DK154022C - PROCEDURE FOR PREPARING BENZOTHIAZEPINE DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING BENZOTHIAZEPINE DERIVATIVES

Info

Publication number
DK154022C
DK154022C DK540382A DK540382A DK154022C DK 154022 C DK154022 C DK 154022C DK 540382 A DK540382 A DK 540382A DK 540382 A DK540382 A DK 540382A DK 154022 C DK154022 C DK 154022C
Authority
DK
Denmark
Prior art keywords
procedure
acetone
benzothiazepine derivatives
preparing
mixture
Prior art date
Application number
DK540382A
Other languages
Danish (da)
Other versions
DK154022B (en
DK540382A (en
Inventor
Mitsunori Gaino
Ikuo Iijima
Shigeru Nishimoto
Kuichiro Ikeda
Tokuo Fujii
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16373149&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK154022(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of DK540382A publication Critical patent/DK540382A/en
Publication of DK154022B publication Critical patent/DK154022B/en
Application granted granted Critical
Publication of DK154022C publication Critical patent/DK154022C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A benzothiazepine derivative of the formula: <IMAGE> (I) wherein R is hydrogen or acetyl, is prepared by condensing a compound of the formula: <IMAGE> (II) wherein R is the same as defined above, with 2-(diamethylamino)ethyl halide (i) in the presence of potassium hydroxide in acetone; or (ii) in the presence of potassium carbonate in acetone, lower alkyl acetate, a mixture of acetone and water or a mixture of lower alkyl acetate and water.
DK540382A 1981-12-07 1982-12-06 PROCEDURE FOR PREPARING BENZOTHIAZEPINE DERIVATIVES DK154022C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56197358A JPS5899471A (en) 1981-12-07 1981-12-07 Novel preparation of benzothiazepin derivative
JP19735881 1981-12-07

Publications (3)

Publication Number Publication Date
DK540382A DK540382A (en) 1983-06-08
DK154022B DK154022B (en) 1988-10-03
DK154022C true DK154022C (en) 1989-02-20

Family

ID=16373149

Family Applications (1)

Application Number Title Priority Date Filing Date
DK540382A DK154022C (en) 1981-12-07 1982-12-06 PROCEDURE FOR PREPARING BENZOTHIAZEPINE DERIVATIVES

Country Status (15)

Country Link
US (1) US4438035B1 (en)
EP (1) EP0081234B1 (en)
JP (1) JPS5899471A (en)
KR (1) KR860002034B1 (en)
AT (1) ATE15799T1 (en)
BG (1) BG38937A3 (en)
CA (1) CA1177075A (en)
DE (1) DE3266583D1 (en)
DK (1) DK154022C (en)
ES (1) ES8401953A1 (en)
FI (1) FI79705C (en)
HK (1) HK95488A (en)
HU (1) HU187431B (en)
IE (1) IE54241B1 (en)
SU (1) SU1176839A3 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
IT1206505B (en) * 1983-07-22 1989-04-27 Schiapparelli Farma NEW BENZOTHIAZEPINONIC DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
GB2154577A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co 1,5-benzothiazepines
IL71538A (en) * 1984-04-13 1987-07-31 Abic Ltd Process for the preparation of benzothiazepine derivatives
US4758954A (en) * 1984-07-25 1988-07-19 Computer Services Corporation Method of adjusting ticket fares
US4652561A (en) * 1986-02-26 1987-03-24 Hoffmann-La Roche Inc. Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) * 1986-03-24 1987-10-20 Hoffmann La Roche Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
US4808580A (en) * 1987-12-17 1989-02-28 Hoffmann-La Roche Inc. Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
IT1226301B (en) * 1988-07-26 1990-12-27 Zambon Spa PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DILTIAZEM.
USRE34935E (en) * 1989-01-11 1995-05-09 Synthelabo Method for preparing (+)-(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5H-1,5-benzothiazepine-4-one and chlorinated derivatives thereof
FR2641535B1 (en) * 1989-01-11 1991-03-15 Synthelabo PROCESS FOR THE PREPARATION OF (+) - (2S, 3S) -HYDROXY-3 (METHOXY-4 PHENYL) -2 DIHYDRO-2,3 5H-BENZOTHIAZEPINE-1,5 ONE-4
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
JPH085869B2 (en) * 1990-03-08 1996-01-24 田辺製薬株式会社 Process for producing 1,5-benzothiazepine derivative
NL9000763A (en) * 1990-03-31 1991-10-16 Stamicarbon PROCESS FOR PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES.
IT1255545B (en) * 1992-10-23 1995-11-09 PROCEDURE FOR THE PREPARATION OF DILTIAZEM
DE69411387T2 (en) * 1994-09-16 1999-02-25 Orion Corp. FERMION, Espoo Process for the preparation of pharmaceutically active benzothiazepine derivatives.
FI97725C (en) * 1995-02-17 1997-02-10 Orion Yhtymae Oy Method for preparing diltiazem
WO1996038429A1 (en) * 1995-06-01 1996-12-05 Acic (Canada) Inc. Method for the manufacture of benzothiazepine derivatives
US5559229A (en) * 1995-06-01 1996-09-24 Acic (Canada) Inc. Method for the manufacture of benzothiazepine
AU709280B2 (en) * 1996-02-23 1999-08-26 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
IL123352A0 (en) 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture
US11241379B2 (en) 2015-12-01 2022-02-08 Sun Pharmaceutical Industries Limited Parenteral dosage form of diltiazem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS57106673A (en) * 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative

Also Published As

Publication number Publication date
FI824165A0 (en) 1982-12-03
DE3266583D1 (en) 1985-10-31
ES517966A0 (en) 1984-01-01
KR860002034B1 (en) 1986-11-17
FI824165L (en) 1983-06-08
FI79705C (en) 1990-02-12
ES8401953A1 (en) 1984-01-01
US4438035B1 (en) 1994-07-26
HK95488A (en) 1988-12-02
HU187431B (en) 1986-01-28
KR840002819A (en) 1984-07-21
JPS6317832B2 (en) 1988-04-15
BG38937A3 (en) 1986-03-14
EP0081234B1 (en) 1985-09-25
SU1176839A3 (en) 1985-08-30
DK154022B (en) 1988-10-03
IE822836L (en) 1983-06-07
ATE15799T1 (en) 1985-10-15
FI79705B (en) 1989-10-31
EP0081234A1 (en) 1983-06-15
CA1177075A (en) 1984-10-30
US4438035A (en) 1984-03-20
JPS5899471A (en) 1983-06-13
IE54241B1 (en) 1989-08-02
DK540382A (en) 1983-06-08

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