DK180688B1 - Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain - Google Patents

Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain Download PDF

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DK180688B1
DK180688B1 DKPA202000169A DKPA202000169A DK180688B1 DK 180688 B1 DK180688 B1 DK 180688B1 DK PA202000169 A DKPA202000169 A DK PA202000169A DK PA202000169 A DKPA202000169 A DK PA202000169A DK 180688 B1 DK180688 B1 DK 180688B1
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starch
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animals
propanoate
feed
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Sander Wilbek Theis
Abildgaard Ole
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Sander Wilbek Theis
Abildgaard Ole
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

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Abstract

Opfindelsen angår anvendelsen af stivelsespropanoat som fodertilsætningsstof og/eller foderingrediens til landbrugsdyr, havbrugsdyr og fiskeopdræt til at fremme væksten. Stivelsespropanoat fungerer som platform for frigivelse af propansyre i tarmsystemet hvor fermentering af kostfibre tager sted, idet det passerer ufordøjet igennem den del af mavetarmsystemet hvor fermentering ikke foregår inden propansyre frakløves i tarmsystemet hvor fermentering af kostfibre finder sted. Frigivet propansyre i mavetarmsystemet stimulerer tarmvæggen og fremmer udviklingen af mavetarmsystemet blandt andet ved at øge villi-længden og dermed overfladen af tarmen og celle-tætheden af tarmvæggen. Derved vil flere næringsstoffer blive optaget. Hos landbrugsdyr, havbrugsdyr og fiskeopdræt vil et sundere mavetarm-system fremme væksten, øge foderudnyttelsen, nedsætte behovet for antibiotika og medicinsk zink. Stivelsespropanoat kan anvendes til at fremme væksten, øge foderudnyttelsen, forebygge brugen af antibiotika og medicinsk zink hos landbrugsdyr, havbrugsdyr og fiskeopdræt.The invention relates to the use of starch propanoate as a feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth. Starch propanoate acts as a platform for the release of propanoic acid in the intestinal system where fermentation of dietary fiber takes place, passing undigested through the part of the gastrointestinal system where fermentation does not take place before propanoic acid is cleaved in the intestinal system where fermentation of dietary fiber takes place. Released propanoic acid in the gastrointestinal tract stimulates the intestinal wall and promotes the development of the gastrointestinal tract, among other things by increasing the villi length and thus the surface of the intestine and the cell density of the intestinal wall. Thereby, more nutrients will be absorbed. In farm animals, aquaculture animals and fish farming, a healthier gastrointestinal system will promote growth, increase feed utilization, reduce the need for antibiotics and medicinal zinc. Starch propanoate can be used to promote growth, increase feed utilization, prevent the use of antibiotics and medicinal zinc in farm animals, aquaculture animals and fish farming.

