection for the treatment of type 2 diabetes
US20220267402A1 (en) Long-lasting glp1 analogue drug for type-2 diabetes
Smyth et al. trials tell us?[version 1; peer review: 2 approved]
Chaplin Lixisenatide (Lyxumia): new GLP‐1 mimetic for type 2 diabetes
Bando Latest Topics on Pharmacotherapy for Obesity Including Glucagon Like Peptide-1receptor Agonists (GLP-1RAs)
Green et al. Exenatide and rimonabant: new treatments that may be useful in the management of diabetes and obesity
Samson et al. Managing high blood sugar (hyperglycemia) during pasireotide treatment: A plain language summary of the B2219 study

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment