DK1530471T3 - Medicines for inhalation containing a new anticholinergic in combination with corticosteroids and beta-mimetics - Google Patents

Medicines for inhalation containing a new anticholinergic in combination with corticosteroids and beta-mimetics

Info

Publication number
DK1530471T3
DK1530471T3 DK03793643T DK03793643T DK1530471T3 DK 1530471 T3 DK1530471 T3 DK 1530471T3 DK 03793643 T DK03793643 T DK 03793643T DK 03793643 T DK03793643 T DK 03793643T DK 1530471 T3 DK1530471 T3 DK 1530471T3
Authority
DK
Denmark
Prior art keywords
beta
combination
anticholinergic
mimetics
corticosteroids
Prior art date
Application number
DK03793643T
Other languages
Danish (da)
Inventor
Michael Paul Pieper
Michel Pairet
Christopher John Montagu Meade
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1530471T3 publication Critical patent/DK1530471T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

An inhalable medicament (A) comprises a combination of 6beta ,7beta -epoxy-3beta -hydroxy-8-methyl-1alpha H,5alpha -H-tropanium salt 2,2-diphenylpropionate ester anticholinergic agent(s) (I) and EFGR kinase inhibitor(s) (II), optionally together with auxiliaries. An inhalable medicament (A) comprises a combination of tropane derivative anticholinergic agent(s) of formula (I), corticosteroid(s) (II) and beta -mimetic agent(s) (III) (optionally in the form of enantiomers, enantiomer mixtures or racemates, or solvates or hydrates), optionally together with pharmaceutical auxiliaries. [Image] X ->monovalent anion, preferably chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulfonate. ACTIVITY : Antiinflammatory; antiasthmatic; antiallergic. MECHANISM OF ACTION : Anticholinergic; beta -mimetic.
DK03793643T 2002-08-17 2003-07-25 Medicines for inhalation containing a new anticholinergic in combination with corticosteroids and beta-mimetics DK1530471T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10237739A DE10237739A1 (en) 2002-08-17 2002-08-17 Inhalable medicament for treating inflammatory or obstructive respiratory diseases, containing synergistic combination of tropane derivative anticholinergic agent, corticosteroid and beta-mimetic agent
PCT/EP2003/008222 WO2004022058A1 (en) 2002-08-17 2003-07-25 Inhalation medicaments containing a novel anticholinesterase drug in conjunction with corticosteroids and betamimetic drugs

Publications (1)

Publication Number Publication Date
DK1530471T3 true DK1530471T3 (en) 2007-10-22

Family

ID=30775387

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03793643T DK1530471T3 (en) 2002-08-17 2003-07-25 Medicines for inhalation containing a new anticholinergic in combination with corticosteroids and beta-mimetics

Country Status (21)