Description

DK 180688 B1 1DK 180688 B1 1

BESKRIVELSE Opfindelsen angår anvendelsen af stivelsespropanoat som foderingrediens og/eller fodertilsæt- ningsstof til landbrugsdyr, havbrugsdyr og fiskeopdræt til at fremme væksten. Stivelsespropanoat som foderingrediens og/eller fodertilsætningsstof kan anvendes til at øge udnyttelsen af foder og 5forbedre mavetarm-systemets udvikling hos landbrugsdyr, havbrugsdyr og ved fiskeopdræt. Ved stivelsespropanoat forstås stivelse der er esterificeret med propansyre i varierende grad. Stivelse består af to forskellige polymere, amylose og amylopektin, og kan komme fra forskellige kilder — for eksempel fra kartofler, ris, hvede og majs. Alt efter kilden kan forholdet af amylose og amyl- opektin variere. Amylose er en lineær polymer af glukose sat sammen via a-1,4-glykosidbindinger 10med varierende længde. Amylopektin er ligeledes en polymer af af glukoseenheder forbundet via a-1,4-glykosidbindinger, men har også forgreninger til andre a-1,4-glykosidkæder via a-1,6-glyko- sidbindinger. Graden af forgrening kan variere, men er ofte i størrelsesorden 5%. Propansyre er en af de tre ”short-chain fatty acids’ (SCFA's), der er naturlige energikilder for dyr. 15De tre SCFA'er er eddikesyre, propansyre og butansyre og er kendt for at have sundhedsfremmende effekter i dyr. SCFA'er bliver hovedsageligt dannet via tarmbakteriernes fermentering af kostfibre i tarmsystemet. Der findes forskellige typer af kostfibre og det er ikke alle der kan fermenteres. Ved fermentering af kostfibre frigives SCFA'er, der derved bliver optaget af tarmen og indgår som en naturlig energikilde. SCFA'er aktiverer desuden forskellige receptorer på tarm-cellerne, der blandt 20andet gør at peptid-hormoner, såsom GLP1, GLP2 og PPY, bliver frigivet. Yderligere forbedres den generelle sundhed af tarmen ved frigivelse af SCFA'er, blandt andet ved at mængden af tarmceller herunder endokrine celler og L-celler bliver forøget. Propansyre og butansyre har i højere grad de sundhedsfremmende effekter i tarmen ifht. eddikesy- 25re, da disse er mere potente idet der er flere SCFA-bindende receptorer der passer til propan- og butansyre. Tilsættes eddikesyre, propansyre eller butansyre direkte til kosten, vil de hurtigt blive absorberet i den øvre del af mavetarmkanalen og blive metaboliseret. SCFA'er optaget i den øvre del af mavetarmen-kanalen fremmer ikke tarmudviklingen længere nede i mavetarm-kanalen. Sale- des er den langsommere frigivelse i den nedre mavetarmkanal essentiel. Denne kan opnås ved at 30visse tarmbakterier fermenterer kostfibre, der frigiver SCFA i den nedre tarmkanal herunder speci- elt for pattedyr i kolon og for havbrugsdyr/fisk blot den nedre tarmkanal. Tilstedeværelsen af SCFA'er hos havbrugsdyr/fisk og landbrugsdyr, såsom fisk, fjerkræ, svin, kvæg og får, er essentielt for en hurtig og sund udvikling af deres mavetarm-kanal. SCFA er kan tilsættes fodret direkte, men dette har en reduceret effekt, da det som nævnt optages hurtigt i mavesækken og den øvre tarm- 35kanal. For at opnå en langsom frigivelse samt frigivelse i den nedre tarmkanal fremstilles og for-DESCRIPTION The invention relates to the use of starch propanoate as a feed ingredient and / or feed additive for agricultural animals, aquaculture animals and fish farming to promote growth. Starch propanoate as a feed ingredient and / or feed additive can be used to increase the utilization of feed and improve the development of the gastrointestinal system in farm animals, aquaculture animals and in fish farming. By starch propanoate is meant starch esterified with propanoic acid to varying degrees. Starch consists of two different polymers, amylose and amylopectin, and can come from different sources - for example from potatoes, rice, wheat and corn. Depending on the source, the ratio of amylose to amylopectin may vary. Amylose is a linear polymer of glucose put together via α-1,4-glycoside bonds of varying length. Amylopectin is also a polymer of of glucose units linked via α-1,4-glycoside bonds, but also has branches to other α-1,4-glycoside chains via α-1,6-glycoside bonds. The degree of branching can vary, but is often in the order of 5%. Propanoic acid is one of the three "short-chain fatty acids" (SCFAs), which are natural energy sources for animals. 15The three SCFAs are acetic acid, propanoic acid and butanoic acid and are known to have health-promoting effects in animals. SCFAs are mainly formed through the fermentation of dietary fibers by the intestinal bacteria in the intestinal system. There are different types of dietary fiber and not all of them can be fermented. When fermenting dietary fiber, SCFAs are released, which are thereby absorbed by the intestine and are included as a natural energy source. SCFAs also activate various receptors on the intestinal cells, which among other things cause peptide hormones, such as GLP1, GLP2 and PPY, to be released. Furthermore, the overall health of the intestine is improved by the release of SCFAs, among other things by increasing the amount of intestinal cells including endocrine cells and L cells. Propanoic acid and butanoic acid have to a greater extent the health-promoting effects in the intestine in relation to acetic acid, as these are more potent as there are several SCFA-binding receptors that are suitable for propanoic and butanoic acid. If acetic acid, propanoic acid or butanoic acid are added directly to the diet, they will be quickly absorbed in the upper part of the gastrointestinal tract and be metabolized. SCFAs admitted to the upper part of the gastrointestinal tract do not promote intestinal development further down the gastrointestinal tract. Thus, the slower release in the lower gastrointestinal tract is essential. This can be achieved by certain intestinal bacteria fermenting dietary fibers that release SCFA in the lower intestinal tract, including especially for mammals in the colon and for aquaculture animals / fish only the lower intestinal tract. The presence of SCFAs in aquaculture animals / fish and farm animals, such as fish, poultry, pigs, cattle and sheep, is essential for the rapid and healthy development of their gastrointestinal tract. SCFA can be added to the feed directly, but this has a reduced effect, as it is absorbed quickly in the stomach and the upper intestinal tract. In order to achieve a slow release as well as release in the lower intestinal tract,

