DK156592A - HUMAN-H1-PREEPRORELAXIN, -PRORELAXIN AND -RELAXIN, AND POLYPEPTIDE WITH RELAXIN ACTIVITY AND PROCEDURE FOR COMPOUNDING THE A AND B CHAINS IN HUMAN-H1-RELAXIN - Google Patents

HUMAN-H1-PREEPRORELAXIN, -PRORELAXIN AND -RELAXIN, AND POLYPEPTIDE WITH RELAXIN ACTIVITY AND PROCEDURE FOR COMPOUNDING THE A AND B CHAINS IN HUMAN-H1-RELAXIN Download PDF

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Publication number
DK156592A
DK156592A DK156592A DK156592A DK156592A DK 156592 A DK156592 A DK 156592A DK 156592 A DK156592 A DK 156592A DK 156592 A DK156592 A DK 156592A DK 156592 A DK156592 A DK 156592A
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DK
Denmark
Prior art keywords
relaxin
human
chains
preeprorelaxin
prorelaxin
Prior art date
Application number
DK156592A
Other languages
Danish (da)
Other versions
DK171683B1 (en
DK156592D0 (en
Inventor
Peter John Hudson
John Shine
Hugh David Niall
Geoffrey William Tregear
Original Assignee
Florey Howard Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Florey Howard Inst filed Critical Florey Howard Inst
Publication of DK156592A publication Critical patent/DK156592A/en
Publication of DK156592D0 publication Critical patent/DK156592D0/en
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Publication of DK171683B1 publication Critical patent/DK171683B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Abstract

Human relaxin analogues which consist of shortened and/or modified forms of the natural A and/or B peptide chains. Methods for synthesis of the peptides involving recombinant DNA techniques.
DK156592A 1982-08-12 1992-12-28 Analogous Process for Preparation of Human H1 Relaxin Analog DK171683B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPF535282 1982-08-12
AUPF535282 1982-08-12

Publications (3)

Publication Number Publication Date
DK156592A true DK156592A (en) 1992-12-28
DK156592D0 DK156592D0 (en) 1992-12-28
DK171683B1 DK171683B1 (en) 1997-03-10

Family

ID=3769689

Family Applications (2)

Application Number Title Priority Date Filing Date
DK366483A DK171827B1 (en) 1982-08-12 1983-08-11 Double stranded DNA fragment encoding human H1 preprorelaxin, human H1 prorelaxin or A and B chains of human H1 relaxin, and DNA transfer vector containing a cDNA deoxynucleotide sequence corresponding to such DNA fragment, cell transformed with such a DNA transfer vector, and method for producing human H1-prorelaxin or -H1-relaxin by growing such a cell
DK156592A DK171683B1 (en) 1982-08-12 1992-12-28 Analogous Process for Preparation of Human H1 Relaxin Analog

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK366483A DK171827B1 (en) 1982-08-12 1983-08-11 Double stranded DNA fragment encoding human H1 preprorelaxin, human H1 prorelaxin or A and B chains of human H1 relaxin, and DNA transfer vector containing a cDNA deoxynucleotide sequence corresponding to such DNA fragment, cell transformed with such a DNA transfer vector, and method for producing human H1-prorelaxin or -H1-relaxin by growing such a cell

Country Status (14)

Country Link
US (1) US4871670A (en)
EP (2) EP0101309B1 (en)
JP (3) JP2537477B2 (en)
KR (1) KR930003515B1 (en)
AT (1) ATE78042T1 (en)
CA (1) CA1340542C (en)
DE (1) DE3382117D1 (en)
DK (2) DK171827B1 (en)
ES (5) ES524885A0 (en)
HU (1) HU197350B (en)
IE (1) IE58682B1 (en)
IL (1) IL69469A (en)
NZ (1) NZ205241A (en)
ZA (1) ZA835963B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320953A (en) * 1982-08-12 1994-06-14 Howard Florey Institute Of Experimental Physiology And Medicine Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
ATE88352T1 (en) * 1988-02-26 1993-05-15 Genentech Inc HUMAN RELAXIN PREPARATIVE.
AU623518B2 (en) * 1989-05-04 1992-05-14 Genentech Inc. Processes and compositions for the isolation of human relaxin
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
JP3954091B2 (en) * 1993-06-21 2007-08-08 ジェネンテック・インコーポレーテッド Method for producing relaxin
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
WO2002085308A2 (en) * 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
US20030088884A1 (en) * 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
JP4836942B2 (en) * 2004-04-30 2011-12-14 コーセラ， インコーポレイテッド Methods and compositions for the control of fetal development by modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8389475B2 (en) 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
HUE045845T2 (en) 2010-08-17 2021-12-28 Ambrx Inc Modified relaxin polypeptides and their uses
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
EP3068891A1 (en) 2013-11-13 2016-09-21 Aequus Biopharma Inc. Engineered glycoproteins and uses thereof
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
CA3024500A1 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding relaxin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

Also Published As

Publication number Publication date
JPH07215998A (en) 1995-08-15
IE58682B1 (en) 1993-11-03
EP0101309B1 (en) 1991-01-16
KR840005739A (en) 1984-11-16
JPS5985292A (en) 1984-05-17
CA1340542C (en) 1999-05-18
ES8802160A1 (en) 1988-04-01
ZA835963B (en) 1984-04-25
ES8801671A1 (en) 1988-02-16
EP0101309A3 (en) 1984-12-27
EP0287820B1 (en) 1992-07-08
JP2892596B2 (en) 1999-05-17
DK171683B1 (en) 1997-03-10
JP2670001B2 (en) 1997-10-29
DK366483A (en) 1984-02-13
ES557506A0 (en) 1988-02-16
ES8802394A1 (en) 1988-05-16
IE831909L (en) 1984-02-12
DK171827B1 (en) 1997-06-23
ES550943A0 (en) 1988-05-16
DK156592D0 (en) 1992-12-28
ES8603579A1 (en) 1985-12-16
EP0101309A2 (en) 1984-02-22
ES540886A0 (en) 1988-04-01
DE3382117D1 (en) 1991-02-21
NZ205241A (en) 1991-01-29
KR930003515B1 (en) 1993-05-01
HU197350B (en) 1989-03-28
JP2537477B2 (en) 1996-09-25
IL69469A0 (en) 1983-11-30
ES8801676A1 (en) 1988-02-16
DK366483D0 (en) 1983-08-11
JPH0690780A (en) 1994-04-05
ES557505A0 (en) 1988-02-16
US4871670A (en) 1989-10-03
ES524885A0 (en) 1985-12-16
ATE78042T1 (en) 1992-07-15
EP0287820A1 (en) 1988-10-26
IL69469A (en) 1991-06-10

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