DK1558640T3 - Trimer-binding proteins for trimer cytokines - Google Patents

Trimer-binding proteins for trimer cytokines

Info

Publication number
DK1558640T3
DK1558640T3 DK03769251.4T DK03769251T DK1558640T3 DK 1558640 T3 DK1558640 T3 DK 1558640T3 DK 03769251 T DK03769251 T DK 03769251T DK 1558640 T3 DK1558640 T3 DK 1558640T3
Authority
DK
Denmark
Prior art keywords
trimer
cytokines
binding proteins
proteins
binding
Prior art date
Application number
DK03769251.4T
Other languages
Danish (da)
Inventor
Thor Las Holtet
Mikkel Holmen Andersen
Helle Krogh Ottow
Original Assignee
Anaphore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaphore Inc filed Critical Anaphore Inc
Priority claimed from PCT/DK2003/000735 external-priority patent/WO2004039841A2/en
Application granted granted Critical
Publication of DK1558640T3 publication Critical patent/DK1558640T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
DK03769251.4T 2002-10-29 2003-10-29 Trimer-binding proteins for trimer cytokines DK1558640T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42180702P 2002-10-29 2002-10-29
DKPA200201634 2002-10-29
PCT/DK2003/000735 WO2004039841A2 (en) 2002-10-29 2003-10-29 Trimeric binding proteins for trimeric cytokines

Publications (1)

Publication Number Publication Date
DK1558640T3 true DK1558640T3 (en) 2011-07-25

Family

ID=35931707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03769251.4T DK1558640T3 (en) 2002-10-29 2003-10-29 Trimer-binding proteins for trimer cytokines

Country Status (6)

Country Link
JP (1) JP4690044B2 (en)
CN (1) CN1720263A (en)
AT (1) ATE505484T1 (en)
DE (1) DE60336746D1 (en)
DK (1) DK1558640T3 (en)
ES (1) ES2367749T3 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2297198B1 (en) * 2008-06-30 2014-12-17 University Of Pennsylvania Fn14/trail fusion proteins
TWI476001B (en) * 2011-12-26 2015-03-11 Ind Tech Res Inst Trimeric fc fusion and uses thereof
CN103172748B (en) * 2013-01-29 2014-11-05 中国人民解放军第三军医大学 Anti-malignant lymphoma fusion protein and preparation method thereof
EP3243836A1 (en) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules
AU2019206573A1 (en) * 2018-01-10 2020-07-16 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor
WO2022089426A1 (en) * 2020-10-27 2022-05-05 细胞图谱有限公司 Method for analyzing peripheral blood sample and kit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010308A1 (en) * 1992-10-23 1994-05-11 Immunex Corporation Methods of preparing soluble, oligomeric proteins
PT1012280E (en) * 1997-06-11 2005-02-28 Borean Pharma As TRIMMING MODULE
US10183986B2 (en) * 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies

Also Published As

Publication number Publication date
JP4690044B2 (en) 2011-06-01
ES2367749T3 (en) 2011-11-08
CN1720263A (en) 2006-01-11
ATE505484T1 (en) 2011-04-15
DE60336746D1 (en) 2011-05-26
JP2006520318A (en) 2006-09-07

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