DK 180688 B1 2 handles produkter til landbrugsdyr, havbrugsdyr og fiskeopdræt, hvor SCFA'er bliver frigivet lang- somt i mavetarm-kanalen på grund af indkapsulering/coating, inkorporering i triglycider eller som salte. Dette har vist sig at fremme væksten og udnyttelsen af fodret, samt udviklingen af mavetarm- systemet. Frigivelsen af SCFA'er i mavetarm-kanalen hos for eksempel svin har vist sig at fremme Scelledelingen i tarmvæggen og nedsætte apoptosis af disse, hvilket netto gør at villi længden forø- ges og sundheden af mavetarm-kanalen dermed forberedes. Mængden og forholdet mellem dannet eddikesyre, propansyre og butansyre ved fermentering i tyktarmen afhænger af, hvilke bakterier der er tilstede og i hvilket omfang de er tilstede.DK 180688 B1 2 products are traded for agricultural animals, aquaculture animals and fish farming, where SCFAs are released slowly in the gastrointestinal tract due to encapsulation / coating, incorporation into triglycides or as salts. This has been shown to promote the growth and utilization of the feed, as well as the development of the gastrointestinal tract. The release of SCFAs in the gastrointestinal tract of, for example, pigs has been shown to promote cell division in the intestinal wall and decrease their apoptosis, which in turn increases the villi length and thus prepares the health of the gastrointestinal tract. The amount and ratio of acetic acid, propanoic acid and butanoic acid formed by fermentation in the colon depends on which bacteria are present and to what extent they are present.

