DK180986A - PROCEDURE FOR THE PREPARATION OF PIRBUTEROL AND ANALOGICAL COMPOUNDS - Google Patents
PROCEDURE FOR THE PREPARATION OF PIRBUTEROL AND ANALOGICAL COMPOUNDS Download PDFInfo
- Publication number
- DK180986A DK180986A DK180986A DK180986A DK180986A DK 180986 A DK180986 A DK 180986A DK 180986 A DK180986 A DK 180986A DK 180986 A DK180986 A DK 180986A DK 180986 A DK180986 A DK 180986A
- Authority
- DK
- Denmark
- Prior art keywords
- pirbuterol
- procedure
- preparation
- analogical
- compounds
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
hvori R* er C^H^Cl·^, og er H eller CH^, eller R* og R^ tilsammen erwherein R * is C ^ H ^ Cl · ^, and is H or CH ^, or R * and R ^ together are
omsættes med N-tert-butyl-benzylamin til dannelse af en amin med formlenis reacted with N-tert-butyl-benzylamine to give an amine of the formula
(X) og denne underkastes hydrogenolyse, eventuelt efter forud-gående solvolyse, hvis R og R tilsammen er(X) and this is subjected to hydrogenolysis, optionally after prior solvolysis if R and R together are
En dannet forbindeIse (1), hvori R er H, kan omdannes til pirbuterol (R = Ct^OH) ved omsætning med h^OH i nærvær af svag base. En dannet forbindelse (I), hvori R er CH^, kan omdannes til pirbuterol ved acetylering til forbindelsenA formed compound (1) wherein R is H may be converted to pirbuterol (R = Ct ^ OH) by reaction with h ^ OH in the presence of weak base. A compound (I) formed wherein R is CH 2 can be converted to pirbuterol by acetylation to the compound
. t C V11) oxidation af denne til N-oxidet med en persyre og opvarmning af N-oxidet i eddikesyreanhydrid til dannelse af forbindelsen. oxidation thereof to the N-oxide with a peracid and heating the N-oxide in acetic anhydride to form the compound
(VII I) og solvolyse af denne. I forhold til de tidligere foretrukne fremgangsmåder går denne via et mindre polært mellemprodukt (X), som lettere isoleres og renses ved standardteknik end det tilsvarende, som mangler benzylgruppen eller aminoalkohol-sidekæden.(VII I) and solar volysis of this. Compared to the previously preferred methods, it passes via a less polar intermediate (X) which is more readily isolated and purified by standard techniques than the corresponding one which lacks the benzyl group or the amino alcohol side chain.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23292381A | 1981-02-09 | 1981-02-09 | |
| DK052182A DK157541C (en) | 1981-02-09 | 1982-02-08 | PROCEDURE FOR THE PREPARATION OF PIRBUTEROL AND ANALOGICAL COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK180986A true DK180986A (en) | 1986-04-21 |
| DK180986D0 DK180986D0 (en) | 1986-04-21 |
Family
ID=26064149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK180986A DK180986D0 (en) | 1981-02-09 | 1986-04-21 | PROCEDURE FOR THE PREPARATION OF PIRBUTEROL AND ANALOGICAL COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK180986D0 (en) |
-
1986
- 1986-04-21 DK DK180986A patent/DK180986D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK180986D0 (en) | 1986-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |