DK154537C - QUICK-DISINTEGRATING COMPRESSED PHARMACEUTICAL PREPARATIONS - Google Patents

QUICK-DISINTEGRATING COMPRESSED PHARMACEUTICAL PREPARATIONS

Info

Publication number
DK154537C
DK154537C DK499181A DK499181A DK154537C DK 154537 C DK154537 C DK 154537C DK 499181 A DK499181 A DK 499181A DK 499181 A DK499181 A DK 499181A DK 154537 C DK154537 C DK 154537C
Authority
DK
Denmark
Prior art keywords
quick
disintegrating
pharmaceutical active
pharmaceutical preparations
compressed pharmaceutical
Prior art date
Application number
DK499181A
Other languages
Danish (da)
Other versions
DK499181A (en
DK154537B (en
Inventor
Helmut Kopf
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK499181A publication Critical patent/DK499181A/en
Publication of DK154537B publication Critical patent/DK154537B/en
Application granted granted Critical
Publication of DK154537C publication Critical patent/DK154537C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

Quick-disintegrating pressed shapes e.g. tablets containing pharmaceutical active substances, which shapes consist essentially of a compressed mixture of a) a pharmaceutical active substance in a granular delayed-release form, and b) a disintegrating agent having a high disintegrating capacity as well as good binding properties. The pharmaceutical active substance is coated with a mixture of ethyl cellulose and a polyacrylate to provide the delayed-release form.
DK499181A 1980-11-12 1981-11-11 QUICK-DISINTEGRATING COMPRESSED PHARMACEUTICAL PREPARATIONS DK154537C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH839380 1980-11-12
CH839380 1980-11-12

Publications (3)

Publication Number Publication Date
DK499181A DK499181A (en) 1982-05-13
DK154537B DK154537B (en) 1988-11-28
DK154537C true DK154537C (en) 1989-04-17

Family

ID=4339640

Family Applications (1)

Application Number Title Priority Date Filing Date
DK499181A DK154537C (en) 1980-11-12 1981-11-11 QUICK-DISINTEGRATING COMPRESSED PHARMACEUTICAL PREPARATIONS

Country Status (20)

Country Link
EP (1) EP0052076B1 (en)
JP (1) JPS57109715A (en)
AT (1) ATE13486T1 (en)
AU (1) AU552861B2 (en)
CA (1) CA1178202A (en)
CY (1) CY1429A (en)
DE (1) DE3170764D1 (en)
DK (1) DK154537C (en)
ES (1) ES8303090A1 (en)
FI (1) FI76254C (en)
GB (1) GB2086725B (en)
GR (1) GR76337B (en)
HK (1) HK53388A (en)
IE (1) IE51827B1 (en)
IL (1) IL64255A0 (en)
MY (1) MY8700132A (en)
NO (1) NO157964C (en)
NZ (1) NZ198937A (en)
PT (1) PT73963B (en)
ZA (1) ZA817795B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3314003A1 (en) * 1983-04-18 1984-10-18 Boehringer Ingelheim KG, 6507 Ingelheim DIVISIBLE TABLET WITH DELAYED ACTIVE SUBSTANCE RELEASE AND METHOD FOR THE PRODUCTION THEREOF
CH658188A5 (en) * 1984-03-23 1986-10-31 Ciba Geigy Ag STORAGE STABLE QUICK DISASSEMBLING PHARMACEUTICAL PRESSELS.
JPS6144811A (en) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd Sustained release diclofenac sodium pharmaceutical
ES8801121A1 (en) * 1985-02-19 1988-01-01 Key Pharma Controlled release potassium chloride.
JPS61210025A (en) * 1985-03-14 1986-09-18 Teisan Seiyaku Kk Stabilized antibioitc complex granule preparation
WO1987001936A1 (en) * 1985-09-25 1987-04-09 Gerhard Gergely Desintegration tablet and process for its manufacture
AU7084587A (en) * 1986-04-01 1987-10-20 Upjohn Company, The Methylprednisolone/sodium carboxymethyl starch tablet composition
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
GB8702411D0 (en) * 1987-02-03 1987-03-11 Zyma Sa Swellable pellets
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
CH675537A5 (en) * 1988-03-25 1990-10-15 Ciba Geigy Ag
JPH0273011A (en) * 1988-07-28 1990-03-13 Warner Lambert Co Aqueous polymer dispersion of cellulose and acrylic polymer for preparing drug administration form
JP2514078B2 (en) * 1988-08-22 1996-07-10 エスエス製薬株式会社 Compressed formulation
SK282071B6 (en) * 1991-01-30 2001-10-08 The Wellcome Foundation Limited Water-dispersible tablet and its preparation method
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US6245351B1 (en) 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
FR2766089B1 (en) * 1997-07-21 2000-06-02 Prographarm Lab IMPROVED MULTIPARTICULAR TABLET WITH RAPID DELIVERY
KR100882156B1 (en) * 2003-08-08 2009-02-06 아지노모토 가부시키가이샤 Pharmaceutical preparation containing nateglinide
JP5122380B2 (en) * 2008-06-16 2013-01-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 Quick-disintegrating tablet with controlled drug release and process for producing the same
EP2253306A1 (en) * 2009-05-18 2010-11-24 Royal College of Surgeons in Ireland Orodispersible dosage forms containing solid drug dispersions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336218C3 (en) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral dosage form
GB1560475A (en) * 1975-10-11 1980-02-06 Lilly Industries Ltd Pharmaceutical formulation
US4143129A (en) * 1975-10-11 1979-03-06 Lilly Industries Limited Cephalexin tablets
US4140756A (en) * 1976-06-10 1979-02-20 Mead Johnson & Company Film-coated matrix core tablet

Also Published As

Publication number Publication date
HK53388A (en) 1988-07-22
FI76254B (en) 1988-06-30
JPS57109715A (en) 1982-07-08
IL64255A0 (en) 1982-02-28
FI76254C (en) 1988-10-10
DE3170764D1 (en) 1985-07-04
IE812643L (en) 1982-05-12
NO157964B (en) 1988-03-14
PT73963A (en) 1981-12-01
AU552861B2 (en) 1986-06-26
GB2086725A (en) 1982-05-19
CY1429A (en) 1988-09-02
ES506981A0 (en) 1983-02-01
NZ198937A (en) 1985-04-30
PT73963B (en) 1983-11-23
EP0052076B1 (en) 1985-05-29
FI813532L (en) 1982-05-13
ZA817795B (en) 1982-10-27
NO813826L (en) 1982-05-13
ATE13486T1 (en) 1985-06-15
DK499181A (en) 1982-05-13
GB2086725B (en) 1985-08-21
NO157964C (en) 1988-06-29
IE51827B1 (en) 1987-04-01
ES8303090A1 (en) 1983-02-01
AU7738281A (en) 1982-05-20
GR76337B (en) 1984-08-04
MY8700132A (en) 1987-12-31
EP0052076A1 (en) 1982-05-19
DK154537B (en) 1988-11-28
JPH0228564B2 (en) 1990-06-25
CA1178202A (en) 1984-11-20

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Legal Events

Date Code Title Description
PBP Patent lapsed