Stivelsespropanoat vil ved indtagelse ikke nedbrydes i den del af tarmsystemet hvor fermentering af kostfibre ikke finder sted, da stivelsen er esterificeret og dermed opfører sig som resistent sti - velse, Det vil sige at frigivelsen ikke sker i mavesækken og i den øvre tarmkanal. Ved fermentering i den del af tarmsystemet hvor fermentering foregår vil propansyren blive frigivet ved hydrolyse- 15ring af ester-bindingerne og dermed øge niveauet af propansyre i denne del af tarmsystemet. Den de-esterificerede stivelse vil sfterfølgende blive fermenteret og funktionelt virke som en ”nor- mal” fermenterhar kostfiber, der giver næring til de fermenterende bakterier. Mængden af propansyre der frigives forøges ved denne fraspaltning i væsentlig større grad end ved normal fermentering ved normale foderstoffer. Fordi grise, fisk og andre dyr til kød opdræt typisk 20hehandles med medicinsk zink samt antibiotika for at nedsætte risikoen for infektioner og forøge vækst tempoet er mængden af bakterier i tarmkanalen hos dyrene reduceret i omfang og i artsvaria- tion. Dette har formodentligt indflydelse på dyrenes mulighed for at producere propansyre i den nedre tarm som følge af bakteriel fermentering af kostfibre herunder resistente stivelser. 25Ved esterificering af stivelse med propansyre opfører stivelsepropanoat sig som resistent stivelse i mave-tarm kanalen, dvs. ender unedbrudt i tyktarmen hvor det bliver fermenteret, men effekten af stivelsespropanoat er langt højere end ved indtagelse af normalt resistent stivelse. 30g stivelsespro- panoat (med fx 8% propansyre og et vandindhold på under 20%) vil selektivt i tyktarmen øge mængden af propansyre med 2 g og derudover også 20 g stivelse til mulig fermentering. Først spal- 30tes esteren ved tilstedeværelse af tyktarmens enzymer til stivelse og propansyre og herefter bliver stivelsen yderligere fermenteret af bakterierne. Effekten af stivelsespropanoat kan altså ikke sidestilles med resistent stivelse og anvendelsen og ef- fekten beskrevet i krav 1-5 adskiller sig således fra anvendelsen og effekten af resistent stivelse. Vi 35anvender således stivelsespropanoat til levering af propansyre til den del af tarmsystemet hvor fer-Ingestion of starch propanoate will not be broken down in the part of the intestinal system where fermentation of dietary fiber does not take place, as the starch is esterified and thus behaves as resistant starch, ie the release does not occur in the stomach and in the upper intestinal tract. During fermentation in the part of the intestinal system where fermentation takes place, the propanoic acid will be released by hydrolysis of the ester bonds and thus increase the level of propanoic acid in this part of the intestinal system. The de-esterified starch will subsequently be fermented and functionally act as a “normal” fermenter with dietary fiber that nourishes the fermenting bacteria. The amount of propanoic acid released is increased by this cleavage to a significantly greater extent than by normal fermentation by normal feeds. Because pigs, fish and other animals for meat breeding are typically treated with medicinal zinc and antibiotics to reduce the risk of infections and increase the growth rate, the amount of bacteria in the intestinal tract of the animals is reduced in scope and in species variation. This presumably affects the ability of the animals to produce propanoic acid in the lower intestine as a result of bacterial fermentation of dietary fiber including resistant starches. When esterifying starch with propanoic acid, starch propanoate behaves like resistant starch in the gastrointestinal tract, ie. ends up uninterrupted in the colon where it is fermented, but the effect of starch propanoate is far higher than when ingested normally resistant starch. 30g of starch propanoate (with eg 8% propanoic acid and a water content of less than 20%) will selectively increase the amount of propanoic acid in the large intestine by 2 g and in addition also 20 g of starch for possible fermentation. First, the ester is cleaved in the presence of colon enzymes to starch and propanoic acid, and then the starch is further fermented by the bacteria. The effect of starch propanoate can thus not be equated with resistant starch and the use and effect described in claims 1-5 thus differ from the use and effect of resistant starch. We thus use starch propanoate to deliver propanoic acid to the part of the intestinal system where

DK 180688 B1 3 mentering finder sted, til at opnå de effekter, der er beskrevet i krav 1-5. Propansyrens esterbindin - ger spaltes og hermed bliver propansyren frivgivet.DK 180688 B1 3 menting takes place to achieve the effects described in claims 1-5. The ester bonds of the propanoic acid are cleaved and the propanoic acid is released.

Det er dette der hovedsageligt øger mængden af propansyre og gør det muligt at anvende stivelsespropanoat til krav 1-5. Således er hovedformålet med esterificeringen af stivelsen med propansyre ikke at omdanne stivelsen til resistent stivelse og Sopna fermentering af denne, men at opnå frigørelse af propansyre direkte hvor fermentering i tarm - systemet af kostfibre finder sted i større mængder samt uafhængigt af bakteriefloraens sammensæt- ning her.It is this that mainly increases the amount of propanoic acid and makes it possible to use starch propanoate for claims 1-5. Thus, the main purpose of the esterification of the starch with propanoic acid is not to convert the starch to resistant starch and Sopna fermentation thereof, but to achieve the release of propanoic acid directly where fermentation in the intestine - the system of dietary fiber takes place in larger quantities and regardless of the bacterial flora composition here .

Ud over at stivelsespropanoat er en langt mere effektiv metode til at øge mængden af propansyre i 10tarmsystemet ifht. resistent stivelse og kostfibre, så sikrer stivelsespropanoat også en forøgelse af propansyre uafhængigt af tarmflora/bakteriesammensætning.In addition to starch propanoate being a far more effective method of increasing the amount of propanoic acid in the 10 intestinal system in terms of resistant starch and dietary fiber, starch propanoate also ensures an increase in propanoic acid regardless of intestinal flora / bacterial composition.

