DK1523572T3 - Pathogenicity determinants that can be used as targets for developmental methods for the prevention and control of bacterial infections and / or systemic dissemination - Google Patents

Pathogenicity determinants that can be used as targets for developmental methods for the prevention and control of bacterial infections and / or systemic dissemination

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Publication number
DK1523572T3
DK1523572T3 DK03762684T DK03762684T DK1523572T3 DK 1523572 T3 DK1523572 T3 DK 1523572T3 DK 03762684 T DK03762684 T DK 03762684T DK 03762684 T DK03762684 T DK 03762684T DK 1523572 T3 DK1523572 T3 DK 1523572T3
Authority
DK
Denmark
Prior art keywords
targets
prevention
control
bacterial infections
serum
Prior art date
Application number
DK03762684T
Other languages
Danish (da)
Inventor
Sonia Escaich
Original Assignee
Mutabilis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mutabilis filed Critical Mutabilis
Application granted granted Critical
Publication of DK1523572T3 publication Critical patent/DK1523572T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising:—using a strain of the pathogenic microorganism,—generating mutants for inactivation in the genes encoding these factors,—determining the virulence of these mutants on an experimental model of infection, and their effect on enteric colonization in an axenic mouse model, and—selecting the bacterial genes essential for resistance to serum in vitro, and essential, in the host, for dissemination in the serum. Application to the screening of compounds which inhibit the products of the genes identified, and to the inhibition in vitro of the proliferation of a pathogenic microorganism in serum.
DK03762684T 2002-07-09 2003-07-09 Pathogenicity determinants that can be used as targets for developmental methods for the prevention and control of bacterial infections and / or systemic dissemination DK1523572T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208636A FR2842210B1 (en) 2002-07-09 2002-07-09 PATHOGENICITY DETERMINANTS FOR USE AS TARGETS FOR PREPARING AND CONTROLLING BACTERIAL INFECTIONS AND / OR SYSTEMIC DISSEMINATION
PCT/EP2003/008209 WO2004005535A2 (en) 2002-07-09 2003-07-09 Pathogenicity proteins which can be used as targets for developing means for preventing and controlling bacterial infections

Publications (1)

Publication Number Publication Date
DK1523572T3 true DK1523572T3 (en) 2008-09-08

Family

ID=29763685

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03762684T DK1523572T3 (en) 2002-07-09 2003-07-09 Pathogenicity determinants that can be used as targets for developmental methods for the prevention and control of bacterial infections and / or systemic dissemination

Country Status (12)

Country Link
US (3) US20060003393A1 (en)
EP (1) EP1523572B1 (en)
JP (1) JP2006515155A (en)
AT (1) ATE394503T1 (en)
AU (2) AU2003266246A1 (en)
CA (1) CA2491847A1 (en)
DE (1) DE60320797D1 (en)
DK (1) DK1523572T3 (en)
ES (1) ES2306891T3 (en)
FR (1) FR2842210B1 (en)
HK (1) HK1078902A1 (en)
WO (1) WO2004005535A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842210B1 (en) * 2002-07-09 2012-12-14 Mutabilis PATHOGENICITY DETERMINANTS FOR USE AS TARGETS FOR PREPARING AND CONTROLLING BACTERIAL INFECTIONS AND / OR SYSTEMIC DISSEMINATION
WO2004050846A2 (en) * 2002-12-02 2004-06-17 Biosynexus Incorporated Wall teichoic acid as a target for anti-staphylococcal therapies and vaccines
HUE027400T2 (en) 2005-02-18 2016-10-28 Glaxosmithkline Biologicals Sa Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli
ES2385045T3 (en) 2005-02-18 2012-07-17 Novartis Vaccines And Diagnostics, Inc. Urotogenic Escherichia coli immunogens
EP1973467B1 (en) * 2006-01-20 2013-10-16 The General Hospital Corporation Systems and process for providing speckle reduction using a wave front modulation for optical coherence tomography
EP2586790A3 (en) 2006-08-16 2013-08-14 Novartis AG Immunogens from uropathogenic Escherichia coli
SG178035A1 (en) 2009-07-16 2012-03-29 Novartis Ag Detoxified escherichia coli immunogens
US20190161785A1 (en) * 2016-04-25 2019-05-30 Aperture Bio, LLC Systems, Devices and Methods for Sequential Analysis of Complex Matrix Samples for High Confidence Bacterial Detection and Drug Susceptibility Prediction Using a Flow Cytometer
JP7515092B2 (en) * 2017-10-18 2024-07-12 北海道公立大学法人 札幌医科大学 Methods for screening antibacterial agents
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN115725607B (en) * 2022-07-14 2023-11-28 山东第一医科大学附属省立医院(山东省立医院) Pathogenic target gene of nocardia melitensis and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020121A (en) * 1995-09-29 2000-02-01 Microcide Pharmaceuticals, Inc. Inhibitors of regulatory pathways
CA2330544A1 (en) * 1998-06-12 1999-12-23 University Of Guelph A novel gene and method of treating a gram negative bacterial infection
DE69937965T2 (en) * 1998-11-09 2009-01-08 Microscience Ltd., Wokingham Virulence genes and proteins and their use
JP2002535007A (en) * 1999-01-27 2002-10-22 エリトラ ファーマシューティカルズ，インコーポレイテッド Genes identified as required for the growth of Escherichia coli
FR2842210B1 (en) * 2002-07-09 2012-12-14 Mutabilis PATHOGENICITY DETERMINANTS FOR USE AS TARGETS FOR PREPARING AND CONTROLLING BACTERIAL INFECTIONS AND / OR SYSTEMIC DISSEMINATION

Also Published As

Publication number Publication date
US20070111229A1 (en) 2007-05-17
US20110236886A1 (en) 2011-09-29
HK1078902A1 (en) 2006-03-24
AU2009201727A1 (en) 2009-05-21
ES2306891T3 (en) 2008-11-16
WO2004005535A3 (en) 2004-11-18
WO2004005535A2 (en) 2004-01-15
EP1523572B1 (en) 2008-05-07
FR2842210B1 (en) 2012-12-14
US20060003393A1 (en) 2006-01-05
EP1523572A2 (en) 2005-04-20
CA2491847A1 (en) 2004-01-15
ATE394503T1 (en) 2008-05-15
FR2842210A1 (en) 2004-01-16
AU2003266246A1 (en) 2004-01-23
DE60320797D1 (en) 2008-06-19
JP2006515155A (en) 2006-05-25

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