Country Link
EP (2) EP1530471B1 (en)
JP (1) JP2006501253A (en)
KR (1) KR101083977B1 (en)
CN (1) CN1688308A (en)
AT (1) ATE366574T1 (en)
AU (1) AU2003255289B2 (en)
BR (1) BR0313526A (en)
CA (1) CA2495454C (en)
CO (1) CO5540380A2 (en)
CY (1) CY1107742T1 (en)
DE (2) DE10237739A1 (en)
DK (1) DK1530471T3 (en)
ES (1) ES2290549T3 (en)
IL (1) IL166891A (en)
MX (1) MXPA05001823A (en)
NZ (1) NZ538834A (en)
PL (1) PL212070B1 (en)
PT (1) PT1530471E (en)
RU (1) RU2332217C2 (en)
WO (1) WO2004022058A1 (en)
ZA (1) ZA200500019B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002012265A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY!-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT
SI1383786T1 (en) 2001-04-30 2009-02-28 Glaxo Group Ltd Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US7745621B2 (en) 2004-05-14 2010-06-29 Boehringer Ingelheim International Gmbh Long acting bronchodilators for the treatment of respiratory diseases
DE102004024453A1 (en) * 2004-05-14 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting bronchodilators for the treatment of respiratory diseases
US20060034776A1 (en) * 2004-08-10 2006-02-16 Boehringer Ingelheim International Gmbh Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics
DE102004056579A1 (en) * 2004-11-23 2006-05-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhaled drugs containing a new anticholinergic, salmeterol and a steroid
DE102004056578A1 (en) * 2004-11-23 2006-05-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhaled drugs containing a new anticholinergic, formoterol and a steroid
CN101119706B (en) 2005-02-25 2013-04-17 奇斯药制品公司 Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a chelating agent
JP2008534611A (en) * 2005-03-30 2008-08-28 シェーリング コーポレイション Drugs and methods combining anticholinergics, corticosteroids and long acting beta agonists
WO2006114379A1 (en) * 2005-04-23 2006-11-02 Boehringer Ingelheim International Gmbh Combination of medicaments to be inhaled, containing a betamimetic agent and a steroid in addition to an anticholinergic agent
CA2619402C (en) 2005-08-15 2015-02-03 Boehringer Ingelheim International Gmbh Method for producing betamimetics
WO2009052624A1 (en) * 2007-10-25 2009-04-30 Merck Frosst Canada Ltd. Combination therapy
LT2435025T (en) 2009-05-29 2016-09-26 Pearl Therapeutics, Inc. Respiratory delivery of active agents
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
RU2479304C1 (en) * 2012-05-29 2013-04-20 Шолекс Девелопмент Гмбх, Stable solution of fenoterol hydrobromide
RU2504382C1 (en) * 2012-06-13 2014-01-20 Шолекс Девелопмент Гмбх Inhalation preparation for treating bronchail asthma and chronic obstructive pulmonary disease and method for preparing it
ES2693779T3 (en) 2012-12-21 2018-12-13 Boehringer Ingelheim Vetmedica Gmbh Ciclesonide for the treatment of respiratory diseases in horses
WO2014096116A1 (en) 2012-12-21 2014-06-26 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical formulation comprising ciclesonide
JP6454323B2 (en) 2013-03-15 2019-01-16 パール セラピューティクス，インコーポレイテッド Method and system for conditioning particulate crystalline materials
WO2015065220A1 (en) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Inhaled drug for the treatment of bronchial asthma and chronic obstructive pulmonary disease and method for producing same
WO2015065223A1 (en) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Stable solution of fenoterol hydrobromide
HUE051527T2 (en) * 2014-06-18 2021-03-01 Boehringer Ingelheim Vetmedica Gmbh Muscarinic antagonists and combinations thereof for the treatment of airway disease in horses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003935D0 (en) * 2000-02-08 2000-04-12 King S College London Formulation for dry powder inhaler
DE10050994A1 (en) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma New diphenylalkanoic acid azabicyclooctane ester quaternary salts useful as anticholinergic agents, especially in treatment of asthma and chronic obstructive pulmonary disease
DE10130371A1 (en) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma New drug compositions based on anticholinergics, corticosteroids and betamimetics

Also Published As

Publication number Publication date
MXPA05001823A (en) 2005-04-19
NZ538834A (en) 2007-10-26
KR20050051644A (en) 2005-06-01
ATE366574T1 (en) 2007-08-15
DE50307659D1 (en) 2007-08-23
RU2005107475A (en) 2006-04-10
CY1107742T1 (en) 2013-04-18
CA2495454C (en) 2011-09-06
EP1785136A3 (en) 2009-04-22
PL212070B1 (en) 2012-08-31
CA2495454A1 (en) 2004-03-18
EP1530471A1 (en) 2005-05-18
ZA200500019B (en) 2006-07-26
IL166891A (en) 2010-04-15
PT1530471E (en) 2007-07-26
WO2004022058A1 (en) 2004-03-18
CO5540380A2 (en) 2005-07-29
KR101083977B1 (en) 2011-11-22
ES2290549T3 (en) 2008-02-16
PL375233A1 (en) 2005-11-28
CN1688308A (en) 2005-10-26
EP1530471B1 (en) 2007-07-11
EP1785136A2 (en) 2007-05-16
BR0313526A (en) 2005-06-28
JP2006501253A (en) 2006-01-12
AU2003255289B2 (en) 2009-08-20
DE10237739A1 (en) 2004-02-26
AU2003255289A1 (en) 2004-03-29
RU2332217C2 (en) 2008-08-27

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