Det er almindelig kendt at resistent stivelse kan nedsætte brugen af antibiotika hos havbrugsdyr/fisk og landbrugsdyr, men denne kan også nedsætte deres vækst pga. nedsat indtag af 15nedbrydelig stivelse, da den resistente stivelse både optager pladsen i fodret og ikke i samme grad bliver fordøjet og frigiver energi til metabolismen [1]. For at undgå dette er der allerede produkter på markedet der selektivt leverer propansyre til mavetarm-systemet uden at opnå dette ved fermen- tering.It is common knowledge that resistant starch can reduce the use of antibiotics in aquaculture animals / fish and farm animals, but this can also reduce their growth due to reduced intake of degradable starch, as the resistant starch both takes up space in the feed and is not digested to the same degree. and releases energy for metabolism [1]. To avoid this, there are already products on the market that selectively deliver propanoic acid to the gastrointestinal tract without achieving this by fermentation.

Et eksempel på dette er produkter fra Biomin, hvor propansyre er indlejret i inorganic phyllo-silicate, der således fremmer væksten og foderudnyttelsen hos dyr [2]. Dette er dog for- 20holdsvist dyrt og det kan diskuteres i hvor høj grad propansyre bliver frigivet i mavetarmkanalen hvor dette ikke er nødvendigt.An example of this is products from Biomin, where propanoic acid is embedded in inorganic phyllo-silicate, thus promoting the growth and feed utilization in animals [2]. However, this is relatively expensive and it can be discussed to what extent propanoic acid is released in the gastrointestinal tract where this is not necessary.

Stivelsespropanoat ville mere effektivt kunne anvendes til det sam- me formål og produceres langt billigere.Starch propanoate could be used more efficiently for the same purpose and produced much cheaper.

Biomin Biotronic giver en bismag ved tilsætning til fodret, der kan komplicere brugen.Biomin Biotronic gives an off-taste when added to the feed, which can complicate use.

Stivelsespropanoat er neutralt smagende og har ikke dette problem.Starch propanoate is neutral tasting and does not have this problem.

Yderligere har stivelsespropanoat den fordel, at det mere specifikt frigiver propansyre hvor fermen- 25tering foregår, samt at den tilbageværende stivelse kan bruges til fermentering af bakterier og der- med indgå i djæten som en fermenterbar kostfiber hos havbrugsdyr/fisk og landbrugsdyr.Furthermore, starch propanoate has the advantage that it more specifically releases propanoic acid where fermentation takes place, and that the remaining starch can be used for fermentation of bacteria and thus included in the diet as a fermentable dietary fiber in aquaculture animals / fish and farm animals.

Udgangs- materialerne og fremstillingen af stivelsespropanoat er generelt også billigere og mere enkel end andre produkter på markedet til at understøtte udviklingen af mavetarm-systemet hos havbrugsdyr/fisk og landbrugsdyr og nedsætte brugen af antibiotika.The starting materials and the manufacture of starch propanoate are generally also cheaper and simpler than other products on the market to support the development of the gastrointestinal system in aquaculture animals / fish and farm animals and to reduce the use of antibiotics.

Således kan det produceres og 30sælges billigere og derved være mere tilgængeligt og blive brugt i højere grad i landbruget.Thus, it can be produced and sold cheaper and thus be more accessible and used to a greater extent in agriculture.

Dette er både en fordel for dyrene, landmændene og samfundet, da dyrene vil være sundere og vokse hurti- gere.This is an advantage for the animals, farmers and society, as the animals will be healthier and grow faster.

DK 180688 B1 4 Fremdragne publikationerDK 180688 B1 4 Extended publications

1. Regassa A, Nyachoti CM. Application of resistant starch in swine and poultry diets with particular reference to gut health and function. Anim Nutr. 2018;4(3):305—310. doi:10.1016/j.ani- 5nu.2018.04.0011. Regassa A, Nyachoti CM. Application of resistant starch in swine and poultry diets with particular reference to good health and function. Anim Nutr. 2018; 4 (3): 305—310. doi: 10.1016 / j.ani- 5nu.2018.04.001

2. N. Senkoylu, H. Samli, M. Kanter, et al. Influence of a combination of formic and propionic acids added to wheat- and barley-based diets on the performance and gut histomorphology of broiler chickens. Acta Veterinaria Hungarica 2007 55:4, 479-490.2. N. Senkoylu, H. Samli, M. Kanter, et al. Influence of a combination of formic and propionic acids added to wheat- and barley-based diets on the performance and gut histomorphology of broiler chickens. Acta Veterinaria Hungarica 2007 55: 4, 479-490.

