DK1786927T3 - Device and method for detecting charged macromolecules - Google Patents
Device and method for detecting charged macromoleculesInfo
- Publication number
- DK1786927T3 DK1786927T3 DK05774381T DK05774381T DK1786927T3 DK 1786927 T3 DK1786927 T3 DK 1786927T3 DK 05774381 T DK05774381 T DK 05774381T DK 05774381 T DK05774381 T DK 05774381T DK 1786927 T3 DK1786927 T3 DK 1786927T3
- Authority
- DK
- Denmark
- Prior art keywords
- detecting charged
- charged macromolecules
- molecule
- sample
- immobilized
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention relates to a device for detecting charged macromolecules, comprising an ion-sensitive layer, on the surface of which a sample molecule is immobilized in order to detect a target molecule, the sample molecule and target molecules that are to be detected being able to create a specific bond. The inventive device is characterized in that the sample molecules are immobilized at a minimum distance from each other on the ion-sensitive layer such that a redistribution of the zone concentration is induced in the intermolecular interstices during bonding with the target molecule. Also disclosed is a method for detecting charged macromolecules with the aid of the inventive device.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004044299A DE102004044299A1 (en) | 2004-09-10 | 2004-09-10 | Apparatus and method for detecting charged macromolecules |
PCT/DE2005/001423 WO2006026946A1 (en) | 2004-09-10 | 2005-08-12 | Device and method for the detection of charged macromolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1786927T3 true DK1786927T3 (en) | 2009-05-04 |
Family
ID=35311912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05774381T DK1786927T3 (en) | 2004-09-10 | 2005-08-12 | Device and method for detecting charged macromolecules |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1786927B1 (en) |
AT (1) | ATE420211T1 (en) |
DE (2) | DE102004044299A1 (en) |
DK (1) | DK1786927T3 (en) |
ES (1) | ES2321118T3 (en) |
WO (1) | WO2006026946A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100434910C (en) * | 2006-10-24 | 2008-11-19 | 东北电力大学 | Array filmsensor for simultaneously detecting Cu2+, Pb2+, Cd2+ and its preparing method |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
EP2092322B1 (en) | 2006-12-14 | 2016-02-17 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale fet arrays |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
EP2588850B1 (en) | 2010-06-30 | 2016-12-28 | Life Technologies Corporation | Method for dry testing isfet arrays |
US9164070B2 (en) | 2010-06-30 | 2015-10-20 | Life Technologies Corporation | Column adc |
AU2011226767B1 (en) | 2010-06-30 | 2011-11-10 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
TWI527245B (en) | 2010-07-03 | 2016-03-21 | 生命技術公司 | Chemically sensitive sensor with lightly doped drains |
WO2012036679A1 (en) | 2010-09-15 | 2012-03-22 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US9835585B2 (en) | 2013-03-15 | 2017-12-05 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
JP2016510895A (en) | 2013-03-15 | 2016-04-11 | ライフ テクノロジーズ コーポレーション | Chemical sensor with consistent sensor surface area |
EP2972281B1 (en) | 2013-03-15 | 2023-07-26 | Life Technologies Corporation | Chemical device with thin conductive element |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
TWI832669B (en) | 2014-12-18 | 2024-02-11 | 美商生命技術公司 | High data rate integrated circuit with transmitter configuration |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1302223A (en) * | 1998-04-06 | 2001-07-04 | 马丁·J·帕特科 | Organic ion-selective membranes |
TWI247113B (en) * | 2002-08-21 | 2006-01-11 | Univ Chung Yuan Christian | A method and fabrication of the potentiometric chemical sensor and biosensor on an uninsulated solid material |
-
2004
- 2004-09-10 DE DE102004044299A patent/DE102004044299A1/en not_active Withdrawn
-
2005
- 2005-08-12 ES ES05774381T patent/ES2321118T3/en active Active
- 2005-08-12 WO PCT/DE2005/001423 patent/WO2006026946A1/en active Application Filing
- 2005-08-12 DE DE502005006434T patent/DE502005006434D1/en active Active
- 2005-08-12 AT AT05774381T patent/ATE420211T1/en active
- 2005-08-12 DK DK05774381T patent/DK1786927T3/en active
- 2005-08-12 EP EP05774381A patent/EP1786927B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
DE102004044299A1 (en) | 2006-03-30 |
DE502005006434D1 (en) | 2009-02-26 |
ES2321118T3 (en) | 2009-06-02 |
EP1786927B1 (en) | 2009-01-07 |
WO2006026946A1 (en) | 2006-03-16 |
ATE420211T1 (en) | 2009-01-15 |
EP1786927A1 (en) | 2007-05-23 |
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