DK156373B - PACKAGE INCLUDING TWO CONTAINERS FOR DENTAL AND ORAL CARE - Google Patents

Description

DK 156373 B

The present invention relates to a package comprising two containers for use in dental and oral care, which provides highly desirable and unique effects, especially by containing materials having calcium and phosphate components or 5 molecular moieties.

Salts of calcium phosphates such as dicalcium orthophosphate dihydrate (DCPD), anhydrous dicalcium orthophosphate (ADCP) and calcium pyrophosphate have long been used in dentifrices such as toothpastes because of the polishing and abrasive effect they provide. Other materials containing calcium and phosphate such as fluorapatite have been described to prevent caries. In particular, the article "Prevention of Dental Caries by Brushing the Teeth with Powders Containing Fluoroapatite", describes McClendon and Foster, Journal of Dental Research, Volume 26, No. 3, July 1947, pages 233-238, The Use of an Impure Fluorapatite, Powdered crude phosphate (71.4% fluorapatite) or a synthetic fluoropatite to reduce caries in vivo. The synthetic fluorapatite can be liberated by dissolution technique with dropwise addition of lime water, orthophosphoric acid and sodium fluoride to distilled water or by adding alcohol and glycerine plus methol or thymal to hydroxyapatite and then adding sodium fluoride. Another article "Orthophosphates Part II.

The Transformations Brushite Fluoroapatite and Monelite 25 Fluoroapatite in Aqueous Potassium Fluoride Solution ", Duff,

Journal of the Chemical Society, Section A, 1971, pages 33-38, describes the chemical conversion of secondary calcium ortho phosphates into a potassium-containing fluorapatite.

33 Hydroxyapatite, a calcium and phosphate-containing material, has been used to promote the remineralization of tooth enamel, as described in U.S. Patent No. 3,679,360.

This patent discloses that dicalcium orthophosphate dihydrate is applied to a damaged tooth in a gel containing orthophosphate ions and a calcium salt such as calcium nitrate and hydroxyapatite crystals are formed over a period of time.

DK 156373 B

2

From French Patent No. 1,434,455, such a mixture of calcium, phosphate and fluoride ions is known to form a supersaturated solution of an apatite analogue. The mixture should be applied to teeth, e.g. in the form of chewing gum, and is said to harden the enamel. No pH conditions have been described and the concentration of the components is not defined.

Ans. No. 5547/73 discloses a two-stage method for applying to teeth of two solutions, one containing cations, e.g. of calcium, and the other containing water-soluble anions, e.g. fluorides, phosphates, etc. The cation-containing solution cannot contain phosphate ions as this would cause the precipitation of a calcium phosphate.

The package according to the present invention is intended for a two-stage dental treatment as is the method according to Ans. No. 5547/73, but unlike the method of using the mixture according to French Patent No. 1,434,455. The package according to the invention is characterized in that it comprises a first container containing an aqueous solution of phosphoric acid containing up to 2% by weight of a water-soluble fluoride, which is not hydrolyzed by phosphoric acid, which solution has a pH value. of 3-4, and another container which is distinguishable from the first container and containing an aqueous solution of a water-soluble calcium salt and a water-soluble monovalent phosphate salt, the solution having a pH of about 7th

It is an advantage of the package of the invention that it contains calcium and phosphate components or molecular parts which produce undesirable effects in the oral cavity such as controlled polishing or grinding, prophylactic benefits such as remineralization, reduction of caries incidence or extent of caries or reduction of bleeding from the gums, as well as 35 cosmetic benefits such as enhanced white appearance of the teeth.

Use of the package according to the invention consists in the fact that:

DK 156373B

3, the contents of the first container which is a source of fluoride ions and a weakly acidified phosphate solution comprising an aqueous solution of orthophosphoric acid having a pH of 3 to 4 are applied to the teeth, and the contents of the second are applied to the teeth. container which is an aqueous neutralizing solution containing calcium ions and osteophosphate ions.

The teeth are thus subjected to fluctuating pH in the presence of fluoride, orthophosphate and calcium ions, which, as has been shown, not only serves to prevent loss of calcium and orthophosphate ions from the apatite crystal structure of the tooth enamel, but also facilitates the growth and development of apatite crystals, so that there may be some remineralization of the cavities and gaps in the tooth enamel. Laboratory studies have also shown that optimum incorporation of fluoride ions into the apatite crystal structure occurs when the pH is rising from approx. 4 to approx. 7th

Many variants of the contents of the first container are possible.

Thus, many different water-soluble fluorides can be used as a source of fluoride ions. Sodium fluoride is an example. Such salts can be dissolved in the orthophosphoric acid solution.

A preferred container solution comprises a dilute aqueous solution of orthophosphoric acid in which up to 2% by weight of sodium fluoride is dissolved, and which solution has a pH of approx. 4th

3 ° Preferably, the second or neutralizing solution is obtained from synthetic brushite preparation (CaH 1 PO 2, 2 50). Synthetic brushite is prepared by slowly mixing a water-soluble calcium salt and a water-soluble monovalent phosphate salt in aqueous solution at a pH in the range of 35 to 4-5 using a small stoichiometric excess of the phosphate. The solution is preferably saturated with calcium and the divalent phosphate ions, but this is not essential.

DK 156373B

4

The invention is illustrated by the following example.

Example 5 A first solution was prepared by dissolving 1 wt.% Sodium fluoride in a 10 aqueous solution of orthophosphoric acid having a pH of approx. Third

Another solution was prepared by mixing equal volumes of 10-½ aqueous calcium nitrate solution, 10 aqueous -2 sodium hydrogen orthophosphate solution, and 10 M aqueous sodium dihydrogen orthophosphate solution with the pH adjusted to ca. 5. After standing, the supernatant was separated from the solid residue of synthetic brushite, and its pH 15 was adjusted to 7 by the addition of sodium hydroxide.

The first solution is applied topically to teeth and left for approx. 5 minutes. The second fluid is then applied topically to the teeth and left for approx. 5 minutes.

20

Loss of calcium and orthophosphate from teeth subjected to this process is reduced and the deposition of fluorapatite on the treated surfaces is encouraged. Remineralization of early caries lesions is promoted and apatitic material is deposited in 25 cavities and slits in the enamel.

Each of the solutions can be applied from special containers in a single device.

Sodium monofluorophosphate can replace sodium fluoride. However, it must be kept separate from orthophosphoric acid solution until the time of use, before it can be premixed immediately before use or applied to the teeth in rapid succession after the orthophosphoric acid solution. Alternatively, either sodium fluoride or sodium monofluorophosphate may be present in the second solution.

Claims (1)

DK 156373 B Patent claims. Package comprising two containers for use in dental and oral care, characterized in that it comprises a first container containing an aqueous solution of phosphoric acid in which up to 2% by weight of a water-soluble fluoride which is not hydrolyzed by phosphoric acid is dissolved. , which solution has a pH of 3-4, and another container which is distinguishable from the first container and containing an aqueous solution of a water-soluble calcium salt and a water-soluble monovalent phosphate salt, which solution has a pH of about . 7. 15 20 25 30 35