Claims (3)

DK 180688 B1 PATENTKRAVDK 180688 B1 PATENTKRAV 1. Anvendelsen af stivelsespropanoat til at fremme væksten og/eller opnåelse af hurtigere vægt- forøgelse som fodertilsætningsstof eller foderingrediens til landbrugsdyr, havbrugsdyr og fiske- opdræt.The use of starch propanoate to promote growth and / or achieve faster weight gain as a feed additive or feed ingredient for farm animals, aquaculture animals and fish farming. 52. Anvendelsen af stivelsespropanoat i følge krav 1, kendetegnet ved at øge udnyttelsen af fodret.The use of starch propanoate according to claim 1, characterized by increasing the utilization of the feed. 3. Anvendelsen af stivelsespropanoat i følge krav 1, kendetegnet ved at fremme udviklingen af mavetarm-systemet.The use of starch propanoate according to claim 1, characterized by promoting the development of the gastrointestinal tract. 4. Anvendelsen af stivelsespropanoat i følge krav 1, hvor den kortkædede fedtsyre esterificeret til stivelsen kan være en hvilken som helst kombination og forhold af de tre SCFA' er: edikkesyre, — propansyre og butansyre.The use of starch propanoate according to claim 1, wherein the short chain fatty acid esterified to the starch may be any combination and ratio of the three SCFAs: acetic acid, propanoic acid and butanoic acid. 5. Anvendelsen af stivelsespropanoat i følge krav 1, kendetegnet ved anvendt til opblanding i mælk til mælkefodrede kalve eller anvendt til opblanding i foder til nyfravænnede smågrise.The use of starch propanoate according to claim 1, characterized by being used for mixing in milk for milk-fed calves or used for mixing in feed for newly weaned piglets. NYHEDSUNDERSØGELSESRAPPORT - PATENT Ansogningsnummer ; PA 2020 00169 i. [OJ ikke-søgbare krav (se boks nr. I).NEWS SURVEY REPORT - PATENT Application number; PA 2020 00169 i. [OJ non-searchable requirements (see box no. I). 2. [J Opfinderisk enhed mangler før nyhedsundersøgelsen (se boks nr. ID).2. J Inventive unit is missing before the news survey (see box no. ID). A. KLASSIFIKATION A23K 10/00 (version 2016.01), A61K 31/19 (version 2006.01), A61K 47/36 ((version 2006.01), A61P 1/12 (version 2006.01) Ifølge International Patent Classification (IPC) B. => UNDERSØGELSESOMRÅDE PCT-minimumsdokumentation undersøgt (klassifikationssystem efterfulgt af klassifikationssymboler) A23K Undersøgt dokumentation ud over PCT-minimum Anvendte elektroniske databaser (navnet på database og evt. søgetermer) EPODOC, WPI, FULDTEKST ENGELSKSPROGEDE PATENTER, XPESP, MEDLINE, BIOSIS C. RELEVANTE DOKUMENTER Citerede dokumenter evt. med angivelse af relevante afsnit Relevant for krav nr.A. CLASSIFICATION A23K 10/00 (version 2016.01), A61K 31/19 (version 2006.01), A61K 47/36 (version 2006.01), A61P 1/12 (version 2006.01) According to the International Patent Classification (IPC) B. => EXAMINATION AREA PCT minimum documentation examined (classification system followed by classification symbols) A23K Examined documentation in addition to PCT minimum Used electronic databases (name of database and possibly search terms) EPODOC, WPI, FULL TEXT ENGELSEPENSPENSPENSEPHELSPE possibly with an indication of relevant sections Relevant for requirement no. X Wi 95/13801 Al (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL 1-10 RESEARCH ORGANISATION) 26. maj 1995 Se [0346], eksempel 5, fig. 6-8, krav 24, 25, 34,41, 44 X Wo 02/62102 A (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH 1-10 ORGANISATION) 10. januar 2002. Se krav 1, 12-13; side 5, linje 27-31, side 11, linje 1-7 XX] Yderligere dokumenter er listet i fortsættelse af Box C.X Wi 95/13801 A1 (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL 1-10 RESEARCH ORGANIZATION) May 26, 1995 See [0346], Example 5, fig. 6-8, claims 24, 25, 34,41, 44 X Wo 02/62102 A (COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH 1-10 ORGANIZATION) January 10, 2002. See claims 1, 12-13; page 5, lines 27-31, page 11, lines 1-7 XX] Additional documents are listed in the continuation of Box C. + Kategori af citerede dokumenter: "pr Dokument, der er publiceret i perioden mellem prioritets- "A" Dokument, der repræsenterer den kendte teknik (teknikkens stade) uden | 98 indleveringsdatoen.+ Category of cited documents: "per Document published in the period between priority" A "Document representing the prior art (state of the art) without | 98 filing date. at foregribe nyhed eller væsentlig adskillelse. T" Dokument, som ikke er i konflikt med ansøgningen, men npn Dokument citeret i ansøgningen. som er citeret for at forstå det grundlæggende princip eller teorien . Ne 0 . bag opfindelsen.to anticipate novelty or significant separation. T "Document which is not in conflict with the application but npn Document cited in the application. Which is cited to understand the basic principle or theory. Ne 0. Behind the invention. "E" Dokument, der har indleverings- eller prioritetsdato, der ligger før on . . indleveringsdatoen for den behandlede ansøgning, men som er X Særlig relevant dokument; opfindelsen har ikke nyhed eller offentliggjort senere end indleveringsdatoen. ad- skiller sig ikke væsentligt fra kendt teknik, når dokumentet "L" Dokument, som kan kaste tvivl over et påstået prioritetskrav, eller som vurderes alene. . Lo citeres for at fastlægge offentliggørelsesdatoen for et andet dokument, eller citeret af | "Y" — Særlig relevant dokument; opfindelsen adskiller sig ikke andre årsager (som specificeret). væsentligt fra kendt teknik, når dokumentet kombineres . Lo . med ét eller flere dokumenter af samme art, og kombinationen af "o" Dokument, der omhandler ikke-skriftlig offentliggørelse, fx fore- drag, | disse er nær- liggende for fagmanden udstillinger eller film. . oo "&" Dokument i samme patentfamilie."E" Document that has a submission or priority date that is before on. . the filing date of the processed application, but which is X Particularly relevant document; the invention is not new or published later than the filing date. does not differ significantly from the prior art when the document "L" Document which may cast doubt on an alleged priority requirement or which is assessed alone. . Lo quoted to determine the date of publication of another document, or quoted by | "Y" - Particularly relevant document; the invention does not differ from other causes (as specified). substantially from prior art when the document is combined. Lo. with one or more documents of the same kind, and the combination of "o" Document dealing with non-written publication, eg lecture, | these are close to the expert exhibitions or films. . oo "&" Document in the same patent family. Patent- og Varemærkestyrelsen Dato for færdiggørelsen af nyhedsundersøgelsen Helgeshøj Allé 81 23. februar 2020 2630 Taastrup Telefon nr. +45 4350 8000 Nyhedsundersøgelsen er udført af Telefon nr. 43 50 83 75 Januar 2019 1The Danish Patent and Trademark Office Date of completion of the news survey Helgeshøj Allé 81 23 February 2020 2630 Taastrup Telephone no. +45 4350 8000 The news survey was carried out by Telephone no. 43 50 83 75 January 2019 1 Ansøgningsnumme NYHEDSUNDERSØGELSESRAPPORT - PATENT r PA 2020 00169 C (Fortsættelse). RELEVANTE DOKUMENTER Citerede dokumenter med angivelse af relevante afsnit Relevant for krav + nr.Application number NEWS SURVEY REPORT - PATENT r PA 2020 00169 C (Continued). RELEVANT DOCUMENTS Cited documents with indication of relevant sections Relevant for requirements + no. A DI FILIPPO S. et al. "Organocatalytic route for the synthesis of propionylated starch”, 1-10 CARBOHYDRATE POLYMERS, 2015, vol. 137, side 198-206. Se abstrakt; side 199, venstre kolonne, 2. afsnit; side 200, Results and discussion, 3.1 I-tartaric acid-catalyzed propionylation of starch Link for one time print: https: //www. renrintsdesk. com/landino/dl.ssøx70=67726548r=23531912 £5 A ANNISON G. et al. "Acetylated, propionylated or butyrylated starches raise large bowel 1-10 short-chain fatty acids preferentially when fed to rats.” THE JOURNAL OF NUTRITION, 2003, vol. 133, nr. 11, Side 3523-3528. De abstrakt. https://www.nchi nim.nih gov/pubmed/tenn= 14608068 A HEDEMANN M.A DI FILIPPO S. et al. "Organocatalytic route for the synthesis of propionylated starch", 1-10 CARBOHYDRATE POLYMERS, 2015, vol. 137, pages 198-206. See abstract; page 199, left column, 2nd paragraph; page 200, Results and discussion, 3.1 I -tartaric acid-catalyzed propionylation of starch Link for one time print: https: // www. renrintsdesk. com / landino / dl.ssøx70 = 67726548r = 23531912 £ 5 A ANNISON G. et al. "Acetylated, propionylated or butyrylated starches raise large bowel 1-10 short-chain fatty acids preferably when fed to rats. ” THE JOURNAL OF NUTRITION, 2003, vol. 133, no. 11, pages 3523-3528. The abstract. https: //www.nchi nim.nih gov / pubmed / tenn = 14608068 A HEDEMANN M. S. et al. ” Resistant starch for weaning pigs - Effect on concentration of 1-10 short chain fatty acids in digesta and intestinal morphology”, LIVESTOCK SCIENCE, 2007, vol. 108, nr. 1-3, side 175-177. Se abstrakt og side 177, venstre kolonne, afsnit lige over ”Discussion” Link for one time print: https: //www. reprintsdesk com/landing/dl.aspx70=677 26568r= 6996601 28 Januar 2019 2S. et al. “Resistant starch for weaning pigs - Effect on concentration of 1-10 short chain fatty acids in digesta and intestinal morphology”, LIVESTOCK SCIENCE, 2007, vol. 108, nos. 1-3, pages 175-177. See abstract and page 177, left column, section just above "Discussion" Link for one time print: https: // www. reprintsdesk com / landing / dl.aspx70 = 677 26568r = 6996601 28 January 2019 2 NYHEDSUNDERSØGELSESRAPPORT - PATENT Ansogningsnummer | PA 2020 00169 Boks nr. I Ikke-søgbare krav Nyhedsundersøgelsen er ikke udført for følgende krav:NEWS SURVEY REPORT - PATENT Application number | PA 2020 00169 Box no. I Non-searchable requirements The news survey has not been conducted for the following requirements: 1. [] Krav nr: fordi de vedrører undtagelsesbestemmelserne og derfor ikke påkræver en nyhedsundersøgelse, specifikt:[] Requirement No: because they relate to the derogations and therefore do not require a novelty, specifically: 2. Krav or. fordi de vedrører dele af patentansøgningen, som ikke lever op til BEK $ 13 i en sådan grad, at en meningsfuld nyhedsundersøgelse ikke kan udføres, spocifikt:Requirements or. because they relate to parts of the patent application that do not live up to BEK $ 13 to such an extent that a meaningful news study cannot be conducted, specifically: 3.0 Krav or. af andre grunde: Boks nr. II Opfinderisk enhed mangler før nyhedsundersøgelsen Der er konstateret flere opfindelser i ansøgningen: Januar 2019 33.0 Requirements or. for other reasons: Box no. II Inventive unit missing before the news survey Several inventions have been identified in the application: January 2019 3 Ansøgningsnummer NYHEDSUNDERSØGELSESRAPPORT - PATENT PA 2020 00169Application number NEWS SURVEY REPORT - PATENT PA 2020 00169 SUPPLERENDE BOKS Fortsættelse af boks nr. [.] Januar 2019 4SUPPLEMENTARY BOX Continuation of box no. [.] January 2019 4
DKPA202000169A 2020-02-11 2020-02-11 Starch propanoate used as feed additive and / or feed ingredient for farm animals, aquaculture animals and fish farming to promote growth and / or achieve faster weight gain DK180688B1 (en)

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PCT/DK2020/050407 WO2021160227A1 (en) 2020-02-11 2020-12-27 Starch propionate to promote growth and/or to obtain a faster weight gain and/or to enhance feed utilization and/or to enhance the development of the gastrointestinal tract used as feed additive or feed ingredient for agricultural animals and aquaculture animals

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